Abstract:
PURPOSE:The benefit of time-of-flight (TOF) information in PET oncology studies is well established, demonstrating improved signal-to-noise ratio and enhanced lesion detection. In cardiac PET studies, tracer distribution and study interpretation differ substantially from oncology PET, and the benefit of TOF is less established. We investigate the impact of TOF on reconstructed myocardial distribution in Rb PET perfusion studies of obese patients, for whom TOF would have most significant impact. METHODS:Cardiac Rb PET data of 13 obese patients (8 male, 5 female patients; weight, mean, 139 kg [range, 109-191 kg]; body mass index, mean, 49 kg/m [range, 36-76 kg/m]) were analyzed retrospectively. Images were reconstructed with and without TOF and with varying number of iterative updates (2-12 iterations). Convergence and clinical relevance of differences were assessed both visually and quantitatively (automated 17-segment scoring). An anthropomorphic torso phantom also was scanned in order to study how TOF affects reconstruction of a myocardial distribution. RESULTS:Time-of-flight imaging provided significant improvement in image quality and convergence rate compared with non-TOF imaging. Time-of-flight reconstruction typically required 2 to 4 iterations to converge versus 8 to 12 iterations for non-TOF reconstruction. Even at 12 iterations, non-TOF images occasionally had apparent differences in relative perfusion compared with TOF images that exceeded 10% and were considered likely to affect clinical interpretation. CONCLUSIONS:Time-of-flight reconstruction has a significant clinical impact on cardiac PET in obese patients. When interpreting cardiac studies from non-TOF-capable PET scanners, one must ensure to reconstruct images with sufficient iterations and to be aware of potential artifacts.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
DiFilippo FP,Brunken RCdoi
10.1097/RLU.0000000000001441subject
Has Abstractpub_date
2017-02-01 00:00:00pages
e103-e108issue
2eissn
0363-9762issn
1536-0229journal_volume
42pub_type
杂志文章abstract::We report the case of a 45-year-old woman diagnosed with non-Hodgkin lymphoma. Six months after completion of R-CHOP, she relapsed, and 2 cycles of R-ESHAP were given, with a view to allograft transplant. One month later, F-FDG PET/CT revealed disease progression. Biopsy of lymph nodes showed reactive changes, without...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001083
更新日期:2016-03-01 00:00:00
abstract::The normal appearance of a gastrointestinal bleeding study using labeled red blood cells has been discussed frequently, but the actual appearance is not well known. In this atlas article, the authors report on unusual findings in non-bleeding subjects and have tabulated the visualization of various structures. Vascula...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198903000-00013
更新日期:1989-03-01 00:00:00
abstract::Left ventricular internal cavity dimensions (LVID) were determined from radionuclide ventriculographic (RNVG) studies using a spatial calibration algorithm and visually defined edges and were compared to the results from two-dimensional echocardiography. Routine clinical cases were used with no additional views and no...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199108000-00011
更新日期:1991-08-01 00:00:00
abstract::We reported a 24-year-old woman who developed a movement disorder of mouth and limbs during systemic lupus erythematosus. Brain MRI did not find any abnormalities. Increased FDG uptake in basal ganglia was found using FDG PET/CT brain scan. The symptoms remitted after therapy and the activities of the original hyperme...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001450
更新日期:2017-01-01 00:00:00
abstract::A 66-year-old white man with amiodarone pneumonitis is presented. The diagnosis was made with the aid of Ga-67 imaging, which is a sensitive method of detecting amiodarone pulmonary toxicity in patients with symptomatic pulmonary infiltrates on chest radiographs. Ga-67 imaging is especially useful in distinguishing am...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198811000-00012
更新日期:1988-11-01 00:00:00
abstract::We report a bone scan finding of bilaterally and symmetrically increased uptake at the lateral orbital rims in a patient with disseminated Hodgkin's disease. Computerized axial tomography (CT) demonstrated lacrimal gland enlargement, presumably due to infiltration by Hodgkin's disease. Both the radionuclide bone scan ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198311000-00011
更新日期:1983-11-01 00:00:00
abstract::A case is presented in which bone imaging over a period of 1 year indicated continued and increased radionuclide uptake. In association with CT and magnetic resonance imaging studies it was determined that the continued increased activity was related to developing bone marrow metastases. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198908000-00009
更新日期:1989-08-01 00:00:00
abstract::A cavernous hemangioma of the liver presented as an area of increased activity on an isotope bone scan. A review of the literature fails to reveal any previous reports of this phenomenon. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198607000-00009
更新日期:1986-07-01 00:00:00
abstract::Four consecutive patients presented with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the conjunctiva. After the initial resection, long-term follow-up without additional therapy showed the clinical relapse. Fluorodeoxyglucose positron emission tomography fused with ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31823ea96d
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:FDG PET-CT plays a critical role in the management of head and neck cancer patients. After therapy, many patterns of altered physiologic FDG uptake have been recognized. In our institution, we noticed patterns of head and neck muscle uptake that were unique in the post-therapy scans of head and neck cancer p...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181e05d94
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the diagnostic capacity of F-18 fluorodeoxyglucose dual-time-point (DTP) positron emission tomography (PET)/computed tomography (CT) for intrathoracic lymph node (LN) metastases in patients with nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS:Thirty-four patients ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31819a1f3d
更新日期:2009-04-01 00:00:00
abstract::An 18-year-old woman presented to the emergency department for bloody stools. A CT scan of the abdomen ruled out intussusception. Meckel's scan was ordered to rule for Meckel's diverticulum before upper endoscopy and colonoscopy. After proper pretreatment with H2 blocker, Tc-pertechnetate Meckel's scan was performed. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003211
更新日期:2020-09-01 00:00:00
abstract::Molecular brain imaging I-FP-CIT SPECT is an important tool in evaluation of patients with parkinsonism. However, various neurodegenerative etiologies cannot be differentiated by I-FP-CIT SPECT alone. We present a case of progressive supranuclear palsy with abnormal I-FP-CIT SPECT and abnormal Tc-HMPAO SPECT depicted ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001400
更新日期:2016-12-01 00:00:00
abstract:AIMS:The aim of this study was to explore the utility of 18F-FDG PET/CT in the assessment of response to antitubercular treatment (ATT) and identification of treatment endpoint. PATIENTS AND METHODS:Forty patients (mean age, 35.3 years; 27 men) with clinically, radiologically, and histopathologically proven joint tube...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003518
更新日期:2021-01-28 00:00:00
abstract::Cerebral vasospasm after subarachnoid hemorrhage is very common, but it is not universally detectable by transcranial Doppler. SPECT imaging of regional cerebral blood flow with Tc-99m exametazime serves as a complementary test to transcranial Doppler in the evaluation of patients at high risk for vasospasm. The signi...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199704000-00006
更新日期:1997-04-01 00:00:00
abstract:PURPOSE:The present study aimed to determine the predictive value of the heart-liver uptake ratio (H/L ratio) of rectally administered (201)Tl scintigraphy for hepatic decompensation, which was conducted in 107 patients with cirrhosis. METHODS:We retrospectively assessed the predictive value of a noninvasive parameter...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31827087e3
更新日期:2013-03-01 00:00:00
abstract::Low back pain with radiation to lower limbs is due to nerve root impingement or involvement in most cases. F-FDG PET/CT has shown sacral nerve root involvement in several peripheral nerve pathologies, including neurolymphomatosis, peripheral nerve sheath tumor, and plexopathies. We present 2 cases of a low back pain w...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003021
更新日期:2020-06-01 00:00:00
abstract::Lipoid pneumonia is uncommon disease caused by presence of macroscopic fat in the lung parenchyma commonly originating from exogenous source secondary to aspiration or inhalation of animal fats or mineral or vegetable oils. Alternatively, it can be due to endogenous fat accumulated in the alveoli in the setting of chr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002299
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Medullary thyroid cancer (MTC) is a rare but potentially life-threatening disease with limited therapeutic options. As a neuroendocrine tumor, MTC expresses somatostatin receptors, and therefore, somatostatin-labeled radiopharmaceuticals could be used to treat patients with MTC. OBJECTIVE:The aims of this s...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/RLU.0000000000000628
更新日期:2015-02-01 00:00:00
abstract::ITP (idiopathic thrombocytopenic purpura) causes rapid sequestration and destruction of thrombocytes by the spleen, liver, bone marrow, and reticuloendothelial elements of other organs. The usefulness of multiple radionuclide functional imaging procedures in the management of a 34-year-old woman with chronic ITP, two ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199208000-00009
更新日期:1992-08-01 00:00:00
abstract::A 61-year-old woman diagnosed with a metastatic well-differentiated neuroendocrine tumor of the cecum was referred for radioisotope therapy. Although her metastatic neuroendocrine tumor was positive on both (123)I-MIBG and (111)In-octreotide, there was a left parotid mass that was octreotide avid but MIBG negative. Fu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000716
更新日期:2015-08-01 00:00:00
abstract::A 50-year-old man with recently diagnosed prostate cancer was referred for Ga-prostate-specific membrane antigen (PSMA) PET/CT with elevated prostate-specific antigen. PET/CT demonstrated increased PSMA uptake in an undisplaced transverse fracture of the L1 vertebral body. This case illustrates that PSMA uptake can oc...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001599
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:A 68-year-old man with metastatic follicular thyroid carcinoma had T3 hyperthyroidism. MATERIAL AND METHODS:A bone scan showed intense uptake in the thyroid and multiple areas of increased uptake in the skeleton. Hyperthyroidism persisted after total thyroidectomy. Treatment with I-131 induced a transient stat...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200502000-00001
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to evaluate whether computed tomography based-attenuation correction (CT-AC) provides any advantage over non-attenuation-corrected (NAC) images for qualitative and quantitative analysis of single photon emission tomography (SPECT) myocardial perfusion imaging (MPI). METHODS:W...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31823ea16b
更新日期:2012-04-01 00:00:00
abstract::SPECT imaging with I-123 IMP or Tc-99m HMPAO was performed in two patients with Creutzfeldt-Jakob disease to evaluate abnormalities in brain perfusion. In the first patient, there was decreased perfusion of the left frontal, parietal, and temporal lobes. CT and MRI were negative. In the second patient, there was patch...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199603000-00010
更新日期:1996-03-01 00:00:00
abstract::The aim of this study was to make a comparison between the uptake of Tc-99m MIBI and Tl-201 in evaluation of musculoskeletal lesions. Fourteen cases were studied. Each study consisted of a Tl-201 study followed by a Tc-99m MIBI scan. In addition, a whole-body bone scan was performed in each patient to visualize bone m...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199602000-00008
更新日期:1996-02-01 00:00:00
abstract::Chronic sclerosing sialadenitis is a benign inflammatory condition that most commonly affects the submandibular gland in elderly individuals. It is currently known to belong to the spectrum of IgG4-related systemic diseases, which is reflected by systemic involvement on F-FDG PET/CT images. We presented a case of a 73...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001482
更新日期:2017-02-01 00:00:00
abstract::Hepatic hydrothorax is a complication in approximately 5% of patients with cirrhosis. Ascites is almost always present and helps to suggest the correct diagnosis. However, when ascites is absent, radionuclide imaging has proven to be helpful in establishing that the pleural effusion originated from ascitic fluid. When...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198905000-00006
更新日期:1989-05-01 00:00:00
abstract::We present plain x-ray examination, bone scintigraphy, computed tomography, and magnetic resonance imaging of 2 patients diagnosed with prostate cancer who complained of hip pain. Bone scintigraphy was suggestive for metastases. Further radiologic investigation revealed benign etiologies for the hip pain; calcific ten...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3180a1acc3
更新日期:2007-08-01 00:00:00
abstract::Autologous bone marrow transplantation is being offered with increasing frequency as a therapeutic alternative to patients who have failed conventional chemotherapy. Presently, these patients are being evaluated with a variety of imaging modalities, including planar radiographs, nuclear bone and bone marrow scans, and...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198901000-00009
更新日期:1989-01-01 00:00:00