Abstract:
:Tc-99m HMPAO, a lipophilic radiotracer used as a brain SPECT imaging agent in the diagnosis of strokes and dementias, is normally localized in the brain and the heart and is excreted through the kidneys (50%) and the hepatobiliary system (14% to 30%). There is no pulmonary localization except in the lungs of smokers. To evaluate pulmonary localization of Tc-99m HMPAO in relation to smoking, 23 patients (aged 27 to 76 years) who were referred for brain imaging studies for strokes or dementias also underwent lung imaging studies immediately following the brain imaging. Anterior and/or posterior lung images were obtained 30 to 45 minutes after IV injection of 15 mCi Tc-99m HMPAO. Diffuse pulmonary uptake was graded semiquantitatively: 3+, pulmonary uptake is equal to or higher than hepatic uptake; 2+, pulmonary uptake is less than hepatic uptake but higher than cardiac uptake; 1+, pulmonary uptake is equal to cardiac uptake; 0, pulmonary uptake is less than cardiac uptake. Each patient's smoking history, including duration and daily consumption, was recorded. Four patients' lung images showed 3+ lung uptake; 6 patients, 2+; 1 patient, 1+; and 12 patients, 0 uptake. Eleven patients with lung uptakes of 3+ to 1+ had a history of cigarette smoking. Twelve patients with lung uptake less than cardiac uptake had no smoking history. Pulmonary distribution of Tc-99m HMPAO is usually negligible in the normal lung. Our results indicate that lung uptake correlates significantly (chi-square = 23, d.f. = 1, P = 0.0001) with smoking history.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Shih WJ,Gruenwald F,Biersack HJ,Berger R,Brandenburg S,Coupal J,Ryo UYdoi
10.1097/00003072-199109000-00012subject
Has Abstractpub_date
1991-09-01 00:00:00pages
668-72issue
9eissn
0363-9762issn
1536-0229journal_volume
16pub_type
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199101000-00005
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journal_title:Clinical nuclear medicine
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pub_type: 杂志文章
doi:10.1097/RLU.0b013e318263907b
更新日期:2012-10-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000245
更新日期:2013-12-01 00:00:00
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journal_title:Clinical nuclear medicine
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更新日期:1992-01-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00003072-198608000-00022
更新日期:1986-08-01 00:00:00
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journal_title:Clinical nuclear medicine
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更新日期:1997-05-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198803000-00005
更新日期:1988-03-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000079396.43884.f1
更新日期:2003-08-01 00:00:00
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更新日期:2011-02-01 00:00:00
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更新日期:1986-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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更新日期:2014-02-01 00:00:00