Technetium-99m red blood cell labeling in patients treated with doxorubicin.

Abstract:

:Radionuclide angiography is useful in monitoring cardiotoxicity of doxorubicin, but in vivo RBC labeling in these patients is believed to be poorer than that in general patients. The left ventricle-to-background activity ratio (R) was not significantly lower in patients treated with doxorubicin (3.24 +/- 1.15, N = 13) than in control patients (3.89 +/- 1.60, N = 14). With both modified in vivo and in vitro labeling, R was significantly improved in patients treated with doxorubicin (4.37 +/- 0.91, N = 8, and 4.37 +/- 1.22, N = 13, respectively). However, with the modified in vivo method, labeling efficiency remained a function of hematocrit, whereas the in vitro method removed this dependency. Both modified in vivo and in vitro labeling result in improved image quality over in vivo labeling in patients treated with doxorubicin, and the choice of method can be based on other factors.

journal_name

Clin Nucl Med

authors

Ballinger JR,Gerson B,Gulenchyn KY,Ruddy TD,Davies RA

doi

10.1097/00003072-198803000-00005

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

169-70

issue

3

eissn

0363-9762

issn

1536-0229

journal_volume

13

pub_type

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