Assessment of cerebral hemodynamics to acetazolamide using brain perfusion SPECT in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Abstract:

:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy caused by mutations in the Notch3 gene located on chromosome 19, leading to 4 cardinal features with aura, cerebrovascular ischemic events, mood disturbances, and dementia. Acetazolamide (ACZ) has been promoted as a drug to determine cerebral hemodynamics, including cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in patients with cerebrovascular disease. In CADASIL patients with small-vessel disease, ACZ may be possible to increase CBF. We present that reduced CBF was dramatically improved after administration of ACZ on Tc-99m ECD brain perfusion SPECT in a CADASIL patient.

journal_name

Clin Nucl Med

authors

Park SA,Yang CY,Choi SS,Kim WH

doi

10.1097/RLU.0b013e3182073c0f

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

158-9

issue

2

eissn

0363-9762

issn

1536-0229

pii

00003072-201102000-00024

journal_volume

36

pub_type

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