Is PET/CT Necessary in the Management of Early Breast Cancer?

Abstract:

PURPOSE:Advanced imaging methods in early breast cancers are not recommended before surgery. In contrast to the accepted guidelines, some recent studies have shown some benefits with the use of PET/CT in early-stage breast cancer. In this study, we aimed to document the efficacy of PET/CT in detection of distant metastasis as well as other primary cancers. PATIENTS AND METHODS:In this retrospective study, we reviewed the records of all women patients diagnosed with early breast cancer between March 2012 and December 2014. Besides demographics, we recorded the clinical TNM stage, histology of the tumor, and hormone receptor status. As PET/CT imaging is a routine procedure in our center for early breast cancer, tumor size, lymph node status, distant metastasis, and possible other primary malignancies detected by PET/CT were also recorded. RESULTS:Of the 419 women included in the study, 24.8% were clinically staged as stage I while the rest were stage II. Distant metastases were detected in 42 patients (10%). The yield of PET/CT in detecting metastasis was significant in stage II patients compared with stage I patients (12.4% vs 2.9%). In subgroup analysis of stage II patients, the performance of PET/CT in detecting metastasis was still evident in stage IIA patients (9.5%). In logistic regression analysis of the significant and near-significant factors (as detected by univariate analysis) effecting PET/CT detected distant metastasis, only nodal status (P = 0.053) was found to be significant. CONCLUSIONS:We suggest the use of PET/CT in investigating metastasis in axilla positive and clinically stage II early breast cancer patients.

journal_name

Clin Nucl Med

authors

Nursal GN,Nursal TZ,Aytac HO,Hasbay B,Torun N,Reyhan M,Yapar AF

doi

10.1097/RLU.0000000000001165

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

362-5

issue

5

eissn

0363-9762

issn

1536-0229

journal_volume

41

pub_type

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