In-111 octreotide imaging in staging of small cell lung cancer.

Abstract:

BACKGROUND:Small cell lung cancer (SCLC) tumors have neuroendocrine features. In vitro and in vivo studies have demonstrated that 50%-75% of SCLC tumors express receptors for somatostatin. This might enable in vivo localization of the primary tumor and its metastases by using scintigraphy with a radiolabeled somatostatin analogue, such as octreotide. PURPOSE AND METHODS:The efficacy of scanning with In-111 labeled octreotide (octreotide scan) was studied in the staging of SCLC patients and compared with the results of conventional staging (liver ECHO, bone scintigraphy, MRI of the brain, spine, and pelvis). Imaging was performed in 29 patients with histologically confirmed SCLC at 4, 24, and 48 hours after intravenous injection of 185 MBq In-111 octreotide. RESULTS:In 24 of 29 patients, the primary tumor was visualized. In these 24 patients, 26 metastases were demonstrated with conventional staging, of which only nine were visualized with octreotide scan. Octreotide scans showed two metastases in the brain that were not visualized by MRI. In the other five patients, five metastases were demonstrated with conventional staging. Only two of these were detected with octreotide scan. However, octreotide scan did show a further metastasis in the brain that was not visualized by MR imaging. CONCLUSION:Octreotide imaging has a limited use in the detection of SCLC metastases compared to conventional staging. It might have some specific value in the detection of brain involvement in patients with limited disease.

journal_name

Clin Nucl Med

authors

Hochstenbag MM,Heidendal GA,Wouters EF,ten Velde GP

doi

10.1097/00003072-199712000-00001

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

811-6

issue

12

eissn

0363-9762

issn

1536-0229

journal_volume

22

pub_type

杂志文章
  • Blood volume determination, a nuclear medicine test in evolution.

    abstract::The method for determining blood volume has evolved substantially since first attempts were made in the latter part of the nineteenth century with the exsanguination of animals. The now accepted methods are based on indicator dilution methodologies. First attempts utilized inert dyes such as Evans Blue and Cardiogreen...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1097/RLU.0b013e318292f370

    authors: Margouleff D

    更新日期:2013-07-01 00:00:00

  • Growing hepatic cavernous hemangioma demonstrated by Tc-99m red blood cell scintigraphy.

    abstract::Hepatic cavernous hemangiomas rarely grow. Although a few cases have been reported in the literature, none used Tc-99m red blood cell scintigraphy. The authors describe such a case here. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-200007000-00003

    authors: Gorenberg M,Sopov W,Groshar D

    更新日期:2000-07-01 00:00:00

  • A Case of Nasal Merkel Cell Carcinoma Draining to a Buccinator Sentinel Lymph Node.

    abstract::A 73-year-old man diagnosed with Merkel cell carcinoma of the left nasal ala was referred for preoperative scintigraphic sentinel lymph node mapping. In three separate foci around the lesion, 0.2 mCi of Tc-sulfur colloid was intradermally administered. Planar images demonstrated accumulation of tracer midway between t...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001351

    authors: Bermo MS,Leung A,Behnia F

    更新日期:2016-11-01 00:00:00

  • Combined (11)C-methionine and 18F-FDG PET imaging in a case of cerebral sparganosis.

    abstract::A 35-year-old man presented with right lower extremity numbness and weakness. CT demonstrated an irregular left parietal hypoattenuation with a punctuate calcification. MRI revealed a T1 low signal and T2 high signal lesion with extensive surrounding edema. Gadolinium-enhanced MRI showed an irregular enhancing lesion....

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3182708352

    authors: Zeng T,Ji ZY,Shi SS

    更新日期:2012-12-01 00:00:00

  • Identification of intrathoracic hemorrhage with Tc-99m sulfur colloid.

    abstract::Tc-99m sulfur colloid has been shown to be accurate in the detection of intrapulmonary bleeding (1,2). The present example demonstrates the usefulness of Tc-99m sulfur colloid in identifying an unusual manifestation of intrathoracic hemorrhage. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198411000-00020

    authors: Sanchez FW,Reinig JW,Bailey GT,Gobien RP,Vujic I

    更新日期:1984-11-01 00:00:00

  • Diagnostic value of SPECT in a case of lower neck uptake on bone scan.

    abstract::Lower neck uptake in bone scan is hard to interpret because of superposition of several structures. Single photon emission computerized tomography can be beneficial, as illustrated in this patient with a laryngeal tumor. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198312000-00012

    authors: Mortelmans LA,DeRoo MJ

    更新日期:1983-12-01 00:00:00

  • Nivolumab-Induced Development of Pulmonary Sarcoidosis in Renal Cell Carcinoma.

    abstract::A 64-year-old woman with metastatic clear cell renal carcinoma who had been on nivolumab immunotherapy for 10 months was referred for a FDG PET scan to monitor disease progress. New bilateral mediastinal and hilar FDG-avid lymphadenopathy was noted. Pathology on subsequent mediastinal nodal biopsy showed well-formed e...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001758

    authors: Zhang M,Schembri G

    更新日期:2017-09-01 00:00:00

  • Resolution of Hypoxic Tissue in Cerebellar Hemispheres After Arterial Bypass Surgery in a Patient With Symptomatic Bilateral Vertebral Artery Occlusion: A 18F-FRP170 PET Study.

    abstract::A 48-year-old man experienced recurrent vertigo refractory to antiplatelet medications. Cerebral angiography showed occlusion of bilateral vertebral arteries with poor collateral circulation. PET using O2 gas showed reduced blood flow and metabolic rate of oxygen and elevated oxygen extraction fraction in bilateral ce...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002469

    authors: Oikawa K,Kobayashi M,Beppu T,Terasaki K,Ogasawara K

    更新日期:2019-04-01 00:00:00

  • Pigmented villonodular synovitis and giant cell tumor of the tendon sheath: scintigraphic findings in 10 cases.

    abstract::The purpose of this report was to determine the pattern of thallium (T1-201) uptake in pigmented villonodular synovitis (PVNS) and giant cell tumor of the tendon sheath (GCTTS) and to evaluate for features that might help to distinguish these lesions from malignant disease. Scintigraphic images from patients subsequen...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000093083.77866.5c

    authors: Mackie GC

    更新日期:2003-11-01 00:00:00

  • 99mTc-MDP SPECT-CT and Ultrasound in the Diagnosis and Staging of Thyroid Metastasis From Osteosarcoma.

    abstract::The classification of thyroid nodules in children is often difficult, especially in pretreated patients with metastatic disease. In osteosarcoma patients, Tc-MDP SPECT/CT is used for primary and follow-up staging. Bone and soft tissue metastases can be revealed because of Tc-MDP imaging of osteoid-producing metastases...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002004

    authors: Roll W,Weckesser M,Pöppelmann M,Schiborr M,Schäfers M,Rahbar K

    更新日期:2018-04-01 00:00:00

  • Transient left ventricular dilatation in the absence of epicardial disease on angiography.

    abstract::A 58-year-old woman with a previous anterior myocardial infarction, recurrent chest pain, transient adenosine-induced left ventricular dilatation but no apparent epicardial disease on angiography is presented. Transient ischemic dilatation during myocardial perfusion imaging, and the reported causes of transient left ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000127088.20310.d0

    authors: Choong KK,Russell PA

    更新日期:2004-06-01 00:00:00

  • Gamma probe-guided resection of a lymph node metastasis with I-123 in papillary thyroid carcinoma.

    abstract::The authors report the case of a 27-year-old woman with gamma probe-guided resection of a recurrent regional lymph node metastasis in papillary thyroid cancer. Reoperation is often impaired in cases with extensive scarring because of previous surgery, high-dose radioiodine therapy, and external irradiation. In this ca...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199709000-00002

    authors: Gallowitsch HJ,Fellinger J,Mikosch P,Kresnik E,Lind P

    更新日期:1997-09-01 00:00:00

  • Grossly abnormal liver-spleen scan in a patient with veno-occlusive disease of the liver that normalized completely on follow-up.

    abstract::A case of veno-occlusive disease of the liver of unknown etiology is reported. In the case, the gross abnormality of liver parenchyma, ascites, and colloid shift to spleen, bones, and lungs found on a Tc-99m SC liver-spleen scan, and confirmed on liver biopsy, resolved completely on follow-up. Histologic correlation a...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199307000-00011

    authors: Joshi MJ,Ford PV,Vogel JM,Lutrin CL

    更新日期:1993-07-01 00:00:00

  • Successful Repeated Peptide Receptor Radionuclide Therapies in Renal Neuroendocrine Tumor With Osseous Metastasis.

    abstract::Renal neuroendocrine tumor (NET) is an extremely rarely occurring disease. The sporadic reports in the literature are mostly case reports, or less commonly small studies. In cases of metastatic disease from renal NET, there are no established therapies. We are reporting our experience with a patient with extensive oss...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001386

    authors: Yordanova A,Mayer K,Essler M,Ahmadzadehfar H

    更新日期:2016-12-01 00:00:00

  • Diagnostic dilemmas in parathyroid scintigraphy.

    abstract:PURPOSE:Tc-99m MIBI scintigraphy can be useful for preoperative localization of parathyroid adenomas, despite its limited sensitivity. To refine interpretation, the authors conducted prospective reviews of the scintigraphic studies of patients with concomitant thyroid nodular disease and revised the false-negative and ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-200112000-00001

    authors: Krausz Y,Shiloni E,Bocher M,Agranovicz S,Manos B,Chisin R

    更新日期:2001-12-01 00:00:00

  • The Effect of Various β Values on Image Quality and Semiquantitative Measurements in 68Ga-RM2 and 68Ga-PSMA-11 PET/MRI Images Reconstructed With a Block Sequential Regularized Expectation Maximization Algorithm.

    abstract:PURPOSE:To compare the block sequential regularized expectation maximization (BSREM) algorithm with the ordered subsets expectation maximization (OSEM) algorithm and to evaluate how different penalty factors (b values) influence image quality and SUV measurements. METHODS:We analyzed data from 78 prostate cancer patie...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003075

    authors: Baratto L,Duan H,Ferri V,Khalighi M,Iagaru A

    更新日期:2020-07-01 00:00:00

  • Supine lung clearance of Tc-99m DTPA and HMPAO aerosols.

    abstract::The speed of Tc-99m DTPA/HMPAO radioaerosol clearance from the lungs that is represented as a slope from lungs to blood was measured in 23 male normal controls using commercial lung radioaerosol delivery units in the supine position in order to avoid the influences of gravity. The right lung was selected and three reg...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199507000-00016

    authors: Kao CH,Lin HT,Yu SL,Wang SJ,Yeh SH

    更新日期:1995-07-01 00:00:00

  • Pulmonary Perfusion Changes Following Single-Lung Transplantation.

    abstract::Following single-lung transplantation (SLT), there is significant redistribution of flow preferentially to the transplanted lung. Altered lung perfusion leads to unusual results when performing pulmonary scintigraphy, which could result in interpretation errors. We present pulmonary scintigraphy images from a 67-year-...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001581

    authors: Tsai J,Rowe SP,Solnes LB,Salas Fragomeni RA

    更新日期:2017-05-01 00:00:00

  • Gallium-67 and pulmonary complications of amiodarone.

    abstract::A 66-year-old white man with amiodarone pneumonitis is presented. The diagnosis was made with the aid of Ga-67 imaging, which is a sensitive method of detecting amiodarone pulmonary toxicity in patients with symptomatic pulmonary infiltrates on chest radiographs. Ga-67 imaging is especially useful in distinguishing am...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198811000-00012

    authors: Lecklitner ML,Johnson DR,Hughes JJ

    更新日期:1988-11-01 00:00:00

  • Splenic Hemangioma as a Potential Pitfall on PSMA-Targeted 18F-DCFPyL PET/CT.

    abstract::A 69-year-old man with biochemical recurrence after radical prostatectomy underwent 6 months of androgen deprivation therapy. Upon discontinuation of androgen deprivation therapy, serum prostate-specific antigen rose again to 0.69 ng/mL, and F-DCFPyL PET/CT was performed to identify the site of recurrence. However, on...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002428

    authors: Chaussé G,Laufer J,Abikhzer G,Probst S

    更新日期:2019-03-01 00:00:00

  • 201Tl Myocardial Perfusion Imaging in a Case of Double-Inlet Left Ventricle: Correlate Anatomic Information of SPECT With MRI.

    abstract::Double-inlet left ventricle (DILV) is a congenital heart disease that only a single left ventricle and a rudimentary right ventricle are developed. Because of lack of anatomic landmark, interpretation of Tl myocardial perfusion imaging in DILV is essentially challenging for unusual anomaly. We report the case of a 44-...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001961

    authors: Chang MC,Lee ML,Yang PT

    更新日期:2018-03-01 00:00:00

  • Focal spinal abnormalities on bone scans in ankylosing spondylitis: a clue to the presence of fracture or pseudarthrosis.

    abstract::Four cases of ankylosing spondylitis are presented in which radionuclide bone studies indicated focal abnormalities of the spine. In three patients, the area of abnormal nuclide uptake corresponded to a site of pseudarthrosis, and in the fourth an acute fracture was present. As such focal lesions on bone scans are unu...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198105000-00007

    authors: Resnick D,Williamson S,Alazraki N

    更新日期:1981-05-01 00:00:00

  • Imaging of irradiated liver with Tc-99m-sulfur colloid and Tc-99m-IDA.

    abstract::In three cases, irradiated regions of liver failed to concentrate Tc-99m-sulfur colloid. In two of these three, imaging with Tc-99m-acetanilide iminodiacetic acid (IDA) agents within five days showed near normal hepatic uptake of this hepatobiliary imaging agent. The hepatic parenchymal cells may be imaged with Tc-99m...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198109000-00003

    authors: Gelfand MJ,Saha S,Aron BS

    更新日期:1981-09-01 00:00:00

  • Tumor detection with 67Ga-citrate: a literature survey (1970--1978).

    abstract::Gallium scan detection of various neoplasms is tabulated by anatomic and histologic categories. The experience with many neoplasms is sufficient to accurately predict the likelihood of detection with gallium. This tabulation helps to point out other areas where the cumulative experience is insufficient to accurately p...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00003072-197812000-00002

    authors: Teates CD,Bray ST,Williamson BR

    更新日期:1978-12-01 00:00:00

  • FDG PET/CT in detection of adrenal metastasis in patients with renal cell carcinoma.

    abstract:AIM:Adrenal metastasis in renal cell carcinoma (RCC) is uncommon. The present study was aimed to evaluate the role of fluoro-deoxy-glucose positron emission tomography (FDG PET)/computed tomography (CT) in the detection of adrenal metastasis in patients with RCC. MATERIALS AND METHODS:A total of 9 FDG PET/CT scans wer...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3182175435

    authors: Kumar R,Shamim SA,Shandal V,Sharma P,Gadodia A,Malhotra A

    更新日期:2011-07-01 00:00:00

  • Hematopoietically Active Adrenal Myelolipoma Mimicking Breast Cancer Metastasis.

    abstract::A 66-year old woman had a left breast mass. Biopsy showed invasive ductal carcinoma. A PET/CT scan demonstrated hypermetabolism in the left breast and atypical heterogeneously increased uptake throughout the skeleton as well as a minimally FDG-avid right adrenal myelolipoma. PET/CT 4 months later after 6 cycles of neo...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002144

    authors: Manov JJ,Diaz-Bode A,Kuker R

    更新日期:2018-08-01 00:00:00

  • Myocardial infarct imaging with 99mTc-pyrophosphate and 99mTc-methylene diphosphonate: lack of correlation.

    abstract::A prospective study of eight patients with recent transmural myocardial infarction was performed using 99mTc-Sn-pyrophosphate and 99mTc-Sn-methylene diphosphonate in each patient. All pyrophosphate scans were strongly positive whereas the diphosphonate scan was strongly positive in only one case. We conclude that 99mT...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-197903000-00001

    authors: Makler PT Jr,Lederman S,Charkes ND,Malmud LS,Warner H,Reilley JJ

    更新日期:1979-03-01 00:00:00

  • "Cold" Spondylodiscitis on 18F-FDG PET/CT in a Patient With Myelofibrosis.

    abstract::A 74-year-old man was evaluated by bone scan for possible rib fractures, which revealed a diffuse skeletal uptake secondary to myelofibrosis and focal midthoracic uptake. Chest CT and F-FDG PET/CT demonstrated pathological vertebral fractures of the midthoracic spine, which appeared as a cold defect on PET comparing t...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001066

    authors: Rousseau E,Keu KV

    更新日期:2016-03-01 00:00:00

  • Impact of FDG PET/CT on delineation of the gross tumor volume for radiation planning in non-small-cell lung cancer.

    abstract:PURPOSE:Computed tomography (CT) remains the gold standard for delineation of tumor volumes for radiotherapy (RT) planning. However, positron emission tomography (PET) overlay on CT has shown to impact the gross target volume (GTV), decrease intraobserver variability, and change the treatment planning in a significant ...

    journal_title:Clinical nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/RLU.0b013e3181d18eb0

    authors: Spratt DE,Diaz R,McElmurray J,Csiki I,Duggan D,Lu B,Delbeke D

    更新日期:2010-04-01 00:00:00

  • Nonvisualization of the liver by indium-111 oxine labeled leukocytes in alcoholic liver disease.

    abstract::The liver was not visualized by In-111 WBC scan in a patient with alcoholic liver disease. The liver was visualized on repeat scan when liver function had improved. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198602000-00002

    authors: Segall GM,Goodwin DA

    更新日期:1986-02-01 00:00:00