Supine lung clearance of Tc-99m DTPA and HMPAO aerosols.

Abstract:

:The speed of Tc-99m DTPA/HMPAO radioaerosol clearance from the lungs that is represented as a slope from lungs to blood was measured in 23 male normal controls using commercial lung radioaerosol delivery units in the supine position in order to avoid the influences of gravity. The right lung was selected and three regions of interest were created for equal subdivisions of the upper, middle, and lower third. The results show that the clearance of Tc-99m DTPA/HMPAO aerosols in the upper lung is slowest. The differences between upper and lower lungs for Tc-99m DTPA/HMPAO aerosol clearances are significant. The clearance of Tc-99m DTPA aerosols was significantly faster than those of Tc-99m HMPAO in any region. The authors conclude that, although the effect of gravity disappears in the supine position in our study, the differences of aerosol clearance in different regions are still significant. Lipophilic Tc-99m HMPAO aerosols were slower than those of hydrophilic Tc-99m DTPA, which suggests there are at least two different mechanisms.

journal_name

Clin Nucl Med

authors

Kao CH,Lin HT,Yu SL,Wang SJ,Yeh SH

doi

10.1097/00003072-199507000-00016

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

633-5

issue

7

eissn

0363-9762

issn

1536-0229

journal_volume

20

pub_type

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