99mTc DPD is the preferential bone tracer for diagnosis of cardiac transthyretin amyloidosis.

Abstract:

:We emphasize the role of Tc-99m-3,3-diphosphono-1,2-propanodicarboxylicacid (DPD) scintigraphy as a noninvasive tool to distinguish transthyretin (TTR)-related cardiac amyloidosis from other forms of cardiac amyloidosis. We report the case of a 76-year-old male patient suffering from congestive heart failure in whom imaging investigation by DPD scintigraphy showed a strong cardiac uptake highly suggestive of TTR amyloidosis variant. TTR-related cardiac amyloidosis was confirmed on myocardial biopsies by immunohistochemistry analysis. This case supports the growing interest in DPD scintigraphy for typing cardiac amyloidosis and for its contribution in the place of invasive myocardial biopsy.

journal_name

Clin Nucl Med

authors

Rossi P,Tessonnier L,Frances Y,Mundler O,Granel B

doi

10.1097/RLU.0b013e318248512c

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

e209-10

issue

8

eissn

0363-9762

issn

1536-0229

pii

00003072-201208000-00036

journal_volume

37

pub_type

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