Abstract:
OBJECTIVES:Anorexia nervosa (AN), a disorder of unknown etiology, has the highest mortality rate of any psychiatric disorder. Drawing the brain metabolic pattern of AN may help to target the core biological and psychological features of the disorder and to perfect the diagnosis and recovery criteria. In this study, we used 18F-FDG PET to show brain metabolic network for AN. METHODS:Glucose metabolism in 6 AN patients and 12 age-matched healthy controls was studied using 18F-FDG PET. SPM2 was used to compare brain metabolism in AN patients with that in healthy controls. Four of 6 AN patients took deep brain stimulation (DBS) targeted in nucleus accumbens (NAcc). About 3 to 6 months after the surgery, the 4 AN patients took another 18F-FDG PET scan to assess the change in brain glucose metabolism. RESULTS:The SPM (statistical parametric mapping ) analysis showed hypermetabolism in the frontal lobe (bilateral, BA10, BA11, BA47), the limbic lobe (bilateral, hippocampus, and amygdala), lentiform nucleus (bilateral), left insula (BA13), and left subcallosal gyrus (BA25). It also showed hypometabolism in the parietal lobe (bilateral, BA7, BA40). The hypermetabolism in frontal lobe, hippocampus, and lentiform nucleus decreased after NAcc-DBS. CONCLUSIONS:The changes in brain glucose metabolism illustrated the brain metabolic pattern in AN patients. Furthermore, the pattern can be modulated by NAcc-DBS, which confirmed specificity of the pattern. The regions with altered metabolism could interconnect to form a network and integrate information related to appetite. Our study may provide information for targeting the potential candidate brain regions for understanding the pathophysiology of AN and assessing the effects of existing and future treatment approaches.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Zhang HW,Li DY,Zhao J,Guan YH,Sun BM,Zuo CTdoi
10.1097/RLU.0000000000000261subject
Has Abstractpub_date
2013-12-01 00:00:00pages
943-8issue
12eissn
0363-9762issn
1536-0229pii
00003072-201312000-00004journal_volume
38pub_type
杂志文章abstract::Determination of left ventricular function with tomographic radionuclide angiocardiography using a seven-pinhole collimator was evaluated by comparing results of invasive contrast studies and planar multigated blood pool imaging to the tomographic study of 25 patients. LAO, seven-pinhole multigated blood pool acquisit...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198204000-00002
更新日期:1982-04-01 00:00:00
abstract::Tl-201 and Tc-99m subtraction imaging is a well-established technique for detecting parathyroid adenomas. We report a case of a brown tumor of the upper sternum mimicking an ectopic mediastinal parathyroid adenoma on Tl-201 and Tc-99m subtraction imaging in a patient with hyperparathyroidism. This brown tumor showed T...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200001000-00010
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abstract::A 31-year-old woman underwent Tc-labeled UBI scanning for diagnosis of possible prosthesis infection evaluation in our department. The scan showed an area of increased tracer uptake in the mid-lateral portion of the left thigh. This was proven to be due to a retained surgical gauze in her left thigh. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001389
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:The need for a low-iodine diet (LID) to maximize the results of radioactive iodine uptake (RAIU), nuclear medicine thyroid scintigraphy, and ultimately treatment of thyroid cancer patients is widely accepted. Failure to follow the prescribed diet can alter RAIU results, thyroid scan findings, and poststudy mana...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181662f9e
更新日期:2008-04-01 00:00:00
abstract::We report two cases of supra-scrotal vasitis incidentally detected in patients who had undergone mesh herniorrhaphy. PET/CT in patients undergoing lymphoma work-up and health check-up revealed hypermetabolic dilatation of vas deferens in the external iliac area. There were no symptoms, and blood test results did not i...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
abstract::Bone scintigraphy is sensitive for detecting bone metastases in patients with malignancies. However, it is often difficult to differentiate bone metastases from other nonmalignant lesions. We encountered a patient with a history of breast cancer who showed substantial elevation of tumor markers 4 years after surgery. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000170058.73956.82
更新日期:2005-08-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
abstract::Avascular necrosis (AVN) of the femoral head is a devastating disease in young adults. Magnetic resonance imaging is considered the most sensitive and specific technique in the diagnosis of this condition. The authors present an interesting image of bilateral AVN of the femoral heads diagnosed on F-fluoride positron e...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318266d036
更新日期:2013-06-01 00:00:00
abstract::Three-phase bone scintigraphy is sometimes of great value in the detection of uncharacteristic metastases and assists the management of patients in terms of primary focus detection. While evaluating the skeletal system with whole-body bone scintigraphy, other system pathologies may also be detected incidentally. In th...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002260
更新日期:2018-11-01 00:00:00
abstract::The images of a patient with acromegaly, who previously underwent operation for pituitary adenoma, were obtained. The MRI scan showed a mass in the right cavernous sinus, with biochemical test results positive for the presence of a hormonally active adenoma. The patient was scheduled for CyberKnife radiotherapy. Radio...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000535
更新日期:2014-12-01 00:00:00
abstract::A case that demonstrates the relationship between malignancy and pulmonary throboembolic disease is presented. Pulmonary embolism, which was diagnosed on a ventilation-perfusion lung scan, initiated a search for the etiology of this condition. Normal examination of the deep venous system of the legs prompted further i...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199011000-00016
更新日期:1990-11-01 00:00:00
abstract::During a Tc-99m DTPA study, activity simultaneously appeared in the kidneys and in a right lateral band. This was due to an inflammatory tract and not to urinary drainage. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198601000-00020
更新日期:1986-01-01 00:00:00
abstract::Tc-99m isonitrile uptake in a metastatic brain tumor is demonstrated using planar and SPECT imaging. Comparison with Tc-99m DTPA shows a different distribution pattern and uptake intensity, suggesting a different mechanism for both tracers. It is possible that Tc-99m CPI could reflect metabolic activity of the tumor c...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199302000-00013
更新日期:1993-02-01 00:00:00
abstract::A case of focal decreased skeletal uptake with In-111 labeled white blood cells representing Paget's disease is reported. Although uncommon, other causes for skeletal photon deficient areas using In-111 white blood cells have been described. To the authors' knowledge, this finding representing Paget's disease has not ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198710000-00004
更新日期:1987-10-01 00:00:00
abstract::Molecular brain imaging I-FP-CIT SPECT is an important tool in evaluation of patients with parkinsonism. However, various neurodegenerative etiologies cannot be differentiated by I-FP-CIT SPECT alone. We present a case of progressive supranuclear palsy with abnormal I-FP-CIT SPECT and abnormal Tc-HMPAO SPECT depicted ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001400
更新日期:2016-12-01 00:00:00
abstract::We report on an incidental detection of a meningioma on [F]-2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (F-FMAU) PET/CT scan that was performed during a prospective investigation of F-FMAU PET/CT for targeted biopsy of potential sites of tumor in men with suspected prostate cancer based on elevated prostate-spe...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002123
更新日期:2018-07-01 00:00:00
abstract::A 64-year-old man was admitted for evaluation of recently developed anemia and bone pain. The bone scan showed diffusely active lesions in the peripheral bones, symmetrically. Interestingly, 18F-FDG PET/CT revealed the hypermetabolic changes in the peripheral bones as well as the internal organs. Biopsy of bone marrow...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31825ae70e
更新日期:2012-08-01 00:00:00
abstract::Cerebrospinal fluid-ventriculoperitoneal shunts are often used in the treatment of hydrocephalus in children. Many complications can arise that may lead to shunt malfunction, including detachment of the distal limb of the shunt. A case is presented where such a complication occurred with distal migration of the detach...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198902000-00011
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to perform multiparametric response assessment of metastatic/advanced pulmonary neuroendocrine tumors (NETs) to Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) (clinical, biochemical, molecular/structural imaging, and survival assessment) and to study the relationship bet...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001639
更新日期:2017-06-01 00:00:00
abstract::Scar involvement is a rare but characteristic cutaneous manifestation of sarcoidosis. The concurrent presence of FDG-avid lymphadenopathy and scar involvement (the "scar sign") is a useful finding on FDG PET/CT to suggest sarcoidosis, especially when biopsy specimens are difficult to obtain. A 46-year-old woman who pr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31827a22e0
更新日期:2013-03-01 00:00:00
abstract::Twenty-eight children (5 girls, 23 boys; age, 20.3 +/- 16.2 months) with Kawasaki disease (KD) were included in this study. The children were treated with aspirin plus intravenous injection of gamma globulin (IVGG). Both Tc-99m HMPAO labeled WBC heart imaging (Tc-WBC) and two-dimensional echocardiograms (2D-Echo) were...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199509000-00012
更新日期:1995-09-01 00:00:00
abstract::Chylous reflux is described as the backflow of chyle through the varicose lymphatics with incompetent lymph valves and leakage of the lymph. The valves in the dilated, varicose, tortuous lymph vessels become incompetent, and as a result, the lymph blended with chyle, reflux into the lower limbs or the genitalia. Reflu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000418
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare 99mTc-MDP bone scanning, 18F NaF PET/CT, 18F FDG PET/CT, and whole-body MRI (WBMRI) for detection of known osseous metastases. PATIENTS AND METHODS:This prospective pilot trial (September 2007-April 2009) enrolled 10 participants (5 men, 5 women, 47-81 years old) diagnose...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/RLU.0b013e3182815f64
更新日期:2013-07-01 00:00:00
abstract::Although positron emission tomography (PET) is an established diagnostic method in brain and lung cancer, its use is often confined to research. The authors report a case of a minimally symptomatic intramedullary spinal cord metastasis, an uncommon and often diagnostically challenging lesion, that was confirmed by PET...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200110000-00006
更新日期:2001-10-01 00:00:00
abstract::Hepatocellular carcinoma rarely involves the major bile duct. Here, we reported a 46-year-old man with liver cancer who underwent FDG PET/CT for staging. The images showed abnormal FDG uptake in the left lobe and hilum of the liver, which was confirmed as hepatocellular carcinoma and hepatic portal bile duct tumor thr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002406
更新日期:2019-02-01 00:00:00
abstract::Renovascular disease is an important cause of hypertension in children and is associated with considerable morbidity and mortality risks. Secondary hypertension is more common in children than in adults, with children accounting for 75% to 80% of cases. In 70% of secondary hypertension in children, the cause is fibrom...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200107000-00005
更新日期:2001-07-01 00:00:00
abstract::Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome. We report a case of a VHL patient with retinal hemangioblastoma who underwent PET/CT scans using F-FDG and Ga-DOTATATE. The tumor showed low-level F-FDG and increased ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001511
更新日期:2017-03-01 00:00:00
abstract::A 60-year-old man with a history of surgical resection of leiomyosarcoma of the right kidney had a bone scan to evaluate possible metastatic osseous disease. The bone scan showed significantly increased Tc-99m MDP activity in the right abdomen, corresponding to a heterogeneous mass in the right retroperitoneal region ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31819675a2
更新日期:2009-03-01 00:00:00
abstract::A 61-year-old-man with persistent anemia was referred for a Tc-99m-labeled red blood cell (RBC) scan to detect any source of gastrointestinal bleeding. RBC scintigraphy revealed a hypervascular mass in the left renal fossa with functional loss in that kidney, suggesting the possibility of a renal cell carcinoma (RCC)....
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000093089.53875.3e
更新日期:2003-11-01 00:00:00
abstract::Metastatic papillary carcinoma was diagnosed in a 42-year-old woman. The cancer had invaded out of the gland and was present in many lymph nodes. After her surgical procedure, she was advised to have radioiodine. However, the patient had total renal failure and was on dialysis. Studies were carried out using a tracer ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199409000-00006
更新日期:1994-09-01 00:00:00