Performance of 18F-FDG, 11C-Methionine, and 18F-FET PET for Glioma Grading: A Meta-analysis.

Abstract:

PURPOSE:Gliomas constitute the most frequent primary brain tumors. Glioblastoma, the most common and malignant glioma in adults, has dismal prognosis with any current therapy. On the other hand, low-grade gliomas, the second most common type of gliomas, are potentially curative with appropriate treatment. METHODS:We conducted a meta-analysis to assess the performance of PET tracers with the best available evidence, namely, fluorodeoxyglucose (FDG), C-methionine (MET), and F-fluoroethyltyrosine (FET), in differentiating low- from high-grade gliomas. RESULTS:Twenty-three studies with a total of 994 participants were included in this meta-analysis. The pooled sensitivities of both MET PET and FET PET were found to be significantly higher than of FDG PET (94%, 88%, and 63% respectively, P < 0.001). The pooled specificity of FDG PET was found to be significantly greater compared with both MET PET and FET PET (89%, 55%, and 57%, respectively; P = 0.002). Fluorodeoxyglucose PET was superior in terms of higher positive likelihood ratio values compared with both FET PET and MET PET. CONCLUSIONS:This meta-analysis indicated that both MET and FET were superior to FDG in terms of sensitivity for identifying glioma grade.

journal_name

Clin Nucl Med

authors

Katsanos AH,Alexiou GA,Fotopoulos AD,Jabbour P,Kyritsis AP,Sioka C

doi

10.1097/RLU.0000000000002654

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

864-869

issue

11

eissn

0363-9762

issn

1536-0229

journal_volume

44

pub_type

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