Abstract:
PURPOSE:Gliomas constitute the most frequent primary brain tumors. Glioblastoma, the most common and malignant glioma in adults, has dismal prognosis with any current therapy. On the other hand, low-grade gliomas, the second most common type of gliomas, are potentially curative with appropriate treatment. METHODS:We conducted a meta-analysis to assess the performance of PET tracers with the best available evidence, namely, fluorodeoxyglucose (FDG), C-methionine (MET), and F-fluoroethyltyrosine (FET), in differentiating low- from high-grade gliomas. RESULTS:Twenty-three studies with a total of 994 participants were included in this meta-analysis. The pooled sensitivities of both MET PET and FET PET were found to be significantly higher than of FDG PET (94%, 88%, and 63% respectively, P < 0.001). The pooled specificity of FDG PET was found to be significantly greater compared with both MET PET and FET PET (89%, 55%, and 57%, respectively; P = 0.002). Fluorodeoxyglucose PET was superior in terms of higher positive likelihood ratio values compared with both FET PET and MET PET. CONCLUSIONS:This meta-analysis indicated that both MET and FET were superior to FDG in terms of sensitivity for identifying glioma grade.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Katsanos AH,Alexiou GA,Fotopoulos AD,Jabbour P,Kyritsis AP,Sioka Cdoi
10.1097/RLU.0000000000002654subject
Has Abstractpub_date
2019-11-01 00:00:00pages
864-869issue
11eissn
0363-9762issn
1536-0229journal_volume
44pub_type
杂志文章,meta分析abstract::A 59-year-old man presented cough, chest pain, and shortness of breath for 2 weeks and fever for 4 days. A contrast chest CT revealed a large right pulmonary artery filling defect, suggestive of pulmonary embolism that failed to respond to anticoagulation therapy. FDG PET/CT was performed to evaluate possible malignan...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001248
更新日期:2016-08-01 00:00:00
abstract:ABSTRACT:We report the case of a 45-year-old woman with a history of right breast reconstruction with silicone implant for breast cancer. An 18F-FDG PET/CT performed several years later revealed the presence of 18F-FDG-avid nodules at the periphery of the silicone implant, in the right internal mammary chain, and in th...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003422
更新日期:2021-02-01 00:00:00
abstract::Tc-99m DTPA and I-131 OIH renography were performed simultaneously in a patient with hepatorenal syndrome. Blood flow was delayed and diminished bilaterally; there was Tc-99m DTPA and I-131 OIH retention in the parenchyma with no evidence of tracer retention in the collecting systems. The I-131 OIH renogram curve demo...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199206000-00008
更新日期:1992-06-01 00:00:00
abstract::Intravenous injection of Tc-99m-labeled radionuclides permits angioscintigraphic and blood pool visualization of both supra- and infradiaphragmatic organs. By adding this procedure to routine bone scans an improvement in the diagnostic yield of incidentally observed renal abnormalities was achieved. Several illustrati...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198003000-00002
更新日期:1980-03-01 00:00:00
abstract::A cavernous hemangioma of the liver presented as an area of increased activity on an isotope bone scan. A review of the literature fails to reveal any previous reports of this phenomenon. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198607000-00009
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:Mammographic screening has led to the identification of more women with nonpalpable breast cancer, many of them to be treated with breast-preserving surgery. To accomplish radical tumor excision, adequate localization techniques such as radioactive seed localization (RSL) are required. For RSL, a radioactive...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001081
更新日期:2016-05-01 00:00:00
abstract::The authors reviewed images of the bladder on 100 consecutive Tc-99m DTPA pediatric renograms for any abnormal distribution of radionuclide or asymmetry suggestive of anatomic bladder abnormality. The results were correlated with radiographic contrast voiding cystourethrograms and ultrasound examination. Of 81 patient...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198909000-00007
更新日期:1989-09-01 00:00:00
abstract::Infections that are associated with health care are a major problem that results in many deaths, suffering, and a great deal of extra monetary costs. Fortunately, there is much that can be done to prevent these infections. This article is a brief introduction to prevention of some of the common hospital acquired infec...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
doi:10.1097/RLU.0000000000001309
更新日期:2016-10-01 00:00:00
abstract::Venous malformations of the parotid glands are uncommon and can be difficult to confirm on routine anatomical imaging alone because of overlap of imaging features with other more common parotid lesions. (99m)Tc RBC scans combined with SPECT/CT offer a noninvasive way to diagnose parotid venous malformations without th...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000792
更新日期:2015-07-01 00:00:00
abstract::A 51-year-old woman with infiltrating ductal carcinoma of left breast, who postsurgery, chemotherapy, and external radiotherapy presented with recurrence in the right chest wall a year after completion of treatment. An excision biopsy of the right chest wall nodule showed deposits of infiltrating ductal carcinoma. She...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181966fb3
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:We performed a systematic review and meta-analysis on the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) derived from pretreatment F-FDG PET/CT in patients with esophageal cancer. METHODS:PubMed and EMBASE databases were searched until April 12, 2018, for studies that evalua...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,meta分析
doi:10.1097/RLU.0000000000002291
更新日期:2018-12-01 00:00:00
abstract::Reduced cortical benzodiazepine receptor binding potential in late images of I-iomazenil SPECT indicates neuronal damage in the cortex. We present the case of a 31-year-old woman with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had focal seizures in the right hand. FLA...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318299610f
更新日期:2014-06-01 00:00:00
abstract::A 54-year-old man with multiple endocrine neoplasia type 1 had previous history of parathyroid surgery and left thyroid lobectomy 5 years earlier, and was referred for recurrent hypoglycemic episodes. Ga-DOTATATE PET/CT had showed multiple lesions in the right lung, liver, and pancreas. Biopsy from pancreas revealed l...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002500
更新日期:2019-06-01 00:00:00
abstract::In a prospective study for evaluation of the use of a monoclonal antibody directed against melanoma in the staging of patients affected by malignant melanoma, we report monoclonal antibody uptake in a follicular thyroid adenoma. Computed tomography, ultrasonography, and pertechnetate scintigraphy did not provide a cer...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199105000-00010
更新日期:1991-05-01 00:00:00
abstract::A 61-year-old-man with persistent anemia was referred for a Tc-99m-labeled red blood cell (RBC) scan to detect any source of gastrointestinal bleeding. RBC scintigraphy revealed a hypervascular mass in the left renal fossa with functional loss in that kidney, suggesting the possibility of a renal cell carcinoma (RCC)....
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000093089.53875.3e
更新日期:2003-11-01 00:00:00
abstract::Incidence of small renal masses is increasing, and preservation of healthy kidney tissue along surgical removal is a challenge, especially if the tumor is small or nonexophytic. To facilitate the location and complete excision of the tumor during surgery, we have implemented the application of the radio-guided occult ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001811
更新日期:2017-11-01 00:00:00
abstract::In three cases, irradiated regions of liver failed to concentrate Tc-99m-sulfur colloid. In two of these three, imaging with Tc-99m-acetanilide iminodiacetic acid (IDA) agents within five days showed near normal hepatic uptake of this hepatobiliary imaging agent. The hepatic parenchymal cells may be imaged with Tc-99m...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198109000-00003
更新日期:1981-09-01 00:00:00
abstract::Amyloidosis in lymph node that is FDG-avid is an unusual diagnosis. FDG PET/CT showed the presence of multifocal lymphadenopathy mainly axillary with a mesenteric mass. Surgical lymph node biopsy with histological examination confirmed the diagnosis of amyloidosis in a 64-year-old woman with an initial left axillary p...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31827a230f
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Recent data suggest that diffuse gliomas carrying mutations in codon 34 of the H3 histone family 3A protein represent a very rare, distinct subgroup of IDH-wild type malignant astrocytic gliomas. However, characteristics detectable by MRI and F-FET PET in H3-G34-mutant gliomas are unknown. METHODS:We report...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002300
更新日期:2018-12-01 00:00:00
abstract::We report a bone scan finding of bilaterally and symmetrically increased uptake at the lateral orbital rims in a patient with disseminated Hodgkin's disease. Computerized axial tomography (CT) demonstrated lacrimal gland enlargement, presumably due to infiltration by Hodgkin's disease. Both the radionuclide bone scan ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198311000-00011
更新日期:1983-11-01 00:00:00
abstract::Myocardial perfusion imaging (MPI) is one of the most commonly used nuclear medicine imaging modalities for coronary artery disease evaluation and risk stratification. The authors present incidental image findings in a patient who underwent MPI twice because of development of seizures just before the first SPECT-MPI a...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002199
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:This report highlights the presence of extensive cerebral dysfunction in a patient with cerebral mitochondrial disorder. MATERIALS AND METHODS:The patient is a 10-year-old girl with a history of hemiparesis, encephalopathy, developmental delay, and seizures. She underwent 1H magnetic resonance spectroscopic im...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31817dec3c
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to evaluate whether computed tomography based-attenuation correction (CT-AC) provides any advantage over non-attenuation-corrected (NAC) images for qualitative and quantitative analysis of single photon emission tomography (SPECT) myocardial perfusion imaging (MPI). METHODS:W...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31823ea16b
更新日期:2012-04-01 00:00:00
abstract::I-131 metaiodobenzylguanidine (MIBG) imaging was performed in 38 patients with advanced neuroblastoma. Abnormal images were found in patients with elevations of urinary vanillylmandelic acid and dopamine and high serum neuron-specific enolase levels. Normal or minimal elevation of markers was seen in patients with neg...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198801000-00014
更新日期:1988-01-01 00:00:00
abstract::Three patients with primary breast lymphoma were reported. All patients had rapidly growing breast masses and these masses showed nonspecific findings in mammography and on ultrasound. They resembled phyllodes tumor or invasive ductal carcinomas. Ga-67 scintigraphy showed intense accumulation was seen in all of the ly...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199611000-00010
更新日期:1996-11-01 00:00:00
abstract::Kimura disease is a chronic inflammatory disorder that occurs mainly in Asians. We present a patient with pulmonary Kimura disease assessed by whole-body 18F-FDG PET/CT examination and proved by pathologic findings. Chest x-ray detected left pulmonary hilum enlargement in a 49-year-old Chinese man. CT showed a soft ti...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182867d70
更新日期:2013-07-01 00:00:00
abstract::Langerhans cell histiocytosis is essentially a pediatric disorder with a large spectrum encompassing focal lytic osseous eosinophilic granuloma, chronic multifocal Hand-Schuller-Christian lesions, and fulminant disseminated Letterer-Siwe syndrome. However, adult involvement is not uncommon. The authors present a case ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181ef0b31
更新日期:2010-10-01 00:00:00
abstract::The authors report a case in which a radionuclide hepatobiliary image was falsely indicative of cystic duct obstruction in a patient with an indwelling cholecystostomy tube and an externalized gallbladder-duodenal stent. Cystic duct patency was demonstrated radiographically shortly before and after the radionuclide st...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198903000-00001
更新日期:1989-03-01 00:00:00
abstract::A retrospective review of two years' experience with radionuclide screening to detect lower gastrointestinal bleeding sites was conducted at New York's Montefiore Medical Center. Of 82 studies performed in 63 patients, 13 identified active bleeding sites. Only three of eight angiograms obtained in these 13 patients we...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198309000-00001
更新日期:1983-09-01 00:00:00
abstract::Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome. We report a case of a VHL patient with retinal hemangioblastoma who underwent PET/CT scans using F-FDG and Ga-DOTATATE. The tumor showed low-level F-FDG and increased ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001511
更新日期:2017-03-01 00:00:00