Phenytoin Could Potentially Increase Hepatic Clearance of 99mTc-Sestamibi in Myocardial Perfusion Imaging.

Abstract:

:Myocardial perfusion imaging (MPI) is one of the most commonly used nuclear medicine imaging modalities for coronary artery disease evaluation and risk stratification. The authors present incidental image findings in a patient who underwent MPI twice because of development of seizures just before the first SPECT-MPI acquisition. The projection images for first MPI done without medication (phenytoin) showed the retention of hepatic tracer activity. After a few days from restarting of phenytoin, the repeat MPI showed complete hepatic clearance of tracer. This case highlights the possible pharmacokinetic interaction between phenytoin intake and Tc-sestamibi, resulting in faster hepatic clearance of the radiotracer.

journal_name

Clin Nucl Med

authors

Kavanal AJ,Singh D,Sood A,Parmar M,Mittal BR

doi

10.1097/RLU.0000000000002199

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

e341-e342

issue

9

eissn

0363-9762

issn

1536-0229

pii

00003072-201809000-00039

journal_volume

43

pub_type

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