Avastin scintigraphy in surveillance of bevacizumab treatment in a patient with neurofibromatosis type 2: a case report.

Abstract:

:A patient with neurofibromatosis type 2 (bilateral vestibular schwannomas) was treated with bevacizumab (anti-vascular endothelial growth factor [VEFG] monoclonal antibody). The left-sided tumor showed intense uptake on pretreatment In-bevacizumab scintigraphy, indicating VEGF production in the tumor, and no uptake 4 weeks later, demonstrating effective binding of nonradiolabeled bevacizumab to the VEGF produced in the tumor. The right-sided tumor showed no tracer uptake at any time point. Significant tumor volume reduction (assessed with MRI) and hearing improvement were observed on the left side. In-bevacizumab scintigraphy may be a promising upfront patient selection tool to identify patients who may benefit from expensive bevacizumab treatment.

journal_name

Clin Nucl Med

authors

Versleijen MW,Verbist BM,Mulder JJ,de Geus-Oei LF,van Herpen CM

doi

10.1097/RLU.0000000000000329

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

277-80

issue

3

eissn

0363-9762

issn

1536-0229

journal_volume

39

pub_type

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