Predictive value of preablation stimulated thyroglobulin and thyroglobulin/thyroid-stimulating hormone ratio in differentiated thyroid cancer.

Abstract:

PURPOSE:Recent studies have shown that thyroglobulin (Tg) concentration is a useful tumor marker in follow-up of differentiated thyroid cancer (DTC) patients after thyroidectomy and subsequent radioiodine (I-131) therapy. However, its role is controversial after total or near-total thyroidectomy before the first I-131 ablative treatment. So, we used thyroid-stimulating hormone (TSH) levels to normalize predictive values of Tg for DTC. METHODS:The study was a retrospective analysis. A total of 244 patients with DTC who had undergone a total thyroidectomy and subsequent I-131 therapy were included. Exclusion criteria were patients with high serum Tg antibody (TgAb) concentration and in whom it was not measured. Patients were divided into 2 groups as M1 and M0, according to whether the patient present with or without distant metastases. RESULTS:Preablative stimulated Tg in group M0 ranged between 0.1 and 348.9 ng/mL and group M1 between 0.2 and 1000 ng/mL. Tg/TSH ratios ranged 0.000667 to 12.143 ng/IU and 0.002948 to 12500 ng/IU. Both Tg and Tg/TSH values were significantly different between the 2 groups (the Wilcoxon rank sum test: Tg P < 0.0001 [z = 8.785]; Tg/TSH P < 0.0001 [z = 8.850]). The areas under receiver operating characteristic curves for Tg concentrations and Tg/TSH ratios were 0.913 and 0.916, respectively. CONCLUSION:Both Tg and Tg/TSH ratios might be considered predictive markers for metastases of DTC just after total thyroidectomy before the first I-131 ablative therapy.

journal_name

Clin Nucl Med

authors

Lin Y,Li T,Liang J,Li X,Qiu L,Wang S,Chen Y,Kang Z,Li F

doi

10.1097/RLU.0b013e3182291c65

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1102-5

issue

12

eissn

0363-9762

issn

1536-0229

pii

00003072-201112000-00005

journal_volume

36

pub_type

杂志文章
  • Tc-99m diphosphonate imaging in the differential diagnosis of thyroid nodules.

    abstract::Early Tc-99m diphosphonate (DP) imaging was performed in 122 patients with cold thyroid nodules in an effort to differentiate benign nodules from malignant. Immediately upon completion of the routine 24-hour I-123 uptake and multiview pinhole imaging, Tc-99m DP was injected intravenously and three serial 3-minute ante...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198208000-00001

    authors: Siddiqui AR,Wellman HN,Park HM,Burney BT

    更新日期:1982-08-01 00:00:00

  • SPECT brain imaging abnormalities in attention deficit hyperactivity disorder.

    abstract::SPECT using N-Isopropyl I-123 IMP was performed, as part of a neuropsychiatric evaluation, on 10 patients with the DSM III-R diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) and 6 patients from a non-ADHD mixed psychiatric group used as controls for comparison. Mean regional I-123 IMP SPECT region of inter...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199501000-00014

    authors: Sieg KG,Gaffney GR,Preston DF,Hellings JA

    更新日期:1995-01-01 00:00:00

  • Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy.

    abstract:ABSTRACT:A 13-year-old boy with mediastinal T-cell lymphoblastic lymphoma demonstrated an altered biodistribution with diffuse activity in subcutaneous white adipose tissue and decreased visceral activity on interim posttreatment FDG PET/CT. This altered biodistribution was attributed to administration of the chemother...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003340

    authors: Young CR,Kulon ME,Boustani AM,Pucar D

    更新日期:2021-03-01 00:00:00

  • Acute varicella infection mimics recurrent Hodgkin's disease on F-18 FDG PET/CT.

    abstract::We report a case where acute varicella infection, chickenpox, mimics the findings of recurrent Hodgkin disease on F-18 FDG PET/CT. A 28-year-old man with a history of Hodgkin disease in remission had fatigue, pyrexia, and a raised ESR. His F-18 FDG PET/CT, performed to exclude lymphoma recurrence, demonstrated FDG-avi...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318148b48f

    authors: Sheehy N,Israel DA

    更新日期:2007-10-01 00:00:00

  • Decreased hippocampal blood flow related to memory impairment after cardiovascular surgery: assessment by reconstructed SPECT parallel to the longitudinal axis of the hippocampal formations.

    abstract::Hippocampal damage has been linked to memory impairment. To clarify the relationship between decreased hippocampal blood flow and memory impairment in patients after cardiovascular surgery, the authors compared Tc-99m HMPAO SPECT findings and Mini Mental State Examination (MMSE) scores. Eight patients who had valve re...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199806000-00004

    authors: Nishimura T,Fukuchi K,Hayashida K,Hirose Y,Iwamoto B

    更新日期:1998-06-01 00:00:00

  • Comparison between cortical distribution of I-123 iomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT.

    abstract:PURPOSE:To compare brain perfusion and synaptic density in Alzheimer's disease assessed using I-123 iomazenil SPECT with brain perfusion assessed using Tc-99m HMPAO SPECT. MATERIALS AND METHODS:Early and delayed I-123 iomazenil SPECT images acquired 20 and 180 minutes after injection were compared with Tc-99m HMPAO SP...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199909000-00004

    authors: Varrone A,Soricelli A,Postiglione A,Salvatore M

    更新日期:1999-09-01 00:00:00

  • Asymmetric abnormality of renal perfusion with symmetric function in aortic dissection.

    abstract::Two cases of aortic dissection are presented in which discordance between renal perfusion and function has been demonstrated with Tc-99m DTPA. Renal perfusion on the affected side was decreased on blood flow imaging, whereas renal function, including parenchymal accumulation and excretion assessed by subsequent sequen...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199201000-00011

    authors: Aburano T,Yokoyama K,Taki J,Takayama T,Shuke N,Tonami N,Hisada K

    更新日期:1992-01-01 00:00:00

  • Obscured Meckel's Diverticulum by the Urinary Bladder: The Value of Lateral View and Post Void Images.

    abstract::We describe a case of a 5-year-old boy with a history of intermittent melena underwent TcO4 scintigraphy. On dynamic images, no abnormal activity was noted. After voiding and also in the lateral view, the focus of activity was noted in the superior and anterior aspect of the urinary bladder, compatible with a Meckel's...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003016

    authors: Pirayesh E

    更新日期:2020-06-01 00:00:00

  • A comparison of the tumor-seeking agent Tc-99m(V) dimercaptosuccinic acid and the renal imaging agent Tc-99m dimercaptosuccinic acid in humans.

    abstract::Being aware of the ideal nuclear properties of Tc-99m, our interest has been focused on the design of the (+5) oxidation state Tc-99m(V) dimercaptosuccinic acid (Tc(V)-DMSA) as a tumor-seeking agent. Tc-99m(V) DMSA holds a TcO4(3-) core and, like PO4(3-), has excellent characteristics for tumor uptake, but has a diffe...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198503000-00006

    authors: Ohta H,Ishii M,Yoshizumi M,Endo K,Sakahara H,Nakajima T,Yomoda I,Masuda H,Horiuchi K,Hata N

    更新日期:1985-03-01 00:00:00

  • Earlier Phases of Bone Scintigraphy Can Better Delineate the Extent of Soft Tissue Involvement of Bone Metastasis.

    abstract::Three-phase bone scintigraphy is sometimes of great value in the detection of uncharacteristic metastases and assists the management of patients in terms of primary focus detection. While evaluating the skeletal system with whole-body bone scintigraphy, other system pathologies may also be detected incidentally. In th...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002260

    authors: Çayir D,Bozkurt M,Gültekin SS,Karaçalioğlu AÖ

    更新日期:2018-11-01 00:00:00

  • Dural MALT Lymphoma Detected by 11C-Methionine PET/CT.

    abstract::A 53-year-old man had a diagnosis of mucosa-associated lymphoid tissue lymphomas of the dura in the left tentorium. The patient underwent whole-body F-FDG PET/CT and C-methionine PET/CT in order to complete the staging of dural mucosa-associated lymphoid tissue lymphoma. C-methionine uptake was detected in multiple me...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001843

    authors: Annunziata S,Cuccaro A,Caldarella C,Hohaus S

    更新日期:2017-12-01 00:00:00

  • Spectrum of the Breast Lesions With Increased 18F-FDG Uptake on PET/CT.

    abstract::Interpretation of F-FDG PET/CT studies in breast is challenging owing to nonspecific FDG uptake in various benign and malignant conditions. Benign conditions include breast changes in pregnancy and lactation, gynecomastia, mastitis, fat necrosis, fibroadenoma, intraductal papilloma, and atypical ductal hyperplasia. Am...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001203

    authors: Dong A,Wang Y,Lu J,Zuo C

    更新日期:2016-07-01 00:00:00

  • Benign fibrous histiocytoma of a rib.

    abstract::Rib benign fibrous histiocytoma (BFH) is an uncommon entity. We came across a 20-year-old Chinese man who complained of right chest pain for 2 weeks. All laboratory examination results were normal. CT of the thorax revealed an expansible bone lesion in the right sixth anterior rib. Whole-body bone scan demonstrated in...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000466

    authors: Li X,Meng Z,Li D,Tan J,Song X

    更新日期:2014-09-01 00:00:00

  • Quality and Safety in Healthcare, Part LVI: Wellness Leaders.

    abstract::All members of the healthcare system should make positive contributions to improve the overall level of wellness. However, leaders should have certain specific responsibilities to prevent burnout and increase happiness and wellness at work. It has been proposed that a chief wellness officer direct the initiatives to i...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002734

    authors: Harolds JA

    更新日期:2020-03-01 00:00:00

  • Isolated Multinodular Soft-Tissue Rosai-Dorfman Disease on FDG PET/CT.

    abstract::Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is a rare systemic histiocytic disorder of unknown etiology characterized by the accumulation of enlarged non-Langerhans histiocytes within lymph nodes and extranodal sites. The histiocytes display characteristic emperipolesis (nondestructive eng...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001921

    authors: Pucar D,Laskin WB,Saperstein L

    更新日期:2018-02-01 00:00:00

  • Tc-99m MIBI scintigraphy in tall cell variant of papillary thyroid carcinoma with negative radioiodine scan.

    abstract::We report on a 45-year-old man who had a mass on the wall of the anterior right hemithorax. An excisional biopsy indicated carcinoma metastasis from thyroid malignancy. Tc-99m methoxyisobutyl isonitrile (MIBI) scintigraphy revealed markedly increased activity on the left side of the thyroid and the thoracic wall mass....

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3181813035

    authors: Kaya M,Cermik TF

    更新日期:2008-09-01 00:00:00

  • Clinical application of captopril renal scintigraphy in Takayasu's arteritis.

    abstract::Takayasu's disease (pulseless disease) is an uncommon chronic inflammatory disease primarily affecting the medium and large arteries, with a strong predilection for the aortic arch and its branches; hence, it sometimes is referred to as aortic arch syndrome. The etiology is unknown, although a systemic immunologic pro...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199309000-00002

    authors: Balingit AG,Anderson JH

    更新日期:1993-09-01 00:00:00

  • (18)F-fluoride PET/CT in avascular necrosis of the femoral head.

    abstract::Avascular necrosis (AVN) of the femoral head is a devastating disease in young adults. Magnetic resonance imaging is considered the most sensitive and specific technique in the diagnosis of this condition. The authors present an interesting image of bilateral AVN of the femoral heads diagnosed on F-fluoride positron e...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318266d036

    authors: Gayana S,Bhattacharya A,Kashyap R,Sen RK,Mittal BR

    更新日期:2013-06-01 00:00:00

  • Incidental 18F-Fluorocholine Uptake in an Esophageal Diverticulum: 18F-FCH in an Esophageal Diverticulum.

    abstract::F-fluorocholine has recently emerged as a very sensitive agent for seeking parathyroid adenomas. We represent a case with esophageal diverticulum incidentally detected on F-fuorocholine PET/CT, which should be kept in mind as a reason of false positivity in primary hyperparathyroidism. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002947

    authors: Araz M,Cinel M,Soydal C,Ozkan E,Kucuk NO

    更新日期:2020-04-01 00:00:00

  • Acute suppurative thyroiditis due to foreign body-induced retropharyngeal abscess presented as thyrotoxicosis.

    abstract::Acute suppurative thyroiditis is an uncommon condition. Most patients have preexisting oropharyngeal fistulae. Penetrating oropharyngeal injuries resulting from swallowed foreign bodies provide an acquired channel of infection spreading into the relatively resistant thyroid gland. The authors describe a patient with i...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-200004000-00001

    authors: Yung BC,Loke TK,Fan WC,Chan JC

    更新日期:2000-04-01 00:00:00

  • FDG PET/CT detection of intussusception caused by lymphoma in a pediatric patient.

    abstract::A previously healthy 9-year-old boy presented to an outside hospital with a history of abdominal pain and vomiting. An abdominal x-ray was unremarkable. A CT of the abdomen and pelvis performed to evaluate possible obstruction after weight loss and vomiting over a 3-week period demonstrated a large retroperitoneal mas...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3182a20e04

    authors: Kang HJ,Beylergil V,Price AP,Abramson SJ,Carrasquillo JA

    更新日期:2014-01-01 00:00:00

  • Optimizing Somatostatin Receptor Imaging in Patients With Neuroendocrine Tumors: The Impact of 99mTc-HYNICTOC SPECT/SPECT/CT Versus 68Ga-DOTATATE PET/CT Upon Clinical Management.

    abstract:AIM:The presence of somatostatin receptors in neuroendocrine tumors allows visualization with radiolabeled somatostatin analogs in vivo. The aim of this prospective study was to compare somatostatin receptor imaging using Tc-HYNICTOC with Ga-DOTATATE (DOTA-DPhe1,Tyr3-octreotate) with respect to sensitivity, specificity...

    journal_title:Clinical nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/RLU.0000000000001877

    authors: Kunikowska J,Lewington V,Krolicki L

    更新日期:2017-12-01 00:00:00

  • Conjunctival MALT lymphoma: utility of FDG PET/CT for diagnosis, staging, and evaluation of treatment response.

    abstract::A 67-year-old woman was referred for staging of a mucosa-associated lymphoid tumor lymphoma involving the left conjunctiva. CT scan had shown paravertebral and pelvic masses, and a breast nodule. FDG PET/CT demonstrated moderately increased uptake in the left ocular conjunctiva and confirmed the paravertebral and pelv...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000356

    authors: Sallak A,Besson FL,Pomoni A,Christinat A,Adler M,Aegerter JP,Nguyen C,de Leval L,Frossard V,Prior JO

    更新日期:2014-03-01 00:00:00

  • Rheumatoid lung disease as seen on PET/CT scan.

    abstract::We present the case of a 63-year-old woman chronic smoker with a history of severe rheumatoid arthritis, who presented with dyspnea and cough. Her chest x-ray film and CT scan (as part of a PET/CT scan) showed multiple lung nodules and a left pleural effusion. A PET scan (as part of a PET/CT scan) revealed no uptake i...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318124fd72

    authors: Bagga S

    更新日期:2007-09-01 00:00:00

  • Thoracic gallium uptake in patients with lymphomatoid granulomatosis.

    abstract::Lymphomatoid granulomatosis (LG) is a rare condition with histological similarities to Wegener's granulomatosis and malignant lymphoma. Characteristically there is an angiocentric, angiodestructive lymphoreticular cell infiltrate. The lungs are usually affected, and, less frequently, the skin, nervous system, kidney, ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198812000-00009

    authors: Tien R,Moore WH,Glasser LM,Dhekne RD,Long SE

    更新日期:1988-12-01 00:00:00

  • Role of technetium-99m N,N-ethylenedicysteine renal scintigraphy in the evaluation of differential renal function and cortical defects.

    abstract:PURPOSE:This study was performed to evaluate the effectiveness of technetium-99m N,N-ethylenedicysteine (Tc-99m EC) in comparison to technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) scintigraphy. Differential renal function (DRF) was calculated by both methods and the cortical-phase images of dynamic Tc-99m EC scin...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000200460.41091.13

    authors: Buyukdereli G,Guney IB

    更新日期:2006-03-01 00:00:00

  • Laparoscopic versus conventional cholecystectomy. Use of biliary scintigraphy.

    abstract::Laparoscopic cholecystectomy has become a popular alternative to traditional open cholecystectomy for uncomplicated, acute cholecystitis. At some centers, laparoscopic cholecystectomy is already the more frequently performed procedure. The presence or suspicion of common bile duct (CBD) stones or obstruction may neces...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199210000-00001

    authors: Nagle CE,Murphy J

    更新日期:1992-10-01 00:00:00

  • Postprandial recurrent hemiplegia.

    abstract:INTRODUCTION:Postprandial hemodynamic disturbances have been previously described. We report a case of postprandial transient ischemic attacks. MATERIALS AND METHODS:Brain magnetic resonance imaging (MRI) (fluid-attenuated inversion recovery sequences, apparent diffusion coefficient), MR angiography, and Tc-99m hexame...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3181c7c138

    authors: Farid K,Renou P,Laffite M,Couffinhal T,Allard M,Fernandez P,Sibon I

    更新日期:2010-02-01 00:00:00

  • Targeted Prostate Gland Biopsy With Combined Transrectal Ultrasound, mpMRI, and 18F-FMAU PET/CT.

    abstract::We report on a 61-year-old man with elevated serum prostate-specific antigen level of 10.5 ng/mL who had undergone prior negative standard transrectal ultrasound biopsy at another institution. He was referred to our medical center for evaluation and underwent a clinical 3-T multiparametric MRI and a research protocol ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000814

    authors: Jadvar H,Chen K,Ukimura O

    更新日期:2015-08-01 00:00:00

  • Kinetics of Tc-99m sestamibi and Tc-99m tetrofosmin in a case of parathyroid adenoma.

    abstract::The uptake of Tc-99m tetrofosmin (TF) is reported in a case of parathyroid adenoma. A 65-year-old woman was studied on different days with TF, Tc-99m sestamibi (MIBI) and Tl-201 chloride (Tl). TF and MIBI injections were preceded by oral administration of potassium perchlorate. Clear identification of the adenoma was ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199609000-00006

    authors: Mansi L,Rambaldi PF,Marino G,Pecori B,Del Vecchio E

    更新日期:1996-09-01 00:00:00