Abstract:
PURPOSE:Recent studies have shown that thyroglobulin (Tg) concentration is a useful tumor marker in follow-up of differentiated thyroid cancer (DTC) patients after thyroidectomy and subsequent radioiodine (I-131) therapy. However, its role is controversial after total or near-total thyroidectomy before the first I-131 ablative treatment. So, we used thyroid-stimulating hormone (TSH) levels to normalize predictive values of Tg for DTC. METHODS:The study was a retrospective analysis. A total of 244 patients with DTC who had undergone a total thyroidectomy and subsequent I-131 therapy were included. Exclusion criteria were patients with high serum Tg antibody (TgAb) concentration and in whom it was not measured. Patients were divided into 2 groups as M1 and M0, according to whether the patient present with or without distant metastases. RESULTS:Preablative stimulated Tg in group M0 ranged between 0.1 and 348.9 ng/mL and group M1 between 0.2 and 1000 ng/mL. Tg/TSH ratios ranged 0.000667 to 12.143 ng/IU and 0.002948 to 12500 ng/IU. Both Tg and Tg/TSH values were significantly different between the 2 groups (the Wilcoxon rank sum test: Tg P < 0.0001 [z = 8.785]; Tg/TSH P < 0.0001 [z = 8.850]). The areas under receiver operating characteristic curves for Tg concentrations and Tg/TSH ratios were 0.913 and 0.916, respectively. CONCLUSION:Both Tg and Tg/TSH ratios might be considered predictive markers for metastases of DTC just after total thyroidectomy before the first I-131 ablative therapy.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Lin Y,Li T,Liang J,Li X,Qiu L,Wang S,Chen Y,Kang Z,Li Fdoi
10.1097/RLU.0b013e3182291c65subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1102-5issue
12eissn
0363-9762issn
1536-0229pii
00003072-201112000-00005journal_volume
36pub_type
杂志文章abstract::Early Tc-99m diphosphonate (DP) imaging was performed in 122 patients with cold thyroid nodules in an effort to differentiate benign nodules from malignant. Immediately upon completion of the routine 24-hour I-123 uptake and multiview pinhole imaging, Tc-99m DP was injected intravenously and three serial 3-minute ante...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198208000-00001
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199806000-00004
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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doi:10.1097/00003072-199201000-00011
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181813035
更新日期:2008-09-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199309000-00002
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journal_title:Clinical nuclear medicine
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doi:10.1097/00003072-200004000-00001
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pub_type: 临床试验,杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318124fd72
更新日期:2007-09-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198812000-00009
更新日期:1988-12-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199210000-00001
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199609000-00006
更新日期:1996-09-01 00:00:00