Abstract:
ABSTRACT:A 13-year-old boy with mediastinal T-cell lymphoblastic lymphoma demonstrated an altered biodistribution with diffuse activity in subcutaneous white adipose tissue and decreased visceral activity on interim posttreatment FDG PET/CT. This altered biodistribution was attributed to administration of the chemotherapeutic enzyme l-asparaginase 3 hours preceding the PET/CT, altering adipocytes amino acid and glucose metabolism. Treatment response assessment was adversely affected by the altered biodistribution, emphasizing the importance of maximizing the time between chemotherapy and PET/CT during successive oncologic treatment cycles. Because adipocytes protect leukemic cells in culture from l-asparaginase, we hypothesize that white adipose tissue-altered biodistribution may be related to l-asparaginase resistance.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Young CR,Kulon ME,Boustani AM,Pucar Ddoi
10.1097/RLU.0000000000003340subject
Has Abstractpub_date
2021-03-01 00:00:00pages
e179-e180issue
3eissn
0363-9762issn
1536-0229pii
00003072-202103000-00039journal_volume
46pub_type
杂志文章abstract::The authors have previously shown that the definition of ablation of thyroid tissue in patients treated with thyroidectomy and radioiodine (I-131) for thyroid carcinoma depends upon the dose of I-131 used to scan the patient. The therapeutic response to I-131 therapy was evaluated in a group of ten differentiated thyr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198510000-00003
更新日期:1985-10-01 00:00:00
abstract:PURPOSE:We describe a new method for measuring brain tumor uptake of TI-201 and Tc-99m sestamibi (MIBI) that permits the semiquantitative comparison of tracer uptake to yield comparable "tumor bulk" ratios. We tested this method in patients treated recently and remotely with chemotherapy to determine if this method cou...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199911000-00010
更新日期:1999-11-01 00:00:00
abstract::A 35-year-old man presented with right lower extremity numbness and weakness. CT demonstrated an irregular left parietal hypoattenuation with a punctuate calcification. MRI revealed a T1 low signal and T2 high signal lesion with extensive surrounding edema. Gadolinium-enhanced MRI showed an irregular enhancing lesion....
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182708352
更新日期:2012-12-01 00:00:00
abstract::Breast cancer is the most common cancer in women with rising incidence worldwide. F-FDG PET/CT imaging has already established itself as a pivotal modality for staging, restating and response assessment in patients with carcinoma breast. The complex biology of this cancer is increasingly being decoded and various mole...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002783
更新日期:2020-02-01 00:00:00
abstract::Single photon emission computed tomography of the brain with Tc-99m labeled hexamethylpropyleneamine oxime was used to evaluate a patient who suffered hypoxic cerebral injury. Hypoperfusion in the right parieto-occipital and left occipital regions was demonstrated on the SPECT images, while both the cranial CT and EEG...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198907000-00003
更新日期:1989-07-01 00:00:00
abstract::A 64-year-old man was admitted for evaluation of recently developed anemia and bone pain. The bone scan showed diffusely active lesions in the peripheral bones, symmetrically. Interestingly, 18F-FDG PET/CT revealed the hypermetabolic changes in the peripheral bones as well as the internal organs. Biopsy of bone marrow...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31825ae70e
更新日期:2012-08-01 00:00:00
abstract::Skeletal visualization during dynamic renal imaging is an uncommon finding that has previously been related to underlying neoplastic disease. The authors report a case of active Paget's disease of the left ilium resulting in uptake of Tc-99m DTPA in the arterial flow and early blood pool images. This report emphasizes...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199001000-00007
更新日期:1990-01-01 00:00:00
abstract::A 23-year-old man with Dyke-Davidoff-Masson syndrome (DDMS) was admitted to the hospital with increasing frequency of epileptic seizures. Physical examination revealed mental retardation, left facial asymmetry, and left-sided spastic hemiparesis. Dysdiadochokinesia on the left upper limb was detected, and there was no...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000890
更新日期:2015-09-01 00:00:00
abstract::The normal appearance of a gastrointestinal bleeding study using labeled red blood cells has been discussed frequently, but the actual appearance is not well known. In this atlas article, the authors report on unusual findings in non-bleeding subjects and have tabulated the visualization of various structures. Vascula...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198903000-00013
更新日期:1989-03-01 00:00:00
abstract::For better delineation of regional ventilation abnormalities, a lateral-view imaging has been employed when one or more areas of abnormal retention were visible in posterior views of 133Xe washout images. It is technically simple to obtain lateral views during the 133Xe washout phase. The resulting images were found t...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197902000-00001
更新日期:1979-02-01 00:00:00
abstract:PURPOSE:Primary hyperparathyroidism is a disease of uncertain etiology that results from hypersecretion of parathyroid hormone (PTH) by the parathyroid gland. In most institutions, the preferred imaging protocol utilizes a dual-phase technique with Tc-99m sestamibi which is reported to be more sensitive than earlier pr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199804000-00003
更新日期:1998-04-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the redifferentiative and antiproliferative effects of rosiglitazone in patients with progressive differentiated thyroid cancer (DTC) without or with negligible overall radioiodine uptake. MATERIALS AND METHODS:A total of 9 patients with progressive DTC with either no or only ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182443ca6
更新日期:2012-03-01 00:00:00
abstract:AIM:The purpose of this study was to conduct a systematic review of the published literature to assess the role (indications, advantages, and limitations) of SPECT/CT for the detection of sentinel lymph node (SLN) in breast cancer. METHODS:The authors searched PubMed for published literature in English addressing this...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,meta分析
doi:10.1097/RLU.0b013e31829af8c0
更新日期:2014-05-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. Often, patients present with inoperable and advanced disease. Selective internal radionuclide therapy offers prolonged survival and improved quality of life by delivering high radiation dose to the tumor with minimal complications. We report 2 inop...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002373
更新日期:2019-02-01 00:00:00
abstract::Contralateral cerebellar diaschisis, hypometabolism in the cerebellum contralateral to a cortical lesion, is a well described phenomenon in patients with stroke and brain tumor. However, few reports exist of patients with cerebellar lesions with the finding of contralateral cortical hypometabolism. The authors present...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
doi:10.1097/00003072-200006000-00008
更新日期:2000-06-01 00:00:00
abstract:PURPOSE OF THE REPORT:Peptide receptor radionuclide therapy (PRRT) is an effective treatment for advanced neuroendocrine tumors (NET); however, long-term survival data are scarce. The aim of this study is to determine long-term survival in patients with metastatic midgut NET, according to response to PRRT. PATIENTS AN...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001457
更新日期:2017-03-01 00:00:00
abstract::Hypophosphatemic osteomalacia, a familial or rarely acquired disorder, is characterized biochemically by hypophosphatemia, decreased renal tubular reabsorption of phosphate, decreased intestinal absorption of calcium, and normal serum calcium. This report concerns a rare case of hypophosphatemic osteomalacia of unknow...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200005000-00003
更新日期:2000-05-01 00:00:00
abstract::Tc-99m labeled RBC imaging was used to conclusively demonstrate continuing intrathoracic hemorrhage from the anastomotic site of a coronary artery bypass graft. Demonstration of continuing hemorrhage and localization of the most likely site of bleeding resulted in timely and appropriate surgical intervention, which re...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198611000-00006
更新日期:1986-11-01 00:00:00
abstract::A 59-year-old man with a pacemaker who was admitted for evaluation of fever was found to have a redundant loop of the ventricular lead and a vegetation attached to it. An FDG PET/CT revealed a focus of FDG uptake at the ventricular lead loop. Surgical extraction of the pacemaker device confirmed a Propionibacterium ac...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002686
更新日期:2020-01-01 00:00:00
abstract::An 83-year-old asymptomatic woman with a history of breast cancer treated with resection, radiation, and chemotherapy was studied with F-18 FDG positron emission tomography/computed tomography (PET/CT) for staging purposes. The whole-body F-18 FDG PET/CT images revealed poorly circumscribed, bilateral soft tissue mass...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000178786.99368.1d
更新日期:2005-10-01 00:00:00
abstract::Tc-99m pertechnetate radionuclide scrotal scanning was performed on nine hospitalized boys with anaphylactoid purpura and acute scrotal tenderness. Scrotal involvement in anaphylactoid purpura is generally a part of the basic pathological process (i.e., vasculitis). Sometimes testicular torsion could not be excluded b...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199304000-00006
更新日期:1993-04-01 00:00:00
abstract::The neuroendocrine small cell carcinoma of the cervix is a rare malignancy that has a poor prognosis due to early lymphatic and hematogenous spread. We herein report a case of a 27- year-old woman who was referred for initial staging of a neuroendocrine small cell carcinoma with previous unremarkable structural imagin...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001498
更新日期:2017-03-01 00:00:00
abstract::Radioimmunoscintigraphy (RIS) with Tc-99m labeled 170H.82, an intact murine monoclonal antibody (MAb) was performed in 27 patients with suspected primary, recurrent, or metastatic breast cancer. For radioimmunoimaging the authors used a double-headed, high-resolution gamma camera. The lesions detected by RIS were eval...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199701000-00007
更新日期:1997-01-01 00:00:00
abstract::A 40-year-old man was examined because he was a potential "healthy" renal donor. However, the routine work-up before surgery revealed hypertension, although there was no family history of this condition. The patient was examined to exclude secondary causes of hypertension. Tc-99m glucoheptonate renal imaging showed ne...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200006000-00018
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Recent data suggest that diffuse gliomas carrying mutations in codon 34 of the H3 histone family 3A protein represent a very rare, distinct subgroup of IDH-wild type malignant astrocytic gliomas. However, characteristics detectable by MRI and F-FET PET in H3-G34-mutant gliomas are unknown. METHODS:We report...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002300
更新日期:2018-12-01 00:00:00
abstract::Malignant melanoma is a relatively uncommon cancer of increasing incidence. The authors report on two cases of malignant melanoma lesions (primary and lymph node metastasis) imaged with Tc-99m MIBI. One patient revealed intense accumulation of the radiotracer in a primary skin lesion of the thorax, whereas the other p...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199607000-00010
更新日期:1996-07-01 00:00:00
abstract::Single-photon emission computed tomography has been proven to detect more abnormalities than planar bone scintigraphy in patients with low back pain (LBP). Both 180 degrees and 360 degrees acquisitions were performed in 24 patients with LBP to determine whether the shorter 180 degrees posterior SPECT is as accurate fo...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199306000-00004
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to perform multiparametric response assessment of metastatic/advanced pulmonary neuroendocrine tumors (NETs) to Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) (clinical, biochemical, molecular/structural imaging, and survival assessment) and to study the relationship bet...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001639
更新日期:2017-06-01 00:00:00
abstract::Numerous expected competencies of a chief nursing officer are outlined in this article including communication, ability to build relationships, expertise about the environment of healthcare and its future directions, leadership, expertise in business matters, combating bullying, encouraging shared decision making, and...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003221
更新日期:2020-08-11 00:00:00
abstract::O-(2-fluoroethyl)-L-tyrosine (FET) PET/CT is a promising imaging modality for brain tumor imaging because of its reported high sensitivity for biologically active tumor tissue. We present a case of biopsy-proven neurosarcoidosis showing FET uptake. It is an important cause of false-positive uptake on FET PET/CT. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001516
更新日期:2017-03-01 00:00:00