Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy.

Abstract:

ABSTRACT:A 13-year-old boy with mediastinal T-cell lymphoblastic lymphoma demonstrated an altered biodistribution with diffuse activity in subcutaneous white adipose tissue and decreased visceral activity on interim posttreatment FDG PET/CT. This altered biodistribution was attributed to administration of the chemotherapeutic enzyme l-asparaginase 3 hours preceding the PET/CT, altering adipocytes amino acid and glucose metabolism. Treatment response assessment was adversely affected by the altered biodistribution, emphasizing the importance of maximizing the time between chemotherapy and PET/CT during successive oncologic treatment cycles. Because adipocytes protect leukemic cells in culture from l-asparaginase, we hypothesize that white adipose tissue-altered biodistribution may be related to l-asparaginase resistance.

journal_name

Clin Nucl Med

authors

Young CR,Kulon ME,Boustani AM,Pucar D

doi

10.1097/RLU.0000000000003340

subject

Has Abstract

pub_date

2021-03-01 00:00:00

pages

e179-e180

issue

3

eissn

0363-9762

issn

1536-0229

pii

00003072-202103000-00039

journal_volume

46

pub_type

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