Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET.

Abstract:

BACKGROUND:Recent data suggest that diffuse gliomas carrying mutations in codon 34 of the H3 histone family 3A protein represent a very rare, distinct subgroup of IDH-wild type malignant astrocytic gliomas. However, characteristics detectable by MRI and F-FET PET in H3-G34-mutant gliomas are unknown. METHODS:We report on MRI and F-FET PET findings in 8 patients from 4 German centers with H3-G34-mutant diffuse gliomas. MRI analyses included multifocality, contrast enhancement, necrosis, cysts, hemorrhages, calcification, and edema. F-FET PET characteristics were evaluated on the basis of static F-FET PET parameters, such as maximal tumor-to-background ratio (TBRmax) and biological tumor volume (BTV), as well as the minimal time-to-peak (TTPmin) obtained from dynamic F-FET PET data. RESULTS:MRI showed multifocal lesions in 2 of 8, contrast enhancement in 6 of 8, necrosis in 3 of 8, cysts in 3 of 8, hemorrhage in 1 of 8, and calcifications in 1 of 8 patients. None of the tumors showed marked peritumoral edema. However, all 8 H3-G34-mutant gliomas were characterized by a high uptake intensity on F-FET PET with a median TBRmax of 3.4 (range, 2.5-11.7) and a relatively diffuse uptake pattern leading to a large BTV (median, 41.9 mL; range, 7.5-115.6). Dynamic PET data revealed a short median TTPmin of 12.5 minutes. CONCLUSIONS:MRI features of diffuse gliomas with H3-G34 mutation may present very heterogeneously with some cases not even fulfilling the imaging criteria of high-grade glioma. In contrast, in F-FET PET, these tumors show an extensive and diffuse tracer uptake resulting in large BTV with a high TBRmax and a short TTPmin, thus resembling PET characteristics of aggressive high-grade gliomas, namely, glioblastomas.

journal_name

Clin Nucl Med

authors

Vettermann FJ,Felsberg J,Reifenberger G,Hasselblatt M,Forbrig R,Berding G,la Fougère C,Galldiks N,Schittenhelm J,Weis J,Albert NL,Schüller U

doi

10.1097/RLU.0000000000002300

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

895-898

issue

12

eissn

0363-9762

issn

1536-0229

journal_volume

43

pub_type

杂志文章
  • A focal pulmonary F-18 FDG uptake without pulmonary CT abnormality in PET/CT probably due to mislocation of the urine F-18 FDG in the left upper renal calyx.

    abstract::We experienced a case of a focal pulmonary F-18 fluoro-2-deoxy-D-glucose (FDG) uptake without pulmonary computed tomography (CT) abnormality probably due to the urine FDG in the upper pole calyx of the left kidney. A 76-year-old male patient was referred for evaluation of the postoperative right lung cancer. Positron ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3181ea32f7

    authors: Tani A,Kajiya Y,Nakajo M,Nakajo M

    更新日期:2010-09-01 00:00:00

  • Dual time point C-11 acetate PET imaging can potentially distinguish focal nodular hyperplasia from primary hepatocellular carcinoma.

    abstract::C-11 acetate positron emission tomography (PET) is known to have high sensitivity in detecting hepatocellular carcinoma. However, one of the shortcomings of C-11 acetate PET in the diagnosis of hepatocellular carcinoma is that C-11 acetate also accumulates in focal nodular hyperplasia, which makes it challenging to di...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3181bed06e

    authors: Huo L,Wu Z,Zhuang H,Fu Z,Dang Y

    更新日期:2009-12-01 00:00:00

  • A rare case of ectopic adrenocorticotropic hormone syndrome caused by a metastatic neuroendocrine tumor of the pancreas detected by 68Ga-DOTANOC and 18F-FDG PET/CT.

    abstract::We report a rare case of ectopic adrenocorticotropic hormone (ACTH) syndrome caused by a metastatic neuroendocrine tumor (NET) of the pancreas detected by PET/CT using different tracers. A 43-year-old female patient with Cushing syndrome (CS) by suspected ectopic ACTH secretion underwent a 68Ga-DOTANOC and a 18F-FDG P...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318279ec68

    authors: Treglia G,Salomone E,Petrone G,Giaccari A,Rindi G,Rufini V

    更新日期:2013-07-01 00:00:00

  • Follow-up FDG PET in the evaluation of unexplained focal activity in the abdomen.

    abstract:PURPOSE:This study assessed the value of a follow-up FDG PET scan when the initial PET demonstrated unexplained findings of focal FDG uptake in the abdomen. METHOD:The records of 3634 patients with PET scans were retrospectively reviewed. Those patients who had follow-up PET scans after the initial PET scan showed une...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e31815c513c

    authors: Zhang Y,Xiu Y,Zhuang H,Dadparvar S,Yu JQ,Dhurairaj T,Alavi A

    更新日期:2008-01-01 00:00:00

  • Background correction in estimating initial renal uptake. Comparison between Tc-99m MAG3 and Tc-99m DTPA.

    abstract::A gamma camera method with no blood sampling assesses differential renal function based on initial renal uptake, and requires background correction. The effect of background correction on estimates of initial renal uptake was compared on renograms using Tc-99m MAG3 and Tc-99m DTPA renographies in 14 patients. Renal co...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199419120-00002

    authors: Inoue Y,Machida K,Honda N,Takahashi T,Mamiya T

    更新日期:1994-12-01 00:00:00

  • Radionuclide imaging of primary tumors and tumor-like conditions of the liver.

    abstract::The unique information provided by radionuclide techniques allows the noninvasive characterization of primary tumors and tumor-like conditions of the liver. A thorough knowledge of the mechanisms of radiopharmaceutical localization and the histologic abnormalities present in each condition is required to optimally use...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198707000-00022

    authors: Drane WE,Krasicky GA,Johnson DA

    更新日期:1987-07-01 00:00:00

  • Acute suppurative thyroiditis due to foreign body-induced retropharyngeal abscess presented as thyrotoxicosis.

    abstract::Acute suppurative thyroiditis is an uncommon condition. Most patients have preexisting oropharyngeal fistulae. Penetrating oropharyngeal injuries resulting from swallowed foreign bodies provide an acquired channel of infection spreading into the relatively resistant thyroid gland. The authors describe a patient with i...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-200004000-00001

    authors: Yung BC,Loke TK,Fan WC,Chan JC

    更新日期:2000-04-01 00:00:00

  • Diffuse thoracoabdominal radioactivity seen in bone imaging.

    abstract::Diffusely increased radioactivity in the thoracoabdominal region (lower thorax and/or upper abdomen) occasionally has been observed when performing Tc-99m phosphonate bone studies. To assess the significance of activity in this finding, 1100 bone scintigrams were reviewed and the clinical data and other diagnostic ima...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198604000-00008

    authors: Shih WJ,Coupal JJ,Domstad PA,DeLand FH

    更新日期:1986-04-01 00:00:00

  • Congenital hypothyroidism: diagnostic scintigraphic evaluation of an organification defect.

    abstract::Quantitative Tc-99m pertechnetate thyroid imaging was performed on a hypothyroid neonate. The image revealed markedly increased trapping in an enlarged, bilobed, eutopic gland. A perchlorate washout test using quantitative imaging with I-123 confirmed an organification problem. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198806000-00006

    authors: Cone L,Oates E,Vazquez R

    更新日期:1988-06-01 00:00:00

  • Fibrous Dysplasia Mimicking Malignancy on 68Ga-DOTATATE PET/CT.

    abstract::Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001527

    authors: Papadakis GZ,Millo C,Sadowski SM,Karantanas AH,Bagci U,Patronas NJ

    更新日期:2017-03-01 00:00:00

  • Diagnostic value of SPECT in a case of lower neck uptake on bone scan.

    abstract::Lower neck uptake in bone scan is hard to interpret because of superposition of several structures. Single photon emission computerized tomography can be beneficial, as illustrated in this patient with a laryngeal tumor. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198312000-00012

    authors: Mortelmans LA,DeRoo MJ

    更新日期:1983-12-01 00:00:00

  • Primary squamous cell carcinoma of the thyroid on FDG PET/CT.

    abstract::Primary squamous cell carcinoma of the thyroid is rare. We present FDG PET/CT findings on 2 male patients with primary squamous cell carcinoma of the thyroid. Elevated FDG activity was visualized on primary thyroid tumor and metastatic lesions on both patients. ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000511

    authors: Cai L,Chen Y,Huang Z,Wu J

    更新日期:2014-11-01 00:00:00

  • A rare case of sebaceous carcinoma with very malignant characteristics.

    abstract::A case of a sebaceous carcinoma is presented. This carcinoma of the skin appendages requires diagnosis by histopathology because the clinical appearance is often atypical. Because of the frequency of metastases to local lymph nodes and bone, a careful physical examination and appropriate radiologic/scintigraphic exami...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199305000-00012

    authors: Verlooy H,Mortelmans L,Schiepers C,De Roo M

    更新日期:1993-05-01 00:00:00

  • 123I MIBG appearance of severe renal artery stenosis.

    abstract::We describe a patient with labile hypertension and elevated metanephrines who underwent 123Iodine metaiodobenzylguanidine (MIBG) for the detection of a possible paraganglioma. The scan revealed markedly abnormal diffusely increased activity in the right renal parenchyma. A CT angiogram showed severe renal artery steno...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000510

    authors: Jordan A,Seltzer M,Siegel A

    更新日期:2014-11-01 00:00:00

  • Liver and vertebral uptake of Tc-99m macroaggregated albumin (MAA).

    abstract::An unusual phenomenon during lung scintigraphy is presented. Besides visualization of the lungs, accumulation of Tc-99m macroaggregated albumin (MAA) was seen in a small part of the liver and in and around several thoracic vertebrae. Contrast-enhanced radiographic computed tomography revealed extensive collateral path...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-200412000-00004

    authors: Esser JP,Oei HY,de Bruin HG,Krenning EP

    更新日期:2004-12-01 00:00:00

  • 68Ga-DOTATATE PET/CT in Focal Fatty Sparing of the Liver.

    abstract::Ga-DOTATATE imaging is commonly used for the detection of metastatic disease in neuroendocrine tumors. We present a case of a 69-year-old woman postsurgery for lung carcinoid tumor in which sequential follow-up Ga-DOTATATE PET/CT studies identified focal hepatic uptake that was presumed to represent a liver metastasis...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002746

    authors: Hod N,Levin D,Anconina R,Taragin BH,Dudnik J,Lantsberg S

    更新日期:2019-10-01 00:00:00

  • Minimal-Invasive Robot-Assisted Image-Guided Resection of Prostate-Specific Membrane Antigen-Positive Lymph Nodes in Recurrent Prostate Cancer.

    abstract::With the rapid expansion of robot-assisted surgical procedures, the need for robot-compliant image guidance technologies has also increased. Examples hereof are the integrated firefly fluorescence camera, the drop-in ultrasound probe, and the recently introduced DROP-IN gamma probe. Combined with Ga-prostate-specific ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002600

    authors: van Leeuwen FWB,van Oosterom MN,Meershoek P,van Leeuwen PJ,Berliner C,van der Poel HG,Graefen M,Maurer T

    更新日期:2019-07-01 00:00:00

  • Findings of subdural hematoma on Tc-99m-TRODAT-1 SPECT.

    abstract::Chronic subdural hematoma (SDH) is difficult to diagnose by clinical manifestations only. Nonspecific neurologic symptoms and signs may lead physicians to make other diagnoses. Although head trauma is the most common cause, it may be considered insignificant or omitted due to its minor initial manifestations. We prese...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e31819a1ed8

    authors: Hsieh TC,Kao CH,Wu YC,Wang CH,Yen KY,Sun SS

    更新日期:2009-04-01 00:00:00

  • Tips for leaders, Part II: Leading a private practice physician group.

    abstract::Leaders of private practice groups face many challenges. Establishing proper governance, having a good mission statement and business plan, having good participation by the members in administrative practice activities, and establishing proper channels of communication are some important steps. Once that is done, effi...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e318223f3cc

    authors: Harolds JA

    更新日期:2011-09-01 00:00:00

  • Role of technetium-99m N,N-ethylenedicysteine renal scintigraphy in the evaluation of differential renal function and cortical defects.

    abstract:PURPOSE:This study was performed to evaluate the effectiveness of technetium-99m N,N-ethylenedicysteine (Tc-99m EC) in comparison to technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) scintigraphy. Differential renal function (DRF) was calculated by both methods and the cortical-phase images of dynamic Tc-99m EC scin...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000200460.41091.13

    authors: Buyukdereli G,Guney IB

    更新日期:2006-03-01 00:00:00

  • Left Ventricular Infected Thrombus Detected by 18F-FDG PET/CT and MRI in Disseminated Staphylococcus Infection.

    abstract::We present the case of a 61-year-old woman with fever and acute meningitis. Clinical evaluation revealed maculopapular rash, right gluteus cellulitis, and centered retinal hemorrhages. In the intensive care unit, persistent Staphylococcus bacteremia was detected. However, transesophageal echocardiography did not revea...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000003301

    authors: García Vicente AM,Villar García M,Blanch Sancho JJ,Soriano Castrejón Á

    更新日期:2020-12-01 00:00:00

  • Hematopoietically Active Adrenal Myelolipoma Mimicking Breast Cancer Metastasis.

    abstract::A 66-year old woman had a left breast mass. Biopsy showed invasive ductal carcinoma. A PET/CT scan demonstrated hypermetabolism in the left breast and atypical heterogeneously increased uptake throughout the skeleton as well as a minimally FDG-avid right adrenal myelolipoma. PET/CT 4 months later after 6 cycles of neo...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002144

    authors: Manov JJ,Diaz-Bode A,Kuker R

    更新日期:2018-08-01 00:00:00

  • An Unusual Bone Metastasis Mimicking SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis) Syndrome on Bone Scintigraphy.

    abstract::The costosternoclavicular region is not a common bone metastasis site, and symmetrical involvement is even rarer. Increased tracer uptake in the manubrium and sternoclavicular joints usually gives the typical "bull-horn" appearance seen in SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis). Herei...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001061

    authors: Ni J,Tang P

    更新日期:2016-02-01 00:00:00

  • Pentavalent technetium-99m DMSA uptake in pseudofractures of osteomalacia.

    abstract::Tc-99m MDP and Tc-99m (V) DMSA images are described from a 49-year-old woman with chronic renal insufficiency complicated by osteomalacia. Clinical, biochemical, and radiologic bone profiles were compatible with osteomalacia. Osteomalacia is a condition associated with disorders in which mineralization of the organic ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-200101000-00017

    authors: Sahin M,Basoglu T,Albayrak S,Canbaz F,Yapici O

    更新日期:2001-01-01 00:00:00

  • FDG PET/CT Imaging of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus.

    abstract::Hepatocellular carcinoma rarely involves the major bile duct. Here, we reported a 46-year-old man with liver cancer who underwent FDG PET/CT for staging. The images showed abnormal FDG uptake in the left lobe and hilum of the liver, which was confirmed as hepatocellular carcinoma and hepatic portal bile duct tumor thr...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002406

    authors: Zhang W,Fang C,Liu H,Chen Y

    更新日期:2019-02-01 00:00:00

  • 18F-FDG PET/CT Features of Chronic Sclerosing Sialadenitis Presenting as Localized IgG4-Related Disease.

    abstract::Chronic sclerosing sialadenitis is a benign inflammatory condition that most commonly affects the submandibular gland in elderly individuals. It is currently known to belong to the spectrum of IgG4-related systemic diseases, which is reflected by systemic involvement on F-FDG PET/CT images. We presented a case of a 73...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000001482

    authors: Kashiwagi N,Enoki E,Hosokawa C,Sakaguchi K,Murakami T

    更新日期:2017-02-01 00:00:00

  • Intrathyroidal parathyroid adenoma.

    abstract::A 54-year-old woman was referred for imaging studies after presentation for palpitations and a palpable thyroid nodule. The patient underwent a dual-phase single-agent Tc-99m sestamibi scan followed later by a thyroid ultrasound at an outside hospital. The Tc-99m sestamibi scan showed a marked focus of activity separa...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000167481.79767.93

    authors: Prasad B,Fleming RM

    更新日期:2005-07-01 00:00:00

  • Skeletal photopenic appearance of Paget's disease with indium-111 white blood cell imaging.

    abstract::A case of focal decreased skeletal uptake with In-111 labeled white blood cells representing Paget's disease is reported. Although uncommon, other causes for skeletal photon deficient areas using In-111 white blood cells have been described. To the authors' knowledge, this finding representing Paget's disease has not ...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-198710000-00004

    authors: Borin BF,Abghari R,Sarkissian A

    更新日期:1987-10-01 00:00:00

  • Clinical study of urinary excretion of Ga-67.

    abstract::Ga-67 urinary excretion was examined in 59 patients. The 72-hour urinary excretion rate ranged from 4.3 to 67.8% of the injected dose. Within the first 24 hours, 60.9% of the 72-hour urinary excretion was excreted. There was no significant difference in the Ga-67 urinary excretion rate between males and females, nor b...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-199004000-00012

    authors: Nakano S,Hasegawa Y,Ibuka K,Hashizume T,Noguchi A,Kojima J,Sasakuma F,Ishigami S

    更新日期:1990-04-01 00:00:00

  • Efficacy of FDG PET/CT imaging for venous thromboembolic disorders: preliminary results from a prospective, observational pilot study.

    abstract:PURPOSE:In recent years, several case reports have described venous thromboembolism (VTE) on FDG PET/CT. In this short communication, we present results from a proof-of-concept pilot study aimed at providing some preliminary data on the efficacy of FDG PET/CT in prospective patients with suspected VTE. PATIENTS AND ME...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000000453

    authors: Hess S,Madsen PH,Iversen ED,Frifelt JJ,Høilund-Carlsen PF,Alavi A

    更新日期:2015-01-01 00:00:00