Treatment rationale in thyroid carcinoma. Effect of scan dose.

Abstract:

:The authors have previously shown that the definition of ablation of thyroid tissue in patients treated with thyroidectomy and radioiodine (I-131) for thyroid carcinoma depends upon the dose of I-131 used to scan the patient. The therapeutic response to I-131 therapy was evaluated in a group of ten differentiated thyroid cancer patients who had a negative 2-mCi (-2 mCi) diagnostic study, but had a positive 10-mCi (+10 mCi) diagnostic study (group 1) during their follow-up evaluation. These results were compared to another group of ten differentiated thyroid cancer patients who received I-131 ablation therapy based on a positive 2-mCi (+2 mCi) I-131 scan (group 2). Six patients in group 1 and eight in group 2 had improvement or ablation of residual tissue based on the 10-mCi scan following therapy. The difference in response between the two groups was not statistically significant (P = 0.63) by two-tailed Fisher's exact test, indicating that even patients with -2-mCi, but +10-mCi scans may respond to I-131 therapy. Whether the large dose therapy makes any impact on the clinical outcome has not been answered by this study.

journal_name

Clin Nucl Med

authors

Ramanna L,Waxman AD,Brachman MB,Tanasescu DE,Chapman N,Braunstein GD

doi

10.1097/00003072-198510000-00003

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

687-9

issue

10

eissn

0363-9762

issn

1536-0229

journal_volume

10

pub_type

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