Findings of 123I-iomazenil SPECT during and after stroke-like episodes in a patient with MELAS.

Abstract:

:Reduced cortical benzodiazepine receptor binding potential in late images of I-iomazenil SPECT indicates neuronal damage in the cortex. We present the case of a 31-year-old woman with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had focal seizures in the right hand. FLAIR imaging in the ictal state revealed a high-intensity lesion in the left post-central gyrus, while I-iomazenil SPECT showed decreased tracer uptake in this lesion. The lesion completely disappeared on FLAIR imaging performed 1 month after the focal seizures; in contrast, I-iomazenil SPECT still revealed a significant decrease in tracer uptake in this lesion.

journal_name

Clin Nucl Med

authors

Taguchi Y,Takashima S,Noguchi K,Tanaka K

doi

10.1097/RLU.0b013e318299610f

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

e334-5

issue

6

eissn

0363-9762

issn

1536-0229

journal_volume

39

pub_type

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