Abstract:
BACKGROUND:We aim to retrospectively evaluate the impact of hormone therapy (HT) on FDG avidity of metastatic lesions in patients with breast cancer (BC) undergoing PET/CT. PATIENTS AND METHODS:Three hundred eight patients with BC were scanned with PET/CT at 2 Italian institutions (mean time from diagnosis 4 yrs, range: 1-24 yrs). Main indications for PET/CT were elevation of tumor markers (34.4%) and clinical or radiological suspicion of relapse (65.6%). The diagnostic accuracy of FDG PET/CT was computed according to the standard method. Student t test was used to assess the mean differences between the study groups, whereas categorical data were compared with chi-square test. Significance was set at P <0.05. RESULTS:Two hundred sixty-four patients with positive estrogen receptor and who had received adjuvant HT were included in the analysis. At the time of PET/CT scan, HT was ongoing in 176 patients (66.7%) and 88 (33.3%) had completed adjuvant HT. Ninety-eight (55.7%) patients on HT and 59 (67%) off HT had a positive PET/CT; therefore, the scan resulted negative in the remaining 107 patients, 78 and 29 on and off HT, 44.3% and 33%, respectively (P < 0.001). At a median follow-up of 7 months (range 1-48 mos), disease recurrence was confirmed in either clinical or radiological examinations in 126 (47.7%) patients; 72 (40.9%) versus 54 (61.4%) patients on and off HT, respectively (P < 0.005). True-positive PET/CT results were found in 82% and 91% of patients on and off HT, respectively, whereas it failed to identify disease relapse in 13 (18%) and 5 (9%) patients on and off HT, respectively. CONCLUSIONS:In our series, FDG PET/CT shows a similar diagnostic accuracy in detecting disease relapse between patients with BC on adjuvant HT versus those who have completed therapy. These preliminary results suggest that the glucose metabolism is not altered by hormonal suppression at the time of the scan.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Evangelista L,Redana S,Racca M,Geuna E,Vinante L,Zago G,De Carolis V,Ghiotto C,Saladini G,Varetto Tdoi
10.1097/RLU.0b013e318287353esubject
Has Abstractpub_date
2014-02-01 00:00:00pages
e135-41issue
2eissn
0363-9762issn
1536-0229pii
00003072-201402000-00033journal_volume
39pub_type
杂志文章abstract::We present the F-FDG and Ga prostate-specific membrane antigen PET/CT images of a 61-year-old patient with a newly diagnosed prostate carcinoma (4 + 4 Gleason score) and high serum prostate-specific antigen levels (460 ng/mL). In F-FDG PET/CT, minimal uptake was demonstrated in the prostatic mass without any accompany...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001176
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000814
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198904000-00007
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abstract::Extramedullary involvement in multiple myeloma is rare, but carries poor prognosis. We describe the FDG PET-CT findings of rare adrenal involvement in a case of multiple myeloma. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002195
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abstract:PURPOSE:This study assessed the value of a follow-up FDG PET scan when the initial PET demonstrated unexplained findings of focal FDG uptake in the abdomen. METHOD:The records of 3634 patients with PET scans were retrospectively reviewed. Those patients who had follow-up PET scans after the initial PET scan showed une...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31815c513c
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002897
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journal_title:Clinical nuclear medicine
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doi:10.1097/RLU.0b013e31827087e3
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journal_title:Clinical nuclear medicine
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doi:10.1097/00003072-198411000-00020
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000242693.69039.70
更新日期:2006-11-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001217
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318219ad31
更新日期:2011-08-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199705000-00006
更新日期:1997-05-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199612000-00007
更新日期:1996-12-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318292eedf
更新日期:2013-07-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197905000-00002
更新日期:1979-05-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182639bd9
更新日期:2012-11-01 00:00:00
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journal_title:Clinical nuclear medicine
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doi:10.1097/00003072-198206000-00003
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001584
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199507000-00006
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198312000-00012
更新日期:1983-12-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198905000-00006
更新日期:1989-05-01 00:00:00
abstract::A 51-year-old woman with infiltrating ductal carcinoma of left breast, who postsurgery, chemotherapy, and external radiotherapy presented with recurrence in the right chest wall a year after completion of treatment. An excision biopsy of the right chest wall nodule showed deposits of infiltrating ductal carcinoma. She...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181966fb3
更新日期:2009-03-01 00:00:00
abstract:UNLABELLED:This study evaluates the diagnostic utility of 3-phase bone scintigraphy for diagnosing osteoradionecrosis of the jaw (ORNJ). METHODS:Thirty-two consecutive patients with a history of radiation to the head and neck region (range, 62-70 Gy; mean, 68 Gy; median, 69 Gy) due to squamous cell cancer and suspecte...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000296
更新日期:2014-01-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002791
更新日期:2019-11-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31827a263e
更新日期:2014-01-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31829af5ed
更新日期:2013-08-01 00:00:00