Abstract:
UNLABELLED:This study evaluates the diagnostic utility of 3-phase bone scintigraphy for diagnosing osteoradionecrosis of the jaw (ORNJ). METHODS:Thirty-two consecutive patients with a history of radiation to the head and neck region (range, 62-70 Gy; mean, 68 Gy; median, 69 Gy) due to squamous cell cancer and suspected ORNJ underwent 3-phase bone scans after injection of 520 to 750 MBq of Tc-MPD. In addition to planar scans, tomographic images (SPECT) were acquired in the second phase and SPECT/CT images during the third phase. Histopathologic findings (n = 18) and clinical follow-up (n = 14) served as reference standard for osteoradionecrosis. RESULTS:The first, second, and third phases of planar images were rated positive in 18/32 patients (56.3%), 25/32 (78.1%), and 27/32 patients (84.4%), respectively. The late SPECT was positive in all patients (32/32, 100%), respectively. Histopathologic findings available in 18/32 patients (56.3%) confirmed ORNJ in all subjects. Acute inflammation was histologically proven in 18/18 specimens (100%) and additional chronic inflammation in 12/18 (66.7%). In 13/18 (72.2%) specimens, superinfection was evident histopathologically. A photopenic defect with surrounding hypermetabolism, a reported hallmark of ORJN, was found in less than 5%. CONCLUSIONS:The predominant scintigraphic pattern of osteoradionecrosis includes increased bone mineralization phase in all patients. Central photopenia, reportedly a typical bone scan finding in bisphosphonate-induced osteonecrosis, was not characteristic for ORNJ. A differentiation of acute from chronic inflammatory processes was not possible.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Lapa C,Linz C,Bluemel C,Mottok A,Mueller-Richter U,Kuebler A,Schneider P,Czernin J,Buck AK,Herrmann Kdoi
10.1097/RLU.0000000000000296subject
Has Abstractpub_date
2014-01-01 00:00:00pages
21-5issue
1eissn
0363-9762issn
1536-0229journal_volume
39pub_type
杂志文章abstract::The use of a simple, noninvasive, isotope scanning technique for the determination of relative portal blood flow and detection of portal hypertension is described. Using this technique the presence of portal hypertension was demonstrated in seven of nine patients known to have elevated portal venous pressure. By contr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198708000-00006
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abstract::Tc-99m hydroxymethylene disphosphonate administered for skeletal scintigraphy may be seen in the extraosseous tissues for various etiologies. This report presents similar abnormal lower extremity skeletal muscle uptake in 2 patients status postorthotopic liver transplant. Although the history and scintigraphic appeara...
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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更新日期:1991-10-01 00:00:00
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doi:10.1097/00003072-199601000-00002
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journal_title:Clinical nuclear medicine
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pub_type: 杂志文章,评审
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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doi:10.1097/RLU.0000000000001990
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abstract::Neurolymphomatosis (NL) is a rare, unique subtype of lymphomatous infiltration of peripheral nerves. Clinical/radiologic diagnosis of NL is challenging. We report F-18 FDG PET/CT findings of a case of breast diffuse large B-cell lymphoma, in which NL developed regardless of regression of systemic lesions during induct...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181f4a03f
更新日期:2011-01-01 00:00:00
abstract::Abnormal accumulation of Tc-99m MDP in the lungs and stomach was observed in a patient with multiple myeloma and refractory hypercalcemia. There was no roentgenographic evidence of calcification. At postmortem examination, the presence of amyloid deposits was confirmed in both organs, while the corresponding metastati...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章,meta分析
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更新日期:2014-05-01 00:00:00
abstract::A 32-month-old female child with a history of stage IV favorable biology neuroblastoma with a 123-I MIBG (metaiodobenzylguanidine scan) avid adrenal mass, with retroperitoneal nodal extension and bony metastasis, was in complete remission after intense multimodal therapy. Seventeen months after diagnosis a surveillanc...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181ea3502
更新日期:2010-09-01 00:00:00
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journal_title:Clinical nuclear medicine
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doi:10.1097/RLU.0b013e3181feeb48
更新日期:2011-01-01 00:00:00