Abstract:
PURPOSE:This study aimed to evaluate the prognostic value of F-FDG uptake of portal vein tumor thrombosis (PVTT) for predicting progression-free survival (PFS) and overall survival (OS) in patients with locally advanced hepatocellular carcinoma (HCC). METHODS:The study retrospectively included 166 HCC patients with PVTT and no extrahepatic metastases who underwent staging FDG PET/CT. Tumor-to-liver uptake ratio (TLR) and PVTT-to-liver uptake ratio (PLR) were measured for each patient, and the prognostic values of clinical factors, TLR, and PLR were assessed. Furthermore, patients were classified into 2 subgroups according to TLR, and the prognostic value of PLR was evaluated in each subgroup. RESULTS:Median PFS and OS were 6.2 and 10.1 months, respectively. On multivariate analysis, tumor size (P = 0.006) and PLR (P = 0.03) were independent prognostic factors for PFS, whereas Child-Pugh class (P = 0.02) and PLR (P = 0.02) were independent prognostic factors for OS. Tumor-to-liver uptake ratio was a significant prognostic factor for PFS and OS on univariate analysis but failed to show significance on multivariate analysis. In both patient subgroups with low and high TLR, PLR remained a significant prognostic factor for predicting OS (P = 0.04 for all). CONCLUSIONS:FDG uptake of PVTT, but not FDG uptake of HCC, is an independent prognostic factor for PFS and OS in HCC patients with PVTT and no extrahepatic metastasis. Given the prognostic significance, it is strongly encouraged to use FDG uptake of PVTT in further risk stratification for HCC patients with PVTT.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Lee JW,Hwang SH,Kim DY,Han KH,Yun Mdoi
10.1097/RLU.0000000000001422subject
Has Abstractpub_date
2017-01-01 00:00:00pages
e35-e40issue
1eissn
0363-9762issn
1536-0229journal_volume
42pub_type
杂志文章abstract::Ga DOTATATE PET/CT in noninvasive characterization of synchronous pituitary neoplasm and meningioma in a 38-year-old man is illustrated. The patient presented with an MRI-detected lobulated enhancing sellar-suprasellar mass with erosion of bony sella measuring 4.5 × 3.5 × 3.4 cm (with differential diagnosis with germ ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001021
更新日期:2016-03-01 00:00:00
abstract::A patient with bilateral adrenal hyperplasia, due to the ectopic adrenocorticotrophic hormone (ACTH) syndrome, received a 3-month course of treatment with 1,1 dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p' DDD), which caused adrenal hypofunction requiring steroid therapy. Eleven months later, Cushing's synd...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198805000-00011
更新日期:1988-05-01 00:00:00
abstract::An 18F-FDG PET/CT scan was performed in a 26-year-old man with a known alveolar rhabdomyosarcoma for staging. The PET/CT scan showed abnormally increased FDG activity involving almost all bones in the imaged regions. In contrast, 99mTc-MDP whole-body bone scan demonstrated only very limited bone metastases. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000277
更新日期:2013-12-01 00:00:00
abstract::The new combined positron emission (PET)/computed tomographic (CT) scanners have many advantages over PET scanners alone. However, physicians must be aware of the potential artefacts observed in PET/CT scanners. A body PET/CT was performed on an 81-year-old man with colorectal cancer. The CT-based, attenuation-correct...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000093095.28642.2b
更新日期:2003-11-01 00:00:00
abstract::Here we describe a 77-year-old man with a solitary fibrous tumor of the pleura showing increasing tracer uptake at Ga-DOTATOC PET/CT, demonstrating that solitary fibrous tumor of the pleura may overexpress somatostatin receptors, therefore mimicking neuroendocrine tumors at somatostatin receptor PET/CT. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001648
更新日期:2017-06-01 00:00:00
abstract::Tc-99m galactosyl-neoglycoalbumin (NGA) is a new liver imaging agent that specifically binds to a hepatocyte specific membrane receptor, the hepatic binding protein. Scintigraphy with Tc-99m NGA is a noninvasive method that provides functional images of the liver. This report deals with one case of fulminant hepatic f...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199504000-00009
更新日期:1995-04-01 00:00:00
abstract::Twenty of 22 patients with tuberculous hepatitis had abnormal Tc-99m tin colloid liver scans. However, in the majority of the patients the changes were mild and nonspecific. The most frequent scintigraphic picture was a decreased uptake of the radiocolloid by the liver, with shunting to the spleen and bone marrow. The...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198402000-00006
更新日期:1984-02-01 00:00:00
abstract::Leprosy is a disease that is widely distributed in underdeveloped tropical regions, with cases also occurring in the United States. The bone scan findings in a patient with leprosy who had developed a reactional state of the disease, erythema nodosum leprosum, are presented. His scan showed bilaterally symmetrical dou...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198703000-00012
更新日期:1987-03-01 00:00:00
abstract::A 61-year-old-man with persistent anemia was referred for a Tc-99m-labeled red blood cell (RBC) scan to detect any source of gastrointestinal bleeding. RBC scintigraphy revealed a hypervascular mass in the left renal fossa with functional loss in that kidney, suggesting the possibility of a renal cell carcinoma (RCC)....
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000093089.53875.3e
更新日期:2003-11-01 00:00:00
abstract::A case of 99mTcO4 accumulation within the thorax is reported, consistent with septic emboli and thyroiditis during routine thyroid scintigraphy for subclinical hyperthyroidism. After antibiotic treatment, repeated 99mTcO4 imaging revealed complete resolution of foci of septic emboli. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000245
更新日期:2013-12-01 00:00:00
abstract::Hemiplegic migraine (HM) is an unusual type of migraine, with few cases reported in the literature. Unlike other types of migraine, aura HM presents accompanying motor deficit manifestations that do not last more than 24 hours. We report a 27-year-old man referred to us from the emergency department to carry out a cer...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31826c0cf1
更新日期:2013-02-01 00:00:00
abstract::Gallium-67 distribution in normal patients is well known; it is also known that the concentration in some tissues may vary according to an individual physiologic stimulus. In this report, the case of a young woman is presented who was studied 15 days after a cesarean section and showed physiologic and pathologic Ga-67...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198402000-00011
更新日期:1984-02-01 00:00:00
abstract::A 38-year-old woman presented with nausea and abdominal distension 15 months after surgical resection of osteoclast-like giant cell tumor in the left lobe of the liver. An 18F-FDG PET/CT scan was performed to evaluate the recurrent tumor. The images demonstrated the recurrent malignancy in the liver. In addition, meta...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31826392c4
更新日期:2012-10-01 00:00:00
abstract::Dermatofibrosarcoma protuberans (DFSP) is a cutaneous tumor of intermediate-grade malignant potential, and it rarely shows dedifferentiation to high-grade fibrosarcoma, which is called "fibrosarcomatous DFSP." We present the enhanced MRI and PET/MRI findings and our comparison with pathological findings in a case of f...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001099
更新日期:2016-03-01 00:00:00
abstract::The authors evaluated the clinical applications of Tc-99m methoxy isobutyl isonitrile (MIBI) in the simultaneous assessment of ventricular function and myocardial perfusion in patients with congenital heart disease. Global ventricular function was assessed by first-pass ECG gated study. Myocardial perfusion was evalua...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199401000-00009
更新日期:1994-01-01 00:00:00
abstract::The authors report atypical findings of discordant bone scans and radiography seen in a patient with transient osteoporosis of the hip (TOH). Presented in the case of a 60-year-old man who had spontaneous onset of left hip pain which worsened for 2 months with weight-bearing on the affected side. Initial and follow-up...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
doi:10.1097/00003072-199803000-00006
更新日期:1998-03-01 00:00:00
abstract::The speed of Tc-99m DTPA/HMPAO radioaerosol clearance from the lungs that is represented as a slope from lungs to blood was measured in 23 male normal controls using commercial lung radioaerosol delivery units in the supine position in order to avoid the influences of gravity. The right lung was selected and three reg...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199507000-00016
更新日期:1995-07-01 00:00:00
abstract::A Tc-99m Technegas MAA-SPECT was performed on an 81-year-old woman to exclude pulmonary embolism. It showed hypoperfusion and practically absent ventilation of the entire left lung, suggesting a left-sided centrally localized airway obstruction or compression with secondary hypoxic vasoconstriction. Subsequent broncho...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3181b06bea
更新日期:2009-09-01 00:00:00
abstract::Hepatobiliary scans are performed frequently to identify gallbladder-related disease. Although gallbladder stones are a common cause of hepatobiliary disease, they are visualized directly only rarely on hepatobiliary scans. Large gallbladder stones produced a photopenic defect in the gallbladder in a hepatobiliary sca...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200101000-00027
更新日期:2001-01-01 00:00:00
abstract:ABSTRACT:We report the case of a 45-year-old woman with a history of right breast reconstruction with silicone implant for breast cancer. An 18F-FDG PET/CT performed several years later revealed the presence of 18F-FDG-avid nodules at the periphery of the silicone implant, in the right internal mammary chain, and in th...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003422
更新日期:2021-02-01 00:00:00
abstract::The images of a patient with acromegaly, who previously underwent operation for pituitary adenoma, were obtained. The MRI scan showed a mass in the right cavernous sinus, with biochemical test results positive for the presence of a hormonally active adenoma. The patient was scheduled for CyberKnife radiotherapy. Radio...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000535
更新日期:2014-12-01 00:00:00
abstract::To assess both ventricular function and myocardial perfusion, five normal volunteers, 19 patients with coronary artery disease, and two patients with cardiomyopathy and normal coronary arteries were injected with 20 mCi of Tc-99m isonitrile (either methoxyisobutyl isonitrile or carbomethoxyisopropyl isonitrile) at pea...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198802000-00001
更新日期:1988-02-01 00:00:00
abstract::Forty-one patients (25 male, 16 female) were studied by RNCA in our institution. There were 42 rest studies and 24 stress studies (66 studies total). Sixteen patients were normal, 15 had ASHD, seven had a cardiomyopathy, and three had left-sided valvular regurgitation. Each study was preprocessed using both the standa...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198406000-00004
更新日期:1984-06-01 00:00:00
abstract::Pituitary macroadenoma constitutes a frequently misdiagnosed benign tumor. We report herein a case where such macroadenoma, a prolactinoma, was incidentally discovered in a 63-year-old man who had been referred to F-FDG PET and F-FDOPA PET imaging for a pharmacoresistant epilepsy. An increased uptake was documented fo...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001721
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:PET scanning of the brain with F-18 FDG and C-11 methionine (MET) is useful for characterizing brain lesions discovered at MRI or CT. Most positive PET scans indicate malignancy. However, this case report demonstrates positive F-18 FDG and C-11 MET PET scans in a patient with a nonmalignant condition, neurosarc...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000222735.19513.bb
更新日期:2006-07-01 00:00:00
abstract::Three cases involving renal scans that showed both severe photopenia and also increase in uptake in a rim surrounding the renal graft are presented. As previously mentioned in the literature, the bad prognostic import of photopenia is confirmed. The increased rim of activity has been rarely mentioned in the literature...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198508000-00012
更新日期:1985-08-01 00:00:00
abstract::A 56-year-old woman presented a history of left chest discomfort for 6 months. A prior CT revealed pericardial thickening, and malignancy cannot be excluded. For this reason, an FDG PET/CT scan was performed, which revealed abnormal activity inside the pericardium. The pathologic examination results after surgery demo...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000396
更新日期:2014-04-01 00:00:00
abstract::Mental nerve neuropathy (numb chin/lip syndrome) is a sensory neuropathy presenting with numbness in the distribution of the inferior alveolar nerve/mental nerve (chin and lower lip). This is typically unilateral and can be secondary to dental disease or malignancy. When caused by malignancy, these symptoms can be eit...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182868ae5
更新日期:2013-05-01 00:00:00
abstract::In order to evaluate the renal excretion quantitatively, the authors analyzed the Tc-99m DTPA renogram using mean transit time (MTT) with deconvolution analysis and compared it to the perfusion index. One hundred thirteen studies consisting of 25 normal, 11 obstruction, 35 transplant-norm, 12 transplant-obstruction, a...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198901000-00003
更新日期:1989-01-01 00:00:00
abstract::Increased bone activity in the sacroiliac joints has been shown to be a sensitive method for detecting sacroiliitis in brucellosis. Because symmetrically increased uptake usually is difficult to detect, this study was performed to improve the sensitivity by quantifying sacroiliac joint uptake. Quantification was accom...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199910000-00005
更新日期:1999-10-01 00:00:00