Follow-up FDG PET in the evaluation of unexplained focal activity in the abdomen.

Abstract:

PURPOSE:This study assessed the value of a follow-up FDG PET scan when the initial PET demonstrated unexplained findings of focal FDG uptake in the abdomen. METHOD:The records of 3634 patients with PET scans were retrospectively reviewed. Those patients who had follow-up PET scans after the initial PET scan showed unexplained FDG activity in the abdomen were further analyzed. The results from the second PET scan were compared with the follow-up data, which included the findings from other imaging modalities, clinical course, and biopsy or surgical pathology interpretations. RESULTS:A total of 59 patients were included in the final analysis. The average time interval between the initial and the follow-up PET scans was 4.2 + 2.3 months. The follow-up PET provided a clear-cut diagnosis in 55 (93.2%) of these patients, whereas diagnoses in only 4 patients remained indeterminate. Follow-up PET scans were negative for abdominal malignancy in 38 patients. Thirty-five of these 38 patients with negative follow-up PET were proven to be without abdominal malignancy, with a negative predictive value of 92.1% (35 of 38). The follow-up PET was positive in 17 patients. Fifteen of these 17 patients with a positive follow-up PET scans were found to have malignancy in the abdomen with a positive predicative value of 88.2% (15 of 17). All 4 patients with indeterminate follow-up scans were proven not to have malignancy. CONCLUSION:Follow-up FDG PET scan provides an effective means for diagnosing unexplained findings in the abdomen that were previously detected on initial PET scan.

journal_name

Clin Nucl Med

authors

Zhang Y,Xiu Y,Zhuang H,Dadparvar S,Yu JQ,Dhurairaj T,Alavi A

doi

10.1097/RLU.0b013e31815c513c

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

19-22

issue

1

eissn

0363-9762

issn

1536-0229

pii

00003072-200801000-00005

journal_volume

33

pub_type

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