Abstract:
:In this response article, we challenge a core assumption that lies at the centre of a round table discussion regarding the Pharmacogenetics to Avoid Loss of Hearing trial. The round table regards a genetic test for a variant (mt.1555A>G) that increases the risk of deafness if a carrier is given the antibiotic gentamicin. The idea is that rapid testing can identify neonates at risk, providing an opportunity to prevent giving an antibiotic that might cause deafness. We challenge the assumption that a positive test unequivocally guides antibiotic choice because, aside from the risk of deafness, all antibiotics for neonatal sepsis are equivalent. We argue that this assumption is faulty and has particularly troubling moral consequences. We claim that giving an alternative to gentamicin is potentially providing inferior treatment and thereby may increase the risk of death. Parents and doctors are faced with a terrible choice as a result of positive point-of-care testing (POCT): give gold-standard treatment and risk deafness or give second line care and risk death. While we do not indicate an answer to this choice, what we do argue is that such a deep and difficult choice is one that may make parents wish genetic testing was never undertaken, and therefore, contra some authors in the round table, provides a reason to gain specific consent for POCT.
journal_name
J Med Ethicsjournal_title
Journal of medical ethicsauthors
Parker J,Wright Ddoi
10.1136/medethics-2020-106807subject
Has Abstractpub_date
2021-02-01 00:00:00pages
114-116issue
2eissn
0306-6800issn
1473-4257pii
medethics-2020-106807journal_volume
47pub_type
杂志文章abstract::This paper re-evaluates euthanasia and assisted suicide from the perspective of eudaimonia, the ancient Greek conception of happiness across one's whole life. It is argued that one cannot be said to have fully flourished or had a truly happy life if one's death is preceded by a period of unbearable pain or suffering t...
journal_title:Journal of medical ethics
pub_type: 历史文章,杂志文章
doi:10.1136/jme.2008.028852
更新日期:2009-09-01 00:00:00
abstract::Most moral dilemmas in medicine are analysed using the four principles with some consideration of consequentialism but these frameworks have limitations. It is not always clear how to judge which consequences are best. When principles conflict it is not always easy to decide which should dominate. They also do not tak...
journal_title:Journal of medical ethics
pub_type: 评论,杂志文章
doi:10.1136/jme.29.5.297
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abstract::The question of whether old age should or should not play a role in medical decision-making for the elderly patient is regularly debated in ethics and medicine. In this paper we investigate exactly how age influences the decision-making process. To explore the normative argumentation in the decisions regarding an elde...
journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2008.025247
更新日期:2008-12-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2019-105635
更新日期:2020-02-01 00:00:00
abstract::The author responds to Professor Kottow's criticisms, explaining numerous errors and misconceptions. ...
journal_title:Journal of medical ethics
pub_type: 评论,杂志文章
doi:10.1136/jme.25.4.344
更新日期:1999-08-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.29.4.261
更新日期:2003-08-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2013-101765
更新日期:2015-05-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2003.006684
更新日期:2005-04-01 00:00:00
abstract::This paper is a response to Dr Shinebourne's response to my recent paper assessing the relative merits of the Staffordshire Protocol on covert video surveillance. Dr Shinebourne does not take the opportunity to rebut the criticisms made of the text of the protocol. It is further suggested that judicial oversight of th...
journal_title:Journal of medical ethics
pub_type: 评论,杂志文章
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更新日期:1996-12-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2006.016162
更新日期:2007-05-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.9.1.28
更新日期:1983-03-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 历史文章,杂志文章
doi:10.1136/jme.5.2.76
更新日期:1979-06-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2015-103222
更新日期:2017-04-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2006.016477
更新日期:2007-01-01 00:00:00
abstract::I sketch a libertarian argument for the right to test in the context of 'direct to consumer' (DTC) genetic testing. A libertarian right to genetic tests, as defined here, relies on the idea of a moral right to self-ownership. I show how a libertarian right to test can be inferred from this general libertarian premise,...
journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2015-102827
更新日期:2016-09-01 00:00:00
abstract::This paper relates two experiences of teaching medical ethics, the first to a small group of clinical medical students, the second to a larger group of GP trainees. :Boyd, a theologian who is Scottish Director of the Institute of Medical Ethics, comments on a day he spent teaching two ethics sessions, one to a group ...
journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.13.3.132
更新日期:1987-09-01 00:00:00
abstract::The concept of evidence-based medicine (EBM) has been invented by physicians mostly from English Canada, mostly from McMaster University, Ontario, Canada. The term EBM first appeared in the biomedical literature in 1991 in an article written by a prominent member of this group-Gordon Guyatt from McMaster University. T...
journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2010.039735
更新日期:2011-03-01 00:00:00
abstract::The passing on of information to GPs by genito-urinary doctors is to be encouraged but is not always possible and ultimately the patient's wishes and confidentiality must be respected if sexually transmitted diseases and HIV infection are to be controlled. Infected health-care workers should seek counselling and medic...
journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.17.4.196
更新日期:1991-12-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 评论,杂志文章
doi:10.1136/medethics-2019-105489
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2019-105983
更新日期:2020-05-04 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章,多中心研究
doi:10.1136/jme.2007.020693
更新日期:2008-05-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2015-103045
更新日期:2017-07-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2007.023341
更新日期:2008-10-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2013-101458
更新日期:2015-05-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.18.4.206
更新日期:1992-12-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2019-105879
更新日期:2020-08-19 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2006.018523
更新日期:2007-12-01 00:00:00
abstract::Judges face difficult choices when the birth and genetic mothers of a child are separate people who dispute maternal access; the views of the general population may help them. Fifty women were asked whether, if they were infertile and could have only one child, they would prefer to be birth mothers (to carry a baby wh...
journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.20.2.87
更新日期:1994-06-01 00:00:00