Abstract：
:The most important tools in killing and overcoming on the microbes and pathogens that cause diseases in medicine and/or in agriculture are the antibiotics. The discovery and synthesis of the microbial natural products or antibiotics has greatly developed genetically and biotechnologically quickly in the last decades. It is necessary to access this great genetic diversity by finding ways to increase the level of expression of these biosynthetic pathways. In this study, we carried out an improvement in the antibiotic production of weak Streptomyces graminofaciens strain NBR9 that has high lipid content; using Ultra-Violet irradiation mutagenesis. This strain was isolated from the Northern Region in the kingdom of Saudi Arabia and identified biochemically and confirmed genetically by sequencing of the 16S rRNA gene as Streptomyces graminofaciens NBR9; Accession No. (MN640578). The resultant mutant strain showed increasing in their antimicrobial activities. The methods and techniques used for the antibiotic extraction, purification, characterization and identification proved that the obtained antibiotic is same with antibiotic Carbomycin.
journal_name
Arch Microbioljournal_title
Archives of microbiologyauthors
Arafat HH,Abu-Tahon MA,Isaac GSdoi
10.1007/s00203-020-02085-6subject
Has Abstractpub_date
2020-10-19 00:00:00eissn
0302-8933issn
1432-072Xpii
10.1007/s00203-020-02085-6pub_type
杂志文章abstract：:Outer membrane vesicles (OMVs) are released from the outer membrane of Gram-negative bacteria. Moreover, Gram-positive bacteria also produce membrane-derived vesicles. As OMVs transport several bacterial components, especially from the cell envelope, their interaction with the host cell, with other bacteria or as immu...
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pub_type： 杂志文章,评审
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journal_title：Archives of microbiology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/BF00406066
更新日期：1978-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2021-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Archives of microbiology
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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pub_type： 杂志文章
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