Abstract:
:Spermatogenesis associated serine rich 2 (SPATS2) has been reported to contribute to the tumorigenesis of multiple malignancies. The molecular function of SPATS2 in hepatocellular carcinoma (HCC) is still not fully understood. In this study, we aimed to investigate the expression pattern and function roles of SPATS2 in HCC. The regulation of SPATS2 expression was also explored. We found that SPATS2 was highly expressed in HCC tissues in comparison with that in adjacent normal tissues. High expression of SPATS2 was associated with vascular invasion, advanced TNM stages, tumor multiplicity, and poor survival. Functionally, SPATS2 was found to promote the proliferation and metastasis of HCC cells both in vitro and in vivo, while knockdown of SPATS2 enhanced apoptosis and G1 arrest of HCC cells in vitro. Mechanistically, bioinformatics analysis revealed that MiR-145-5p directly targeted SPATS2 and functional rescue experiments verified that MiR-145-5p overexpression could abolish the effect of SPATS2 on the regulation of HCC malignant phenotype. Taken together, our findings suggest that SPATS2 functions as an oncogene in HCC. The MiR-145-5p/SPATS2 axis provides a novel mechanism underlying HCC progression and may serve as a potential therapeutic target for HCC.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Dong G,Zhang S,Shen S,Sun L,Wang X,Wang H,Wu J,Liu T,Wang C,Wang H,Lu T,Rao B,Ren Zdoi
10.1038/s41419-020-03039-ysubject
Has Abstractpub_date
2020-10-09 00:00:00pages
837issue
10issn
2041-4889pii
10.1038/s41419-020-03039-yjournal_volume
11pub_type
杂志文章abstract::DEP-domain containing mTOR-interacting protein (DEPTOR), a natural mTOR inhibitor, has essential roles in several processes, including cell growth, metabolism, apoptosis, and immunity. DEPTOR expression has been shown to be diversely controlled at transcriptional levels in cell- and context-specific manners. However, ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03185-3
更新日期:2020-11-12 00:00:00
abstract::Gastric epithelial cells (GECs) provide the first point of contact of the host by Helicobacter pylori (H. pylori), and the interaction between H. pylori and GECs plays a critical role in H. pylori-associated diseases. Aberrant expression of transcription factors (TFs) contributes to the pathogenesis of inflammatory di...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2705-8
更新日期:2020-07-01 00:00:00
abstract::Increasing studies showed that long-noncoding RNAs (lncRNAs) play important roles in the biological processes, including cancer initiation and progression. However, little is known about the exact role and regulation mechanism of lncRNA UCA1 during the progression of gastric cancer (GC). In this study, we found that U...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1170-0
更新日期:2018-11-21 00:00:00
abstract::Monoglyceride lipase (MGL) is a recently discovered cancer-related protein. The role of MGL in tumorigenesis remains to be fully elucidated. We have previously shown that MGL expression was reduced or absent in multiple human malignancies, and overexpression of MGL inhibited cancer cell growth. Here, we have generated...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0188-z
更新日期:2018-01-18 00:00:00
abstract::Lung cancer is the leading cause of cancer-related mortality worldwide. Recently, accumulating data indicate that long noncoding RNAs (LncRNAs) function as novel crucial regulators of diverse biological processes, including proliferation and metastasis, in tumorigenesis. Lnc NONHSAT081507.1 (LINC81507) is associated w...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1740-9
更新日期:2019-07-11 00:00:00
abstract::Serum deprivation or withdrawal induces apoptosis in endothelial cells, resulting in endothelial cell dysfunction that is associated with cardiovascular disease. However, there is still limited information on the role of miRNA in serum deprivation-induced apoptosis. Here we found that serum deprivation increased caspa...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.219
更新日期:2017-05-18 00:00:00
abstract::Renal tubular cell death is the key factor of the pathogenesis of ischemia/reperfusion (I/R) kidney injury. Ferroptosis is a type of regulated cell death (RCD) found in various diseases. However, the underlying molecular mechanisms related to ferroptosis in renal I/R injury remain unclear. In the present study, we inv...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03135-z
更新日期:2020-10-28 00:00:00
abstract::Highly conserved microRNA-9 (miR-9) has a critical role in various cellular processes including neurogenesis. However, its regulation by neurotropins that are known to mediate neurogenesis remains poorly defined. In this study, we identify platelet-derived growth factor-BB (PDGF-BB)-mediated upregulation of miR-9, whi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.486
更新日期:2013-12-12 00:00:00
abstract::Human pluripotent stem cells provide a versatile platform for regenerative studies, drug testing and disease modeling. That the expression of only four transcription factors, Oct4, Klf4, Sox2 and c-Myc (OKSM), is sufficient for generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells has ...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
doi:10.1038/cddis.2015.167
更新日期:2015-07-23 00:00:00
abstract::Cancer cells secrete abundant exosomes, and the secretion can be promoted by an increase of intracellular Ca2+. Stromal interaction molecule 1 (STIM1) plays a key role in shaping Ca2+ signals. MicroRNAs (miRNAs) have been reported to be potential therapeutic targets for many diseases, including breast cancer. Recently...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03304-0
更新日期:2021-01-04 00:00:00
abstract::Abdominal Aortic aneurysm (AAA) is associated with chronic inflammation, cells apoptosis, and impairment of autophagy. BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-κB, as well as regulate autophagy. However, its...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2326-2
更新日期:2020-02-18 00:00:00
abstract::The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand bindi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2011.85
更新日期:2011-09-01 00:00:00
abstract::The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information. ...
journal_title:Cell death & disease
pub_type: 已发布勘误
doi:10.1038/s41419-018-0834-0
更新日期:2018-07-16 00:00:00
abstract::Acute pancreatitis (AP) is an acute inflammatory process of the pancreas that is characterized by inflammation, edema, vacuolization and necrosis, which has significant morbidity and lethality. The pathogenesis of AP has not been established completely. An early and critical feature of AP is the aberrant signaling of ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0073-9
更新日期:2018-01-19 00:00:00
abstract::As a deubiqutinase Otub1 stabilizes and promotes the oncogenic activity of the transcription factor c-Maf in multiple myeloma (MM), a malignancy of plasma cells. In the screen for bioactive inhibitors of the Otub1/c-Maf axis for MM treatment, nanchangmycin (Nam), a polyketide antibiotic, was identified to suppress c-M...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03017-4
更新日期:2020-09-30 00:00:00
abstract::Reactive oxygen species (ROS) accumulation are involved in noise- and ototoxic drug-induced hair cell loss, which is the major cause of hearing loss. Bmi1 is a member of the Polycomb protein family and has been reported to regulate mitochondrial function and ROS level in thymocytes and neurons. In this study, we repor...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.549
更新日期:2015-01-22 00:00:00
abstract::Death-associated protein kinase 1 (DAPK1, DAPk, DAPK) is known for its involvement in apoptosis and autophagy-associated cell death. Here, we identified an unexpected function of DAPK1 in suppressing necroptosis. DAPK1-deficiency renders macrophages and dendritic cells susceptible to necroptotic death. We also observe...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2534-9
更新日期:2020-05-04 00:00:00
abstract::Our recent study identified a list of differentially expressed microRNAs (miRNAs) in human prostate cancer (PCa) tissues compared to adjacent benign prostate tissues. In the current study, to identify the crucial miRNA-mRNA regulatory biomodule involved into prostate carcinogenesis based on the previous miRNA expressi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0293-7
更新日期:2018-02-21 00:00:00
abstract::Induction of lethal autophagy has become a strategy to eliminate glioma cells, but it remains elusive whether autophagy contributes to cell death via causing mitochondria damage and nuclear translocation of apoptosis inducing factor (AIF). In this study, we find that silibinin induces AIF translocation from mitochondr...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02866-3
更新日期:2020-08-14 00:00:00
abstract::Lipid rafts and mitochondria are promising targets in cancer therapy. The synthetic antitumor alkyl-lysophospholipid analog edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) has been reported to target lipid rafts. Here, we have found that edelfosine induced loss of mitochondrial membrane potential an...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2011.41
更新日期:2011-05-19 00:00:00
abstract::Apoptotic cysteine-aspartate proteases (caspases) are essential for the progression and execution of apoptosis, and detection of caspase fragmentation or activity is often used as markers of apoptosis. Cisplatin (cis-diamminedichloroplatinum (II)) is a chemotherapeutic drug that is clinically used for the treatment of...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2010.54
更新日期:2010-09-23 00:00:00
abstract::Sepsis is a systemic inflammation caused by infection. The balance between M1-M2 macrophage polarization has an essential role in the pathogenesis of sepsis. However, the exact mechanism underlying macrophage polarization is unclear. We previously showed that levels of malignant fibrous histiocytoma amplified sequence...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.102
更新日期:2017-05-04 00:00:00
abstract::Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20% of sporadic breast cancers and is an aggressive disease. While targeted therapies have greatly improved its management, primary and acquired resistance remain a ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-021-03414-3
更新日期:2021-01-26 00:00:00
abstract::Extracorporeal photochemotherapy (ECP) is employed for the management of cutaneous T cell lymphoma (CTCL). ECP involves the extracorporeal exposure of white blood cells (WBCs) to a photosensitizer, 8-methoxypsoralen (8-MOP), in the context of ultraviolet A (UVA) radiation, followed by WBC reinfusion. Historically, the...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1819-3
更新日期:2019-08-02 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) can be divided into groups based on biomarkers of poor prognosis. The expression of the tyrosine kinase ZAP-70 (member of the Syk tyrosine kinase family) in CLL cells is associated with shorter overall survival in CLL patients. Currently, there is a lack of targeted therapies for pat...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.391
更新日期:2014-10-02 00:00:00
abstract::Arachidonic acid (AA) is largely released during injury, but it has not been fully studied yet how AA modulates wound repair with stem cells. Therefore, we investigated skin wound-healing effect of AA-stimulated human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in vivo and its molecular mechanism i...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.114
更新日期:2015-05-07 00:00:00
abstract::The proapoptotic protein, prostate apoptosis response-4 (Par-4), acts as a tumor suppressor in prostate cancer cells. The serine/threonine kinase casein kinase 2 (CK2) has a well-reported role in prostate cancer resistance to apoptotic agents or anticancer drugs. However, the mechanistic understanding on how CK2 suppo...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.532
更新日期:2014-01-23 00:00:00
abstract::Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood. The purpose of current study was to investigate the role of Mas receptor in lipid-induced kidney injury. In mice fed with high-fat diet (HFD), the protein abu...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03375-z
更新日期:2021-01-21 00:00:00
abstract::Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we conf...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.519
更新日期:2017-10-12 00:00:00
abstract::Intestinal epithelial cells (IECs) not only have a critical function in the absorption of nutrients, but also act as a physical barrier between our body and the outside world. Damage and death of the epithelial cells lead to the breakdown of this barrier function and inflammation due to access of the immune system to ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.183
更新日期:2014-05-15 00:00:00