A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy.


:Abdominal Aortic aneurysm (AAA) is associated with chronic inflammation, cells apoptosis, and impairment of autophagy. BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-κB, as well as regulate autophagy. However, its role in vascular inflammation and AAA progression remains to be elucidated. In the present study, the effect and potential mechanisms of BP-1-102 on angiotensin II (AngII) induced AAA in ApoE-/- mice were investigated. AAA was induced in ApoE-/- mice with infusion of AngII for 28 days. BP-1-102 was administrated orally to mice every other day. Mice were sacrificed on day 7, day 14, and day 28 to evaluate the treatment effects. BP-1-102 markedly decreased AAA incidence and aortic diameter, maintained elastin structure and volume, reduced the expression of pro-inflammatory cytokines and MMPs, and inhibited inflammatory cells infiltration. Moreover, BP-1-102 dramatically reduced the expression of JAK2, p-STAT3, p-NF-κB, and Bcl-xL but maintained the expression of LC3B and Beclin in AAA tissues. In vitro, vascular smooth muscle cells (VSMCs) were treated with AngII and/or BP-1-102 at indicated time and concentration. BP-1-102 inhibited AngII-induced JAK2/STAT3 and NF-κB signaling activation and maintained autophagy-related proteins expression in VSMCs. Taken together, our findings suggest that BP-1-102 inhibits vascular inflammation and AAA progression through decreasing JAK2/STAT3 and NF-κB activation and maintaining autophagy.


Cell Death Dis


Cell death & disease


Wu QY,Cheng Z,Zhou YZ,Zhao Y,Li JM,Zhou XM,Peng HL,Zhang GS,Liao XB,Fu XM




Has Abstract


2020-02-18 00:00:00












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    abstract::We recently reported that microRNA (miR)-145 is downregulated and induces apoptosis in human bladder cancer cells. Also, it is suggested that the ectopic expression of miR-145 induces apoptosis with the induction of TRAIL expression in several cancer cells. Here, we demonstrated a novel mechanism of apoptosis inductio...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Noguchi S,Yamada N,Kumazaki M,Yasui Y,Iwasaki J,Naito S,Akao Y

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  • Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy.

    abstract::Natural-food-based compounds show substantial promise for prevention and biotherapy of cancers including leukemia. In general, their mechanism of action remains unclear, hampering rational use of these compounds. Herein we show that the common dietary flavonoid apigenin has anticancer activity, but also may decrease c...

    journal_title:Cell death & disease

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    authors: Ruela-de-Sousa RR,Fuhler GM,Blom N,Ferreira CV,Aoyama H,Peppelenbosch MP

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  • cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities.

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    journal_title:Cell death & disease

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    authors: Bleicken S,Hofhaus G,Ugarte-Uribe B,Schröder R,García-Sáez AJ

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  • Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling.

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    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Cao YY,Yu J,Liu TT,Yang KX,Yang LY,Chen Q,Shi F,Hao JJ,Cai Y,Wang MR,Lu WH,Zhang Y

    更新日期:2018-01-16 00:00:00

  • miR-218-5p restores sensitivity to gemcitabine through PRKCE/MDR1 axis in gallbladder cancer.

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    journal_title:Cell death & disease

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    authors: Wang H,Zhan M,Xu SW,Chen W,Long MM,Shi YH,Liu Q,Mohan M,Wang J

    更新日期:2017-05-11 00:00:00

  • A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.

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    journal_title:Cell death & disease

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    authors: Di Angelantonio S,Murana E,Cocco S,Scala F,Bertollini C,Molinari MG,Lauro C,Bregestovski P,Limatola C,Ragozzino D

    更新日期:2014-10-30 00:00:00

  • The lncRNA TUG1 modulates proliferation in trophoblast cells via epigenetic suppression of RND3.

    abstract::Due to limited treatment options, pre-eclampsia (PE) is associated with fetal perinatal and maternal morbidity and mortality. During the causes of PE, failure of uterine spiral artery remodeling which might be related to functioning abnormally of trophoblast cells, result in the occurrence and progression of PE. Recen...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Xu Y,Ge Z,Zhang E,Zuo Q,Huang S,Yang N,Wu D,Zhang Y,Chen Y,Xu H,Huang H,Jiang Z,Sun L

    更新日期:2017-10-12 00:00:00

  • Circ_0002770, acting as a competitive endogenous RNA, promotes proliferation and invasion by targeting miR-331-3p in melanoma.

    abstract::Melanoma is a kind of tumor that originates from melanocytes and is characterized by chemoresistance and distant metastasis. Although the complete pathogenesis of melanoma remains unclear, increasing evidence suggests that circular RNAs (circRNAs) may be involved. In the present study, we identified a circular RNA, ci...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Qian P,Linbo L,Xiaomei Z,Hui P

    更新日期:2020-04-23 00:00:00

  • Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection.

    abstract::Recent studies have documented the diverse role of host immunity in infection by the protozoan parasite, Toxoplasma gondii. However, the contribution of the β-catenin pathway in this process has not been explored. Here, we show that AKT-mediated phosphorylated β-catenin supports T. gondii multiplication which is arres...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Majumdar T,Sharma S,Kumar M,Hussain MA,Chauhan N,Kalia I,Sahu AK,Rana VS,Bharti R,Haldar AK,Singh AP,Mazumder S

    更新日期:2019-02-15 00:00:00

  • SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis.

    abstract::The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis and cancer progression. However, the role of SOX12 and the mechanism by which it is dysregulated in colorectal cancer (CRC) remain unclear. Here we analyzed SOX12 expression patterns in two independent CRC cohorts (cohort I, n = 3...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Du F,Chen J,Liu H,Cai Y,Cao T,Han W,Yi X,Qian M,Tian D,Nie Y,Wu K,Fan D,Xia L

    更新日期:2019-03-11 00:00:00

  • Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells.

    abstract::While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting the need for TRAIL-sensitizing agents. Here we report that TRAIL-induced apoptosis in PDA cell li...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Zhang JS,Herreros-Villanueva M,Koenig A,Deng Z,de Narvajas AA,Gomez TS,Meng X,Bujanda L,Ellenrieder V,Li XK,Kaufmann SH,Billadeau DD

    更新日期:2014-03-27 00:00:00

  • Metabolism addiction in pancreatic cancer.

    abstract::Pancreatic ductal adenocarcinoma, an aggressively invasive, treatment-resistant malignancy and the fourth leading cause of cancer deaths in the United States, is usually detectable only when already inevitably fatal. Despite advances in genetic screening, mapping and molecular characterization, its pathology remains l...

    journal_title:Cell death & disease

    pub_type: 杂志文章,评审


    authors: Blum R,Kloog Y

    更新日期:2014-02-20 00:00:00

  • Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome.

    abstract::HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome represents a life-threatening pregnancy disorder with high fetal and maternal mortality, but its underlying molecular mechanisms remain unknown. Although apoptosis has been implicated in HELLP syndrome, its pathogenic role remains largely unclear. In th...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: John K,Wielgosz S,Schulze-Osthoff K,Bantel H,Hass R

    更新日期:2013-10-24 00:00:00

  • PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.

    abstract::Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis. PIM1, an attractive molecular target, has been identified as a potential prognostic biomarker for haematological and epithelial malignancies. However, to dat...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Zhao B,Liu L,Mao J,Zhang Z,Wang Q,Li Q

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    journal_title:Cell death & disease

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    authors: Carlisi D,Buttitta G,Di Fiore R,Scerri C,Drago-Ferrante R,Vento R,Tesoriere G

    更新日期:2016-04-14 00:00:00

  • Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress.

    abstract::Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. Calcineurin has been proven to affect a series of signalling pathways and to exert a proapoptotic effect in cardiomyocytes. However, whether it is able to regulate autophagy remains largely unknown. Here, we report that p...

    journal_title:Cell death & disease

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    authors: He H,Liu X,Lv L,Liang H,Leng B,Zhao D,Zhang Y,Du Z,Chen X,Li S,Lu Y,Shan H

    更新日期:2014-01-16 00:00:00

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    abstract::Glioblastoma (GBM) is the most common and aggressive brain tumor and is associated with poor prognosis. GBM cells are frequently resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and finding new combinatorial therapies to sensitize glioma cells to TRAIL remains an important challenge. PIM ki...

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    authors: Serrano-Saenz S,Palacios C,Delgado-Bellido D,López-Jiménez L,Garcia-Diaz A,Soto-Serrano Y,Casal JI,Bartolomé RA,Fernández-Luna JL,López-Rivas A,Oliver FJ

    更新日期:2019-01-18 00:00:00

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    journal_title:Cell death & disease

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    authors: Luo X,Wang D,Zhu X,Wang G,You Y,Ning Z,Li Y,Jin S,Huang Y,Hu Y,Chen T,Meng Y,Li X

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    journal_title:Cell death & disease

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    authors: Xu L,Fan Q,Wang X,Zhao X,Wang L

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  • 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27.

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    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Yalcin A,Clem BF,Imbert-Fernandez Y,Ozcan SC,Peker S,O'Neal J,Klarer AC,Clem AL,Telang S,Chesney J

    更新日期:2014-07-17 00:00:00

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    journal_title:Cell death & disease

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    authors: Yu F,Zhang W,Yan C,Yan D,Zhou M,Chen J,Zhao X,Zhu A,Zhou J,Liu H,Sun H,Fu Y

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    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Gao J,Kang XY,Sun S,Li L,Zhang BL,Li YQ,Gao DS

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  • CD10-/ALDH- cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy.

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    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Ffrench B,Gasch C,Hokamp K,Spillane C,Blackshields G,Mahgoub TM,Bates M,Kehoe L,Mooney A,Doyle R,Doyle B,O'Donnell D,Gleeson N,Hennessy BT,Stordal B,O'Riain C,Lambkin H,O'Toole S,O'Leary JJ,Gallagher MF

    更新日期:2017-10-19 00:00:00

  • Crosstalk between Dpp and Tor signaling coordinates autophagy-dependent midgut degradation.

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    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Denton D,Xu T,Dayan S,Nicolson S,Kumar S

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    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Scudiero I,Mazzone P,D'Andrea LE,Ferravante A,Zotti T,Telesio G,De Rubis G,Reale C,Pizzulo M,Muralitharan S,Vito P,Stilo R

    更新日期:2017-02-23 00:00:00

  • Anti-inflammatory effects of a Chinese herbal medicine in atherosclerosis via estrogen receptor β mediating nitric oxide production and NF-κB suppression in endothelial cells.

    abstract::Bu-Shen-Ning-Xin Decoction (BSNXD) administration has alleviated the early pathologic damage of atherosclerosis by inhibiting the adhesion molecule expression and upregulating the estrogen receptor (ER) β expression in endothelial cells, and increasing the serum nitric oxide (NO) level without any effect on serum lipi...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Wang L,Qiu XM,Hao Q,Li DJ

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    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Bessa C,Soares J,Raimundo L,Loureiro JB,Gomes C,Reis F,Soares ML,Santos D,Dureja C,Chaudhuri SR,Lopez-Haber C,Kazanietz MG,Gonçalves J,Simões MF,Rijo P,Saraiva L

    更新日期:2018-01-18 00:00:00

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    journal_title:Cell death & disease

    pub_type: 杂志文章


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    更新日期:2020-11-06 00:00:00

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    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Hui B,Ji H,Xu Y,Wang J,Ma Z,Zhang C,Wang K,Zhou Y

    更新日期:2019-02-27 00:00:00

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    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Li Y,He LR,Gao Y,Zhou NN,Liu Y,Zhou XK,Liu JF,Guan XY,Ma NF,Xie D

    更新日期:2019-02-04 00:00:00