Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf.

abstract：:A major hallmark of Parkinson's disease (PD) is the degeneration of dopaminergic neurons in the substantia nigra, and the causative mechanism is thought to be the activation of programmed neuronal death. Necroptosis is a regulated process of cell death triggered by RIPK1. Although the pathophysiology of PD has been st...

journal_title：Cell death & disease

authors： Hu YB,Zhang YF,Wang H,Ren RJ,Cui HL,Huang WY,Cheng Q,Chen HZ,Wang G

更新日期：2019-08-05 00:00:00

abstract：:HFM1 (helicase for meiosis 1) is widely recognized as an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. HFM1 is a candidate gene of premature ovarian failure (POF), hence it is also known as POF9. However, the roles of HFM1 in mammalian oocytes remain uncertain. To investigate the functions of ...

journal_title：Cell death & disease

authors： Wang H,Zhong C,Yang R,Yin Y,Tan R,Gao L,Gao C,Cui Y,Pu D,Wu J

更新日期：2020-06-30 00:00:00

abstract：:Japanese encephalitis virus (JEV), which is a causative agent of sporadic encephalitis, harbours itself inside the neural stem/progenitor cells. It is a well-known fact that JEV infects neural stem/progenitor cells and decreases their proliferation capacity. With mass spectrometry-based quantitative proteomic study, i...

journal_title：Cell death & disease

authors： Mukherjee S,Singh N,Sengupta N,Fatima M,Seth P,Mahadevan A,Shankar SK,Bhattacharyya A,Basu A

更新日期：2017-01-19 00:00:00

abstract：:Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we conf...

journal_title：Cell death & disease

authors： Xu X,Yin Y,Tang J,Xie Y,Han Z,Zhang X,Liu Q,Qin X,Huang X,Sun B

更新日期：2017-10-12 00:00:00

abstract：:Vascular endothelial growth factor receptor (VEGFR) and neuropilins (NRPs), a co-receptor of VEGF, play a key role in the formation and development of blood vessels and in tumour growth and metastasis. However, whether VEGFR1/2 and NRP1 are regulated by the same upstream mechanism is unclear, especially in gastric can...

journal_title：Cell death & disease

authors： Mei B,Chen J,Yang N,Peng Y

更新日期：2020-04-17 00:00:00

abstract：:Dysfunctional mitochondria have been shown to enhance cancer cell proliferation, reduce apoptosis, and increase chemoresistance. Chemoresistance develops in nearly all patients with colorectal cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. However, the effect of dynamin-related prote...

journal_title：Cell death & disease

authors： Huang CY,Chiang SF,Chen WT,Ke TW,Chen TW,You YS,Lin CY,Chao KSC,Huang CY

更新日期：2018-09-26 00:00:00

abstract：:Tumor-associated macrophages (TAMs) represent potential targets for anticancer treatments as these cells play critical roles in tumor progression and frequently antagonize the response to treatments. TAMs are usually associated to an M2-like phenotype, characterized by anti-inflammatory and protumoral properties. This...

journal_title：Cell death & disease

authors： Genard G,Wera AC,Huart C,Le Calve B,Penninckx S,Fattaccioli A,Tabarrant T,Demazy C,Ninane N,Heuskin AC,Lucas S,Michiels C

更新日期：2018-06-27 00:00:00

abstract：:HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the HMG20A gene have been linked to type 2 diabetes mellitus (T2DM) yet neither expression nor function of this T2DM candidate gene in islets is known. Herein we dem...

journal_title：Cell death & disease

authors： Mellado-Gil JM,Fuente-Martín E,Lorenzo PI,Cobo-Vuilleumier N,López-Noriega L,Martín-Montalvo A,Gómez IGH,Ceballos-Chávez M,Gómez-Jaramillo L,Campos-Caro A,Romero-Zerbo SY,Rodríguez-Comas J,Servitja JM,Rojo-Martinez G,Hmadcha

更新日期：2018-02-15 00:00:00

abstract：:Monoglyceride lipase (MGL) is a recently discovered cancer-related protein. The role of MGL in tumorigenesis remains to be fully elucidated. We have previously shown that MGL expression was reduced or absent in multiple human malignancies, and overexpression of MGL inhibited cancer cell growth. Here, we have generated...

journal_title：Cell death & disease

authors： Liu R,Wang X,Curtiss C,Landas S,Rong R,Sheikh MS,Huang Y

更新日期：2018-01-18 00:00:00

abstract：:The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target. However, directly inhibiting this target requires the disruption of high-affinity protein-protei...

journal_title：Cell death & disease

authors： Leverson JD,Zhang H,Chen J,Tahir SK,Phillips DC,Xue J,Nimmer P,Jin S,Smith M,Xiao Y,Kovar P,Tanaka A,Bruncko M,Sheppard GS,Wang L,Gierke S,Kategaya L,Anderson DJ,Wong C,Eastham-Anderson J,Ludlam MJ,Sampath D,F

更新日期：2015-01-15 00:00:00

abstract：:miR-148a-3p downregulation has emerged as a critical factor in cancer progression yet, the underlying mechanisms of miR-148a-3p expression pattern and its function in bladder cancer remains to be elucidated. Here, we illustrate that miR-148a-3p is frequently downregulated in bladder cancer and that its expression may ...

journal_title：Cell death & disease

authors： Wang X,Liang Z,Xu X,Li J,Zhu Y,Meng S,Li S,Wang S,Xie B,Ji A,Liu B,Zheng X,Xie L

更新日期：2016-12-01 00:00:00

abstract：:The ubiquitin E3 ligase DELTEX1 (DTX1) is specifically downregulated in gastric cancer tissues, and expression of DTX1 is linked to better prognoses and survival in gastric cancer. Cellular FLICE inhibitory protein (c-FLIP) is known for its pivotal role in the resistance of cancer cells to death receptor-induced cell ...

journal_title：Cell death & disease

authors： Hsu TS,Mo ST,Hsu PN,Lai MZ

更新日期：2018-01-26 00:00:00

abstract：:In response to infection, polymorphonuclear neutrophils (PMN) are recruited in the infectious sites, and employ three major strategies to fight against the microbes including phagocytosis, degranulation, and neutrophil extracellular traps (NETs). NETs are a meshwork of chromatin fibers mixed with granule-derived antim...

journal_title：Cell death & disease

authors： Chen L,Zhao Y,Lai D,Zhang P,Yang Y,Li Y,Fei K,Jiang G,Fan J

更新日期：2018-05-22 00:00:00

abstract：:The aberrant expression of long noncoding RNAs (lncRNAs) has been reported frequently in specific cancers, including high-grade serous ovarian cancer (HGSOC). The purpose of the present study was to explore the clinical significance and underlying mechanisms of a significantly dysregulated lncRNA (NEAT1) in HGSOC. Our...

journal_title：Cell death & disease

authors： Yong W,Yu D,Jun Z,Yachen D,Weiwei W,Midie X,Xingzhu J,Xiaohua W

更新日期：2018-08-28 00:00:00

abstract：:Many cancer therapies are being developed for the induction of durable anti-tumor immunity, especially for malignant tumors. The activation of antigen-presenting cells (APCs), including macrophages and dendritic cells (DCs), can bridge innate and adaptive immune responses against tumors. However, APCs have an immunosu...

journal_title：Cell death & disease

authors： He K,Jia S,Lou Y,Liu P,Xu LX

更新日期：2019-03-04 00:00:00

abstract：:Transplantation of neural progenitors derived from human embryonic stem cells (hESCs) provides a potential therapy for ischemic stroke. However, poor graft survival within the host environment has hampered the benefits and applications of cell-based therapies. The present investigation tested a preconditioning strateg...

journal_title：Cell death & disease

authors： Francis KR,Wei L

更新日期：2010-01-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a major role in the pat...

journal_title：Cell death & disease

authors： Ugun-Klusek A,Tatham MH,Elkharaz J,Constantin-Teodosiu D,Lawler K,Mohamed H,Paine SM,Anderson G,John Mayer R,Lowe J,Ellen Billett E,Bedford L

更新日期：2017-01-05 00:00:00

abstract：:Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...

journal_title：Cell death & disease

authors： Silva-Pavez E,Villar P,Trigo C,Caamaño E,Niechi I,Pérez P,Muñoz JP,Aguayo F,Burzio VA,Varas-Godoy M,Castro AF,Colombo MI,Tapia JC

更新日期：2019-01-25 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) have demonstrated therapeutic effects for colitis through immunomodulation and anti-inflammation. However, whether MSC-derived exosomes possessed the similar function remains unclear. In present study, exosomes were isolated from control and IFN-γ-primed MSCs and was verified ...

journal_title：Cell death & disease

authors： Yang R,Huang H,Cui S,Zhou Y,Zhang T,Zhou Y

更新日期：2020-07-30 00:00:00

abstract：:Hepatocyte transplantation as a substitute strategy of orthotopic liver transplantation is being studied for treating end-stage liver diseases. Several technical hurdles must be overcome in order to achieve the therapeutic liver repopulation, such as the problem of insufficient expansion of the transplanted hepatocyte...

journal_title：Cell death & disease

authors： Xiang D,Liu CC,Wang MJ,Li JX,Chen F,Yao H,Yu B,Lu L,Borjigin U,Chen YX,Zhong L,Wangensteen KJ,He ZY,Wang X,Hu YP

更新日期：2014-05-22 00:00:00

abstract：:Paired-box 6 (PAX6) is an important transcription factor required for the function of human neuroectodermal epithelial tissues. Previous studies have suggested that it is also expressed in several types of tumors and has an oncogenic role. However, little is known about its role in non-small cell lung cancer (NSCLC). ...

journal_title：Cell death & disease

authors： Wu DM,Zhang T,Liu YB,Deng SH,Han R,Liu T,Li J,Xu Y

更新日期：2019-04-25 00:00:00

abstract：:The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation and PCa progression in mice. Curiously, low expression of hepsin is associated with poor survival in different cancer types, and transgenic overexpression of hepsin leads to loss of viability...

journal_title：Cell death & disease

authors： Willbold R,Wirth K,Martini T,Sültmann H,Bolenz C,Wittig R

更新日期：2019-08-09 00:00:00

abstract：:We have recently found that primary rat embryonic fibroblasts (REFs) could be immortalized by overexpression of the human mitochondrial ribosomal protein MRPS18-2 (S18-2). A derived cell line, designated 18IM, expressed the embryonic stem cell markers SSEA-1 and Sox2. Upon inoculation into severe combined immunodefici...

journal_title：Cell death & disease

authors： Yenamandra SP,Darekar SD,Kashuba V,Matskova L,Klein G,Kashuba E

更新日期：2012-01-19 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been identified as potential prognostic tools and therapeutic biomarkers for a variety of human cancers. However, the functional roles and underlying mechanisms of key lncRNAs affecting laryngeal squamous cell carcinomas (LSCCs) are largely unknown. Here, we adopted a novel subpathwa...

journal_title：Cell death & disease

authors： Li X,Xu F,Meng Q,Gong N,Teng Z,Xu R,Zhao M,Xia M

更新日期：2020-06-18 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein. Because TP53 inactivating mutations, frequently found in human tumors, could interfere with Granzyme B-mediated cell...

journal_title：Cell death & disease

authors： Chollat-Namy M,Ben Safta-Saadoun T,Haferssas D,Meurice G,Chouaib S,Thiery J

更新日期：2019-09-20 00:00:00

abstract：:Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented coregulator of an increasing number of transcription factors and cofactors involved in cell death and proliferation in several organs and systems. As Hipk2(-/-) mice show behavioral abnormalities consistent with cerebellar dysfunction, we investigated...

journal_title：Cell death & disease

authors： Anzilotti S,Tornincasa M,Gerlini R,Conte A,Brancaccio P,Cuomo O,Bianco G,Fusco A,Annunziato L,Pignataro G,Pierantoni GM

更新日期：2015-12-03 00:00:00

abstract：:Chromatin conformation plays a key role in regulating gene expression and controlling cell differentiation. However, the whole-genome chromatin conformation changes that occur during leukemia cell differentiation are poorly understood. Here, we characterized the changes in chromatin conformation, histone states, chrom...

journal_title：Cell death & disease

authors： Li Y,He Y,Liang Z,Wang Y,Chen F,Djekidel MN,Li G,Zhang X,Xiang S,Wang Z,Gao J,Zhang MQ,Chen Y

更新日期：2018-02-08 00:00:00

abstract：:Maintaining mesothelial cell viability is critical to long-term successful peritoneal dialysis (PD) treatment. To clarify the viability mechanism of peritoneal mesothelial cells under PD solutions exposure, we examined the mechanisms of cellular response to this stress conditions. Here we report that the proteasome ac...

journal_title：Cell death & disease

authors： Wang HH,Lin CY,Su SH,Chuang CT,Chang YL,Lee TY,Lee SC,Chang CJ

更新日期：2016-07-21 00:00:00

abstract：:The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information. ...

journal_title：Cell death & disease

authors： Jiang Q,Wang F,Shi L,Zhao X,Gong M,Liu W,Song C,Li Q,Chen Y,Wu H,Han D

更新日期：2018-07-16 00:00:00

abstract：:Increasing evidence indicates that dysregulation of microRNAs (miRNAs) plays a crucial role in human malignancies. Here, we showed that microRNA-422a (miR-422a) expression was dramatically downregulated in gastric cancer (GC) samples and cell lines compared with normal controls, and that its expression level was inver...

journal_title：Cell death & disease

authors： He Z,Li Z,Zhang X,Yin K,Wang W,Xu Z,Li B,Zhang L,Xu J,Sun G,Wang L,Li Q,Huang X,Zhang L,Zhang D,Xu H,Xu Z

更新日期：2018-05-01 00:00:00