Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification.

abstract：:Inhibitor of Apoptosis Proteins act as E3 ubiquitin ligases to regulate NF-κB signalling from multiple pattern recognition receptors including NOD2, as well as TNF Receptor Superfamily members. Loss of XIAP in humans causes X-linked Lymphoproliferative disease type 2 (XLP-2) and is often associated with Crohn's diseas...

journal_title：Cell death & disease

authors： Gradzka S,Thomas OS,Kretz O,Haimovici A,Vasilikos L,Wong WW,Häcker G,Gentle IE

更新日期：2018-05-01 00:00:00

abstract：:Withanolide E, a steroidal lactone from Physalis peruviana, was found to be highly active for sensitizing renal carcinoma cells and a number of other human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. Withanolide E, the most potent and least toxic of five TRAIL-se...

journal_title：Cell death & disease

authors： Henrich CJ,Brooks AD,Erickson KL,Thomas CL,Bokesch HR,Tewary P,Thompson CR,Pompei RJ,Gustafson KR,McMahon JB,Sayers TJ

更新日期：2015-02-26 00:00:00

abstract：:Hepatocellular carcinoma is the sixth most common cancer and gives rise to numerous deaths around the world every year. However, the molecular mechanism that controls hepatocarcinogenesis remains largely unknown. Here we found out an uncharacterized long noncoding RNA named lncAKHE. We found that lncAKHE was highly ex...

journal_title：Cell death & disease

authors： Huang G,Jiang H,Lin Y,Wu Y,Cai W,Shi B,Luo Y,Jian Z,Zhou X

更新日期：2018-05-01 00:00:00

abstract：:Cellular senescence is an initial barrier to tumor development that prevents the proliferation of premalignant cells. However, some of the features of senescent cells seem to promote tumor progression via senescence-associated secretory phenotype (SASP). Here, we demonstrated that the protein level of forkhead box Q1 ...

journal_title：Cell death & disease

authors： Wang P,Lv C,Zhang T,Liu J,Yang J,Guan F,Hong T

更新日期：2017-07-20 00:00:00

abstract：:SOX4, a member of the SOX (sex-determining region Y-related HMG box) transcription factor family, has been reported to be abnormally expressed in a wide variety of cancers, and to exert a pleiotropic function. However, its function in progression of cervical cancer (CC) remains unknown. In this study, we found that SO...

journal_title：Cell death & disease

authors： Sun R,Jiang B,Qi H,Zhang X,Yang J,Duan J,Li Y,Li G

更新日期：2015-11-19 00:00:00

abstract：:The pressure towards innovation and creation of new model systems in regenerative medicine and cancer research has fostered the development of novel potential therapeutic applications. Kidney injuries provoke a high request of organ transplants making it the most demanding system in the field of regenerative medicine....

journal_title：Cell death & disease

authors： Grassi L,Alfonsi R,Francescangeli F,Signore M,De Angelis ML,Addario A,Costantini M,Flex E,Ciolfi A,Pizzi S,Bruselles A,Pallocca M,Simone G,Haoui M,Falchi M,Milella M,Sentinelli S,Di Matteo P,Stellacci E,Gallucci M,

更新日期：2019-02-27 00:00:00

abstract：:Growing evidence indicates that clear cell renal cell carcinoma (ccRCC) is a metabolism-related disease. Changes in fatty acid (FA) and cholesterol metabolism play important roles in ccRCC development. As a nuclear transcription factor receptor, Liver X receptor (LXR) regulates a variety of key molecules associated wi...

journal_title：Cell death & disease

authors： Wu G,Wang Q,Xu Y,Li J,Zhang H,Qi G,Xia Q

更新日期：2019-05-28 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are frequently found near pancreatic cancer cells, but it is uncertain whether they are involved in pancreatic cancer progression and the Warburg effect. Here, we show that CCL18 secreted by TAMs facilitates malignant progression and induced a glycolytic phenotype in pancreatic canc...

journal_title：Cell death & disease

authors： Ye H,Zhou Q,Zheng S,Li G,Lin Q,Wei L,Fu Z,Zhang B,Liu Y,Li Z,Chen R

更新日期：2018-05-01 00:00:00

abstract：:We studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-free survival and overall survival. Cell sensitivity to SC66 was inversely correlated with phospho-Akt and COL1...

journal_title：Cell death & disease

authors： Wu YH,Huang YF,Chen CC,Chou CY

更新日期：2019-04-11 00:00:00

abstract：:Multiple myeloma (MM) is an incurable malignancy with an unmet need for innovative treatment options. Histone deacetylase inhibitors (HDACi) are a new class of anticancer agent that have demonstrated activity in hematological malignancies. Here, we investigated the efficacy and safety of HDACi (vorinostat, panobinosta...

journal_title：Cell death & disease

authors： Matthews GM,Lefebure M,Doyle MA,Shortt J,Ellul J,Chesi M,Banks KM,Vidacs E,Faulkner D,Atadja P,Bergsagel PL,Johnstone RW

更新日期：2013-09-12 00:00:00

abstract：:P300/CBP-associated factor (PCAF), a histone acetyltransferase (HAT), has been found to regulate numerous cell signaling pathways controlling cell fate by acetylating both histone and non-histone proteins. We previously reported that PCAF upregulates cell apoptosis by inactivating Serine/Threonine Protein Kinase 1 (AK...

journal_title：Cell death & disease

authors： Gai X,Tu K,Li C,Lu Z,Roberts LR,Zheng X

更新日期：2015-04-09 00:00:00

abstract：:Catecholaminergic Polymorphic Ventricular Tachycardia type 2 (CPVT2) is a highly lethal recessive arrhythmogenic disease caused by mutations in the calsequestrin-2 (CASQ2) gene. We have previously demonstrated that viral transfer of the wild-type (WT) CASQ2 gene prevents the development of CPVT2 in a genetically induc...

journal_title：Cell death & disease

authors： Lodola F,Morone D,Denegri M,Bongianino R,Nakahama H,Rutigliano L,Gosetti R,Rizzo G,Vollero A,Buonocore M,Napolitano C,Condorelli G,Priori SG,Di Pasquale E

更新日期：2016-10-06 00:00:00

abstract：:The aim of the present report was to investigate whether, in the mammalian spinal cord, cell death induced by transient excitotoxic stress could trigger activation and proliferation of endogenous neuroprogenitor cells as a potential source of a lesion repair process and the underlying time course. Because it is diffic...

journal_title：Cell death & disease

authors： Mazzone GL,Mladinic M,Nistri A

更新日期：2013-10-31 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating cancer cell proliferation, and invasion, but how the premalignant stromal fibroblasts trigger epithelial changes remain unclear. We demonstrate that atypical ductal hyperplasia-associated fibroblasts (AHFs) are one kind of activated fibroblasts ...

journal_title：Cell death & disease

authors： Sun Y,Yang D,Xi L,Chen Y,Fu L,Sun K,Yin J,Li X,Liu S,Qin Y,Liu M,Hou Y

更新日期：2018-01-26 00:00:00

abstract：:The tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that p53 physically interacts with histone deacetylase SIRT6 in vitro and in vivo, and this interaction increases following palmitic acid (PA) ...

journal_title：Cell death & disease

authors： Li M,Hou T,Gao T,Lu X,Yang Q,Zhu Q,Li Z,Liu C,Mu G,Liu G,Bao Y,Wen H,Wang L,Wang H,Zhao Y,Gu W,Yang Y,Zhu WG

更新日期：2018-09-20 00:00:00

abstract：:Only a few types of inflammasomes have been described in central nervous system cells. Among these, the absent in melanoma 2 (AIM2) inflammasome is primarily found in neurons, is highly specific and can be activated only by double-stranded DNA. Although it has been demonstrated that the AIM2 inflammasome is activated ...

journal_title：Cell death & disease

authors： Yuan B,Zhou XM,You ZQ,Xu WD,Fan JM,Chen SJ,Han YL,Wu Q,Zhang X

更新日期：2020-01-30 00:00:00

abstract：:Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used in the clinic for bone defect reconstruction because of its powerful osteoinductive capacity. However, commercially available rhBMP-2 requires a high concentration in the clinical setting for consistent bone formation. A high dose of rhBMP-2 induc...

journal_title：Cell death & disease

authors： Huang RL,Sun Y,Ho CK,Liu K,Tang QQ,Xie Y,Li Q

更新日期：2018-02-02 00:00:00

abstract：:Our previous studies have shown that microRNA-383 (miR-383) expression is downregulated in the testes of infertile men with maturation arrest (MA). However, the underlying mechanisms of miR-383 involved in the pathogenesis of MA remain unknown. In this study, we showed that downregulation of miR-383 was associated wit...

journal_title：Cell death & disease

authors： Lian J,Tian H,Liu L,Zhang XS,Li WQ,Deng YM,Yao GD,Yin MM,Sun F

更新日期：2010-11-04 00:00:00

abstract：:Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche generated by the presence of anti-neurogenic signals, which impa...

journal_title：Cell death & disease

authors： Domínguez-García S,Geribaldi-Doldán N,Gómez-Oliva R,Ruiz FA,Carrascal L,Bolívar J,Verástegui C,Garcia-Alloza M,Macías-Sánchez AJ,Hernández-Galán R,Nunez-Abades P,Castro C

更新日期：2020-04-22 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) participate in organ fibrosis and various pulmonary diseases, but its role in idiopathic pulmonary fibrosis (IPF) is not fully understood. In this study, we found lncRNA Hoxaas3 (Hoxaas3) was up-regulated in the mice model of BLM-induced PF and TGF-β1-induced fibrogenesis in lung fibrobla...

journal_title：Cell death & disease

authors： Lin S,Zhang R,Xu L,Ma R,Xu L,Zhu L,Hu J,An X

更新日期：2020-08-26 00:00:00

abstract：:As a key member of the forkhead box transcription factors, forkhead box F2 (FOXF2) serves as a transcriptional regulator and regulates downstream gene expression in embryonic development, metabolism and in some common diseases, such as stroke and gastroparesis. Recent studies have shown that aberrant expression of FOX...

journal_title：Cell death & disease

authors： He W,Kang Y,Zhu W,Zhou B,Jiang X,Ren C,Guo W

更新日期：2020-06-05 00:00:00

abstract：:Gastric cancer (GC) is one of the most frequent malignancies, and increasing evidence supports the contribution of microRNA (miRNAs) to cancer progression. miR-1254 has been confirmed to participate in the regulation of various cancers, while the function of miR-1254 in GC remains unknown. In this study, we investigat...

journal_title：Cell death & disease

authors： Jiang M,Shi L,Yang C,Ge Y,Lin L,Fan H,He Y,Zhang D,Miao Y,Yang L

更新日期：2019-01-10 00:00:00

abstract：:Activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its in vivo significance in diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-specific Rac1-deficient mouse strain and showed that specific inhibition of Rac1...

journal_title：Cell death & disease

authors： Lv Z,Hu M,Fan M,Li X,Lin J,Zhen J,Wang Z,Jin H,Wang R

更新日期：2018-03-01 00:00:00

abstract：:Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of several toxic and damaging molecules. These are necessary to figh...

journal_title：Cell death & disease

authors： Cauwels A,Rogge E,Vandendriessche B,Shiva S,Brouckaert P

更新日期：2014-03-06 00:00:00

abstract：:Alternatively activated macrophages have been reported to be helpful to alleviate systematic lupus erythematosus (SLE), and azithromycin could serve as an immunomodulator by promoting alternatively activated macrophage phenotype. However, the effect of azithromycin in SLE and the involved mechanism remain undetermined...

journal_title：Cell death & disease

authors： Wang J,Xie L,Wang S,Lin J,Liang J,Xu J

更新日期：2018-10-22 00:00:00

abstract：:A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldow...

journal_title：Cell death & disease

authors： Cardinali B,Cappella M,Provenzano C,Garcia-Manteiga JM,Lazarevic D,Cittaro D,Martelli F,Falcone G

更新日期：2016-02-04 00:00:00

abstract：:Adipogenesis is a process which induces or represses many genes in a way to drive irreversible changes of cell phenotypes; lipid accumulation, round cell-shape, secreting many adipokines. As a master transcription factor (TF), PPARγ2 induces several target genes to orchestrate these adipogenic changes. Thus induction ...

journal_title：Cell death & disease

authors： Park B,Chang S,Lee GJ,Kang B,Kim JK,Park H

更新日期：2019-01-08 00:00:00

abstract：:KLF5 is frequently deleted and downregulated in prostate cancer, and recently it has been reported that KLF5 loss is enriched in the aggressive branches of prostate cancer evolution. However, why KLF5 loss is associated with prostate cancer aggressiveness is still not clear. Herein, we analyzed KLF5 expression in TCGA...

journal_title：Cell death & disease

authors： Ma JB,Bai JY,Zhang HB,Jia J,Shi Q,Yang C,Wang X,He D,Guo P

更新日期：2020-06-16 00:00:00

abstract：:Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...

journal_title：Cell death & disease

authors： Cai S,Chen Y,Shang Y,Cui J,Li Z,Li Y

更新日期：2018-02-15 00:00:00

abstract：:Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cance...

journal_title：Cell death & disease

authors： Cheteh EH,Augsten M,Rundqvist H,Bianchi J,Sarne V,Egevad L,Bykov VJ,Östman A,Wiman KG

更新日期：2017-06-01 00:00:00