Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice.

abstract：:The subversion of the normal function exerted by the cellular prion protein (PrP(C)) in neurons by pathogenic prions is assumed to have a central role in the pathogenesis of transmissible spongiform encephalopathies. Using two murine models of prion infection, the 1C11 neuronal cell line and neurospheres, we document ...

journal_title：Cell death & disease

authors： Pradines E,Hernandez-Rapp J,Villa-Diaz A,Dakowski C,Ardila-Osorio H,Haik S,Schneider B,Launay JM,Kellermann O,Torres JM,Mouillet-Richard S

更新日期：2013-01-10 00:00:00

abstract：:ZAK, a mixed lineage kinase, is often described as a positive or negative regulator of cell growth. We identified it as one of the top hits in our kinome cDNA screen for potent regulators of epithelial mesenchymal transition (EMT). Ectopic expression of ZAK promoted EMT phenotypes and apoptosis resistance in multiple ...

journal_title：Cell death & disease

authors： Li L,Su N,Zhou T,Zheng D,Wang Z,Chen H,Yuan S,Li W

更新日期：2018-02-02 00:00:00

abstract：:Our previous study showed that angiotensin II (Ang II) exposure diminished the interaction between nephrin and c-Abl, then c-Abl mediated SHIP2-Akt pathway in the process of podocyte injury in vivo and vitro. However, the relationship between nephrin and c-Abl was unknown. Recently, various studies showed that nephrin...

journal_title：Cell death & disease

authors： Ma Y,Yang Q,Zhong Z,Liang W,Zhang L,Yang Y,Ding G

更新日期：2018-02-07 00:00:00

abstract：:MicroRNAs (miRNAs) deregulation is frequent in human gastric cancers (GCs), but the role of specific miRNAs involved in this disease remains elusive. MiR-22 was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in GC are largely ...

journal_title：Cell death & disease

authors： Zuo QF,Cao LY,Yu T,Gong L,Wang LN,Zhao YL,Xiao B,Zou QM

更新日期：2015-11-26 00:00:00

abstract：:MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases and cellular process. Decreased expression of miR-181a has been observed in the patients with coronary artery disease, but its function and mechanism in atherogenesis is not clear. This study was...

journal_title：Cell death & disease

authors： Su Y,Yuan J,Zhang F,Lei Q,Zhang T,Li K,Guo J,Hong Y,Bu G,Lv X,Liang S,Ou J,Zhou J,Luo B,Shang J

更新日期：2019-05-07 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating cancer cell proliferation, and invasion, but how the premalignant stromal fibroblasts trigger epithelial changes remain unclear. We demonstrate that atypical ductal hyperplasia-associated fibroblasts (AHFs) are one kind of activated fibroblasts ...

journal_title：Cell death & disease

authors： Sun Y,Yang D,Xi L,Chen Y,Fu L,Sun K,Yin J,Li X,Liu S,Qin Y,Liu M,Hou Y

更新日期：2018-01-26 00:00:00

abstract：:Studies on human intestinal injury induced by acute exposure to γ-radiation commonly rely on use of animal models because culture systems do not faithfully mimic human intestinal physiology. Here we used a human Gut-on-a-Chip (Gut Chip) microfluidic device lined by human intestinal epithelial cells and vascular endoth...

journal_title：Cell death & disease

authors： Jalili-Firoozinezhad S,Prantil-Baun R,Jiang A,Potla R,Mammoto T,Weaver JC,Ferrante TC,Kim HJ,Cabral JMS,Levy O,Ingber DE

更新日期：2018-02-14 00:00:00

abstract：:Primary cells respond to irradiation by activation of the DNA damage response and cell cycle arrest, which eventually leads to senescence or apoptosis. It is not clear in detail which signaling pathways or networks regulate the induction of either apoptosis or senescence. Primary human fibroblasts are able to withstan...

journal_title：Cell death & disease

authors： Bluwstein A,Kumar N,Léger K,Traenkle J,Oostrum Jv,Rehrauer H,Baudis M,Hottiger MO

更新日期：2013-02-14 00:00:00

abstract：:As a common female malignancy, triple-negative breast cancer (TNBC) is the most serious subtype in breast cancer (BC). BAALC binder of MAP3K1 and KLF4 (BAALC) is a common oncogene in acute myelocytic leukemia (AML). We sought to explore the role of BAALC in TNBC. In this study, BAALC was significantly upregulated in T...

journal_title：Cell death & disease

authors： Li S,Wu D,Jia H,Zhang Z

更新日期：2020-08-18 00:00:00

abstract：:Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuronal loss that initiates in the substantia nigra pars compacta and by the formation of intracellular inclusions mainly constituted by aberrant α-synuclein (α-syn) deposits known as Lewy bodies. Most cases ...

journal_title：Cell death & disease

authors： Vicario M,Cieri D,Vallese F,Catoni C,Barazzuol L,Berto P,Grinzato A,Barbieri L,Brini M,Calì T

更新日期：2019-11-12 00:00:00

abstract：:Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a recently identified gene associated with malignant tumor progression and patient chemotherapy resistance in human hepatocellular carcinoma (HCC). Previously, we found an association between CHD1L overexpression and poor patient survival in non-s...

journal_title：Cell death & disease

authors： Li Y,He LR,Gao Y,Zhou NN,Liu Y,Zhou XK,Liu JF,Guan XY,Ma NF,Xie D

更新日期：2019-02-04 00:00:00

abstract：:SHP2 participates in multiple signaling events by mediating T-cell development and function, and regulates cytokine-dependent granulopoiesis. To explore whether and how SHP2 can regulate bone-marrow eosinophil differentiation, we investigate the contribution of SHP2 in the bone-marrow eosinophil development in allergi...

journal_title：Cell death & disease

authors： Xia LX,Hua W,Jin Y,Tian BP,Qiu ZW,Zhang C,Che LQ,Zhou HB,Wu YF,Huang HQ,Lan F,Ke YH,Lee JJ,Li W,Ying SM,Chen ZH,Shen HH

更新日期：2016-04-07 00:00:00

abstract：:Gastric cancer (GC) ranks among the top five malignant tumors worldwide by the incidence and mortality rate. However, the mechanisms underlying its progression are poorly understood. In this study, we investigated the role of SIRT1, a class III deacetylase, in the invasion and metastasis of GC. Here, we found that kno...

journal_title：Cell death & disease

authors： Dong G,Wang B,An Y,Li J,Wang X,Jia J,Yang Q

更新日期：2018-09-24 00:00:00

abstract：:Estrogen-dependent breast cancer is often treated with the aromatase inhibitors or estrogen receptor (ER) antagonists. Tamoxifen as a major ER antagonist is usually used to treat those patients with ERα-positive breast cancer. However, a majority of patients with ERα positive fail to respond to tamoxifen due to the pr...

journal_title：Cell death & disease

authors： Zhu J,Zou Z,Nie P,Kou X,Wu B,Wang S,Song Z,He J

更新日期：2016-11-03 00:00:00

abstract：:Polo-like kinase 1 (PLK1) is an important mitotic kinase and its expression is tightly regulated in the cell cycle and in the DNA damage response. PLK1 expression is previously shown to be suppressed by p53 and/or p21. Here, we demonstrate that the CCAAT box in the PLK1 promoter is pivotal for p53/p21-mediated PLK1 re...

journal_title：Cell death & disease

authors： Lin YC,Chen YN,Lin KF,Wang FF,Chou TY,Chen MY

更新日期：2014-01-09 00:00:00

abstract：:Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...

journal_title：Cell death & disease

authors： Silva-Pavez E,Villar P,Trigo C,Caamaño E,Niechi I,Pérez P,Muñoz JP,Aguayo F,Burzio VA,Varas-Godoy M,Castro AF,Colombo MI,Tapia JC

更新日期：2019-01-25 00:00:00

abstract：:UV irradiation elicits acute inflammation in the skin by increasing proinflammatory cytokine production in keratinocytes. However, the downstream protein target(s) that link UV radiation to the activation of signaling pathways responsible for cytokine expression have not been fully elucidated. In this study, we report...

journal_title：Cell death & disease

authors： Lee SJ,Lee KB,Son YH,Shin J,Lee JH,Kim HJ,Hong AY,Bae HW,Kwon MA,Lee WJ,Kim JH,Lee DH,Jeong EM,Kim IG

更新日期：2017-10-26 00:00:00

abstract：:The DEAD/DEAH box helicase 11 (DDX11) plays vital roles in regulating the initiation of DNA replication. However, its precise function and regulation in hepatocellular carcinoma (HCC) have never been reported yet. In the current study, we found that DDX11 was overexpressed in HCC tissues. High DDX11 expression was pos...

journal_title：Cell death & disease

authors： Yu Y,Zhao D,Li K,Cai Y,Xu P,Li R,Li J,Chen X,Chen P,Cui G

更新日期：2020-04-24 00:00:00

abstract：:Recent reports show that B7-H4 is highly expressed in a variety of tumor cells, functions as a negative regulator of T cells and then promotes tumor progression. However, its expression and role in intrahepatic cholangiocarcinoma (ICC) remain unclear. In present study, B7-H4 expression in ICC and peritumoral tissues w...

journal_title：Cell death & disease

authors： Xie N,Cai JB,Zhang L,Zhang PF,Shen YH,Yang X,Lu JC,Gao DM,Kang Q,Liu LX,Zhang C,Huang XY,Zou H,Zhang XY,Song ZJ,Sun HX,Fu BM,Ke AW,Shi GM

更新日期：2017-12-13 00:00:00

abstract：:Inflammasomes are multimeric protein complexes that assemble upon sensing of a variety of stress factors. Their formation results in caspase-1-mediated activation and secretion of the pro-inflammatory cytokines pro-interleukin(IL)-1β and -18, which induce an inflammatory response. Inflammation is supported by a lytic ...

journal_title：Cell death & disease

authors： Sand J,Haertel E,Biedermann T,Contassot E,Reichmann E,French LE,Werner S,Beer HD

更新日期：2018-01-18 00:00:00

abstract：:Aberrant regulation of cholesterol homeostasis is associated with obesity as well as multiple types of cancer. However, the mechanism behind these is largely missing. Here, we show that microRNA (miRNA)-128-2 is not only a pro-apoptotic microRNA but it also alters the expression of genes involved in cellular cholester...

journal_title：Cell death & disease

authors： Adlakha YK,Khanna S,Singh R,Singh VP,Agrawal A,Saini N

更新日期：2013-08-29 00:00:00

abstract：:Intrinsic apoptosis relies on the ability of the BCL-2 family to induce the formation of pores on the outer mitochondrial membrane. Previous studies have shown that both BAX and BAK are essential during murine embryogenesis, and reports in human cancer cell lines identified non-canonical roles for BAX and BAK in mitoc...

journal_title：Cell death & disease

authors： Joshi P,Bodnya C,Rasmussen ML,Romero-Morales AI,Bright A,Gama V

更新日期：2020-09-25 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been reported to localize in colorectal carcinomas, and participate in the formation of the tumor microenvironment. They have recently been isolated from colorectal cancer tissues, and are implicated in the growth, invasion, and metastasis of cancer cells. However, the roles and deta...

journal_title：Cell death & disease

authors： Zhang X,Hu F,Li G,Li G,Yang X,Liu L,Zhang R,Zhang B,Feng Y

更新日期：2018-01-18 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease that is characterized by enhanced changes in stem cell differentiation and fibroblast proliferation. Resident mesenchymal stem cells (LR-MSCs) can undergo phenotype conversion to myofibroblasts to augment extracellular matrix producti...

journal_title：Cell death & disease

authors： Chen X,Shi C,Cao H,Chen L,Hou J,Xiang Z,Hu K,Han X

更新日期：2018-05-29 00:00:00

abstract：:Emerging evidence suggests that long noncoding RNA (lncRNA) plays pivotal roles in regulating various biological process in human cancers. Titin-antisense RNA1 (TTN-AS1) has been regarded as a tumor promoting lncRNA in numerous cancers. However, the clinical significance and biological function of TTN-AS1 in lung aden...

journal_title：Cell death & disease

authors： Jia Y,Duan Y,Liu T,Wang X,Lv W,Wang M,Wang J,Liu L

更新日期：2019-07-30 00:00:00

abstract：:While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting the need for TRAIL-sensitizing agents. Here we report that TRAIL-induced apoptosis in PDA cell li...

journal_title：Cell death & disease

authors： Zhang JS,Herreros-Villanueva M,Koenig A,Deng Z,de Narvajas AA,Gomez TS,Meng X,Bujanda L,Ellenrieder V,Li XK,Kaufmann SH,Billadeau DD

更新日期：2014-03-27 00:00:00

abstract：:Given the dense stroma and poor vascularization, access to nutrients is limited in the microenvironment of pancreatic ductal adenocarcinoma (PDA). PDA cells can efficiently recycle various metabolic substrates through the activation of different rescuing pathways, including the autophagy pathway. However, the precise ...

journal_title：Cell death & disease

authors： Meng Q,Xu J,Liang C,Liu J,Hua J,Zhang Y,Ni Q,Shi S,Yu X

更新日期：2018-12-11 00:00:00

abstract：:Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, their precise mechanism of communication in gastric cancer remains largely unclear. Here, we found that patients with GC showed a significantly higher mast cell infiltration in tumors. Mas...

journal_title：Cell death & disease

authors： Lv YP,Peng LS,Wang QH,Chen N,Teng YS,Wang TT,Mao FY,Zhang JY,Cheng P,Liu YG,Kong H,Wu XL,Hao CJ,Chen W,Zhu J,Han B,Ma Q,Li K,Zou Q,Zhuang Y

更新日期：2018-10-10 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by CAFs stimulates malignant progression and gemcitabine resistance...

journal_title：Cell death & disease

authors： Wei L,Ye H,Li G,Lu Y,Zhou Q,Zheng S,Lin Q,Liu Y,Li Z,Chen R

更新日期：2018-10-18 00:00:00

abstract：:HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the HMG20A gene have been linked to type 2 diabetes mellitus (T2DM) yet neither expression nor function of this T2DM candidate gene in islets is known. Herein we dem...

journal_title：Cell death & disease

authors： Mellado-Gil JM,Fuente-Martín E,Lorenzo PI,Cobo-Vuilleumier N,López-Noriega L,Martín-Montalvo A,Gómez IGH,Ceballos-Chávez M,Gómez-Jaramillo L,Campos-Caro A,Romero-Zerbo SY,Rodríguez-Comas J,Servitja JM,Rojo-Martinez G,Hmadcha

更新日期：2018-02-15 00:00:00