Abstract:
:Adipogenesis is a process which induces or represses many genes in a way to drive irreversible changes of cell phenotypes; lipid accumulation, round cell-shape, secreting many adipokines. As a master transcription factor (TF), PPARγ2 induces several target genes to orchestrate these adipogenic changes. Thus induction of Pparg2 gene is tightly regulated by many adipogenic and also anti-adipogenic factors. Four hours after the treatment of adipogenic hormones, more than fifteen TFs including glucocorticoid receptor (GR), C/EBPβ and AP-1 cooperatively bind the promoter of Pparg2 gene covering 400 bps, termed "hotspot". In this study, we show that TEA domain family transcription factor (TEAD)4 reinforces occupancy of both GR and C/EBPβ on the hotspot of Pparg2 during early adipogenesis. Our findings that TEAD4 requires GR for its expression and for the ability to bind its own promoter and the hotspot region of Pparg2 gene indicate that GR is a common component of two positive circuits, which regulates the expression of both Tead4 and Pparg2. Wnt3a disrupts these mutually related positive circuits by limiting the nuclear location of GR in a β-catenin dependent manner. The antagonistic effects of β-catenin extend to cytoskeletal remodeling during the early phase of adipogenesis. GR is necessary for the rearrangements of both cytoskeleton and chromatin of Pparg2, whereas Wnt3a inhibits both processes in a β-catenin-dependent manner. Our results suggest that hotspot formation during early adipogenesis is related to cytoskeletal remodeling, which is regulated by the antagonistic action of GR and β-catenin, and that Wnt3a reinforces β-catenin function.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Park B,Chang S,Lee GJ,Kang B,Kim JK,Park Hdoi
10.1038/s41419-018-1249-7subject
Has Abstractpub_date
2019-01-08 00:00:00pages
16issue
1issn
2041-4889pii
10.1038/s41419-018-1249-7journal_volume
10pub_type
杂志文章abstract::Chemotherapy is a standard treatment for non-small-cell lung cancer (NSCLC). However, the dose-limiting toxicity of drugs and the development of chemoresistance are major clinical challenges to successful management of NSCLC. Asian traditional medicine is gaining global attention as a non-toxic alternative to chemothe...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0277-7
更新日期:2018-02-14 00:00:00
abstract::The high mortality in breast cancer is often associated with metastatic progression in patients. Previously we have demonstrated that testes-specific protease 50 (TSP50), an oncogene overexpressed in breast cancer samples, could promote cell proliferation and tumorigenesis. However, whether TSP50 also has a key role i...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.61
更新日期:2015-03-26 00:00:00
abstract::The aberrant expression of long noncoding RNAs (lncRNAs) has been reported frequently in specific cancers, including high-grade serous ovarian cancer (HGSOC). The purpose of the present study was to explore the clinical significance and underlying mechanisms of a significantly dysregulated lncRNA (NEAT1) in HGSOC. Our...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0908-z
更新日期:2018-08-28 00:00:00
abstract::The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation. To identify chromatin and epigenetic factors possibly involved in the process of EMT, we compare...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1310-1
更新日期:2019-01-31 00:00:00
abstract::Long non-coding RNAs (lncRNAs) play a vital role in tumourigenesis, including that of glioma. Small nucleolar RNA host gene 1 (SNHG1) is a relatively novel lncRNA that is involved in the development of multiple human tumours. However, its underlying molecular mechanism in glioma has not been completely clarified. In t...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1698-7
更新日期:2019-06-12 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the m...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.59
更新日期:2015-03-19 00:00:00
abstract::Hepatocyte transplantation as a substitute strategy of orthotopic liver transplantation is being studied for treating end-stage liver diseases. Several technical hurdles must be overcome in order to achieve the therapeutic liver repopulation, such as the problem of insufficient expansion of the transplanted hepatocyte...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.230
更新日期:2014-05-22 00:00:00
abstract::Alzheimer's disease (AD) is a multifactorial neurological condition associated with a genetic profile that is still not completely understood. In this study, using a whole gene microarray approach, we investigated age-dependent gene expression profile changes occurring in the hippocampus of young and old transgenic AD...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.11
更新日期:2014-02-13 00:00:00
abstract::The subversion of the normal function exerted by the cellular prion protein (PrP(C)) in neurons by pathogenic prions is assumed to have a central role in the pathogenesis of transmissible spongiform encephalopathies. Using two murine models of prion infection, the 1C11 neuronal cell line and neurospheres, we document ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.195
更新日期:2013-01-10 00:00:00
abstract::The proteins of the Bcl-2 family have a crucial role in mitochondrial outer membrane permeabilization during apoptosis and in the regulation of mitochondrial dynamics. Current models consider that Bax forms toroidal pores at mitochondria that are responsible for the release of cytochrome c, whereas Bcl-xL inhibits por...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.34
更新日期:2016-02-25 00:00:00
abstract::Transplantation of neural progenitors derived from human embryonic stem cells (hESCs) provides a potential therapy for ischemic stroke. However, poor graft survival within the host environment has hampered the benefits and applications of cell-based therapies. The present investigation tested a preconditioning strateg...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2009.22
更新日期:2010-01-01 00:00:00
abstract::Hyperoxia treatment has been known to induce neuronal and glial death in the developing central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in premature infants and a major cause of childhood vision impairment. Studies indicate that, in addition to vascular injury, retinal neurons are als...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.23
更新日期:2014-02-20 00:00:00
abstract::Pathological retinal neovascularization is the most common cause of vision loss. PKCθ has been shown to play a role in type 2 diabetes, which is linked to retinal neovascularization. Based on these clues, we have studied the role of PKCθ and its downstream target genes JunB and VEGFR3 in retinal neovascularization usi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2522-0
更新日期:2020-05-07 00:00:00
abstract::Due to limited treatment options, pre-eclampsia (PE) is associated with fetal perinatal and maternal morbidity and mortality. During the causes of PE, failure of uterine spiral artery remodeling which might be related to functioning abnormally of trophoblast cells, result in the occurrence and progression of PE. Recen...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.503
更新日期:2017-10-12 00:00:00
abstract::Cytokinesis is the last step of cell division and is concluded by the abscission of the intercellular bridge that connects two daughter cells. The tight regulation of cytokinesis completion is essential because cytokinesis failure is associated with various human diseases. Here, we report that iASPP, a member of the a...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0561-6
更新日期:2018-05-01 00:00:00
abstract::Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage from reactive oxygen species (ROS). However, its function in trophoblasts at the maternal-fetal interface has not been clarified yet. In th...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.301
更新日期:2017-06-29 00:00:00
abstract::Hippo signalling regulates eye growth during embryogenesis through its effectors YAP and TAZ. Taking advantage of a Yap heterozygous mouse line, we here sought to examine its function in adult neural retina, where YAP expression is restricted to Müller glia. We first discovered an unexpected temporal dynamic of gene c...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02860-9
更新日期:2020-08-14 00:00:00
abstract::Natural-food-based compounds show substantial promise for prevention and biotherapy of cancers including leukemia. In general, their mechanism of action remains unclear, hampering rational use of these compounds. Herein we show that the common dietary flavonoid apigenin has anticancer activity, but also may decrease c...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2009.18
更新日期:2010-01-01 00:00:00
abstract::Transient receptor potential vanilloid 4 (TRPV4) is highly expressed in heart and vessels and can be activated during myocardial ischemia/reperfusion (I/R). Recently, we found that treatment with a selective TRPV4 antagonist HC-067047 significantly reduced infarct size, decreased troponin T levels and improved cardiac...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.227
更新日期:2017-05-25 00:00:00
abstract::Lipid rafts and mitochondria are promising targets in cancer therapy. The synthetic antitumor alkyl-lysophospholipid analog edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) has been reported to target lipid rafts. Here, we have found that edelfosine induced loss of mitochondrial membrane potential an...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2011.41
更新日期:2011-05-19 00:00:00
abstract::It has been recognized that myocardial apoptosis is one major factor in the development of heart dysfunction and autophagy has been shown to influence the apoptosis. In previous studies, we reported that anti-β1-adrenergic receptor autoantibodies (β1-AABs) decreased myocardial autophagy, but the role of decreased auto...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0445-9
更新日期:2018-03-14 00:00:00
abstract::Our previous study showed that angiotensin II (Ang II) exposure diminished the interaction between nephrin and c-Abl, then c-Abl mediated SHIP2-Akt pathway in the process of podocyte injury in vivo and vitro. However, the relationship between nephrin and c-Abl was unknown. Recently, various studies showed that nephrin...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0225-y
更新日期:2018-02-07 00:00:00
abstract::Cellular acetylation homeostasis is a kinetic balance precisely controlled by histone acetyl-transferase (HAT) and histone deacetylase (HDAC) activities. The loss of the counterbalancing function of basal HAT activity alters the precious HAT:HDAC balance towards enhanced histone deacetylation, resulting in a loss of a...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.465
更新日期:2017-01-26 00:00:00
abstract::Advanced glycation end products (AGEs) can stimulate osteoblast apoptosis and have a critical role in the pathophysiology of diabetic osteoporosis. Mitochondrial abnormalities are closely related to osteoblast dysfunction. However, it remains unclear whether mitochondrial abnormalities are involved in AGE-induced oste...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0718-3
更新日期:2018-06-04 00:00:00
abstract::As a key member of the forkhead box transcription factors, forkhead box F2 (FOXF2) serves as a transcriptional regulator and regulates downstream gene expression in embryonic development, metabolism and in some common diseases, such as stroke and gastroparesis. Recent studies have shown that aberrant expression of FOX...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
doi:10.1038/s41419-020-2604-z
更新日期:2020-06-05 00:00:00
abstract::Lung adenocarcinoma remains a threat to human health due to its high rate of recurrence and distant metastasis. However, the molecular mechanism underlying lung adenocarcinoma metastasis remains yet incompletely understood. Here, we show that upregulated expression of polypeptide N-acetylgalactosaminyltransferase6 (GA...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2537-6
更新日期:2020-05-11 00:00:00
abstract::15-Lipoxygenase-1 (15-LO-1) is involved in many pathological processes. The purpose of this study was to determine the potential role of 15-LO-1 in osteoarthritis (OA). The levels of 15-LO-1 expression were measured by western blotting and quantitative real-time PCR in articular cartilage from the OA rat models and OA...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.511
更新日期:2017-10-12 00:00:00
abstract::Nutlin-3 selectively activates p53 by inhibiting the interaction of this tumor suppressor with its negative regulator murine double minute 2 (mdm2), while trichostatin A (TSA) is one of the most potent histone deacetylase (HDAC) inhibitors currently available. As both Nutlin-3 and TSA increase the levels of the cell c...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.61
更新日期:2013-03-07 00:00:00
abstract::The high resistance against current therapies found in non-small-cell lung cancer (NSCLC) has been associated to cancer stem-like cells (CSCs), a population for which the identification of targets and biomarkers is still under development. In this study, primary cultures from early-stage NSCLC patients were establishe...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1898-1
更新日期:2019-09-10 00:00:00
abstract::The 37/67 kDa laminin receptor (LAMR) is a multifunctional protein, acting as an extracellular receptor, localizing to the nucleus, and playing roles in rRNA processing and ribosome assembly. LAMR is important for cell viability; however, it is unclear which of its functions are essential. We developed a silent mutant...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2010.19
更新日期:2010-01-01 00:00:00