TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells.

abstract：:The high resistance against current therapies found in non-small-cell lung cancer (NSCLC) has been associated to cancer stem-like cells (CSCs), a population for which the identification of targets and biomarkers is still under development. In this study, primary cultures from early-stage NSCLC patients were establishe...

journal_title：Cell death & disease

authors： Herreros-Pomares A,de-Maya-Girones JD,Calabuig-Fariñas S,Lucas R,Martínez A,Pardo-Sánchez JM,Alonso S,Blasco A,Guijarro R,Martorell M,Escorihuela E,Chiara MD,Duréndez E,Gandía C,Forteza J,Sirera R,Jantus-Lewintre E,Farr

更新日期：2019-09-10 00:00:00

abstract：:In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamyci...

journal_title：Cell death & disease

authors： Blagosklonny MV

更新日期：2014-12-04 00:00:00

abstract：:HOXA5 is considered a regulator involved in embryonic development and cellular differentiation and a tumor suppressor. Nevertheless, its biological role in cervical carcinoma is still unclear. In the present study, immunohistochemistry showed that HOXA5 expression gradually decreased as the degree of cervical lesions ...

journal_title：Cell death & disease

authors： Ma HM,Cui N,Zheng PS

更新日期：2020-06-04 00:00:00

abstract：:Hereditary pancreatitis (HP) is an autosomal dominant disease that displays the features of both acute and chronic pancreatitis. Mutations in human cationic trypsinogen (PRSS1) are associated with HP and have provided some insight into the pathogenesis of pancreatitis, but mechanisms responsible for the initiation of ...

journal_title：Cell death & disease

authors： Athwal T,Huang W,Mukherjee R,Latawiec D,Chvanov M,Clarke R,Smith K,Campbell F,Merriman C,Criddle D,Sutton R,Neoptolemos J,Vlatković N

更新日期：2014-04-10 00:00:00

abstract：:Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes. However, their functions in cerebral ischemia remain largely unknown. Through an lncRNA array analysis in a rat model of focal cerebral ischemia/reperfusion (I/R), we have identified CAMK2D-associ...

journal_title：Cell death & disease

authors： Xu Q,Deng F,Xing Z,Wu Z,Cen B,Xu S,Zhao Z,Nepomuceno R,Bhuiyan MI,Sun D,Wang QJ,Ji A

更新日期：2016-03-31 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common brain tumour, characterized by a central and partially necrotic (i.e., hypoxic) core enriched in cancer stem cells (CSCs). We previously showed that the most hypoxic and immature (i.e., CSCs) GBM cells were resistant to Temozolomide (TMZ) in vitro, owing to a particular...

journal_title：Cell death & disease

authors： Persano L,Pistollato F,Rampazzo E,Della Puppa A,Abbadi S,Frasson C,Volpin F,Indraccolo S,Scienza R,Basso G

更新日期：2012-10-18 00:00:00

abstract：:The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila melanogaster upon exposure to the superoxide generator and neurotoxic ...

journal_title：Cell death & disease

authors： Minois N,Carmona-Gutierrez D,Bauer MA,Rockenfeller P,Eisenberg T,Brandhorst S,Sigrist SJ,Kroemer G,Madeo F

更新日期：2012-10-11 00:00:00

abstract：:Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer (CRC) patients. The role of the differentially expressed lncRNAs in 5-Fluorouracil chemoresistance has not fully explained. Here, we observed lncRNA H19 was associated with the 5-Fu resistance in CRC. Quantitative analysis in...

journal_title：Cell death & disease

authors： Wang M,Han D,Yuan Z,Hu H,Zhao Z,Yang R,Jin Y,Zou C,Chen Y,Wang G,Gao X,Wang X

更新日期：2018-11-19 00:00:00

abstract：:The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows that long noncoding RNAs (lncRNAs) play vital roles in cancer initiation and progression. However, the inherited...

journal_title：Cell death & disease

authors： Yao M,Shi X,Li Y,Xiao Y,Butler W,Huang Y,Du L,Wu T,Bian X,Shi G,Ye D,Fu G,Wang J,Ren S

更新日期：2020-08-15 00:00:00

abstract：:Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage liver diseases as hepatocellular carcinoma and cirrhosis. Sinusoidal endothelial cells contribute to myofibroblast activation and liver fibrosis by undergoing endothelial-mesenchymal transition (EndMT). The...

journal_title：Cell death & disease

authors： Li Z,Chen B,Dong W,Kong M,Fan Z,Yu L,Wu D,Lu J,Xu Y

更新日期：2019-11-27 00:00:00

abstract：:The homolog of p53 gene, p63, encodes multiple p63 protein isoforms. TAp63 proteins contain an N-terminal transactivation domain similar to that of p53 and function as tumor suppressors; whereas ΔNp63 isoforms, which lack the intact N-terminal transactivation domain, are associated with human tumorigenesis. Accumulati...

journal_title：Cell death & disease

authors： Li C,Chang DL,Yang Z,Qi J,Liu R,He H,Li D,Xiao ZX

更新日期：2013-12-05 00:00:00

abstract：:Cigarette smoking is one of the most important and preventable risk factors for atherosclerosis. However, because of the complex composition of cigarette smoke, the detailed pathophysiological mechanisms are not fully understood. Based on controversial reports on the pro-atherogenic activity of cigarette smoke condens...

journal_title：Cell death & disease

authors： Messner B,Frotschnig S,Steinacher-Nigisch A,Winter B,Eichmair E,Gebetsberger J,Schwaiger S,Ploner C,Laufer G,Bernhard D

更新日期：2012-11-15 00:00:00

abstract：:Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cancer cells often resist chemotherapy by evading apoptosis. Antagonists of an inhibitor of apoptosis proteins (IAPs) can restore defective a...

journal_title：Cell death & disease

authors： Fichtner M,Bozkurt E,Salvucci M,McCann C,McAllister KA,Halang L,Düssmann H,Kinsella S,Crawford N,Sessler T,Longley DB,Prehn JHM

更新日期：2020-11-30 00:00:00

abstract：:Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. Recent studies have shown that gbMSCs consist of two distinct subpopulations (CD90+ and CD90- gbMSCs). However, the different roles in glioma progression have not been exp...

journal_title：Cell death & disease

authors： Zhang Q,Yi DY,Xue BZ,Wen WW,Lu YP,Abdelmaksou A,Sun MX,Yuan DT,Zhao HY,Xiong NX,Xiang W,Fu P

更新日期：2018-10-27 00:00:00

abstract：:Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood. The purpose of current study was to investigate the role of Mas receptor in lipid-induced kidney injury. In mice fed with high-fat diet (HFD), the protein abu...

journal_title：Cell death & disease

authors： Kong Y,Zhao X,Qiu M,Lin Y,Feng P,Li S,Liang B,Zhu Q,Huang H,Li C,Wang W

更新日期：2021-01-21 00:00:00

abstract：:Little is known about the function of Keratin 80 (KRT80), an epithelial keratin, in cancer. This study investigated the role of KRT80 in the prognosis of colorectal carcinoma (CRC) and the underlying mechanisms involved in CRC migration and invasion. We analyzed the expression of KRT80 using The Cancer Genome Atlas an...

journal_title：Cell death & disease

authors： Li C,Liu X,Liu Y,Liu X,Wang R,Liao J,Wu S,Fan J,Peng Z,Li B,Wang Z

更新日期：2018-09-27 00:00:00

abstract：:Hypoxia is an all but ubiquitous phenomenon in cancers. Two known hypoxia-inducible factors (HIFs), HIF-1α and HIF-2α, primarily mediate the transcriptional response to hypoxia. Despite the high homology between HIF-1α and HIF-2α, emerging evidence suggests differences between both molecules in terms of transcriptiona...

journal_title：Cell death & disease

authors： Zhao J,Du F,Shen G,Zheng F,Xu B

更新日期：2015-01-15 00:00:00

abstract：:The Pierre Robin Sequence (PRS), consisting of cleft palate, glossoptosis and micrognathia, is a common human birth defect. However, how this abnormality occurs remains largely unknown. Here we report that neural crest cell (NCC)-specific knockout of transferrin receptor (Tfrc), a well known transferrin transporter pr...

journal_title：Cell death & disease

authors： Lei R,Zhang K,Liu K,Shao X,Ding Z,Wang F,Hong Y,Zhu M,Li H,Li H

更新日期：2016-06-30 00:00:00

abstract：:Drug resistance is one of the major hurdles for cancer treatment. However, the underlying mechanisms are still largely unknown and therapeutic options remain limited. In this study, we show that microRNA (miR)-587 confers resistance to 5-fluorouracil (5-FU)-induced apoptosis in vitro and reduces the potency of 5-FU in...

journal_title：Cell death & disease

authors： Zhang Y,Talmon G,Wang J

更新日期：2015-08-06 00:00:00

abstract：:Vascularization deficiency caused a lot of diseases, such as diabetes ulcer and myocardial infarction. Mesenchymal stem cells (MSCs), with the self-renewal and multipotent differentiation capacities, have been used for many diseases treatment through regulation microenvironment. Numerous studies reported that MSCs tra...

journal_title：Cell death & disease

authors： An Y,Liu WJ,Xue P,Ma Y,Zhang LQ,Zhu B,Qi M,Li LY,Zhang YJ,Wang QT,Jin Y

更新日期：2018-01-19 00:00:00

abstract：:Triple negative breast cancers (TNBC) are highly aggressive and lack specific targeted therapies. Recent studies have reported high expression of the transcription factor Kaiso in triple negative tumors, and this correlates with their increased aggressiveness. However, little is known about the clinical relevance of K...

journal_title：Cell death & disease

authors： Bassey-Archibong BI,Rayner LG,Hercules SM,Aarts CW,Dvorkin-Gheva A,Bramson JL,Hassell JA,Daniel JM

更新日期：2017-03-23 00:00:00

abstract：:The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expres...

journal_title：Cell death & disease

authors： Chen M,Li Y,Xiao L,Dai G,Lu P,Wang Y,Rui Y

更新日期：2020-03-18 00:00:00

abstract：:Circular RNAs (circRNAs) have been shown to play critical roles in cancer biology, but their functions in nonalcoholic steatohepatitis (NASH) remain unexplored. Full length of circRNA_002581 was amplified and sequenced, followed by RNA immunoprecipitation, RNA-Fluorescence in Situ Hybridization and dual luciferase rep...

journal_title：Cell death & disease

authors： Jin X,Gao J,Zheng R,Yu M,Ren Y,Yan T,Huang Y,Li Y

更新日期：2020-02-13 00:00:00

abstract：:KLF5 is frequently deleted and downregulated in prostate cancer, and recently it has been reported that KLF5 loss is enriched in the aggressive branches of prostate cancer evolution. However, why KLF5 loss is associated with prostate cancer aggressiveness is still not clear. Herein, we analyzed KLF5 expression in TCGA...

journal_title：Cell death & disease

authors： Ma JB,Bai JY,Zhang HB,Jia J,Shi Q,Yang C,Wang X,He D,Guo P

更新日期：2020-06-16 00:00:00

abstract：:Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) poses a serious threat to the world's public health yet without a cure. Certain JEV-infected neural cells express a subset of previously identified intrinsic antiviral interferon stimulated genes (ISGs), indicating brain cells retain autonomous ant...

journal_title：Cell death & disease

authors： Zhang B,He Y,Xu Y,Mo F,Mi T,Shen QS,Li C,Li Y,Liu J,Wu Y,Chen G,Zhu W,Qin C,Hu B,Zhou G

更新日期：2018-06-18 00:00:00

abstract：:New spinal cord injury (SCI) cases are frequently due to non-traumatic causes, including vascular disorders. To develop mechanism-based neuroprotective strategies for acute SCI requires full understanding of the early pathophysiological changes to prevent disability and paralysis. The aim of our study was to identify ...

journal_title：Cell death & disease

authors： Bianchetti E,Mladinic M,Nistri A

更新日期：2013-07-04 00:00:00

abstract：:Natural-food-based compounds show substantial promise for prevention and biotherapy of cancers including leukemia. In general, their mechanism of action remains unclear, hampering rational use of these compounds. Herein we show that the common dietary flavonoid apigenin has anticancer activity, but also may decrease c...

journal_title：Cell death & disease

authors： Ruela-de-Sousa RR,Fuhler GM,Blom N,Ferreira CV,Aoyama H,Peppelenbosch MP

更新日期：2010-01-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is involved in insulin resistance (IR) and diabetic retinopathy. In retinal pigment epithelial (RPE) cells, insulin activates the mTOR pathway, inducing hypoxia-inducible factor-1α (HIF-1α) and HIF-dependent transcription in serum-free minimum essential medium Eagle (MEM). Serendip...

journal_title：Cell death & disease

authors： Leontieva OV,Demidenko ZN,Blagosklonny MV

更新日期：2014-05-08 00:00:00

abstract：:Renal tubular cell death is the key factor of the pathogenesis of ischemia/reperfusion (I/R) kidney injury. Ferroptosis is a type of regulated cell death (RCD) found in various diseases. However, the underlying molecular mechanisms related to ferroptosis in renal I/R injury remain unclear. In the present study, we inv...

journal_title：Cell death & disease

authors： Ding C,Ding X,Zheng J,Wang B,Li Y,Xiang H,Dou M,Qiao Y,Tian P,Xue W

更新日期：2020-10-28 00:00:00

abstract：:Abdominal Aortic aneurysm (AAA) is associated with chronic inflammation, cells apoptosis, and impairment of autophagy. BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-κB, as well as regulate autophagy. However, its...

journal_title：Cell death & disease

authors： Wu QY,Cheng Z,Zhou YZ,Zhao Y,Li JM,Zhou XM,Peng HL,Zhang GS,Liao XB,Fu XM

更新日期：2020-02-18 00:00:00