Keratin 80 promotes migration and invasion of colorectal carcinoma by interacting with PRKDC via activating the AKT pathway.


:Little is known about the function of Keratin 80 (KRT80), an epithelial keratin, in cancer. This study investigated the role of KRT80 in the prognosis of colorectal carcinoma (CRC) and the underlying mechanisms involved in CRC migration and invasion. We analyzed the expression of KRT80 using The Cancer Genome Atlas and Oncomine databases. Higher expression of KRT80 was found to be significantly associated with multiple pathological parameters, lower disease-free survival, and overall survival in CRC patients. Also, KRT80 was an independent prognostic indicator for CRC. Furthermore, altered KRT80 expression impacted migration and invasion of CRC cells, as well as the expression of epithelial-mesenchymal transition (EMT)-related markers and cell morphology via the AKT pathway. Inhibiting the expression of AKT could reverse these phenomena. Liquid Chromatograph Mass Spectrometer/Mass Spectromete, Co-immunoprecipitation, and laser scanning confocal microscopy techniques showed that KRT80 could interact with protein kinase, DNA-activated, catalytic polypeptide (PRKDC). Suppressing PRKDC could inhibit the expression of AKT and EMT, as well as the migration and invasion of CRC cells. Taken together, these results demonstrated that KRT80 was an independent prognostic biomarker for CRC and promoted CRC migration and invasion by interacting with PRKDC via activation of the AKT pathway.


Cell Death Dis


Cell death & disease


Li C,Liu X,Liu Y,Liu X,Wang R,Liao J,Wu S,Fan J,Peng Z,Li B,Wang Z




Has Abstract


2018-09-27 00:00:00












  • Lobaplatin promotes 125I-induced apoptosis and inhibition of proliferation in hepatocellular carcinoma by upregulating PERK-eIF2α-ATF4-CHOP pathway.

    abstract::We investigated the mechanism underlying the effect of a combination treatment of 125I radioactive seed implantation and lobaplatin (LBP) in hepatocellular carcinoma. The effects of administration of HCC cells and subcutaneous tumor model of mice with different doses of 125I or a sensitizing concentration of LBP alone...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Li D,Wang WJ,Wang YZ,Wang YB,Li YL

    更新日期:2019-10-03 00:00:00

  • miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer.

    abstract::miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). However, the mechanisms by which miR-195 represses the tumorigenesis of NSCLC cells are not fully understood. We performed a high-throughput screen using an miRNA mimic library and con...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Yu X,Zhang Y,Cavazos D,Ma X,Zhao Z,Du L,Pertsemlidis A

    更新日期:2018-02-07 00:00:00

  • Inhibition of autophagy increased AGE/ROS-mediated apoptosis in mesangial cells.

    abstract::The aim of our study was to investigate the role of autophagy, a homeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins, in regulating the survival of mesangial cells treated with advanced glycation end products (AGEs). In the present study, AGEs induced mitochondrial depolar...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Xu L,Fan Q,Wang X,Zhao X,Wang L

    更新日期:2016-11-03 00:00:00

  • Enhanced osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis: a study based on a three-dimensional biomimetic environment.

    abstract::The mechanism of pathological osteogenesis in Ankylosing spondylitis (AS) is largely unknown. Our previous studies demonstrated that the imbalance between BMP-2 and Noggin secretion induces abnormal osteogenic differentiation of marrow-derived mesenchymal stem cells (MSCs) from AS patients in a two-dimensional culture...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Zheng G,Xie Z,Wang P,Li J,Li M,Cen S,Tang S,Liu W,Ye G,Li Y,Wang S,Wu X,Su H,Wu Y,Shen H

    更新日期:2019-04-25 00:00:00

  • Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients.

    abstract::A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity has come out as a determinant for COVID-19 clinical outcomes, and several studies investigated the immune profiling of SARS-CoV-2 infected people to properly direct the clinical management of the disease. Thus, lymphopenia, T-cell...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Angioni R,Sánchez-Rodríguez R,Munari F,Bertoldi N,Arcidiacono D,Cavinato S,Marturano D,Zaramella A,Realdon S,Cattelan A,Viola A,Molon B

    更新日期:2020-11-06 00:00:00

  • DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress.

    abstract::The unfolded protein response (UPR) triggered by endoplasmic reticulum (ER) stress is a feature of many neurodegenerative diseases including Alzheimer's disease, Huntington's disease and Parkinson's disease (PD). Although the vast majority of PD is sporadic, mutations in a number of genes including PARK7 which encodes...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Yang J,Kim KS,Iyirhiaro GO,Marcogliese PC,Callaghan SM,Qu D,Kim WJ,Slack RS,Park DS

    更新日期:2019-02-12 00:00:00

  • Correction: Mechanism of Snhg8/miR-384/Hoxa13/FAM3A axis regulating neuronal apoptosis in ischemic mice model.

    abstract::Following the publication of this article, the authors realized there was an error in Figure 6H in which two versions of the figure appear.This does not impact the conclusions of the article. ...

    journal_title:Cell death & disease

    pub_type: 已发布勘误


    authors: Liu J,An P,Xue Y,Che D,Liu X,Zheng J,Liu Y,Yang C,Li Z,Yu B

    更新日期:2019-08-21 00:00:00

  • MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion.

    abstract::Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer's disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and ...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Chen X,Jiang XM,Zhao LJ,Sun LL,Yan ML,Tian Y,Zhang S,Duan MJ,Zhao HM,Li WR,Hao YY,Wang LB,Xiong QJ,Ai J

    更新日期:2017-06-01 00:00:00

  • Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis.

    abstract::The role of autophagy in cancer onset and progression appears still controversial. On one hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on the other hand, once internal energy resources are exhausted, it leads to cell death. In addition, autophagy interpheres with cell cycle pr...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Buccarelli M,Marconi M,Pacioni S,De Pascalis I,D'Alessandris QG,Martini M,Ascione B,Malorni W,Larocca LM,Pallini R,Ricci-Vitiani L,Matarrese P

    更新日期:2018-08-06 00:00:00

  • FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression.

    abstract::Cellular senescence is an initial barrier to tumor development that prevents the proliferation of premalignant cells. However, some of the features of senescent cells seem to promote tumor progression via senescence-associated secretory phenotype (SASP). Here, we demonstrated that the protein level of forkhead box Q1 ...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Wang P,Lv C,Zhang T,Liu J,Yang J,Guan F,Hong T

    更新日期:2017-07-20 00:00:00

  • From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine.

    abstract::Our understanding of the mitochondrial or intrinsic apoptosis pathway and its role in chemotherapy resistance has increased significantly in recent years by a combination of experimental studies and mathematical modelling. This combined approach enhanced the quantitative and kinetic understanding of apoptosis signal t...

    journal_title:Cell death & disease

    pub_type: 杂志文章,评审


    authors: Würstle ML,Zink E,Prehn JH,Rehm M

    更新日期:2014-05-29 00:00:00

  • GATA3 recruits UTX for gene transcriptional activation to suppress metastasis of breast cancer.

    abstract::GATA3 has emerged as a prominent transcription factor required for maintaining mammary-gland homeostasis. GATA3 loss is associated with aggressive breast cancer development, but the mechanism by which breast cancer is affected by the loss of GATA3 function remains unclear. Here, we report that GATA3 expression is posi...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Yu W,Huang W,Yang Y,Qiu R,Zeng Y,Hou Y,Sun G,Shi H,Leng S,Feng D,Chen Y,Wang S,Teng X,Yu H,Wang Y

    更新日期:2019-11-04 00:00:00

  • AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.

    abstract::The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expres...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Chen M,Li Y,Xiao L,Dai G,Lu P,Wang Y,Rui Y

    更新日期:2020-03-18 00:00:00

  • LncRNA TTN-AS1 promotes migration, invasion, and epithelial mesenchymal transition of lung adenocarcinoma via sponging miR-142-5p to regulate CDK5.

    abstract::Emerging evidence suggests that long noncoding RNA (lncRNA) plays pivotal roles in regulating various biological process in human cancers. Titin-antisense RNA1 (TTN-AS1) has been regarded as a tumor promoting lncRNA in numerous cancers. However, the clinical significance and biological function of TTN-AS1 in lung aden...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Jia Y,Duan Y,Liu T,Wang X,Lv W,Wang M,Wang J,Liu L

    更新日期:2019-07-30 00:00:00

  • A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.

    abstract::Glioma patients commonly suffer from epileptic seizures. However, the mechanisms of glioma-associated epilepsy are far to be completely understood. Using glioma-neurons co-cultures, we found that tumor cells are able to deeply influence neuronal chloride homeostasis, by depolarizing the reversal potential of γ-aminobu...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Di Angelantonio S,Murana E,Cocco S,Scala F,Bertollini C,Molinari MG,Lauro C,Bregestovski P,Limatola C,Ragozzino D

    更新日期:2014-10-30 00:00:00

  • IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b.

    abstract::Bone marrow mesenchymal stem cells (MSCs) have demonstrated therapeutic effects for colitis through immunomodulation and anti-inflammation. However, whether MSC-derived exosomes possessed the similar function remains unclear. In present study, exosomes were isolated from control and IFN-γ-primed MSCs and was verified ...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Yang R,Huang H,Cui S,Zhou Y,Zhang T,Zhou Y

    更新日期:2020-07-30 00:00:00

  • MicroRNA-153-5p promotes the proliferation and metastasis of renal cell carcinoma via direct targeting of AGO1.

    abstract::MicroRNAs (miRNAs) have been demonstrated to affect the biological processes of cancers and showed great potential for prognostic biomarkers. In this study, we screened differentially expressed miRNAs in ccRCC based on three dimensions of metastasis, prognosis, and differential expression compared to normal tissue usi...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Li Z,Zhao S,Zhu S,Fan Y

    更新日期:2021-01-04 00:00:00

  • Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis.

    abstract::The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis execution. However, the mechanisms that control MLKL activity are not completely understood. Here, we identify the molecular chaperone Hsp90 as ...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Zhao XM,Chen Z,Zhao JB,Zhang PP,Pu YF,Jiang SH,Hou JJ,Cui YM,Jia XL,Zhang SQ

    更新日期:2016-02-11 00:00:00

  • Release and activity of histone in diseases.

    abstract::Histones and their post-translational modifications have key roles in chromatin remodeling and gene transcription. Besides intranuclear functions, histones act as damage-associated molecular pattern molecules when they are released into the extracellular space. Administration of exogenous histones to animals leads to ...

    journal_title:Cell death & disease

    pub_type: 杂志文章,评审


    authors: Chen R,Kang R,Fan XG,Tang D

    更新日期:2014-08-14 00:00:00

  • Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers.

    abstract::Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years...

    journal_title:Cell death & disease

    pub_type: 杂志文章,评审


    authors: Hamam R,Hamam D,Alsaleh KA,Kassem M,Zaher W,Alfayez M,Aldahmash A,Alajez NM

    更新日期:2017-09-07 00:00:00

  • Costello syndrome model mice with a HrasG12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis.

    abstract::Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations. Patients with Costello syndrome present craniofacial abnormalities, cardiac defects, and cancer predisposition, as well as skin abnormalities, including papillomas, keratosis pilaris, and eczematous dermatitis. However, the ...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Katata Y,Inoue SI,Asao A,Kobayashi S,Terui H,Inoue-Shibui A,Abe T,Niihori T,Aiba S,Ishii N,Kure S,Aoki Y

    更新日期:2020-08-13 00:00:00

  • MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression.

    abstract::MEIS2 has an important role in development and organogenesis, and is implicated in the pathogenesis of human cancer. The molecular basis of MEIS2 action in tumorigenesis is not clear. Here, we show that MEIS2 is highly expressed in human neuroblastoma cell lines and is required for neuroblastoma cell survival and prol...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Zha Y,Xia Y,Ding J,Choi JH,Yang L,Dong Z,Yan C,Huang S,Ding HF

    更新日期:2014-09-11 00:00:00

  • HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.

    abstract::Dysfunctional mitochondria have been shown to enhance cancer cell proliferation, reduce apoptosis, and increase chemoresistance. Chemoresistance develops in nearly all patients with colorectal cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. However, the effect of dynamin-related prote...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Huang CY,Chiang SF,Chen WT,Ke TW,Chen TW,You YS,Lin CY,Chao KSC,Huang CY

    更新日期:2018-09-26 00:00:00

  • microRNA-874 suppresses tumor proliferation and metastasis in hepatocellular carcinoma by targeting the DOR/EGFR/ERK pathway.

    abstract::The δ opioid receptor (DOR) is involved in the regulation of malignant transformation and tumor progression of hepatocellular carcinoma (HCC). However, regulation of the DOR in HCC remains poorly defined. We found that miR-874 was identified as a negative regulator of the DOR, which is a direct and functional target o...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Zhang Y,Wei Y,Li X,Liang X,Wang L,Song J,Zhang X,Zhang C,Niu J,Zhang P,Ren Z,Tang B

    更新日期:2018-01-26 00:00:00

  • Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.

    abstract::Withanolide E, a steroidal lactone from Physalis peruviana, was found to be highly active for sensitizing renal carcinoma cells and a number of other human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. Withanolide E, the most potent and least toxic of five TRAIL-se...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Henrich CJ,Brooks AD,Erickson KL,Thomas CL,Bokesch HR,Tewary P,Thompson CR,Pompei RJ,Gustafson KR,McMahon JB,Sayers TJ

    更新日期:2015-02-26 00:00:00

  • Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage.

    abstract::Inactivation of the retinoblastoma protein (Rb) has a key role in tumorigenesis. It is well established that Rb function is largely regulated by a dynamic balance of phosphorylation and dephosphorylation. Although much research has been done to understand the mechanisms and function of RB phosphorylation, the regulati...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Tong Y,Ying H,Liu R,Li L,Bergholz J,Xiao ZX

    更新日期:2015-02-12 00:00:00

  • Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.

    abstract::The repeated treatment of cancer cells with chemo- or radiotherapy induces therapy resistance, but it was previously unknown whether the same effect occurs upon continuous exposure of cancer cells to diet-derived chemopreventive agents. We elucidated this interesting question in pancreatic ductal adenocarcinoma, which...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Fan P,Zhang Y,Liu L,Zhao Z,Yin Y,Xiao X,Bauer N,Gladkich J,Mattern J,Gao C,Schemmer P,Gross W,Herr I

    更新日期:2016-06-02 00:00:00

  • The erythropoietin-derived peptide MK-X and erythropoietin have neuroprotective effects against ischemic brain damage.

    abstract::Erythropoietin (EPO) has been well known as a hematopoietic cytokine over the past decades. However, recent reports have demonstrated that EPO plays a neuroprotective role in the central nervous system, and EPO has been considered as a therapeutic target in neurodegenerative diseases such as ischemic stroke. Despite t...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Yoo SJ,Cho B,Lee D,Son G,Lee YB,Soo Han H,Kim E,Moon C,Moon C

    更新日期:2017-08-17 00:00:00

  • High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling.

    abstract::Aldehyde dehydrogenase 1A1 (ALDH1A1) is one of cancer stem cell (CSC) markers, and high ALDH1 expression has been related to drug resistance and facilitated tumor growth. In this study, we investigated the potential involvement of nuclear factor erythroid 2-like 2 (NFE2L2/NRF2) in CSC-like properties of ALDH-high ovar...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Kim D,Choi BH,Ryoo IG,Kwak MK

    更新日期:2018-08-30 00:00:00

  • Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.

    abstract::Alzheimer's disease (AD) is pathologically characterised by the age-dependent deposition of β-amyloid (Aβ) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death. Neuroinflammation, typified by the accumulation of activated microglia and reactive astroc...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Garwood CJ,Pooler AM,Atherton J,Hanger DP,Noble W

    更新日期:2011-06-02 00:00:00