Abstract:
:Triple negative breast cancers (TNBC) are highly aggressive and lack specific targeted therapies. Recent studies have reported high expression of the transcription factor Kaiso in triple negative tumors, and this correlates with their increased aggressiveness. However, little is known about the clinical relevance of Kaiso in the growth and survival of TNBCs. Herein, we report that Kaiso depletion attenuates TNBC cell proliferation, and delays tumor onset in mice xenografted with the aggressive MDA-231 breast tumor cells. We further demonstrate that Kaiso depletion attenuates the survival of TNBC cells and increases their propensity for apoptotic-mediated cell death. Notably, Kaiso depletion downregulates BRCA1 expression in TNBC cells expressing mutant-p53 and we found that high Kaiso and BRCA1 expression correlates with a poor overall survival in breast cancer patients. Collectively, our findings reveal a role for Kaiso in the proliferation and survival of TNBC cells, and suggest a relevant role for Kaiso in the prognosis and treatment of TNBCs.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Bassey-Archibong BI,Rayner LG,Hercules SM,Aarts CW,Dvorkin-Gheva A,Bramson JL,Hassell JA,Daniel JMdoi
10.1038/cddis.2017.92subject
Has Abstractpub_date
2017-03-23 00:00:00pages
e2689issue
3issn
2041-4889pii
cddis201792journal_volume
8pub_type
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