Abstract:
:Epithelial-mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the molecular mechanisms remain to be fully determined. Here, we reported that insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a potential tumor suppressor, controls EMT in colorectal cancer progression. We revealed the inhibitory role of IGFBP-rP1 through analyses of clinical colorectal cancer samples and various EMT and metastasis models in vitro and in vivo. Moreover, we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-β-mediated EMT through the Smad signaling cascade. These data establish that IGFBP-rP1 functions as a suppressor of EMT and metastasis in colorectal cancer.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Zhu S,Zhang J,Xu F,Xu E,Ruan W,Ma Y,Huang Q,Lai Mdoi
10.1038/cddis.2015.59subject
Has Abstractpub_date
2015-03-19 00:00:00pages
e1695issn
2041-4889pii
cddis201559journal_volume
6pub_type
杂志文章abstract::B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated apoptosis. We have investigated the structure and function of the least characterized Bcl-2 family member, Bcl-B, solving the crystal structure of a Bcl-B:Bim complex to 1.9 Å resolution. Bcl-B is distinguished from other Bcl-2 family ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.178
更新日期:2012-12-13 00:00:00
abstract::It has been recognized that myocardial apoptosis is one major factor in the development of heart dysfunction and autophagy has been shown to influence the apoptosis. In previous studies, we reported that anti-β1-adrenergic receptor autoantibodies (β1-AABs) decreased myocardial autophagy, but the role of decreased auto...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0445-9
更新日期:2018-03-14 00:00:00
abstract::Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K27 hypomethylation accompanied by H3K27 hyperacetylation. Hyperacetylati...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02800-7
更新日期:2020-08-21 00:00:00
abstract::As a common female malignancy, triple-negative breast cancer (TNBC) is the most serious subtype in breast cancer (BC). BAALC binder of MAP3K1 and KLF4 (BAALC) is a common oncogene in acute myelocytic leukemia (AML). We sought to explore the role of BAALC in TNBC. In this study, BAALC was significantly upregulated in T...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02821-2
更新日期:2020-08-18 00:00:00
abstract::Studies on human intestinal injury induced by acute exposure to γ-radiation commonly rely on use of animal models because culture systems do not faithfully mimic human intestinal physiology. Here we used a human Gut-on-a-Chip (Gut Chip) microfluidic device lined by human intestinal epithelial cells and vascular endoth...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0304-8
更新日期:2018-02-14 00:00:00
abstract::Diffuse large B cell lymphoma (DLBCL) is a common and fatal hematological malignancy. Long noncoding RNAs (lncRNAs) have emerged as crucial biomarkers and regulators in many cancers. Novel lncRNA biomarker in DLBCL needs to be investigated badly, as well as its function and molecular mechanism. To further explore, mic...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1479-3
更新日期:2019-03-15 00:00:00
abstract::Plastic phenotype convention between glioma stem cells (GSCs) and non-stem tumor cells (NSTCs) significantly fuels glioblastoma heterogeneity that causes therapeutic failure. Recent progressions indicate that glucose metabolic reprogramming could drive cell fates. However, the metabolic pattern of GSCs and NSTCs and i...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1015-x
更新日期:2018-09-24 00:00:00
abstract::Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.458
更新日期:2014-11-06 00:00:00
abstract::We reported previously that adult (HRAS-/-; NRAS-/-) double knockout (DKO) mice showed no obvious external phenotype although lower-than-expected numbers of weaned DKO animals were consistently tallied after crossing NRAS-KO and HRAS-KO mice kept on mixed genetic backgrounds. Using mouse strains kept on pure C57Bl/6 b...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-2075-2
更新日期:2019-11-04 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cell death & disease
pub_type: 已发布勘误
doi:10.1038/s41419-019-2189-6
更新日期:2020-01-06 00:00:00
abstract::Acute lung injury (ALI) is a pulmonary disorder, which can result in fibrosis of the lung tissues. Recently, mesenchymal stem cell (MSC) has become a novel therapeutic method for ALI. However, the potential mechanism by which MSC regulates the progression of ALI remains blurry. The present study focused on investigati...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03034-3
更新日期:2020-10-15 00:00:00
abstract::SHP2 participates in multiple signaling events by mediating T-cell development and function, and regulates cytokine-dependent granulopoiesis. To explore whether and how SHP2 can regulate bone-marrow eosinophil differentiation, we investigate the contribution of SHP2 in the bone-marrow eosinophil development in allergi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.74
更新日期:2016-04-07 00:00:00
abstract::G-protein-coupled receptor (GPCR)-related proteins are dysregulated and the GPCR CC-chemokine receptor 10 (CCR10) is significantly upregulated in inflammation-driven HCC. However, CCR10's role in inflammation-driven hepatocarcinogenesis remains unknown. The aim of this study was to evaluate the role of CCR10 in inflam...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0267-9
更新日期:2018-02-14 00:00:00
abstract::Holliday junction recognition protein (HJURP) refers to a histone H3 chaperone that has been implicated in different kinds of malignancies. Yet, its character in pancreatic cancer remains unclear. The expression of HJURP was assessed in PDAC tissues by RT-qPCR, immunoblotting, and immunohistochemistry. HJURP-deficient...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2595-9
更新日期:2020-05-21 00:00:00
abstract::Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cance...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.225
更新日期:2017-06-01 00:00:00
abstract::Acute pancreatitis (AP) is an acute inflammatory process of the pancreas that is characterized by inflammation, edema, vacuolization and necrosis, which has significant morbidity and lethality. The pathogenesis of AP has not been established completely. An early and critical feature of AP is the aberrant signaling of ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0073-9
更新日期:2018-01-19 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-κB signalling has been shown to be critical for this profound cell-autonomous resistance against chemotherapeutic drugs and death receptor-induced apoptosis, bu...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.417
更新日期:2014-10-09 00:00:00
abstract::Aberrant de novo lipogenesis (DNL) results in excessive hepatic lipid accumulation and liver steatosis, the causative factors of many liver diseases, such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). However, the underlying mechanism of DNL dys...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03075-8
更新日期:2020-10-10 00:00:00
abstract::Glioma stem cells are highly resistant to cell death and as such are supposed to contribute to tumor recurrence by eluding anticancer treatments. Here, we show that spheroids that contain rat neural stem cells (NSCs) or rat glioma stem cells (cancer stem cells, CSCs) express isoforms 1 and 2 of pyruvate kinase (PKM1 a...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.561
更新日期:2014-01-30 00:00:00
abstract::Long-term use of glucocorticoids is a widespread clinical problem, which currently has no effective solution other than discontinuing the use. Eicosapentaenoic acid (EPA), an omega-3 long chain polyunsaturated fatty acid (n-3 PUFA), which is largely contained in fish or fish oil, has been reported to promote cell viab...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.144
更新日期:2016-05-26 00:00:00
abstract::The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expres...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2386-3
更新日期:2020-03-18 00:00:00
abstract::Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be targeted. We used mes...
journal_title:Cell death & disease
pub_type: 杂志文章,收录出版
doi:10.1038/cddis.2016.268
更新日期:2016-10-13 00:00:00
abstract::The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis execution. However, the mechanisms that control MLKL activity are not completely understood. Here, we identify the molecular chaperone Hsp90 as ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.390
更新日期:2016-02-11 00:00:00
abstract::Cancer cells have developed chemoresistance and have improved their survival through the upregulation of autophagic mechanisms that protect mitochondrial function. Here, we report that the traditional Chinese anticancer agent tubeimoside I (Tub), which is a potent inhibitor of autophagy, can promote mitochondria-assoc...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02915-x
更新日期:2020-08-26 00:00:00
abstract::Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. Calcineurin has been proven to affect a series of signalling pathways and to exert a proapoptotic effect in cardiomyocytes. However, whether it is able to regulate autophagy remains largely unknown. Here, we report that p...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.533
更新日期:2014-01-16 00:00:00
abstract::Bone marrow mesenchymal stem cells (MSCs) have demonstrated therapeutic effects for colitis through immunomodulation and anti-inflammation. However, whether MSC-derived exosomes possessed the similar function remains unclear. In present study, exosomes were isolated from control and IFN-γ-primed MSCs and was verified ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02788-0
更新日期:2020-07-30 00:00:00
abstract::Mitochondrial dysfunction and synaptic damage are critical early features of Alzheimer's disease (AD) associated with amyloid β (Aβ) and τ. We previously reported that the scaffolding protein RanBP9, which is overall increased in AD, simultaneously promotes Aβ generation and focal adhesion disruption by accelerating t...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.203
更新日期:2013-01-24 00:00:00
abstract::Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs to the repeats-in-toxin family, is believed to be one of its virulence factors and to have an important role in the bacterium's pathogenic...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2011.6
更新日期:2011-03-10 00:00:00
abstract::Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0337-z
更新日期:2018-02-15 00:00:00
abstract::Long noncoding RNAs (lncRNAs) participate in organ fibrosis and various pulmonary diseases, but its role in idiopathic pulmonary fibrosis (IPF) is not fully understood. In this study, we found lncRNA Hoxaas3 (Hoxaas3) was up-regulated in the mice model of BLM-induced PF and TGF-β1-induced fibrogenesis in lung fibrobla...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02889-w
更新日期:2020-08-26 00:00:00