AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.

abstract：:The homolog of p53 gene, p63, encodes multiple p63 protein isoforms. TAp63 proteins contain an N-terminal transactivation domain similar to that of p53 and function as tumor suppressors; whereas ΔNp63 isoforms, which lack the intact N-terminal transactivation domain, are associated with human tumorigenesis. Accumulati...

journal_title：Cell death & disease

authors： Li C,Chang DL,Yang Z,Qi J,Liu R,He H,Li D,Xiao ZX

更新日期：2013-12-05 00:00:00

abstract：:Alternatively activated macrophages have been reported to be helpful to alleviate systematic lupus erythematosus (SLE), and azithromycin could serve as an immunomodulator by promoting alternatively activated macrophage phenotype. However, the effect of azithromycin in SLE and the involved mechanism remain undetermined...

journal_title：Cell death & disease

authors： Wang J,Xie L,Wang S,Lin J,Liang J,Xu J

更新日期：2018-10-22 00:00:00

abstract：:Podocyte damage is commonly accompanied by destabilization of the podocalyxin (PC)/ezrin complex. Serum- and glucocorticoid-inducible kinase 3 (SGK3) plays a role in the maintenance of podocyte function, but the details of this role are poorly understood. Herein we demonstrated that SGK3 and its downstream target prot...

journal_title：Cell death & disease

authors： Yuan YP,Zhao H,Peng LQ,Li ZF,Liu S,Yuan CY,Mwamunyi MJ,Pearce D,Yao LJ

更新日期：2018-11-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) represent potential targets for anticancer treatments as these cells play critical roles in tumor progression and frequently antagonize the response to treatments. TAMs are usually associated to an M2-like phenotype, characterized by anti-inflammatory and protumoral properties. This...

journal_title：Cell death & disease

authors： Genard G,Wera AC,Huart C,Le Calve B,Penninckx S,Fattaccioli A,Tabarrant T,Demazy C,Ninane N,Heuskin AC,Lucas S,Michiels C

更新日期：2018-06-27 00:00:00

abstract：:The growing number of studies suggested that inhibition of autophagy enhances the efficacy of Akt kinase inhibitors in cancer therapy. Here, we provide evidence that ML-9, a widely used inhibitor of Akt kinase, myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1), represents the 'two-in-one' com...

journal_title：Cell death & disease

authors： Kondratskyi A,Yassine M,Slomianny C,Kondratska K,Gordienko D,Dewailly E,Lehen'kyi V,Skryma R,Prevarskaya N

更新日期：2014-04-24 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and aberrant alternative splicing. Despite many were revealed to function ...

journal_title：Cell death & disease

authors： Shen X,Xu F,Li M,Wu S,Zhang J,Wang A,Xu L,Liu Y,Zhu G

更新日期：2020-10-22 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality worldwide. Recently, accumulating data indicate that long noncoding RNAs (LncRNAs) function as novel crucial regulators of diverse biological processes, including proliferation and metastasis, in tumorigenesis. Lnc NONHSAT081507.1 (LINC81507) is associated w...

journal_title：Cell death & disease

authors： Peng W,He D,Shan B,Wang J,Shi W,Zhao W,Peng Z,Luo Q,Duan M,Li B,Cheng Y,Dong Y,Tang F,Zhang C,Duan C

更新日期：2019-07-11 00:00:00

abstract：:The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target. However, directly inhibiting this target requires the disruption of high-affinity protein-protei...

journal_title：Cell death & disease

authors： Leverson JD,Zhang H,Chen J,Tahir SK,Phillips DC,Xue J,Nimmer P,Jin S,Smith M,Xiao Y,Kovar P,Tanaka A,Bruncko M,Sheppard GS,Wang L,Gierke S,Kategaya L,Anderson DJ,Wong C,Eastham-Anderson J,Ludlam MJ,Sampath D,F

更新日期：2015-01-15 00:00:00

abstract：:Increasing the sensitivity of glioblastoma cells to radiation is a promising approach to improve survival in patients with glioblastoma multiforme (GBM). This study aims to determine if serine/threonine phosphatase (protein phosphatase 6 (PP6)) is a molecular target for GBM radiosensitization treatment. The GBM orthot...

journal_title：Cell death & disease

authors： Shen Y,Wang Y,Sheng K,Fei X,Guo Q,Larner J,Kong X,Qiu Y,Mi J

更新日期：2011-12-08 00:00:00

abstract：:Wnt signaling pathways are a highly conserved pathway, which plays an important role from the embryonic development to bone formation. The effect of Wnt pathway on osteogenesis relies on their cellular environment and the expression of target genes. However, the molecular mechanism of that remains unclear. On the basi...

journal_title：Cell death & disease

authors： Liu W,Liu Y,Guo T,Hu C,Luo H,Zhang L,Shi S,Cai T,Ding Y,Jin Y

更新日期：2013-03-14 00:00:00

abstract：:Treatment options for necrotizing enterocolitis (NEC) remain inadequate. Here we examined if and how prolyl hydroxylase 2 (PHD2) silencing enhances the paracrine effects of bone-marrow-derived mesenchymal stem cells (BM-MSCs) on NEC. In this study, BM-MSCs were transduced with lentiviruses containing GFP (GFP-MSC) or ...

journal_title：Cell death & disease

authors： Chen H,Zhang H,Zheng Y,Min X,Luo Y,Zhou W,Ma F,Li J,Lu Q,Zhang C,Cai H,Sha W

更新日期：2020-03-16 00:00:00

abstract：:Death-associated protein kinase 1 (DAPK1, DAPk, DAPK) is known for its involvement in apoptosis and autophagy-associated cell death. Here, we identified an unexpected function of DAPK1 in suppressing necroptosis. DAPK1-deficiency renders macrophages and dendritic cells susceptible to necroptotic death. We also observe...

journal_title：Cell death & disease

authors： Wu YH,Chou TF,Young L,Hsieh FY,Pan HY,Mo ST,Brown SB,Chen RH,Kimchi A,Lai MZ

更新日期：2020-05-04 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurological condition associated with a genetic profile that is still not completely understood. In this study, using a whole gene microarray approach, we investigated age-dependent gene expression profile changes occurring in the hippocampus of young and old transgenic AD...

journal_title：Cell death & disease

authors： Gatta V,D'Aurora M,Granzotto A,Stuppia L,Sensi SL

更新日期：2014-02-13 00:00:00

abstract：:The identification of specific drug targets guides the development of precise cancer treatments. Compared with oncogenes, tumor suppressor genes have been poorly studied in the treatment of breast cancer. We integrate the microRNA expression array from GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas) d...

journal_title：Cell death & disease

authors： Li M,Han Y,Zhou H,Li X,Lin C,Zhang E,Chi X,Hu J,Xu H

更新日期：2018-01-24 00:00:00

abstract：:Polo-like kinase 1 (PLK1) is an important mitotic kinase and its expression is tightly regulated in the cell cycle and in the DNA damage response. PLK1 expression is previously shown to be suppressed by p53 and/or p21. Here, we demonstrate that the CCAAT box in the PLK1 promoter is pivotal for p53/p21-mediated PLK1 re...

journal_title：Cell death & disease

authors： Lin YC,Chen YN,Lin KF,Wang FF,Chou TY,Chen MY

更新日期：2014-01-09 00:00:00

abstract：:Inflammasomes are multimeric protein complexes that assemble upon sensing of a variety of stress factors. Their formation results in caspase-1-mediated activation and secretion of the pro-inflammatory cytokines pro-interleukin(IL)-1β and -18, which induce an inflammatory response. Inflammation is supported by a lytic ...

journal_title：Cell death & disease

authors： Sand J,Haertel E,Biedermann T,Contassot E,Reichmann E,French LE,Werner S,Beer HD

更新日期：2018-01-18 00:00:00

abstract：:Resistin is an adipokine that is associated with obesity, inflammation, and various cancers. Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. VEGF-A is a critical angiogenic factor that is known to promote angiogenesis and metastasis in chondrosarcoma. It is unknown as to whether resistin ...

journal_title：Cell death & disease

authors： Chen SS,Tang CH,Chie MJ,Tsai CH,Fong YC,Lu YC,Chen WC,Lai CT,Wei CY,Tai HC,Chou WY,Wang SW

更新日期：2019-01-10 00:00:00

abstract：:Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, especially in patients not amenable for curative treatments. The multi-kinase inhibitor sorafenib represents the first-line treatment option for advanced HCC; nevertheless, its effect...

journal_title：Cell death & disease

authors： Pollutri D,Patrizi C,Marinelli S,Giovannini C,Trombetta E,Giannone FA,Baldassarre M,Quarta S,Vandewynckel YP,Vandierendonck A,Van Vlierberghe H,Porretti L,Negrini M,Bolondi L,Gramantieri L,Fornari F

更新日期：2018-01-05 00:00:00

abstract：:Cancer cells have developed chemoresistance and have improved their survival through the upregulation of autophagic mechanisms that protect mitochondrial function. Here, we report that the traditional Chinese anticancer agent tubeimoside I (Tub), which is a potent inhibitor of autophagy, can promote mitochondria-assoc...

journal_title：Cell death & disease

authors： Wang K,Zhan Y,Chen B,Lu Y,Yin T,Zhou S,Zhang W,Liu X,Du B,Wei X,Xiao J

更新日期：2020-08-26 00:00:00

abstract：:Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-...

journal_title：Cell death & disease

authors： Baldelli S,Aquilano K,Ciriolo MR

更新日期：2014-11-06 00:00:00

abstract：:We demonstrate that EphB3 receptors mediate oligodendrocyte (OL) cell death in the injured spinal cord through dependence receptor mechanism. OLs in the adult spinal cord express EphB3 as well as other members of the Eph receptor family. Spinal cord injury (SCI) is associated with tissue damage, cellular loss and dist...

journal_title：Cell death & disease

authors： Tsenkina Y,Ricard J,Runko E,Quiala-Acosta MM,Mier J,Liebl DJ

更新日期：2015-10-15 00:00:00

abstract：: ...

journal_title：Cell death & disease

authors： Gatie MI,Assabgui AR,Kelly GM

更新日期：2018-10-22 00:00:00

abstract：:Mitochondrial dysfunction and synaptic damage are critical early features of Alzheimer's disease (AD) associated with amyloid β (Aβ) and τ. We previously reported that the scaffolding protein RanBP9, which is overall increased in AD, simultaneously promotes Aβ generation and focal adhesion disruption by accelerating t...

journal_title：Cell death & disease

authors： Liu T,Roh SE,Woo JA,Ryu H,Kang DE

更新日期：2013-01-24 00:00:00

abstract：:The intrinsic apoptotic pathway is controlled by the BCL-2 family of proteins, which exhibit either a pro-death or pro-survival function. Gene knockout studies revealed that different pro-survival BCL-2 proteins are critical for the survival of distinct cell types, although overlapping functions amongst such proteins ...

journal_title：Cell death & disease

authors： Ke F,Lancaster GI,Grabow S,Murphy AJ,Strasser A

更新日期：2020-03-13 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi-cycle use of this chemotherapeutic agent. One of the major mechanisms of cancer drug resistance is enhanced activity of a DNA repair enz...

journal_title：Cell death & disease

authors： Fan CH,Liu WL,Cao H,Wen C,Chen L,Jiang G

更新日期：2013-10-24 00:00:00

abstract：:Circular RNAs (circRNAs) have been identified play a vital role in various different types of cancer via sponging miRNAs (microRNAs). However, their role in lung adenocarcinoma (LUAD) remains largely unclear. In this study, we systematically characterized the circRNA expression profiles in the LUAD cancer tissues and ...

journal_title：Cell death & disease

authors： Wang J,Zhao X,Wang Y,Ren F,Sun D,Yan Y,Kong X,Bu J,Liu M,Xu S

更新日期：2020-01-16 00:00:00

abstract：:Elongation factor Tu GTP binding domain containing 2 (EFTUD2), a spliceosomal GTPase, plays a pivotal role in multiple organ development and innate immune. It has been reported that EFTUD2 is a new host factor with activity against HCV infection. However, the role of EFTUD2 in solid tumors, including hepatocellular ca...

journal_title：Cell death & disease

authors： Tu M,He L,You Y,Li J,Yao N,Qu C,Huang W,Xu L,Luo R,Hong J

更新日期：2020-10-06 00:00:00

abstract：:Extracorporeal photochemotherapy (ECP) is employed for the management of cutaneous T cell lymphoma (CTCL). ECP involves the extracorporeal exposure of white blood cells (WBCs) to a photosensitizer, 8-methoxypsoralen (8-MOP), in the context of ultraviolet A (UVA) radiation, followed by WBC reinfusion. Historically, the...

journal_title：Cell death & disease

authors： Tatsuno K,Yamazaki T,Hanlon D,Han P,Robinson E,Sobolev O,Yurter A,Rivera-Molina F,Arshad N,Edelson RL,Galluzzi L

更新日期：2019-08-02 00:00:00

abstract：:The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting M2-like TAMs toward the M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and the secretion o...

journal_title：Cell death & disease

authors： Li M,Lai X,Zhao Y,Zhang Y,Li M,Li D,Kong J,Zhang Y,Jing P,Li H,Qin H,Shen L,Yao L,Li J,Dou K,Zhang J

更新日期：2018-02-14 00:00:00

abstract：:Lipid rafts and mitochondria are promising targets in cancer therapy. The synthetic antitumor alkyl-lysophospholipid analog edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) has been reported to target lipid rafts. Here, we have found that edelfosine induced loss of mitochondrial membrane potential an...

journal_title：Cell death & disease

authors： Mollinedo F,Fernández M,Hornillos V,Delgado J,Amat-Guerri F,Acuña AU,Nieto-Miguel T,Villa-Pulgarín JA,González-García C,Ceña V,Gajate C

更新日期：2011-05-19 00:00:00