c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells.

abstract：:HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome represents a life-threatening pregnancy disorder with high fetal and maternal mortality, but its underlying molecular mechanisms remain unknown. Although apoptosis has been implicated in HELLP syndrome, its pathogenic role remains largely unclear. In th...

journal_title：Cell death & disease

authors： John K,Wielgosz S,Schulze-Osthoff K,Bantel H,Hass R

更新日期：2013-10-24 00:00:00

abstract：:Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening diseases that are associated with high mortality rates due to treatment limitations. Neutrophils play key roles in the pathogenesis of ALI/ARDS by promoting the inflammation and injury of the alveolar mic...

journal_title：Cell death & disease

authors： Zhang Y,Liu H,Yao J,Huang Y,Qin S,Sun Z,Xu Y,Wan S,Cheng H,Li C,Zhang X,Ke Y

更新日期：2016-11-10 00:00:00

abstract：:Inhibitor of Apoptosis Proteins act as E3 ubiquitin ligases to regulate NF-κB signalling from multiple pattern recognition receptors including NOD2, as well as TNF Receptor Superfamily members. Loss of XIAP in humans causes X-linked Lymphoproliferative disease type 2 (XLP-2) and is often associated with Crohn's diseas...

journal_title：Cell death & disease

authors： Gradzka S,Thomas OS,Kretz O,Haimovici A,Vasilikos L,Wong WW,Häcker G,Gentle IE

更新日期：2018-05-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most leading malignancies. Long noncoding RNA is related to GC. In this study, 11 miRNAs in the exosomes and six lncRNAs in the tissues was examined by qRT-PCR. Correlation analysis was used to analyze the relationship between miRNAs in exosome and lncRNAs in the tissues. Four miRNAs ...

journal_title：Cell death & disease

authors： Zhang J,Qiu WQ,Zhu H,Liu H,Sun JH,Chen Y,Shen H,Qian CL,Shen ZY

更新日期：2020-09-19 00:00:00

abstract：:Mitochondrial apoptosis-inducing factor (AIF) influences the oxidative phosphorylation (OXPHOS) system and can be recruited as a mediator of cell death. Pathogenic mutations in the AIFM1 gene cause severe human diseases. Clinical manifestations include inherited peripheral neuropathies, prenatal cerebral abnormalities...

journal_title：Cell death & disease

authors： Meyer K,Buettner S,Ghezzi D,Zeviani M,Bano D,Nicotera P

更新日期：2015-07-09 00:00:00

abstract：:Advanced glycation end products (AGEs) can stimulate osteoblast apoptosis and have a critical role in the pathophysiology of diabetic osteoporosis. Mitochondrial abnormalities are closely related to osteoblast dysfunction. However, it remains unclear whether mitochondrial abnormalities are involved in AGE-induced oste...

journal_title：Cell death & disease

authors： Mao YX,Cai WJ,Sun XY,Dai PP,Li XM,Wang Q,Huang XL,He B,Wang PP,Wu G,Ma JF,Huang SB

更新日期：2018-06-04 00:00:00

abstract：:Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-...

journal_title：Cell death & disease

authors： Baldelli S,Aquilano K,Ciriolo MR

更新日期：2014-11-06 00:00:00

abstract：:The Notch cascade is a fundamental and highly conserved pathway able to control cell-fate. The Notch pathway arises from the interaction of one of the Notch receptors (Notch1-4) with different types of ligands; in particular, the Notch pathway can be activated canonically (through the ligands Jagged1, Jagged2, DLL1, D...

journal_title：Cell death & disease

authors： Fazio C,Ricciardiello L

更新日期：2016-12-08 00:00:00

abstract：:The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target. Although this proposition is supported by the clinical success of proteasome inhibitors in some malignancies, most cancers are resistant to proteasome inhibition. The ...

journal_title：Cell death & disease

authors： Parzych K,Chinn TM,Chen Z,Loaiza S,Porsch F,Valbuena GN,Kleijnen MF,Karadimitris A,Gentleman E,Keun HC,Auner HW

更新日期：2015-12-31 00:00:00

abstract：:Mitochondrial ferritin (FtMt) is a mitochondrially localized protein possessing ferroxidase activity and the ability to store iron. FtMt overexpression in cultured cells protects against oxidative damage by sequestering redox-active, intracellular iron. Here, we found that acute exhaustive exercise significantly incre...

journal_title：Cell death & disease

authors： Wu W,Chang S,Wu Q,Xu Z,Wang P,Li Y,Yu P,Gao G,Shi Z,Duan X,Chang YZ

更新日期：2016-11-17 00:00:00

abstract：:The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are well established regulators of glucose metabolism via their synt...

journal_title：Cell death & disease

authors： Yalcin A,Clem BF,Imbert-Fernandez Y,Ozcan SC,Peker S,O'Neal J,Klarer AC,Clem AL,Telang S,Chesney J

更新日期：2014-07-17 00:00:00

abstract：:DNA damage regulated autophagy modulator 1 (DRAM1) is a stress-inducible regulator of autophagy and cell death. DRAM1 has been implicated in cancer, myocardial infarction, and infectious diseases, but the molecular and cellular functions of this transmembrane protein remain poorly understood. Previously, we have propo...

journal_title：Cell death & disease

authors： Zhang R,Varela M,Forn-Cuní G,Torraca V,van der Vaart M,Meijer AH

更新日期：2020-04-24 00:00:00

abstract：:Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be targeted. We used mes...

journal_title：Cell death & disease

authors： Javaheri T,Kazemi Z,Pencik J,Pham HT,Kauer M,Noorizadeh R,Sax B,Nivarthi H,Schlederer M,Maurer B,Hofbauer M,Aryee DN,Wiedner M,Tomazou EM,Logan M,Hartmann C,Tuckermann JP,Kenner L,Mikula M,Dolznig H,Üren A,Richt

更新日期：2016-10-13 00:00:00

abstract：:New bone anabolic agents for the effective treatment of bone metabolic diseases like osteoporosis are of high clinical demand. In the present study, we reveal the function of salt-inducible kinase 1 (SIK1) in regulating osteoblast differentiation. Gene knockdown of SIK1 but not of SIK2 or SIK3 expression in primary pr...

journal_title：Cell death & disease

authors： Kim MK,Kwon JO,Song MK,Kim B,Kim H,Lee ZH,Koo SH,Kim HH

更新日期：2019-10-31 00:00:00

abstract：:Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play important roles in cancer stemness, respectively. However, little is known about interaction between CAFs and PTK7 in cancers. In this study, we showed that PTK7 was significantly correlated with the Wnt/β-Catenin pathway and aggressive cli...

journal_title：Cell death & disease

authors： Yu B,Wu K,Wang X,Zhang J,Wang L,Jiang Y,Zhu X,Chen W,Yan M

更新日期：2018-10-22 00:00:00

abstract：:Noncoding RNAs plays an important role in hepatocellular carcinoma (HCC). Here, we show that miR-124 was downregulated in HCC tissues and that the ectopic expression of miR-124 inhibited the proliferation and migration of HCC cells. We proposed that aquaporin 3 (AQP3) is a direct target of miR-124. AQP3 was upregulate...

journal_title：Cell death & disease

authors： Chen G,Shi Y,Liu M,Sun J

更新日期：2018-02-07 00:00:00

abstract：:We previously showed that mice with knockout of Cytl1, a functionally uncharacterized cytokine candidate, exhibit normal endochondral ossification and long-bone development. Here, we investigated the potential functions of CYTL1 in bone homeostasis. We found that Cytl1-/- mice exhibited higher bone mass than wild-type...

journal_title：Cell death & disease

authors： Shin Y,Won Y,Yang JI,Chun JS

更新日期：2019-01-18 00:00:00

abstract：:It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the relationship between CS...

journal_title：Cell death & disease

authors： Ffrench B,Gasch C,Hokamp K,Spillane C,Blackshields G,Mahgoub TM,Bates M,Kehoe L,Mooney A,Doyle R,Doyle B,O'Donnell D,Gleeson N,Hennessy BT,Stordal B,O'Riain C,Lambkin H,O'Toole S,O'Leary JJ,Gallagher MF

更新日期：2017-10-19 00:00:00

abstract：:A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldow...

journal_title：Cell death & disease

authors： Cardinali B,Cappella M,Provenzano C,Garcia-Manteiga JM,Lazarevic D,Cittaro D,Martelli F,Falcone G

更新日期：2016-02-04 00:00:00

abstract：:Methamphetamine (METH), a commonly used controlled substance, is known to exacerbate neuropathological dysfunction in HIV-infected individuals. The neuropathological manifestation results from cell death or dysfunction in the central nervous system (CNS) wherein autophagy is expected to have an important role. Autopha...

journal_title：Cell death & disease

authors： Cao L,Fu M,Kumar S,Kumar A

更新日期：2016-10-20 00:00:00

abstract：:Holliday junction recognition protein (HJURP) refers to a histone H3 chaperone that has been implicated in different kinds of malignancies. Yet, its character in pancreatic cancer remains unclear. The expression of HJURP was assessed in PDAC tissues by RT-qPCR, immunoblotting, and immunohistochemistry. HJURP-deficient...

journal_title：Cell death & disease

authors： Wang CJ,Li X,Shi P,Ding HY,Liu YP,Li T,Lin PP,Wang YS,Zhang GQ,Cao Y

更新日期：2020-05-21 00:00:00

abstract：:The majority of developmentally programmed cell death (PCD) is mediated by caspase-dependent apoptosis; however, additional modalities, including autophagy-dependent cell death, have important spatiotemporally restricted functions. Autophagy involves the engulfment of cytoplasmic components in a double membrane vesicl...

journal_title：Cell death & disease

authors： Denton D,Xu T,Dayan S,Nicolson S,Kumar S

更新日期：2019-02-08 00:00:00

abstract：:Adenanthin, a natural diterpenoid isolated from the leaves of Isodon adenanthus, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On the other hand, increasing lines of evidence propose that these Prx proteins would become potential targets to screen drugs ...

journal_title：Cell death & disease

authors： Hou JK,Huang Y,He W,Yan ZW,Fan L,Liu MH,Xiao WL,Sun HD,Chen GQ

更新日期：2014-09-04 00:00:00

abstract：:Hyperoxia treatment has been known to induce neuronal and glial death in the developing central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in premature infants and a major cause of childhood vision impairment. Studies indicate that, in addition to vascular injury, retinal neurons are als...

journal_title：Cell death & disease

authors： Narayanan SP,Xu Z,Putluri N,Sreekumar A,Lemtalsi T,Caldwell RW,Caldwell RB

更新日期：2014-02-20 00:00:00

abstract：:Skeletal muscle atrophy is one of the clinical symptoms of myotonic dystrophy type 1 (DM1). A decline in skeletal muscle regeneration is an important contributor to muscle atrophy. Skeletal muscle satellite cells (SSCs) drive skeletal muscle regeneration. Increased autophagy can reduce the proliferative capacity of SS...

journal_title：Cell death & disease

authors： Song KY,Guo XM,Wang HQ,Zhang L,Huang SY,Huo YC,Zhang G,Feng JZ,Zhang RR,Ma Y,Hu QZ,Qin XY

更新日期：2020-07-18 00:00:00

abstract：:Erythropoietin (EPO) is an evolutionarily conserved hormone well documented for its erythropoietic role via binding the homodimeric EPO receptor (EPOR)2. In past decades, evidence has proved that EPO acts far beyond erythropoiesis. By binding the tissue-protective receptor (TPR), EPO suppresses proinflammatory cytokin...

journal_title：Cell death & disease

authors： Peng B,Kong G,Yang C,Ming Y

更新日期：2020-02-03 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) of podocytes had been reported to be involved in the glomerular fibrosis in diabetic kidney diseases, which was regulated by TGFβ and NFκB pathways. And apelin, an adipokine which is upregulated in diabetic kidney diseases, was reported to be negatively correlated to TGFβ in...

journal_title：Cell death & disease

authors： Yin J,Wang Y,Chang J,Li B,Zhang J,Liu Y,Lai S,Jiang Y,Li H,Zeng X

更新日期：2018-10-09 00:00:00

abstract：:In endometriosis, the increased survival potential of shed endometrial cells (which normally undergo anoikis) is suggested to promote lesion development. One mechanism that may alter anoikis is autophagy. Using an autophagic flux inhibitor hydroxychloroquine (HCQ), we identified that it reduces the in vitro survival c...

journal_title：Cell death & disease

authors： Ruiz A,Rockfield S,Taran N,Haller E,Engelman RW,Flores I,Panina-Bordignon P,Nanjundan M

更新日期：2016-01-14 00:00:00

abstract：:Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer's disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and ...

journal_title：Cell death & disease

authors： Chen X,Jiang XM,Zhao LJ,Sun LL,Yan ML,Tian Y,Zhang S,Duan MJ,Zhao HM,Li WR,Hao YY,Wang LB,Xiong QJ,Ai J

更新日期：2017-06-01 00:00:00

abstract：:The mechanism by which tumor-associated macrophages (TAMs) affect cancer progression is not fully understood. This study developed a microfluidic-based co-culture device to mimic the tumor microenvironment to assess TAM effects on invasion and metastasis in NSCLC. The results showed lung carcinoma cells could cause ma...

journal_title：Cell death & disease

authors： Guo Z,Song J,Hao J,Zhao H,Du X,Li E,Kuang Y,Yang F,Wang W,Deng J,Wang Q

更新日期：2019-05-16 00:00:00