Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells.

abstract：:Cancer cells secrete abundant exosomes, and the secretion can be promoted by an increase of intracellular Ca2+. Stromal interaction molecule 1 (STIM1) plays a key role in shaping Ca2+ signals. MicroRNAs (miRNAs) have been reported to be potential therapeutic targets for many diseases, including breast cancer. Recently...

journal_title：Cell death & disease

authors： Pan S,Zhao X,Shao C,Fu B,Huang Y,Zhang N,Dou X,Zhang Z,Qiu Y,Wang R,Jin M,Kong D

更新日期：2021-01-04 00:00:00

abstract：:Brown adipose tissue (BAT) dissipates metabolic energy and mediates non-shivering thermogenesis, thereby boosting energy expenditure. Increasing BAT mass and activity is expected to be a promising strategy for combating obesity; however, few medications effectively and safely recruit and activate BAT in humans. Berber...

journal_title：Cell death & disease

authors： Wu L,Xia M,Duan Y,Zhang L,Jiang H,Hu X,Yan H,Zhang Y,Gu Y,Shi H,Li J,Gao X,Li J

更新日期：2019-06-13 00:00:00

abstract：:Mitochondrial reactive oxygen species (mtROS) homeostasis plays an essential role in preventing oxidative injury in endothelial cells, an initial step in atherogenesis. Resveratrol (RSV) possesses a variety of cardioprotective activities, however, little is known regarding the effects of RSV on mtROS homeostasis in en...

journal_title：Cell death & disease

authors： Zhou X,Chen M,Zeng X,Yang J,Deng H,Yi L,Mi MT

更新日期：2014-12-18 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a heterogeneous population of cells that proliferate in vitro as plastic-adherent cells, have a fibroblast-like morphology, form colonies in vitro and can differentiate into bone, cartilage and fat cells. The abundance, ease and repeatable access to subcutaneous adipose tissue and the...

journal_title：Cell death & disease

authors： Kim JY,Shin KK,Lee AL,Kim YS,Park HJ,Park YK,Bae YC,Jung JS

更新日期：2014-08-21 00:00:00

abstract：:Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used in the clinic for bone defect reconstruction because of its powerful osteoinductive capacity. However, commercially available rhBMP-2 requires a high concentration in the clinical setting for consistent bone formation. A high dose of rhBMP-2 induc...

journal_title：Cell death & disease

authors： Huang RL,Sun Y,Ho CK,Liu K,Tang QQ,Xie Y,Li Q

更新日期：2018-02-02 00:00:00

abstract：:WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family and functions as a scaffold protein during telomerase assembly, Cajal body formation and DNA double strand break repair. We have previously shown that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung ca...

journal_title：Cell death & disease

authors： Sun Y,Cao L,Sheng X,Chen J,Zhou Y,Yang C,Deng T,Ma H,Feng P,Liu J,Tan W,Ye M

更新日期：2017-04-13 00:00:00

abstract：:Hyperoxia treatment has been known to induce neuronal and glial death in the developing central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in premature infants and a major cause of childhood vision impairment. Studies indicate that, in addition to vascular injury, retinal neurons are als...

journal_title：Cell death & disease

authors： Narayanan SP,Xu Z,Putluri N,Sreekumar A,Lemtalsi T,Caldwell RW,Caldwell RB

更新日期：2014-02-20 00:00:00

abstract：:During reproductive life, the mammary epithelium undergoes consecutive cycles of proliferation, differentiation and apoptosis. Doing so relies on the retained proliferative capacity, prolonged lifespan and developmental potency of mammary stem cells (MaSCs). ΔNp63α, the predominant TP63 isoform in mammary epithelia, i...

journal_title：Cell death & disease

authors： DeCastro AJ,Dunphy KA,Hutchinson J,Balboni AL,Cherukuri P,Jerry DJ,DiRenzo J

更新日期：2013-02-28 00:00:00

abstract：:Bevacizumab in neoadjuvant therapy provides a new hope of improved survival for patients with triple-negative breast cancer (TNBC) by targeting vascular endothelial growth factor in combination with chemotherapy, but curative effect is limited by bevacizumab's continuous use while mechanisms remain incompletely unders...

journal_title：Cell death & disease

authors： Liu Y,Ji X,Kang N,Zhou J,Liang X,Li J,Han T,Zhao C,Yang T

更新日期：2020-11-19 00:00:00

abstract：:Our previous study showed that angiotensin II (Ang II) exposure diminished the interaction between nephrin and c-Abl, then c-Abl mediated SHIP2-Akt pathway in the process of podocyte injury in vivo and vitro. However, the relationship between nephrin and c-Abl was unknown. Recently, various studies showed that nephrin...

journal_title：Cell death & disease

authors： Ma Y,Yang Q,Zhong Z,Liang W,Zhang L,Yang Y,Ding G

更新日期：2018-02-07 00:00:00

abstract：:Nutlin-3 selectively activates p53 by inhibiting the interaction of this tumor suppressor with its negative regulator murine double minute 2 (mdm2), while trichostatin A (TSA) is one of the most potent histone deacetylase (HDAC) inhibitors currently available. As both Nutlin-3 and TSA increase the levels of the cell c...

journal_title：Cell death & disease

authors： Sachweh MC,Drummond CJ,Higgins M,Campbell J,Laín S

更新日期：2013-03-07 00:00:00

abstract：:Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical tr...

journal_title：Cell death & disease

authors： Bittner S,Knoll G,Ehrenschwender M

更新日期：2017-08-03 00:00:00

abstract：:A major hallmark of Parkinson's disease (PD) is the degeneration of dopaminergic neurons in the substantia nigra, and the causative mechanism is thought to be the activation of programmed neuronal death. Necroptosis is a regulated process of cell death triggered by RIPK1. Although the pathophysiology of PD has been st...

journal_title：Cell death & disease

authors： Hu YB,Zhang YF,Wang H,Ren RJ,Cui HL,Huang WY,Cheng Q,Chen HZ,Wang G

更新日期：2019-08-05 00:00:00

abstract：:Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, disease treatment, and organ transplantation. As the ethical issue of human ESCs and similarity of pig in human genome and physiological characteristics, the porcine iPSCs (piPSCs) have become an ideal ...

journal_title：Cell death & disease

authors： Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Wang F,Wang Y,Wang X

更新日期：2019-02-20 00:00:00

abstract：:Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host response to infection that leads to uncontrolled inflammatory response followed by immunosuppression. However, despite the high mortality rate, no specific treatment modality or drugs with high efficacy is available for sepsis to date....

journal_title：Cell death & disease

authors： Cao C,Yu M,Chai Y

更新日期：2019-10-14 00:00:00

abstract：:The enteric pathogen enterohemorrhagic Escherichia coli (EHEC) is responsible for outbreaks of bloody diarrhea and hemolytic uremic syndrome (HUS) worldwide. Several molecular mechanisms have been described for the pathogenicity of EHEC; however, the role of bacterial metabolism in the virulence of EHEC during infecti...

journal_title：Cell death & disease

authors： Kuo CJ,Wang ST,Lin CM,Chiu HC,Huang CR,Lee DY,Chang GD,Chou TC,Chen JW,Chen CS

更新日期：2018-03-07 00:00:00

abstract：:N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial-mesenchymal transition. However, the role of NMI in the regulation of cancer stem cells (CSCs) remains poorly understood. In this stud...

journal_title：Cell death & disease

authors： Feng X,Xu X,Xiao X,Zou K,Yu W,Wu J,Tang R,Gao Y,Hao J,Zhao X,Liao Y,Chen Y,Huang W,Guo W,Kang L,Deng W

更新日期：2017-05-11 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gastric cancer (GC) patients. Here, we have identified a novel subset of CD45+CD33lowCD11bdim MDSCs in the periphe...

journal_title：Cell death & disease

authors： Mao FY,Zhao YL,Lv YP,Teng YS,Kong H,Liu YG,Wu XL,Hao CJ,Chen W,Duan MB,Han B,Ma Q,Wang TT,Peng LS,Zhang JY,Cheng P,Su CY,Fu XL,Zou QM,Guo G,Guo XL,Zhuang Y

更新日期：2018-07-09 00:00:00

abstract：:15-Lipoxygenase-1 (15-LO-1) is involved in many pathological processes. The purpose of this study was to determine the potential role of 15-LO-1 in osteoarthritis (OA). The levels of 15-LO-1 expression were measured by western blotting and quantitative real-time PCR in articular cartilage from the OA rat models and OA...

journal_title：Cell death & disease

authors： Chen K,Yan Y,Li C,Yuan J,Wang F,Huang P,Qian N,Qi J,Zhou H,Zhou Q,Deng L,He C,Guo L

更新日期：2017-10-12 00:00:00

abstract：:miRNAs are involved in many physiologic and disease processes by virtue of degrading specific mRNAs or inhibiting their translation. miR-148a has been implicated in the control of tumor growth and cholesterol and triglyceride homeostasis using in vitro or in vivo gene expression- and silencing-based approaches. Here m...

journal_title：Cell death & disease

authors： Cheng L,Zhu Y,Han H,Zhang Q,Cui K,Shen H,Zhang J,Yan J,Prochownik E,Li Y

更新日期：2017-07-13 00:00:00

abstract：:B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. Bax is latent and monomeric in the cytosol but transforms into its lethal, mitochondria-embedded oligomeric form in response to cell stress, leading to the rele...

journal_title：Cell death & disease

authors： Xu XP,Zhai D,Kim E,Swift M,Reed JC,Volkmann N,Hanein D

更新日期：2013-06-20 00:00:00

abstract：:The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as well as solid tumors, but shows dose-dependent potentially life-threatening toxicities and can induce secondary malignancies. Thus, the clinical utility of CTX wo...

journal_title：Cell death & disease

authors： Alexandrova EM,Xu S,Moll UM

更新日期：2017-03-16 00:00:00

abstract：:Parkin (Park2), a RING-between-RING-type E3 ubiquitin ligase, has been implicated in regulating NF-κB. Mutations in Parkin are associated with Parkinson's disease. Here we investigated the interaction of Parkin with Receptor-interacting protein kinase 1 (RIPK1) kinase, a key mediator of multiple signaling pathways act...

journal_title：Cell death & disease

authors： Wang Y,Shan B,Liang Y,Wei H,Yuan J

更新日期：2018-06-28 00:00:00

abstract：:Redox imbalance generates multiple cellular damages leading to oxidative stress-mediated pathological conditions such as neurodegenerative diseases and cancer progression. Therefore, maintenance of reactive oxygen species (ROS) homeostasis is most important that involves well-defined antioxidant machinery. In the pres...

journal_title：Cell death & disease

authors： Srivastava S,Sinha D,Saha PP,Marthala H,D'Silva P

更新日期：2014-08-28 00:00:00

abstract：:The phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of the catalytic subunit p110 and the regulatory subunit p85. The PI3K/Akt pathway is strongly deregulated in breast cancer (BC) representing one of the mechanisms of resistance to therapies. Therefore, the identification of inhibitors of PI3K componen...

journal_title：Cell death & disease

authors： Folgiero V,Di Carlo SE,Bon G,Spugnini EP,Di Benedetto A,Germoni S,Pia Gentileschi M,Accardo A,Milella M,Morelli G,Bossi G,Mottolese M,Falcioni R

更新日期：2012-12-06 00:00:00

abstract：:Hepatocellular carcinoma is the sixth most common cancer and gives rise to numerous deaths around the world every year. However, the molecular mechanism that controls hepatocarcinogenesis remains largely unknown. Here we found out an uncharacterized long noncoding RNA named lncAKHE. We found that lncAKHE was highly ex...

journal_title：Cell death & disease

authors： Huang G,Jiang H,Lin Y,Wu Y,Cai W,Shi B,Luo Y,Jian Z,Zhou X

更新日期：2018-05-01 00:00:00

abstract：:The intrinsic apoptotic pathway is controlled by the BCL-2 family of proteins, which exhibit either a pro-death or pro-survival function. Gene knockout studies revealed that different pro-survival BCL-2 proteins are critical for the survival of distinct cell types, although overlapping functions amongst such proteins ...

journal_title：Cell death & disease

authors： Ke F,Lancaster GI,Grabow S,Murphy AJ,Strasser A

更新日期：2020-03-13 00:00:00

abstract：:In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing so via means of systemic analysis pivotal to inform pathophysiological...

journal_title：Cell death & disease

authors： Martín-Jiménez R,Faccenda D,Allen E,Reichel HB,Arcos L,Ferraina C,Strobbe D,Russell C,Campanella M

更新日期：2018-06-04 00:00:00

abstract：:Estrogen receptor-alpha positive (ER(+)) breast cancers comprise the majority of human breast cancers, but molecular mechanisms underlying this subtype of breast cancers remain poorly understood. Here, we show that ER(+) mammary luminal tumors arising in Tip30(-/-)MMTV-Neu mice exhibited increased enrichment of lumina...

journal_title：Cell death & disease

authors： Chen F,Li A,Gao S,Hollern D,Williams M,Liu F,VanSickle EA,Andrechek E,Zhang C,Yang C,Luo R,Xiao H

更新日期：2014-05-22 00:00:00

abstract：:Global cerebral ischemia/reperfusion (I/R) facilitates the activation of procaspase-3 and promotes apoptosis in hippocampus. But the mechanisms have remained uncharacterized. Protein S-nitrosylation and denitrosylation is an important reversible posttranslational modification, which is a common mechanism in signal tra...

journal_title：Cell death & disease

authors： Sun N,Hao JR,Li XY,Yin XH,Zong YY,Zhang GY,Gao C

更新日期：2013-08-15 00:00:00