miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease.

abstract：:Bladder cancer (BCa) is the one of the most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates that DLK1-DIO3 genomic region especially the miRNA cluster in this region is involved in several pathologic processes and various cancers, and miR-323a-3p is a member of ...

journal_title：Cell death & disease

authors： Li J,Xu X,Meng S,Liang Z,Wang X,Xu M,Wang S,Li S,Zhu Y,Xie B,Lin Y,Zheng X,Liu B,Xie L

更新日期：2017-08-24 00:00:00

abstract：:The skin is a high turnover organ, and its constant renewal depends on the rapid proliferation of its progenitor cells. The energy requirement for these metabolically active cells is met by mitochondrial respiration, an ATP generating process driven by a series of protein complexes collectively known as the electron t...

journal_title：Cell death & disease

authors： Sreedhar A,Aguilera-Aguirre L,Singh KK

更新日期：2020-06-09 00:00:00

abstract：:Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that specifically recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif. The Pin1-mediated structural transformation posttranslationally regulates the biofunctions of multiple proteins. Pin1 is involved in many cel...

journal_title：Cell death & disease

authors： Chen Y,Wu YR,Yang HY,Li XZ,Jie MM,Hu CJ,Wu YY,Yang SM,Yang YB

更新日期：2018-08-29 00:00:00

abstract：:During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS. Reserve i...

journal_title：Cell death & disease

authors： Chen F,Zhang Y,Hu S,Shi X,Wang Z,Deng Z,Lin L,Zhang J,Pan Y,Bai Y,Liu F,Zhang H,Shao C

更新日期：2020-07-06 00:00:00

abstract：:The biological function of E26 transformation-specific (ETS) transcription factor EHF/ESE-3 in human cancers remains largely unknown, particularly gastric cancer. The aim of this study was to explore the role of EHF in tumorigenesis and its potential as a therapeutic target in gastric cancer. By using quantitative RT-...

journal_title：Cell death & disease

authors： Shi J,Qu Y,Li X,Sui F,Yao D,Yang Q,Shi B,Ji M,Hou P

更新日期：2016-10-27 00:00:00

abstract：:Mesothelin (MSLN) is an attractive antigen for chimeric antigen receptor (CAR) T therapy and the epitope selection within MSLN is essential. In this study, we constructed two types of CARs targeting either region I of MSLN (meso1 CAR, also known as a membrane-distal region) or region III of MSLN (meso3 CAR, also known...

journal_title：Cell death & disease

authors： Zhang Z,Jiang D,Yang H,He Z,Liu X,Qin W,Li L,Wang C,Li Y,Li H,Xu H,Jin H,Qian Q

更新日期：2019-06-17 00:00:00

abstract：:Mucin is an important physical barrier against enteric pathogens. VvpE is an elastase encoded by Gram-negative bacterium Vibrio vulnificus; however, the functional role of VvpE in intestinal mucin (Muc) production is yet to be elucidated. The recombinant protein (r) VvpE significantly reduced the level of Muc2 in huma...

journal_title：Cell death & disease

authors： Lee SJ,Jung YH,Oh SY,Jang KK,Lee HS,Choi SH,Han HJ

更新日期：2015-06-18 00:00:00

abstract：:Acute lung injury (ALI) is characterized by pulmonary endothelial and epithelial cell damage, and loss of the alveolar-capillary barrier. We have previously shown that P2X7 receptor (P2X7R), a cell death receptor, is specifically expressed in alveolar epithelial type I cells (AEC I). In this study, we hypothesized tha...

journal_title：Cell death & disease

authors： Guo Y,Mishra A,Weng T,Chintagari NR,Wang Y,Zhao C,Huang C,Liu L

更新日期：2014-06-12 00:00:00

abstract：:The acquisition of MDR1-mediated chemoresistance poses a major obstacle to the success of conventional chemotherapeutic agents. HSF1 is also involved in chemoresistance, and several studies have demonstrated the relationship between HSF1 and MDR1 but without any consistent results. Paclitaxel- and doxorubicin-resistan...

journal_title：Cell death & disease

authors： Mun GI,Choi E,Lee Y,Lee YS

更新日期：2020-05-26 00:00:00

abstract：:The longevity-associated variant (LAV) of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been found significantly enriched in long-living individuals. Neuroinflammation is a key player in Huntington's disease (HD), a neurodegenerative disorder caused by neural death due to expa...

journal_title：Cell death & disease

authors： Di Pardo A,Ciaglia E,Cattaneo M,Maciag A,Montella F,Lopardo V,Ferrario A,Villa F,Madonna M,Amico E,Carrizzo A,Damato A,Pepe G,Marracino F,Auricchio A,Vecchione C,Maglione V,Puca AA

更新日期：2020-07-18 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality worldwide. Recently, accumulating data indicate that long noncoding RNAs (LncRNAs) function as novel crucial regulators of diverse biological processes, including proliferation and metastasis, in tumorigenesis. Lnc NONHSAT081507.1 (LINC81507) is associated w...

journal_title：Cell death & disease

authors： Peng W,He D,Shan B,Wang J,Shi W,Zhao W,Peng Z,Luo Q,Duan M,Li B,Cheng Y,Dong Y,Tang F,Zhang C,Duan C

更新日期：2019-07-11 00:00:00

abstract：:Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation, leading to cell death. Recently, the induction of autophagy has been suggested during ferroptosis. However, this relationship between autophagy and ferroptosis is still controversial and th...

journal_title：Cell death & disease

authors： Park E,Chung SW

更新日期：2019-10-28 00:00:00

abstract：:Protein acetylation has a crucial role in energy metabolism. Here we performed the first large-scale profiling of acetylome in rat islets, showing that almost all enzymes in core metabolic pathways related to insulin secretion were acetylated. Label-free quantitative acetylome of islets in response to high glucose rev...

journal_title：Cell death & disease

authors： Zhang Y,Zhou F,Bai M,Liu Y,Zhang L,Zhu Q,Bi Y,Ning G,Zhou L,Wang X

更新日期：2019-01-25 00:00:00

abstract：:B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. Bax is latent and monomeric in the cytosol but transforms into its lethal, mitochondria-embedded oligomeric form in response to cell stress, leading to the rele...

journal_title：Cell death & disease

authors： Xu XP,Zhai D,Kim E,Swift M,Reed JC,Volkmann N,Hanein D

更新日期：2013-06-20 00:00:00

abstract：:Catecholaminergic Polymorphic Ventricular Tachycardia type 2 (CPVT2) is a highly lethal recessive arrhythmogenic disease caused by mutations in the calsequestrin-2 (CASQ2) gene. We have previously demonstrated that viral transfer of the wild-type (WT) CASQ2 gene prevents the development of CPVT2 in a genetically induc...

journal_title：Cell death & disease

authors： Lodola F,Morone D,Denegri M,Bongianino R,Nakahama H,Rutigliano L,Gosetti R,Rizzo G,Vollero A,Buonocore M,Napolitano C,Condorelli G,Priori SG,Di Pasquale E

更新日期：2016-10-06 00:00:00

abstract：:CCAAT/enhancer binding protein beta (C/EBPβ), a transcription factor expressed in muscle satellite cells (SCs), inhibits the myogenic program and is downregulated early in differentiation. In a conditional null model in which C/EBPβ expression is knocked down in paired box protein 7+ (Pax7+) SCs, cardiotoxin (CTX) inj...

journal_title：Cell death & disease

authors： Marchildon F,Fu D,Lala-Tabbert N,Wiper-Bergeron N

更新日期：2016-02-25 00:00:00

abstract：:Podocyte damage is commonly accompanied by destabilization of the podocalyxin (PC)/ezrin complex. Serum- and glucocorticoid-inducible kinase 3 (SGK3) plays a role in the maintenance of podocyte function, but the details of this role are poorly understood. Herein we demonstrated that SGK3 and its downstream target prot...

journal_title：Cell death & disease

authors： Yuan YP,Zhao H,Peng LQ,Li ZF,Liu S,Yuan CY,Mwamunyi MJ,Pearce D,Yao LJ

更新日期：2018-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been validated to play prominent roles in the occurrence and development of bladder cancer (BCa). MiR-22 was previously reported to act as a tumor suppressor or oncomiRNA in various types of cancer. However, its accurate expression, function, and mechanism in BCa remain unclear. Here, we find t...

journal_title：Cell death & disease

authors： Xu M,Li J,Wang X,Meng S,Shen J,Wang S,Xu X,Xie B,Liu B,Xie L

更新日期：2018-02-12 00:00:00

abstract：:MicroRNAs (miRNAs) deregulation is frequent in human gastric cancers (GCs), but the role of specific miRNAs involved in this disease remains elusive. MiR-22 was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in GC are largely ...

journal_title：Cell death & disease

authors： Zuo QF,Cao LY,Yu T,Gong L,Wang LN,Zhao YL,Xiao B,Zou QM

更新日期：2015-11-26 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Dry AMD is characterized by a progressive macular degeneration of the retinal pigment epithelium (RPE) and photoreceptors, and the RPE oxidative damage/dystrophy is at the core of the disease. Recent population/patients-based stud...

journal_title：Cell death & disease

authors： Ma H,Yang F,Ding XQ

更新日期：2020-01-13 00:00:00

abstract：:Therapeutic resistance of neoplasms is mainly attributed to gradual evolution of mutational profile1. Here, we demonstrate a microRNA-mediated mechanism that effectively improves fitness of SKBR3 mammary carcinoma cells by cytoplasmic reprogramming. The reprogramming is triggered by endogenous miR4673 transcribed from...

journal_title：Cell death & disease

authors： Dökümcü K,Simonian M,Farahani RM

更新日期：2018-10-19 00:00:00

abstract：:Inflammasomes are multimeric protein complexes that assemble upon sensing of a variety of stress factors. Their formation results in caspase-1-mediated activation and secretion of the pro-inflammatory cytokines pro-interleukin(IL)-1β and -18, which induce an inflammatory response. Inflammation is supported by a lytic ...

journal_title：Cell death & disease

authors： Sand J,Haertel E,Biedermann T,Contassot E,Reichmann E,French LE,Werner S,Beer HD

更新日期：2018-01-18 00:00:00

abstract：:Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells (MSCs) in processes which are tightly controlled by various growth factors, signaling molecules, transcriptional factors and microRNAs. Recently, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) was identified as a ...

journal_title：Cell death & disease

authors： Jeong BC,Kang IH,Hwang YC,Kim SH,Koh JT

更新日期：2014-11-20 00:00:00

abstract：:Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening diseases that are associated with high mortality rates due to treatment limitations. Neutrophils play key roles in the pathogenesis of ALI/ARDS by promoting the inflammation and injury of the alveolar mic...

journal_title：Cell death & disease

authors： Zhang Y,Liu H,Yao J,Huang Y,Qin S,Sun Z,Xu Y,Wan S,Cheng H,Li C,Zhang X,Ke Y

更新日期：2016-11-10 00:00:00

abstract：:Acute pancreatitis (AP) is an acute inflammatory process of the pancreas that is characterized by inflammation, edema, vacuolization and necrosis, which has significant morbidity and lethality. The pathogenesis of AP has not been established completely. An early and critical feature of AP is the aberrant signaling of ...

journal_title：Cell death & disease

authors： Zhu ZD,Yu T,Liu HJ,Jin J,He J

更新日期：2018-01-19 00:00:00

abstract：:CEMIP (for "Cell migration-inducing protein" also called KIAA1199 and Hybid for "Hyaluronan-binding protein") expression is increased in cancers and described as a regulator of cell survival, growth and invasion. In rheumatoid arthritis, CEMIP is referred to as an angiogenic marker and participates in hyaluronic acid ...

journal_title：Cell death & disease

authors： Deroyer C,Charlier E,Neuville S,Malaise O,Gillet P,Kurth W,Chariot A,Malaise M,de Seny D

更新日期：2019-02-04 00:00:00

abstract：:Mitochondrial Lon is a multi-function matrix protease with chaperone activity. However, little literature has been undertaken into detailed investigations on how Lon regulates apoptosis through its chaperone activity. Accumulating evidences indicate that various stresses induce transportation of p53 to mitochondria an...

journal_title：Cell death & disease

authors： Sung YJ,Kao TY,Kuo CL,Fan CC,Cheng AN,Fang WC,Chou HY,Lo YK,Chen CH,Jiang SS,Chang IS,Hsu CH,Lee JC,Lee AY

更新日期：2018-06-13 00:00:00

abstract：:We investigated the mechanism underlying the effect of a combination treatment of 125I radioactive seed implantation and lobaplatin (LBP) in hepatocellular carcinoma. The effects of administration of HCC cells and subcutaneous tumor model of mice with different doses of 125I or a sensitizing concentration of LBP alone...

journal_title：Cell death & disease

authors： Li D,Wang WJ,Wang YZ,Wang YB,Li YL

更新日期：2019-10-03 00:00:00

abstract：:Epidemiology studies indicate that consumption of high-fat diet (HFD) is directly associated with the development of colorectal cancer (CRC). However, the exact component in HFD and the mechanism underlying its effect on CRC growth remained unclear. Our study shows that HFD feeding increases β2AR expression in the xen...

journal_title：Cell death & disease

authors： Fatima S,Hu X,Huang C,Zhang W,Cai J,Huang M,Gong RH,Chen M,Ho AHM,Su T,Wong HLX,Bian Z,Kwan HY

更新日期：2019-09-26 00:00:00

abstract：:The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis and cancer progression. However, the role of SOX12 and the mechanism by which it is dysregulated in colorectal cancer (CRC) remain unclear. Here we analyzed SOX12 expression patterns in two independent CRC cohorts (cohort I, n = 3...

journal_title：Cell death & disease

authors： Du F,Chen J,Liu H,Cai Y,Cao T,Han W,Yi X,Qian M,Tian D,Nie Y,Wu K,Fan D,Xia L

更新日期：2019-03-11 00:00:00