Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia.

abstract：:Cancer stem cells (CSCs) represent a population of cancer cells that possess unique self-renewal and differentiation characteristics required for tumorigenesis and are resistant to chemotherapy-induced apoptosis. Lung CSCs can be enriched by several markers including drug-resistant side population (SP), CD133(pos) and...

journal_title：Cell death & disease

authors： Akunuru S,James Zhai Q,Zheng Y

更新日期：2012-07-19 00:00:00

abstract：:Breast cancer is the most significant threat to female health. Breast cancer metastasis is the major cause of mortality in breast cancer patients. To fully unravel the molecular mechanisms that underlie the breast cancer cell metastasis is critical for developing strategies to improve survival and prognosis in breast ...

journal_title：Cell death & disease

authors： Liu L,Zhang Y,Lu J

更新日期：2020-09-14 00:00:00

abstract：:Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis. The smoothened (Smo) receptor is one of the main upstream transducers of the ...

journal_title：Cell death & disease

authors： Infante P,Alfonsi R,Ingallina C,Quaglio D,Ghirga F,D'Acquarica I,Bernardi F,Di Magno L,Canettieri G,Screpanti I,Gulino A,Botta B,Mori M,Di Marcotullio L

更新日期：2016-09-22 00:00:00

abstract：:Enhanced SNHG1 (small nucleolar RNA host gene 1) expression has been found to play a critical role in the initiation and progression of hepatocellular carcinoma (HCC) with its detailed mechanism largely unknown. In this study, we show that SNHG1 promotes the HCC progression through epigenetically silencing CDKN1A and ...

journal_title：Cell death & disease

authors： Li B,Li A,You Z,Xu J,Zhu S

更新日期：2020-10-02 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) play a vital role in tumourigenesis, including that of glioma. Small nucleolar RNA host gene 1 (SNHG1) is a relatively novel lncRNA that is involved in the development of multiple human tumours. However, its underlying molecular mechanism in glioma has not been completely clarified. In t...

journal_title：Cell death & disease

authors： Liu L,Shi Y,Shi J,Wang H,Sheng Y,Jiang Q,Chen H,Li X,Dong J

更新日期：2019-06-12 00:00:00

abstract：:p63 is a p53 family transcription factor, which besides unique roles in epithelial development, shares tumor suppressive activity with its homolog p53. The p63 gene has different transcriptional start sites, which generate two N-terminal isoforms (transactivation domain (TA)p63 and amino terminal truncated protein(ΔN)...

journal_title：Cell death & disease

authors： Celardo I,Grespi F,Antonov A,Bernassola F,Garabadgiu AV,Melino G,Amelio I

更新日期：2013-05-23 00:00:00

abstract：:Chronic hyperglycemia causes a progressive decrease of β-cell function and mass in type 2 diabetic patients. Growing evidence suggests that augment of autophagy may be an effective approach to protect β cells against various extra-/intracellular stimuli. In this study, we thus investigated whether bone marrow-derived ...

journal_title：Cell death & disease

authors： Zhao K,Hao H,Liu J,Tong C,Cheng Y,Xie Z,Zang L,Mu Y,Han W

更新日期：2015-09-17 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor characterized by distant metastasis. Deletion or down-regulation of the tumor suppressor protein ras-association domain family protein1 isoform A (RASSF1A) has been confirmed to be a key event in NPC progression; however, little is known about the effects or ...

journal_title：Cell death & disease

authors： Liang YY,Deng XB,Lin XT,Jiang LL,Huang XT,Mo ZW,Yuan YW,Teh MT

更新日期：2020-10-14 00:00:00

abstract：:Mitogen-activated protein kinase kinase 3 (MAP2K3, MKK3) is a member of the dual specificity protein kinase group that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic or stress-inducing stimuli and participates in the MAP kinase-mediated signaling cascade, leading to cell proliferation a...

journal_title：Cell death & disease

authors： Baldari S,Ubertini V,Garufi A,D'Orazi G,Bossi G

更新日期：2015-01-29 00:00:00

abstract：:It has been recognized that myocardial apoptosis is one major factor in the development of heart dysfunction and autophagy has been shown to influence the apoptosis. In previous studies, we reported that anti-β1-adrenergic receptor autoantibodies (β1-AABs) decreased myocardial autophagy, but the role of decreased auto...

journal_title：Cell death & disease

authors： Wang L,Li Y,Ning N,Wang J,Yan Z,Zhang S,Jiao X,Wang X,Liu H

更新日期：2018-03-14 00:00:00

abstract：:Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. Recent studies have shown that gbMSCs consist of two distinct subpopulations (CD90+ and CD90- gbMSCs). However, the different roles in glioma progression have not been exp...

journal_title：Cell death & disease

authors： Zhang Q,Yi DY,Xue BZ,Wen WW,Lu YP,Abdelmaksou A,Sun MX,Yuan DT,Zhao HY,Xiong NX,Xiang W,Fu P

更新日期：2018-10-27 00:00:00

abstract：:miRNAs are involved in many physiologic and disease processes by virtue of degrading specific mRNAs or inhibiting their translation. miR-148a has been implicated in the control of tumor growth and cholesterol and triglyceride homeostasis using in vitro or in vivo gene expression- and silencing-based approaches. Here m...

journal_title：Cell death & disease

authors： Cheng L,Zhu Y,Han H,Zhang Q,Cui K,Shen H,Zhang J,Yan J,Prochownik E,Li Y

更新日期：2017-07-13 00:00:00

abstract：:T-cell-mediated immune responses aim to protect mammals against cancers and infections, and are also involved in the pathogenesis of various inflammatory or autoimmune diseases. Cellular uptake and the utilization of nutrients is closely related to the T-cell fate decision and function. Research in this area has yield...

journal_title：Cell death & disease

authors： Ren W,Liu G,Yin J,Tan B,Wu G,Bazer FW,Peng Y,Yin Y

更新日期：2017-03-02 00:00:00

abstract：:Studies on human intestinal injury induced by acute exposure to γ-radiation commonly rely on use of animal models because culture systems do not faithfully mimic human intestinal physiology. Here we used a human Gut-on-a-Chip (Gut Chip) microfluidic device lined by human intestinal epithelial cells and vascular endoth...

journal_title：Cell death & disease

authors： Jalili-Firoozinezhad S,Prantil-Baun R,Jiang A,Potla R,Mammoto T,Weaver JC,Ferrante TC,Kim HJ,Cabral JMS,Levy O,Ingber DE

更新日期：2018-02-14 00:00:00

abstract：:It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the relationship between CS...

journal_title：Cell death & disease

authors： Ffrench B,Gasch C,Hokamp K,Spillane C,Blackshields G,Mahgoub TM,Bates M,Kehoe L,Mooney A,Doyle R,Doyle B,O'Donnell D,Gleeson N,Hennessy BT,Stordal B,O'Riain C,Lambkin H,O'Toole S,O'Leary JJ,Gallagher MF

更新日期：2017-10-19 00:00:00

abstract：:Synapsin I is a phosphoprotein that coats the cytoplasmic side of synaptic vesicles and regulates their trafficking within nerve terminals. Autoantibodies against Syn I have been described in sera and cerebrospinal fluids of patients with numerous neurological diseases, including limbic encephalitis and clinically iso...

journal_title：Cell death & disease

authors： Rocchi A,Sacchetti S,De Fusco A,Giovedi S,Parisi B,Cesca F,Höltje M,Ruprecht K,Ahnert-Hilger G,Benfenati F

更新日期：2019-11-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Moon H-,Cao Y,Yang J,Lee JH,Choi HS,Jin Y

更新日期：2020-02-12 00:00:00

abstract：:We demonstrate that EphB3 receptors mediate oligodendrocyte (OL) cell death in the injured spinal cord through dependence receptor mechanism. OLs in the adult spinal cord express EphB3 as well as other members of the Eph receptor family. Spinal cord injury (SCI) is associated with tissue damage, cellular loss and dist...

journal_title：Cell death & disease

authors： Tsenkina Y,Ricard J,Runko E,Quiala-Acosta MM,Mier J,Liebl DJ

更新日期：2015-10-15 00:00:00

abstract：:Macrophages are involved in tumor growth and progression. They infiltrate into tumors and cause inflammation, which creates a microenvironment favoring tumor growth and metastasis. However, certain stimuli may induce macrophages to act as tumor terminators. Here we report that the calcineurin B subunit (CnB) synergize...

journal_title：Cell death & disease

authors： Su Z,Yang R,Zhang W,Xu L,Zhong Y,Yin Y,Cen J,DeWitt JP,Wei Q

更新日期：2015-05-07 00:00:00

abstract：:The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin has been shown to induce apoptosis in different cancer cells and to suppress growth of human cancer xenografts in vivo. However, its direct targets remain unknown. In this...

journal_title：Cell death & disease

authors： Polier G,Ding J,Konkimalla BV,Eick D,Ribeiro N,Köhler R,Giaisi M,Efferth T,Desaubry L,Krammer PH,Li-Weber M

更新日期：2011-07-21 00:00:00

abstract：:The development of nephrotoxicity largely limits the clinical use of chemotherapy. MiRNAs are able to target various genes and involved in the regulation of diverse cellular processes, including cell apoptosis and death. Our study showed that miR-181a expression was significantly increased after 5-fluorouracil (5-FU) ...

journal_title：Cell death & disease

authors： Liu XY,Zhang FR,Shang JY,Liu YY,Lv XF,Yuan JN,Zhang TT,Li K,Lin XC,Liu X,Lei Q,Fu XD,Zhou JG,Liang SJ

更新日期：2018-05-23 00:00:00

abstract：:Our recent study identified a list of differentially expressed microRNAs (miRNAs) in human prostate cancer (PCa) tissues compared to adjacent benign prostate tissues. In the current study, to identify the crucial miRNA-mRNA regulatory biomodule involved into prostate carcinogenesis based on the previous miRNA expressi...

journal_title：Cell death & disease

authors： Zhang Y,Jiang F,He H,Ye J,Mao X,Guo Q,Wu SL,Zhong W,Wu CL,Lin N

更新日期：2018-02-21 00:00:00

abstract：:Cancer is the second leading cause of death worldwide. Current treatment strategies based on multi-agent chemotherapy and/or radiation regimens have improved overall survival in some cases. However, resistance to apoptosis often develops in cancer cells, and its occurrence is thought to contribute to treatment failure...

journal_title：Cell death & disease

authors： Wang L,Gundelach JH,Bram RJ

更新日期：2017-05-18 00:00:00

abstract：:The vascular leakage in diabetic retinopathy leads to macular edema and vision loss. Although astrocyte play an important role in regulating blood-brain barrier integrity in the brain, the precise role of astrocyte in blood-retinal barrier was yet to be elucidated. This study aimed to investigate the role of angiopoie...

journal_title：Cell death & disease

authors： Yun JH,Park SW,Kim JH,Park YJ,Cho CH,Kim JH

更新日期：2016-02-18 00:00:00

abstract：:Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs to the repeats-in-toxin family, is believed to be one of its virulence factors and to have an important role in the bacterium's pathogenic...

journal_title：Cell death & disease

authors： Kelk P,Abd H,Claesson R,Sandström G,Sjöstedt A,Johansson A

更新日期：2011-03-10 00:00:00

abstract：:Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important role in tumor suppression. Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and EMT. However, un...

journal_title：Cell death & disease

authors： Ali A,Zhang P,Liangfang Y,Wenshe S,Wang H,Lin X,Dai Y,Feng XH,Moses R,Wang D,Li X,Xiao J

更新日期：2015-03-12 00:00:00

abstract：:Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging and aging-associated diseases. Senescence is also recognized as a mechanism for limiting the regenerative potential of stem cells and to protect cells from cancer development. The senescence program is realized through autocrin...

journal_title：Cell death & disease

authors： Severino V,Alessio N,Farina A,Sandomenico A,Cipollaro M,Peluso G,Galderisi U,Chambery A

更新日期：2013-11-07 00:00:00

abstract：:Pluripotency makes human pluripotent stem cells (hPSCs) promising for regenerative medicine, but the teratoma formation has been considered to be a major obstacle for their clinical applications. Here, we determined that the downregulation of miR-302 suppresses the teratoma formation, hampers the self-renewal and plur...

journal_title：Cell death & disease

authors： Li HL,Wei JF,Fan LY,Wang SH,Zhu L,Li TP,Lin G,Sun Y,Sun ZJ,Ding J,Liang XL,Li J,Han Q,Zhao RC

更新日期：2016-01-28 00:00:00

abstract：:Hippo signaling plays critical roles in intestinal regeneration. However, the mechanisms which regulate its activity in vivo are largely unknown. We hypothesize that protease-activated receptor 2 (PAR2) signaling, which could be activated by trypsin, might affect YAP activity in the setting of tissue damage and regene...

journal_title：Cell death & disease

authors： He L,Ma Y,Li W,Han W,Zhao X,Wang H

更新日期：2018-09-20 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Talty A,Deegan S,Ljujic M,Mnich K,Naicker SD,Quandt D,Zeng Q,Patterson JB,Gorman AM,Griffin MD,Samali A,Logue SE

更新日期：2020-01-06 00:00:00