Autoantibodies to synapsin I sequestrate synapsin I and alter synaptic function.

abstract：:The intrinsic apoptotic pathway is controlled by the BCL-2 family of proteins, which exhibit either a pro-death or pro-survival function. Gene knockout studies revealed that different pro-survival BCL-2 proteins are critical for the survival of distinct cell types, although overlapping functions amongst such proteins ...

journal_title：Cell death & disease

authors： Ke F,Lancaster GI,Grabow S,Murphy AJ,Strasser A

更新日期：2020-03-13 00:00:00

abstract：:Autophagy (macroautophagy) is an evolutionarily conserved lysosomal degradation process, in which a cell degrades long-lived proteins and damaged organelles. Recently, accumulating evidence has revealed the core molecular machinery of autophagy in carcinogenesis; however, the intricate relationship between autophagy a...

journal_title：Cell death & disease

authors： Liu B,Wen X,Cheng Y

更新日期：2013-10-31 00:00:00

abstract：:Adaptive responses of skeletal muscle regulate the nuclear shuttling of the sarcomeric protein Ankrd2 that can transduce different stimuli into specific adaptations by interacting with both structural and regulatory proteins. In a genome-wide expression study on Ankrd2-knockout or -overexpressing primary proliferating...

journal_title：Cell death & disease

authors： Bean C,Verma NK,Yamamoto DL,Chemello F,Cenni V,Filomena MC,Chen J,Bang ML,Lanfranchi G

更新日期：2014-01-16 00:00:00

abstract：:The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are well established regulators of glucose metabolism via their synt...

journal_title：Cell death & disease

authors： Yalcin A,Clem BF,Imbert-Fernandez Y,Ozcan SC,Peker S,O'Neal J,Klarer AC,Clem AL,Telang S,Chesney J

更新日期：2014-07-17 00:00:00

abstract：:Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented coregulator of an increasing number of transcription factors and cofactors involved in cell death and proliferation in several organs and systems. As Hipk2(-/-) mice show behavioral abnormalities consistent with cerebellar dysfunction, we investigated...

journal_title：Cell death & disease

authors： Anzilotti S,Tornincasa M,Gerlini R,Conte A,Brancaccio P,Cuomo O,Bianco G,Fusco A,Annunziato L,Pignataro G,Pierantoni GM

更新日期：2015-12-03 00:00:00

abstract：:Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extrac...

journal_title：Cell death & disease

authors： Cerella C,Muller F,Gaigneaux A,Radogna F,Viry E,Chateauvieux S,Dicato M,Diederich M

更新日期：2015-06-11 00:00:00

abstract：:Interleukin-17 receptor B (IL-17RB), a member of the IL-17 receptor family activated by IL-17B/IL-17E, has been shown to be involved in inflammatory diseases. However, the regulation and function of IL-17RB in Helicobacter pylori (H. pylori) infection, especially in the early-phase is still unknown. Here, we found tha...

journal_title：Cell death & disease

authors： Teng YS,Liu YG,Chen XH,Wang TT,Cheng P,Lv YP,Kong H,Mao FY,Hao CJ,Yang SM,Chen W,Zhang JY,Peng LS,Han B,Ma Q,Han J,Zou QM,Zhuang Y

更新日期：2019-01-28 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Talty A,Deegan S,Ljujic M,Mnich K,Naicker SD,Quandt D,Zeng Q,Patterson JB,Gorman AM,Griffin MD,Samali A,Logue SE

更新日期：2020-01-06 00:00:00

abstract：:New spinal cord injury (SCI) cases are frequently due to non-traumatic causes, including vascular disorders. To develop mechanism-based neuroprotective strategies for acute SCI requires full understanding of the early pathophysiological changes to prevent disability and paralysis. The aim of our study was to identify ...

journal_title：Cell death & disease

authors： Bianchetti E,Mladinic M,Nistri A

更新日期：2013-07-04 00:00:00

abstract：:Autophagy is an evolutionarily conserved lysosomal degradation pathway that plays important roles in cell maintenance, expansion and differentiation. Removal of genes essential for autophagy from embryonic neural stem and precursor cells reduces the survival and inhibits neuronal differentiation of adult-generated neu...

journal_title：Cell death & disease

authors： Xi Y,Dhaliwal JS,Ceizar M,Vaculik M,Kumar KL,Lagace DC

更新日期：2016-03-03 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipocyte differentiation and has an important role in metabolic syndrome. Phosphorylation of the receptor's ligand-binding domain at serine 273 has been shown to change the expression of a large number of genes implicated in obesity. The d...

journal_title：Cell death & disease

authors： Jurkowski W,Roomp K,Crespo I,Schneider JG,Del Sol A

更新日期：2011-08-11 00:00:00

abstract：:p53-mutated tumors often exhibit increased resistance to standard chemotherapy and enhanced metastatic potential. Here we demonstrate that inhibition of dihydroorotate dehydrogenase (DHODH), a key enzyme of the de novo pyrimidine synthesis pathway, effectively decreases proliferation of cancer cells via induction of r...

journal_title：Cell death & disease

authors： Hubackova S,Davidova E,Boukalova S,Kovarova J,Bajzikova M,Coelho A,Terp MG,Ditzel HJ,Rohlena J,Neuzil J

更新日期：2020-02-07 00:00:00

abstract：:miR-148a-3p downregulation has emerged as a critical factor in cancer progression yet, the underlying mechanisms of miR-148a-3p expression pattern and its function in bladder cancer remains to be elucidated. Here, we illustrate that miR-148a-3p is frequently downregulated in bladder cancer and that its expression may ...

journal_title：Cell death & disease

authors： Wang X,Liang Z,Xu X,Li J,Zhu Y,Meng S,Li S,Wang S,Xie B,Ji A,Liu B,Zheng X,Xie L

更新日期：2016-12-01 00:00:00

abstract：:Autophagy is a pivotal intracellular process by which cellular macromolecules are degraded upon various stimuli. A failure in the degradation of autophagic substrates such as impaired organelles and protein aggregates leads to their accumulations, which are characteristics of many neurodegenerative diseases. Pharmacol...

journal_title：Cell death & disease

authors： Yoon YS,Cho ED,Jung Ahn W,Won Lee K,Lee SJ,Lee HJ

更新日期：2017-10-05 00:00:00

abstract：:The multi-BCL-2 homology domain pro-apoptotic BCL-2 family members BAK and BAX have critical roles in apoptosis. They are essential for mitochondrial outer-membrane permeabilization, leading to the release of apoptogenic factors such as cytochrome-c, which promote activation of the caspase cascade and cellular demolit...

journal_title：Cell death & disease

authors： Ke F,Bouillet P,Kaufmann T,Strasser A,Kerr J,Voss AK

更新日期：2013-06-06 00:00:00

abstract：:Plant-derived dietary antioxidants have attracted considerable interest in recent past for their chemopreventive and cancer therapeutic abilities in animal models. Thymoquinone (TQ) is the major bioactive constituent of volatile oil of Nigella sativa and has been shown to exert various pharmacological properties, such...

journal_title：Cell death & disease

authors： Zubair H,Khan HY,Sohail A,Azim S,Ullah MF,Ahmad A,Sarkar FH,Hadi SM

更新日期：2013-06-06 00:00:00

abstract：:Recent studies have documented the diverse role of host immunity in infection by the protozoan parasite, Toxoplasma gondii. However, the contribution of the β-catenin pathway in this process has not been explored. Here, we show that AKT-mediated phosphorylated β-catenin supports T. gondii multiplication which is arres...

journal_title：Cell death & disease

authors： Majumdar T,Sharma S,Kumar M,Hussain MA,Chauhan N,Kalia I,Sahu AK,Rana VS,Bharti R,Haldar AK,Singh AP,Mazumder S

更新日期：2019-02-15 00:00:00

abstract：:Inflammasomes are multimeric protein complexes that assemble upon sensing of a variety of stress factors. Their formation results in caspase-1-mediated activation and secretion of the pro-inflammatory cytokines pro-interleukin(IL)-1β and -18, which induce an inflammatory response. Inflammation is supported by a lytic ...

journal_title：Cell death & disease

authors： Sand J,Haertel E,Biedermann T,Contassot E,Reichmann E,French LE,Werner S,Beer HD

更新日期：2018-01-18 00:00:00

abstract：:KLF5 is frequently deleted and downregulated in prostate cancer, and recently it has been reported that KLF5 loss is enriched in the aggressive branches of prostate cancer evolution. However, why KLF5 loss is associated with prostate cancer aggressiveness is still not clear. Herein, we analyzed KLF5 expression in TCGA...

journal_title：Cell death & disease

authors： Ma JB,Bai JY,Zhang HB,Jia J,Shi Q,Yang C,Wang X,He D,Guo P

更新日期：2020-06-16 00:00:00

abstract：:Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis. However, the underlying molecular mechanisms of N...

journal_title：Cell death & disease

authors： Zhang LQ,Van Haandel L,Xiong M,Huang P,Heruth DP,Bi C,Gaedigk R,Jiang X,Li DY,Wyckoff G,Grigoryev DN,Gao L,Li L,Wu M,Leeder JS,Ye SQ

更新日期：2017-03-23 00:00:00

abstract：:Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play important roles in cancer stemness, respectively. However, little is known about interaction between CAFs and PTK7 in cancers. In this study, we showed that PTK7 was significantly correlated with the Wnt/β-Catenin pathway and aggressive cli...

journal_title：Cell death & disease

authors： Yu B,Wu K,Wang X,Zhang J,Wang L,Jiang Y,Zhu X,Chen W,Yan M

更新日期：2018-10-22 00:00:00

abstract：:miRNAs have emerged as a pivotal component of gene regulatory networks, mediating cytokines secretion, cell cycle, and differentiation regulation. However, how miRNAs collaborate with transcription factors and downstream effector proteins that determine the fate of ovarian cancer cells remains to be understood, especi...

journal_title：Cell death & disease

authors： Wu B,Zhang L,Yu Y,Lu T,Zhang Y,Zhu W,Song Q,Lv C,Guo J,Tian Y,Deng N

更新日期：2020-05-11 00:00:00

abstract：:Members of the transforming growth factor-β (TGF-β) superfamily participate in numerous biological phenomena in multiple tissues, including in cell proliferation, differentiation, and migration. TGF-β superfamily proteins therefore have prominent roles in wound healing, fibrosis, bone formation, and carcinogenesis. Ho...

journal_title：Cell death & disease

authors： Goto K,Tong KI,Ikura J,Okada H

更新日期：2011-12-01 00:00:00

abstract：:Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite...

journal_title：Cell death & disease

authors： Li Y,Zhang L,Qu T,Tang X,Li L,Zhang G

更新日期：2017-07-06 00:00:00

abstract：:We previously showed that mice with knockout of Cytl1, a functionally uncharacterized cytokine candidate, exhibit normal endochondral ossification and long-bone development. Here, we investigated the potential functions of CYTL1 in bone homeostasis. We found that Cytl1-/- mice exhibited higher bone mass than wild-type...

journal_title：Cell death & disease

authors： Shin Y,Won Y,Yang JI,Chun JS

更新日期：2019-01-18 00:00:00

abstract：:The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila melanogaster upon exposure to the superoxide generator and neurotoxic ...

journal_title：Cell death & disease

authors： Minois N,Carmona-Gutierrez D,Bauer MA,Rockenfeller P,Eisenberg T,Brandhorst S,Sigrist SJ,Kroemer G,Madeo F

更新日期：2012-10-11 00:00:00

abstract：:NRLP3 inflammasome is a protein complex involved in the maturation of IL1β. In the onset of type 1 diabetes as well as in islet transplantation, IL-1β is one of the cytokines involved in the recruitment of immune cells in islets and eventually in islet destruction. Whether IL-1β is produced by islet cells is still und...

journal_title：Cell death & disease

authors： Lebreton F,Berishvili E,Parnaud G,Rouget C,Bosco D,Berney T,Lavallard V

更新日期：2018-06-25 00:00:00

abstract：:Autophagy is a major self-degradative process that maintains cellular homeostasis and function in mammalian cells. Autophagic dysfunction occurs in the early pathogenesis of Alzheimer's disease (AD) and directly regulates amyloid-β (Aβ) metabolism. Although it has been proven that the cytokine IFN-γ enhances autophagy...

journal_title：Cell death & disease

authors： He Z,Yang Y,Xing Z,Zuo Z,Wang R,Gu H,Qi F,Yao Z

更新日期：2020-06-08 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a heterogeneous population of cells that proliferate in vitro as plastic-adherent cells, have a fibroblast-like morphology, form colonies in vitro and can differentiate into bone, cartilage and fat cells. The abundance, ease and repeatable access to subcutaneous adipose tissue and the...

journal_title：Cell death & disease

authors： Kim JY,Shin KK,Lee AL,Kim YS,Park HJ,Park YK,Bae YC,Jung JS

更新日期：2014-08-21 00:00:00

abstract：:Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Although studies have implicated bioactive sphingolipids (SL) in senescence, the specific mechanisms remain unclear. Here, using MCF10A mammary epithelial cells, we demonstr...

journal_title：Cell death & disease

authors： Trayssac M,Clarke CJ,Stith JL,Snider JM,Newen N,Gault CR,Hannun YA,Obeid LM

更新日期：2021-01-04 00:00:00