Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β.

Abstract:

:An amendment to this paper has been published and can be accessed via a link at the top of the paper.

journal_name

Cell Death Dis

journal_title

Cell death & disease

authors

Talty A,Deegan S,Ljujic M,Mnich K,Naicker SD,Quandt D,Zeng Q,Patterson JB,Gorman AM,Griffin MD,Samali A,Logue SE

doi

10.1038/s41419-019-2189-6

subject

Has Abstract

pub_date

2020-01-06 00:00:00

pages

12

issue

1

issn

2041-4889

pii

10.1038/s41419-019-2189-6

journal_volume

11

pub_type

已发布勘误
  • IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b.

    abstract::Bone marrow mesenchymal stem cells (MSCs) have demonstrated therapeutic effects for colitis through immunomodulation and anti-inflammation. However, whether MSC-derived exosomes possessed the similar function remains unclear. In present study, exosomes were isolated from control and IFN-γ-primed MSCs and was verified ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-020-02788-0

    authors: Yang R,Huang H,Cui S,Zhou Y,Zhang T,Zhou Y

    更新日期:2020-07-30 00:00:00

  • Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage.

    abstract::Only a few types of inflammasomes have been described in central nervous system cells. Among these, the absent in melanoma 2 (AIM2) inflammasome is primarily found in neurons, is highly specific and can be activated only by double-stranded DNA. Although it has been demonstrated that the AIM2 inflammasome is activated ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-020-2248-z

    authors: Yuan B,Zhou XM,You ZQ,Xu WD,Fan JM,Chen SJ,Han YL,Wu Q,Zhang X

    更新日期:2020-01-30 00:00:00

  • FOXF2 acts as a crucial molecule in tumours and embryonic development.

    abstract::As a key member of the forkhead box transcription factors, forkhead box F2 (FOXF2) serves as a transcriptional regulator and regulates downstream gene expression in embryonic development, metabolism and in some common diseases, such as stroke and gastroparesis. Recent studies have shown that aberrant expression of FOX...

    journal_title:Cell death & disease

    pub_type: 杂志文章,评审

    doi:10.1038/s41419-020-2604-z

    authors: He W,Kang Y,Zhu W,Zhou B,Jiang X,Ren C,Guo W

    更新日期:2020-06-05 00:00:00

  • MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling.

    abstract::β-Catenin has been widely implicated in the regulation of mammalian development and cellular homeostasis. However, the mechanisms by which Wnt/β-catenin signaling components regulate physiological events during brain development remain undetermined. Inactivation of glycogen synthase kinase (GSK)-3β leads to β-catenin ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2014.439

    authors: Shin J,Shin Y,Oh SM,Yang H,Yu WJ,Lee JP,Huh SO,Lee SH,Suh YH,Chung S,Kim HS

    更新日期:2014-10-16 00:00:00

  • Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry.

    abstract::Recent studies identified a highly tumorigenic subpopulation of glioma stem cells (GSCs) within malignant gliomas. GSCs are proposed to originate from transformed neural stem cells (NSCs). Several pathways active in NSCs, including the Notch pathway, were shown to promote proliferation and tumorigenesis in GSCs. Notch...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2012.65

    authors: Tchorz JS,Tome M,Cloëtta D,Sivasankaran B,Grzmil M,Huber RM,Rutz-Schatzmann F,Kirchhoff F,Schaeren-Wiemers N,Gassmann M,Hemmings BA,Merlo A,Bettler B

    更新日期:2012-06-21 00:00:00

  • Treatment response, survival, safety, and predictive factors to chimeric antigen receptor T cell therapy in Chinese relapsed or refractory B cell acute lymphoblast leukemia patients.

    abstract::This study aimed to evaluate treatment response, survival, safety profiles, and predictive factors to chimeric antigen receptor T cell (CAR-T) therapy in Chinese patients with relapsed or refractory B cell acute lymphoblast leukemia (R/R B-ALL). 39R/R B-ALL patients who underwent CAR-T therapy were included. Baseline ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-020-2388-1

    authors: Li L,Liu J,Xu M,Yu H,Lv C,Cao F,Wang Z,Fu Y,Zhang M,Meng H,Zhang X,Kang L,Zhang Z,Li J,Feng J,Lian X,Yu L,Zhou J

    更新日期:2020-03-30 00:00:00

  • PAX6, modified by SUMOylation, plays a protective role in corneal endothelial injury.

    abstract::Treating corneal endothelial diseases tends to be challenging as human corneal endothelial cells (CECs) do not proliferate in vivo. The pathogenesis or mechanisms underlying injured CECs need further studies. The abnormal expression of PAX6, which is an essential transcription factor for corneal homeostasis, exhibits ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-020-02848-5

    authors: Yu F,Zhang W,Yan C,Yan D,Zhou M,Chen J,Zhao X,Zhu A,Zhou J,Liu H,Sun H,Fu Y

    更新日期:2020-08-12 00:00:00

  • Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity.

    abstract::The clinical use of the antineoplastic drug cisplatin is limited by its deleterious nephrotoxic side effect. Cisplatin-induced nephrotoxicity is associated with an increase in oxidative stress, leading ultimately to renal cell death and irreversible kidney dysfunction. Oxidative stress could be modified by the cystic ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2013.355

    authors: Rubera I,Duranton C,Melis N,Cougnon M,Mograbi B,Tauc M

    更新日期:2013-10-03 00:00:00

  • Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.

    abstract::Alzheimer's disease (AD) is pathologically characterised by the age-dependent deposition of β-amyloid (Aβ) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death. Neuroinflammation, typified by the accumulation of activated microglia and reactive astroc...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2011.50

    authors: Garwood CJ,Pooler AM,Atherton J,Hanger DP,Noble W

    更新日期:2011-06-02 00:00:00

  • Bmi1 regulates auditory hair cell survival by maintaining redox balance.

    abstract::Reactive oxygen species (ROS) accumulation are involved in noise- and ototoxic drug-induced hair cell loss, which is the major cause of hearing loss. Bmi1 is a member of the Polycomb protein family and has been reported to regulate mitochondrial function and ROS level in thymocytes and neurons. In this study, we repor...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2014.549

    authors: Chen Y,Li L,Ni W,Zhang Y,Sun S,Miao D,Chai R,Li H

    更新日期:2015-01-22 00:00:00

  • Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity.

    abstract::The development of nephrotoxicity largely limits the clinical use of chemotherapy. MiRNAs are able to target various genes and involved in the regulation of diverse cellular processes, including cell apoptosis and death. Our study showed that miR-181a expression was significantly increased after 5-fluorouracil (5-FU) ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-018-0677-8

    authors: Liu XY,Zhang FR,Shang JY,Liu YY,Lv XF,Yuan JN,Zhang TT,Li K,Lin XC,Liu X,Lei Q,Fu XD,Zhou JG,Liang SJ

    更新日期:2018-05-23 00:00:00

  • MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail.

    abstract::MicroRNAs (miRNAs) deregulation is frequent in human gastric cancers (GCs), but the role of specific miRNAs involved in this disease remains elusive. MiR-22 was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in GC are largely ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2015.297

    authors: Zuo QF,Cao LY,Yu T,Gong L,Wang LN,Zhao YL,Xiao B,Zou QM

    更新日期:2015-11-26 00:00:00

  • Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.

    abstract::Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis. The smoothened (Smo) receptor is one of the main upstream transducers of the ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2016.195

    authors: Infante P,Alfonsi R,Ingallina C,Quaglio D,Ghirga F,D'Acquarica I,Bernardi F,Di Magno L,Canettieri G,Screpanti I,Gulino A,Botta B,Mori M,Di Marcotullio L

    更新日期:2016-09-22 00:00:00

  • Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer.

    abstract::The biological function of E26 transformation-specific (ETS) transcription factor EHF/ESE-3 in human cancers remains largely unknown, particularly gastric cancer. The aim of this study was to explore the role of EHF in tumorigenesis and its potential as a therapeutic target in gastric cancer. By using quantitative RT-...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2016.346

    authors: Shi J,Qu Y,Li X,Sui F,Yao D,Yang Q,Shi B,Ji M,Hou P

    更新日期:2016-10-27 00:00:00

  • Mitochondrial DNA damage induces apoptosis in senescent cells.

    abstract::Senescence is a cellular response to damage and stress. The senescence response prevents cancer by suppressing the proliferation of cells with a compromised genome and contributes to optimal wound healing in normal tissues. Persistent senescent cells are also thought to drive aging and age-associated pathologies throu...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2013.199

    authors: Laberge RM,Adler D,DeMaria M,Mechtouf N,Teachenor R,Cardin GB,Desprez PY,Campisi J,Rodier F

    更新日期:2013-07-18 00:00:00

  • circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma.

    abstract::Circular RNAs (circRNAs) have been identified play a vital role in various different types of cancer via sponging miRNAs (microRNAs). However, their role in lung adenocarcinoma (LUAD) remains largely unclear. In this study, we systematically characterized the circRNA expression profiles in the LUAD cancer tissues and ...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-020-2230-9

    authors: Wang J,Zhao X,Wang Y,Ren F,Sun D,Yan Y,Kong X,Bu J,Liu M,Xu S

    更新日期:2020-01-16 00:00:00

  • Histamine deficiency aggravates cardiac injury through miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis.

    abstract::Histamine is a widely distributed biogenic amine involved in the regulation of an array of biological processes. Serum histamine level is markedly elevated in the early stages of acute myocardial infarction, whereas the role it plays remains unclear. Histidine decarboxylase (HDC) is the unique enzyme responsible for h...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-018-0723-6

    authors: Ding S,Abudupataer M,Zhou Z,Chen J,Li H,Xu L,Zhang W,Zhang S,Zou Y,Hong T,Wang TC,Yang X,Ge J

    更新日期:2018-06-07 00:00:00

  • Ca2+-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity.

    abstract::Neonatal jaundice is prevalent among newborns and can lead to severe neurological deficits, particularly sensorimotor dysfunction. Previous studies have shown that bilirubin (BIL) enhances the intrinsic excitability of central neurons and this can potentially contribute to their overexcitation, Ca2+ overload, and neur...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-019-1979-1

    authors: Shi HS,Lai K,Yin XL,Liang M,Ye HB,Shi HB,Wang LY,Yin SK

    更新日期:2019-10-10 00:00:00

  • Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.

    abstract::Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients. The mechanism of radiation-induced salivary gland damage is not completely understood. Cellular senescence is a permanent stat...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-020-03074-9

    authors: Peng X,Wu Y,Brouwer U,van Vliet T,Wang B,Demaria M,Barazzuol L,Coppes RP

    更新日期:2020-10-14 00:00:00

  • Correction: CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Cell death & disease

    pub_type: 已发布勘误

    doi:10.1038/s41419-019-1869-6

    authors: Han X,Shi H,Sun Y,Shang C,Luan T,Wang D,Ba X,Zeng X

    更新日期:2019-09-05 00:00:00

  • Alterations of specific chromatin conformation affect ATRA-induced leukemia cell differentiation.

    abstract::Chromatin conformation plays a key role in regulating gene expression and controlling cell differentiation. However, the whole-genome chromatin conformation changes that occur during leukemia cell differentiation are poorly understood. Here, we characterized the changes in chromatin conformation, histone states, chrom...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-017-0173-6

    authors: Li Y,He Y,Liang Z,Wang Y,Chen F,Djekidel MN,Li G,Zhang X,Xiang S,Wang Z,Gao J,Zhang MQ,Chen Y

    更新日期:2018-02-08 00:00:00

  • Control of glioma cell death and differentiation by PKM2-Oct4 interaction.

    abstract::Glioma stem cells are highly resistant to cell death and as such are supposed to contribute to tumor recurrence by eluding anticancer treatments. Here, we show that spheroids that contain rat neural stem cells (NSCs) or rat glioma stem cells (cancer stem cells, CSCs) express isoforms 1 and 2 of pyruvate kinase (PKM1 a...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2013.561

    authors: Morfouace M,Lalier L,Oliver L,Cheray M,Pecqueur C,Cartron PF,Vallette FM

    更新日期:2014-01-30 00:00:00

  • Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway.

    abstract::The identification of specific drug targets guides the development of precise cancer treatments. Compared with oncogenes, tumor suppressor genes have been poorly studied in the treatment of breast cancer. We integrate the microRNA expression array from GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas) d...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-017-0128-y

    authors: Li M,Han Y,Zhou H,Li X,Lin C,Zhang E,Chi X,Hu J,Xu H

    更新日期:2018-01-24 00:00:00

  • Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells.

    abstract::Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K27 hypomethylation accompanied by H3K27 hyperacetylation. Hyperacetylati...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-020-02800-7

    authors: Wiese M,Hamdan FH,Kubiak K,Diederichs C,Gielen GH,Nussbaumer G,Carcaboso AM,Hulleman E,Johnsen SA,Kramm CM

    更新日期:2020-08-21 00:00:00

  • Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation.

    abstract::The homolog of p53 gene, p63, encodes multiple p63 protein isoforms. TAp63 proteins contain an N-terminal transactivation domain similar to that of p53 and function as tumor suppressors; whereas ΔNp63 isoforms, which lack the intact N-terminal transactivation domain, are associated with human tumorigenesis. Accumulati...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2013.468

    authors: Li C,Chang DL,Yang Z,Qi J,Liu R,He H,Li D,Xiao ZX

    更新日期:2013-12-05 00:00:00

  • EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition.

    abstract::Recent evidence indicates that long noncoding RNAs (lncRNAs) have a critical role in the regulation of cellular processes such as differentiation, proliferation, and metastasis. These lncRNAs are dysregulated in a variety of cancers and many function as tumor suppressors; however, the regulatory factors involved in si...

    journal_title:Cell death & disease

    pub_type: 临床试验,杂志文章

    doi:10.1038/cddis.2014.256

    authors: Sun M,Liu XH,Lu KH,Nie FQ,Xia R,Kong R,Yang JS,Xu TP,Liu YW,Zou YF,Lu BB,Yin R,Zhang EB,Xu L,De W,Wang ZX

    更新日期:2014-06-26 00:00:00

  • Modifying PTEN recruitment promotes neuron survival, regeneration, and functional recovery after CNS injury.

    abstract::Phosphatase and tensin homolog (PTEN) regulates apoptosis and axonal growth in the developing and adult central nervous system (CNS). Here, we show that human PTEN C-terminal PDZ interactions play a critical role in neuronal apoptosis and axon regeneration after traumatic CNS injury and stroke, highlighted by the find...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/s41419-019-1802-z

    authors: Shabanzadeh AP,D'Onofrio PM,Magharious M,Choi KAB,Monnier PP,Koeberle PD

    更新日期:2019-07-29 00:00:00

  • socs7, a target gene of microRNA-145, regulates interferon-β induction through STAT3 nuclear translocation in bladder cancer cells.

    abstract::We recently reported that microRNA (miR)-145 is downregulated and induces apoptosis in human bladder cancer cells. Also, it is suggested that the ectopic expression of miR-145 induces apoptosis with the induction of TRAIL expression in several cancer cells. Here, we demonstrated a novel mechanism of apoptosis inductio...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2013.11

    authors: Noguchi S,Yamada N,Kumazaki M,Yasui Y,Iwasaki J,Naito S,Akao Y

    更新日期:2013-02-07 00:00:00

  • MicroRNA-302 induces proliferation and inhibits oxidant-induced cell death in human adipose tissue-derived mesenchymal stem cells.

    abstract::Mesenchymal stem cells (MSCs) are a heterogeneous population of cells that proliferate in vitro as plastic-adherent cells, have a fibroblast-like morphology, form colonies in vitro and can differentiate into bone, cartilage and fat cells. The abundance, ease and repeatable access to subcutaneous adipose tissue and the...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2014.344

    authors: Kim JY,Shin KK,Lee AL,Kim YS,Park HJ,Park YK,Bae YC,Jung JS

    更新日期:2014-08-21 00:00:00

  • WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway.

    abstract::WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family and functions as a scaffold protein during telomerase assembly, Cajal body formation and DNA double strand break repair. We have previously shown that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung ca...

    journal_title:Cell death & disease

    pub_type: 杂志文章

    doi:10.1038/cddis.2017.162

    authors: Sun Y,Cao L,Sheng X,Chen J,Zhou Y,Yang C,Deng T,Ma H,Feng P,Liu J,Tan W,Ye M

    更新日期:2017-04-13 00:00:00