Correction: Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway.


:An amendment to this paper has been published and can be accessed via a link at the top of the paper.


Cell Death Dis


Cell death & disease


Moon H-,Cao Y,Yang J,Lee JH,Choi HS,Jin Y




Has Abstract


2020-02-12 00:00:00












  • Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Cell death & disease

    pub_type: 已发布勘误


    authors: Talty A,Deegan S,Ljujic M,Mnich K,Naicker SD,Quandt D,Zeng Q,Patterson JB,Gorman AM,Griffin MD,Samali A,Logue SE

    更新日期:2020-01-06 00:00:00

  • Autoantibodies to synapsin I sequestrate synapsin I and alter synaptic function.

    abstract::Synapsin I is a phosphoprotein that coats the cytoplasmic side of synaptic vesicles and regulates their trafficking within nerve terminals. Autoantibodies against Syn I have been described in sera and cerebrospinal fluids of patients with numerous neurological diseases, including limbic encephalitis and clinically iso...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Rocchi A,Sacchetti S,De Fusco A,Giovedi S,Parisi B,Cesca F,Höltje M,Ruprecht K,Ahnert-Hilger G,Benfenati F

    更新日期:2019-11-14 00:00:00

  • GALNT6 promotes invasion and metastasis of human lung adenocarcinoma cells through O-glycosylating chaperone protein GRP78.

    abstract::Lung adenocarcinoma remains a threat to human health due to its high rate of recurrence and distant metastasis. However, the molecular mechanism underlying lung adenocarcinoma metastasis remains yet incompletely understood. Here, we show that upregulated expression of polypeptide N-acetylgalactosaminyltransferase6 (GA...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Song J,Liu W,Wang J,Hao J,Wang Y,You X,Du X,Zhou Y,Ben J,Zhang X,Ye M,Wang Q

    更新日期:2020-05-11 00:00:00

  • HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.

    abstract::Dysfunctional mitochondria have been shown to enhance cancer cell proliferation, reduce apoptosis, and increase chemoresistance. Chemoresistance develops in nearly all patients with colorectal cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. However, the effect of dynamin-related prote...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Huang CY,Chiang SF,Chen WT,Ke TW,Chen TW,You YS,Lin CY,Chao KSC,Huang CY

    更新日期:2018-09-26 00:00:00

  • Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis.

    abstract::In endometriosis, the increased survival potential of shed endometrial cells (which normally undergo anoikis) is suggested to promote lesion development. One mechanism that may alter anoikis is autophagy. Using an autophagic flux inhibitor hydroxychloroquine (HCQ), we identified that it reduces the in vitro survival c...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Ruiz A,Rockfield S,Taran N,Haller E,Engelman RW,Flores I,Panina-Bordignon P,Nanjundan M

    更新日期:2016-01-14 00:00:00

  • The role of autophagy in asparaginase-induced immune suppression of macrophages.

    abstract::Erwinia asparaginase, a bacteria-derived enzyme drug, has been used in the treatment of various cancers, especially acute lymphoblastic leukemia (ALL). One of the most significant side effects associated with asparaginase administration is immune suppression, which limits its application in clinic. Macrophages are pha...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Song P,Wang Z,Zhang X,Fan J,Li Y,Chen Q,Wang S,Liu P,Luan J,Ye L,Ju D

    更新日期:2017-03-30 00:00:00

  • RGD-modifided oncolytic adenovirus exhibited potent cytotoxic effect on CAR-negative bladder cancer-initiating cells.

    abstract::Cancer-initiating cell (CIC) is critical in cancer development, maintenance and recurrence. The reverse expression pattern of coxsackie and adenovirus receptor (CAR) and αν integrin in bladder cancer decreases the infection efficiency of adenovirus. We constructed Arg-Gly-Asp (RGD)-modified oncolytic adenovirus, carry...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Yang Y,Xu H,Shen J,Yang Y,Wu S,Xiao J,Xu Y,Liu XY,Chu L

    更新日期:2015-05-14 00:00:00

  • MiR-22 suppresses epithelial-mesenchymal transition in bladder cancer by inhibiting Snail and MAPK1/Slug/vimentin feedback loop.

    abstract::MicroRNAs (miRNAs) have been validated to play prominent roles in the occurrence and development of bladder cancer (BCa). MiR-22 was previously reported to act as a tumor suppressor or oncomiRNA in various types of cancer. However, its accurate expression, function, and mechanism in BCa remain unclear. Here, we find t...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Xu M,Li J,Wang X,Meng S,Shen J,Wang S,Xu X,Xie B,Liu B,Xie L

    更新日期:2018-02-12 00:00:00

  • H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis.

    abstract::H. pylori infection is one of the leading causes of gastric cancer and the pathogenicity of H. pylori infection is associated with its ability to induce chronic inflammation and apoptosis resistance. While H. pylori infection-induced expression of pro-inflammatory cytokines for chronic inflammation is well studied, th...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Chen Y,Sheppard D,Dong X,Hu X,Chen M,Chen R,Chakrabarti J,Zavros Y,Peek RM,Chen LF

    更新日期:2020-08-21 00:00:00

  • SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2.

    abstract::SOX4, a member of the SOX (sex-determining region Y-related HMG box) transcription factor family, has been reported to be abnormally expressed in a wide variety of cancers, and to exert a pleiotropic function. However, its function in progression of cervical cancer (CC) remains unknown. In this study, we found that SO...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Sun R,Jiang B,Qi H,Zhang X,Yang J,Duan J,Li Y,Li G

    更新日期:2015-11-19 00:00:00

  • Correction: Aberrant iPSC-derived human astrocytes in Alzheimer's disease.

    abstract::The original version of this Article contained an error in Fig. 1, in which a number of incorrect fluorescence images were inadvertently incorporated into the panel. This has been corrected in both the PDF and HTML versions of the Article. ...

    journal_title:Cell death & disease

    pub_type: 已发布勘误


    authors: Jones VC,Atkinson-Dell R,Verkhratsky A,Mohamet L

    更新日期:2019-03-12 00:00:00

  • HMGB1 released from intestinal epithelia damaged by cholera toxin adjuvant contributes to activation of mucosal dendritic cells and induction of intestinal cytotoxic T lymphocytes and IgA.

    abstract::Cholera toxin (CT) is a potent mucosal adjuvant and oral administration of ovalbumin (OVA) antigens plus CT induces OVA-specific CD8+ cytotoxic T lymphocytes (CTLs) and IgA production in intestinal mucosa. However, the mechanisms of induction of these immune responses remain unknown. Intestinal OVA-specific CD8+ CTLs ...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Wakabayashi A,Shimizu M,Shinya E,Takahashi H

    更新日期:2018-05-24 00:00:00

  • Extracellular ATP drives systemic inflammation, tissue damage and mortality.

    abstract::Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of several toxic and damaging molecules. These are necessary to figh...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Cauwels A,Rogge E,Vandendriessche B,Shiva S,Brouckaert P

    更新日期:2014-03-06 00:00:00

  • Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.

    abstract::Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be targeted. We used mes...

    journal_title:Cell death & disease

    pub_type: 杂志文章,收录出版


    authors: Javaheri T,Kazemi Z,Pencik J,Pham HT,Kauer M,Noorizadeh R,Sax B,Nivarthi H,Schlederer M,Maurer B,Hofbauer M,Aryee DN,Wiedner M,Tomazou EM,Logan M,Hartmann C,Tuckermann JP,Kenner L,Mikula M,Dolznig H,Üren A,Richt

    更新日期:2016-10-13 00:00:00

  • Tubeimoside I-induced lung cancer cell death and the underlying crosstalk between lysosomes and mitochondria.

    abstract::Cancer cells have developed chemoresistance and have improved their survival through the upregulation of autophagic mechanisms that protect mitochondrial function. Here, we report that the traditional Chinese anticancer agent tubeimoside I (Tub), which is a potent inhibitor of autophagy, can promote mitochondria-assoc...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Wang K,Zhan Y,Chen B,Lu Y,Yin T,Zhou S,Zhang W,Liu X,Du B,Wei X,Xiao J

    更新日期:2020-08-26 00:00:00

  • Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage.

    abstract::Inactivation of the retinoblastoma protein (Rb) has a key role in tumorigenesis. It is well established that Rb function is largely regulated by a dynamic balance of phosphorylation and dephosphorylation. Although much research has been done to understand the mechanisms and function of RB phosphorylation, the regulati...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Tong Y,Ying H,Liu R,Li L,Bergholz J,Xiao ZX

    更新日期:2015-02-12 00:00:00

  • Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy.

    abstract::Natural-food-based compounds show substantial promise for prevention and biotherapy of cancers including leukemia. In general, their mechanism of action remains unclear, hampering rational use of these compounds. Herein we show that the common dietary flavonoid apigenin has anticancer activity, but also may decrease c...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Ruela-de-Sousa RR,Fuhler GM,Blom N,Ferreira CV,Aoyama H,Peppelenbosch MP

    更新日期:2010-01-01 00:00:00

  • EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation.

    abstract::Psoriasis is characterized by keratinocyte hyperproliferation. While significant progress has been made in understanding the molecular mechanism regulating the proliferation of keratinocytes, little is known about the epigenetic factors that control this process. EZH2 and EZH2 mediated trimethylation of histone H3 lys...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Zhang T,Yang L,Ke Y,Lei J,Shen S,Shao S,Zhang C,Zhu Z,Dang E,Wang G

    更新日期:2020-10-03 00:00:00

  • Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis.

    abstract::Normal cells require adhesion to extracellular matrix for survival. Cell detachment causes a drastic increase in reactive oxygen species (ROS) that promotes anoikis. In the present study, we observed that upon detachment from matrix, human mammary epithelial cells strongly upregulate manganese superoxide dismutase (Mn...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Kamarajugadda S,Cai Q,Chen H,Nayak S,Zhu J,He M,Jin Y,Zhang Y,Ai L,Martin SS,Tan M,Lu J

    更新日期:2013-02-21 00:00:00

  • MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion.

    abstract::Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer's disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and ...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Chen X,Jiang XM,Zhao LJ,Sun LL,Yan ML,Tian Y,Zhang S,Duan MJ,Zhao HM,Li WR,Hao YY,Wang LB,Xiong QJ,Ai J

    更新日期:2017-06-01 00:00:00

  • The interaction of interleukin-8 and PTEN inactivation promotes the malignant progression of head and neck squamous cell carcinoma via the STAT3 pathway.

    abstract::Interleukin-8 (IL-8) expression correlates with poor prognosis in many cancers, including head and neck squamous cell carcinoma (HNSCC), but the underlying mechanism is poorly understood. In this study, we found that overexpression of IL-8 correlated with poor outcome in HNSCC patients. IL-8 significantly increased ce...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Xu Q,Ma H,Chang H,Feng Z,Zhang C,Yang X

    更新日期:2020-05-29 00:00:00

  • Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis.

    abstract::Reactive gliosis is an early pathological feature common to most neurodegenerative diseases, yet its regulation and impact remain poorly understood. Normally astrocytes maintain a critical homeostatic balance. After stress or injury they undergo rapid parainflammatory activation, characterized by hypertrophy, and incr...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Livne-Bar I,Lam S,Chan D,Guo X,Askar I,Nahirnyj A,Flanagan JG,Sivak JM

    更新日期:2016-09-29 00:00:00

  • Bmi1 regulates auditory hair cell survival by maintaining redox balance.

    abstract::Reactive oxygen species (ROS) accumulation are involved in noise- and ototoxic drug-induced hair cell loss, which is the major cause of hearing loss. Bmi1 is a member of the Polycomb protein family and has been reported to regulate mitochondrial function and ROS level in thymocytes and neurons. In this study, we repor...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Chen Y,Li L,Ni W,Zhang Y,Sun S,Miao D,Chai R,Li H

    更新日期:2015-01-22 00:00:00

  • Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma.

    abstract::Increasing the sensitivity of glioblastoma cells to radiation is a promising approach to improve survival in patients with glioblastoma multiforme (GBM). This study aims to determine if serine/threonine phosphatase (protein phosphatase 6 (PP6)) is a molecular target for GBM radiosensitization treatment. The GBM orthot...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Shen Y,Wang Y,Sheng K,Fei X,Guo Q,Larner J,Kong X,Qiu Y,Mi J

    更新日期:2011-12-08 00:00:00

  • EFTUD2 maintains the survival of tumor cells and promotes hepatocellular carcinoma progression via the activation of STAT3.

    abstract::Elongation factor Tu GTP binding domain containing 2 (EFTUD2), a spliceosomal GTPase, plays a pivotal role in multiple organ development and innate immune. It has been reported that EFTUD2 is a new host factor with activity against HCV infection. However, the role of EFTUD2 in solid tumors, including hepatocellular ca...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Tu M,He L,You Y,Li J,Yao N,Qu C,Huang W,Xu L,Luo R,Hong J

    更新日期:2020-10-06 00:00:00

  • Enhanced osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis: a study based on a three-dimensional biomimetic environment.

    abstract::The mechanism of pathological osteogenesis in Ankylosing spondylitis (AS) is largely unknown. Our previous studies demonstrated that the imbalance between BMP-2 and Noggin secretion induces abnormal osteogenic differentiation of marrow-derived mesenchymal stem cells (MSCs) from AS patients in a two-dimensional culture...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Zheng G,Xie Z,Wang P,Li J,Li M,Cen S,Tang S,Liu W,Ye G,Li Y,Wang S,Wu X,Su H,Wu Y,Shen H

    更新日期:2019-04-25 00:00:00

  • Japanese encephalitis virus induces human neural stem/progenitor cell death by elevating GRP78, PHB and hnRNPC through ER stress.

    abstract::Japanese encephalitis virus (JEV), which is a causative agent of sporadic encephalitis, harbours itself inside the neural stem/progenitor cells. It is a well-known fact that JEV infects neural stem/progenitor cells and decreases their proliferation capacity. With mass spectrometry-based quantitative proteomic study, i...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Mukherjee S,Singh N,Sengupta N,Fatima M,Seth P,Mahadevan A,Shankar SK,Bhattacharyya A,Basu A

    更新日期:2017-01-19 00:00:00

  • The p75 receptor mediates axon growth inhibition through an association with PIR-B.

    abstract::The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand bindi...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Fujita Y,Takashima R,Endo S,Takai T,Yamashita T

    更新日期:2011-09-01 00:00:00

  • HOXA5 inhibits the proliferation and neoplasia of cervical cancer cells via downregulating the activity of the Wnt/β-catenin pathway and transactivating TP53.

    abstract::HOXA5 is considered a regulator involved in embryonic development and cellular differentiation and a tumor suppressor. Nevertheless, its biological role in cervical carcinoma is still unclear. In the present study, immunohistochemistry showed that HOXA5 expression gradually decreased as the degree of cervical lesions ...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Ma HM,Cui N,Zheng PS

    更新日期:2020-06-04 00:00:00

  • Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2.

    abstract::Histone deacetylases (HDACs) are epigenetic regulators that are important for the control of various pathophysiological events. We found that HDAC inhibitors completely abolished transforming growth factor-β1 (TGF-β1)-induced apoptosis in AML-12 and primary mouse hepatocytes. Expression of a dominant-negative mutant o...

    journal_title:Cell death & disease

    pub_type: 杂志文章


    authors: Lei WW,Zhang KH,Pan XC,Wang DM,Hu Y,Yang YN,Song JG

    更新日期:2010-05-20 00:00:00