Abstract:
:We demonstrate that EphB3 receptors mediate oligodendrocyte (OL) cell death in the injured spinal cord through dependence receptor mechanism. OLs in the adult spinal cord express EphB3 as well as other members of the Eph receptor family. Spinal cord injury (SCI) is associated with tissue damage, cellular loss and disturbances in EphB3-ephrinB3 protein balance acutely (days) after the initial impact creating an environment for a dependence receptor-mediated cell death to occur. Genetic ablation of EphB3 promotes OL survival associated with increased expression of myelin basic protein and improved locomotor function in mice after SCI. Moreover, administration of its ephrinB3 ligand to the spinal cord after injury also promotes OL survival. Our in vivo findings are supported by in vitro studies showing that ephrinB3 administration promotes the survival of both oligodendroglial progenitor cells and mature OLs cultured under pro-apoptotic conditions. In conclusion, the present study demonstrates a novel dependence receptor role of EphB3 in OL cell death after SCI, and supports further development of ephrinB3-based therapies to promote recovery.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Tsenkina Y,Ricard J,Runko E,Quiala-Acosta MM,Mier J,Liebl DJdoi
10.1038/cddis.2015.262subject
Has Abstractpub_date
2015-10-15 00:00:00pages
e1922issn
2041-4889pii
cddis2015262journal_volume
6pub_type
杂志文章abstract::Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and the prognosis of this malignancy is poor due to the strong chemotherapy resistance in patients. Notch pathway components mediate cell survival and epithelial-mesenchymal transition (EMT), and also participate in the induction of...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0804-6
更新日期:2018-07-03 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0353-z
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abstract::Cannabinoids exert antiproliferative effects in a wide range of tumoral cells, including hepatocellular carcinoma (HCC) cells. In this study, we examined whether the PPARγ-activated pathway contributed to the antitumor effect of two cannabinoids, Δ9-tetrahydrocannabinol (THC) and JWH-015, against HepG2 and HUH-7 HCC c...
journal_title:Cell death & disease
pub_type: 杂志文章
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abstract::Heme oxygenase-1 (HO-1), an inducible enzyme up-regulated in Alzheimer's disease, catabolises heme to biliverdin, Fe2+ and carbon monoxide (CO). CO can protect neurones from oxidative stress-induced apoptosis by inhibiting Kv2.1 channels, which mediates cellular K+ efflux as an early step in the apoptotic cascade. Sin...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.529
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-2081-4
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abstract::Podocyte damage is commonly accompanied by destabilization of the podocalyxin (PC)/ezrin complex. Serum- and glucocorticoid-inducible kinase 3 (SGK3) plays a role in the maintenance of podocyte function, but the details of this role are poorly understood. Herein we demonstrated that SGK3 and its downstream target prot...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1161-1
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abstract::The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expres...
journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1716-9
更新日期:2019-06-20 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.102
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.439
更新日期:2014-10-16 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most prevalent form of malignant brain tumor. Amlexanox, a novel compound, has been shown to have anti-cancer potential. In this study, the anti-tumoral effects and the underlying mechanisms of amlexanox were investigated. Amlexanox significantly suppressed proliferation and invasi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.396
更新日期:2017-08-31 00:00:00
abstract::Parkinson's disease (PD) is a common neurodegenerative disease characterized by Lewy body formation and progressive dopaminergic neuron death in the substantia nigra (SN). Genetic susceptibility is a strong risk factor for PD. Previously, a rare gain-of-function variant of GLUD2 glutamate dehydrogenase (T1492G) was re...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03043-2
更新日期:2020-10-22 00:00:00
abstract::Obesity has been associated with increased incidence and mortality of a wide variety of human cancers including colorectal cancer. However, the molecular mechanism by which adipocytes regulate the metabolism of colon cancer cells remains elusive. In this study, we showed that adipocytes isolated from adipose tissues o...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.21
更新日期:2017-02-02 00:00:00
abstract::The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila melanogaster upon exposure to the superoxide generator and neurotoxic ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.139
更新日期:2012-10-11 00:00:00
abstract::CCAAT/enhancer binding protein beta (C/EBPβ), a transcription factor expressed in muscle satellite cells (SCs), inhibits the myogenic program and is downregulated early in differentiation. In a conditional null model in which C/EBPβ expression is knocked down in paired box protein 7+ (Pax7+) SCs, cardiotoxin (CTX) inj...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.4
更新日期:2016-02-25 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.282
更新日期:2015-12-10 00:00:00
abstract::The NF-κB family of transcription factors is important for many cellular functions, in particular initiation and propagation of inflammatory and immune responses. However, recent data has suggested that different subunits of the NF-κB family can suppress the inflammatory response. NF-κB1, from the locus nfκb1, can inh...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.233
更新日期:2017-06-15 00:00:00
abstract::As an important modality for the local control of colorectal cancer (CRC), radiotherapy or neoadjuvant radiotherapy is widely applied in the clinic, but radioresistance has become a major obstacle for CRC radiotherapy. Here we reported that B7-H3, an important costimulatory molecule, is associated with radioresistance...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03041-4
更新日期:2020-10-03 00:00:00
abstract::Although targeting of the death receptors (DRs) DR4 and DR5 still appears a suitable antitumoral strategy, the limited clinical responses to recombinant soluble TNF-related apoptosis inducing ligand (TRAIL) necessitate novel reagents with improved apoptotic activity/tumor selectivity. Apoptosis induction by a single-c...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.29
更新日期:2012-04-12 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2011-08-11 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0677-8
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-2117-9
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.144
更新日期:2016-05-26 00:00:00
abstract::Long noncoding RNAs (lncRNAs) participate in organ fibrosis and various pulmonary diseases, but its role in idiopathic pulmonary fibrosis (IPF) is not fully understood. In this study, we found lncRNA Hoxaas3 (Hoxaas3) was up-regulated in the mice model of BLM-induced PF and TGF-β1-induced fibrogenesis in lung fibrobla...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02889-w
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abstract::Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening diseases that are associated with high mortality rates due to treatment limitations. Neutrophils play key roles in the pathogenesis of ALI/ARDS by promoting the inflammation and injury of the alveolar mic...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.365
更新日期:2016-11-10 00:00:00
abstract::Following the publication of this article, the authors realized there was an error in Figure 6H in which two versions of the figure appear.This does not impact the conclusions of the article. ...
journal_title:Cell death & disease
pub_type: 已发布勘误
doi:10.1038/s41419-019-1865-x
更新日期:2019-08-21 00:00:00
abstract::The positive results of the apatinib phase III trial have cast new light on treatment for patients with advanced gastric cancer (GC). However, in terms of safety, apatinib toxicities may lead to a dose modification or treatment interruption. Therefore, proper intervention is urgently needed to help patients benefit fr...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2352-0
更新日期:2020-03-05 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2019-02-06 00:00:00
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journal_title:Cell death & disease
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doi:10.1038/s41419-020-2444-x
更新日期:2020-04-23 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.62
更新日期:2015-03-12 00:00:00