Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity.

abstract：:Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used in the clinic for bone defect reconstruction because of its powerful osteoinductive capacity. However, commercially available rhBMP-2 requires a high concentration in the clinical setting for consistent bone formation. A high dose of rhBMP-2 induc...

journal_title：Cell death & disease

authors： Huang RL,Sun Y,Ho CK,Liu K,Tang QQ,Xie Y,Li Q

更新日期：2018-02-02 00:00:00

abstract：:Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening diseases that are associated with high mortality rates due to treatment limitations. Neutrophils play key roles in the pathogenesis of ALI/ARDS by promoting the inflammation and injury of the alveolar mic...

journal_title：Cell death & disease

authors： Zhang Y,Liu H,Yao J,Huang Y,Qin S,Sun Z,Xu Y,Wan S,Cheng H,Li C,Zhang X,Ke Y

更新日期：2016-11-10 00:00:00

abstract：:Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host response to infection that leads to uncontrolled inflammatory response followed by immunosuppression. However, despite the high mortality rate, no specific treatment modality or drugs with high efficacy is available for sepsis to date....

journal_title：Cell death & disease

authors： Cao C,Yu M,Chai Y

更新日期：2019-10-14 00:00:00

abstract：:Macrophages are involved in tumor growth and progression. They infiltrate into tumors and cause inflammation, which creates a microenvironment favoring tumor growth and metastasis. However, certain stimuli may induce macrophages to act as tumor terminators. Here we report that the calcineurin B subunit (CnB) synergize...

journal_title：Cell death & disease

authors： Su Z,Yang R,Zhang W,Xu L,Zhong Y,Yin Y,Cen J,DeWitt JP,Wei Q

更新日期：2015-05-07 00:00:00

abstract：:MicroRNAs (miRNAs) are important class of functional regulators involved in human cancers development, including colorectal cancer (CRC). Exploring aberrantly expressed miRNAs may provide us with new insights into the initiation and development of CRC by functioning as oncogenes or tumor suppressors. The aim of our st...

journal_title：Cell death & disease

authors： Chen X,Zeng K,Xu M,Liu X,Hu X,Xu T,He B,Pan Y,Sun H,Wang S

更新日期：2019-02-12 00:00:00

abstract：:Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...

journal_title：Cell death & disease

authors： Silva-Pavez E,Villar P,Trigo C,Caamaño E,Niechi I,Pérez P,Muñoz JP,Aguayo F,Burzio VA,Varas-Godoy M,Castro AF,Colombo MI,Tapia JC

更新日期：2019-01-25 00:00:00

abstract：:G-protein-coupled receptor (GPCR)-related proteins are dysregulated and the GPCR CC-chemokine receptor 10 (CCR10) is significantly upregulated in inflammation-driven HCC. However, CCR10's role in inflammation-driven hepatocarcinogenesis remains unknown. The aim of this study was to evaluate the role of CCR10 in inflam...

journal_title：Cell death & disease

authors： Wu Q,Chen JX,Chen Y,Cai LL,Wang XZ,Guo WH,Zheng JF

更新日期：2018-02-14 00:00:00

abstract：:Breast cancer is the most common cancer type in women. Long non-coding RNAs (lncRNAs) have been reported as potential new diagnostic markers, prognostic factors, and therapeutic targets in cancer. However, the specific roles and mechanisms of lncRNAs in breast cancer remain to be elucidated. Here we demonstrated the d...

journal_title：Cell death & disease

authors： Luo L,Zhang J,Tang H,Zhai D,Huang D,Ling L,Wang X,Liu T,Zhang Q,Zhang Z,He Z,Zheng G

更新日期：2020-05-07 00:00:00

abstract：:miR-148a-3p downregulation has emerged as a critical factor in cancer progression yet, the underlying mechanisms of miR-148a-3p expression pattern and its function in bladder cancer remains to be elucidated. Here, we illustrate that miR-148a-3p is frequently downregulated in bladder cancer and that its expression may ...

journal_title：Cell death & disease

authors： Wang X,Liang Z,Xu X,Li J,Zhu Y,Meng S,Li S,Wang S,Xie B,Ji A,Liu B,Zheng X,Xie L

更新日期：2016-12-01 00:00:00

abstract：:Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extrac...

journal_title：Cell death & disease

authors： Cerella C,Muller F,Gaigneaux A,Radogna F,Viry E,Chateauvieux S,Dicato M,Diederich M

更新日期：2015-06-11 00:00:00

abstract：:Prostate cancer stem cells (PCSCs) play a critical role in prostate cancer progression and metastasis, which remains an obstacle for successful prostate cancer treatment. Tumor-associated macrophages (TAMs) are the most abundant immune cell population within the tumor microenvironment (TME). Systematic investigation o...

journal_title：Cell death & disease

authors： Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

更新日期：2020-04-16 00:00:00

abstract：:Parkin (Park2), a RING-between-RING-type E3 ubiquitin ligase, has been implicated in regulating NF-κB. Mutations in Parkin are associated with Parkinson's disease. Here we investigated the interaction of Parkin with Receptor-interacting protein kinase 1 (RIPK1) kinase, a key mediator of multiple signaling pathways act...

journal_title：Cell death & disease

authors： Wang Y,Shan B,Liang Y,Wei H,Yuan J

更新日期：2018-06-28 00:00:00

abstract：:Dihydroartemisinin (DHA) and its analogs are reported to possess selective anticancer activity. Here, we reported a novel DHA derivative DHA-37 that exhibited more potent anticancer activity on the cells tested. Distinct from DHA-induced apoptosis, DHA-37 triggered excessive autophagic cell death, and became the main ...

journal_title：Cell death & disease

authors： Liu X,Wu J,Fan M,Shen C,Dai W,Bao Y,Liu JH,Yu BY

更新日期：2018-10-15 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) play a vital role in tumourigenesis, including that of glioma. Small nucleolar RNA host gene 1 (SNHG1) is a relatively novel lncRNA that is involved in the development of multiple human tumours. However, its underlying molecular mechanism in glioma has not been completely clarified. In t...

journal_title：Cell death & disease

authors： Liu L,Shi Y,Shi J,Wang H,Sheng Y,Jiang Q,Chen H,Li X,Dong J

更新日期：2019-06-12 00:00:00

abstract：:Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K27 hypomethylation accompanied by H3K27 hyperacetylation. Hyperacetylati...

journal_title：Cell death & disease

authors： Wiese M,Hamdan FH,Kubiak K,Diederichs C,Gielen GH,Nussbaumer G,Carcaboso AM,Hulleman E,Johnsen SA,Kramm CM

更新日期：2020-08-21 00:00:00

abstract：:MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases and cellular process. Decreased expression of miR-181a has been observed in the patients with coronary artery disease, but its function and mechanism in atherogenesis is not clear. This study was...

journal_title：Cell death & disease

authors： Su Y,Yuan J,Zhang F,Lei Q,Zhang T,Li K,Guo J,Hong Y,Bu G,Lv X,Liang S,Ou J,Zhou J,Luo B,Shang J

更新日期：2019-05-07 00:00:00

abstract：:Detailed understanding of the mechanistic steps underlying tumor initiation and malignant progression is critical for insights of potentially novel therapeutic modalities. Cellular reprogramming is an approach of particular interest because it can provide a means to reset the differentiation state of the cancer cells ...

journal_title：Cell death & disease

authors： Yao J,Zhang L,Hu L,Guo B,Hu X,Borjigin U,Wei Z,Chen Y,Lv M,Lau JT,Wang X,Li G,Hu YP

更新日期：2016-07-28 00:00:00

abstract：:The mechanism by which tumor-associated macrophages (TAMs) affect cancer progression is not fully understood. This study developed a microfluidic-based co-culture device to mimic the tumor microenvironment to assess TAM effects on invasion and metastasis in NSCLC. The results showed lung carcinoma cells could cause ma...

journal_title：Cell death & disease

authors： Guo Z,Song J,Hao J,Zhao H,Du X,Li E,Kuang Y,Yang F,Wang W,Deng J,Wang Q

更新日期：2019-05-16 00:00:00

abstract：:Current preclinical models in tumor biology are limited in their ability to recapitulate relevant (patho-) physiological processes, including autophagy. Three-dimensional (3D) growth cultures have frequently been proposed to overcome the lack of correlation between two-dimensional (2D) monolayer cell cultures and huma...

journal_title：Cell death & disease

authors： Bingel C,Koeneke E,Ridinger J,Bittmann A,Sill M,Peterziel H,Wrobel JK,Rettig I,Milde T,Fernekorn U,Weise F,Schober A,Witt O,Oehme I

更新日期：2017-08-24 00:00:00

abstract：:The majority of developmentally programmed cell death (PCD) is mediated by caspase-dependent apoptosis; however, additional modalities, including autophagy-dependent cell death, have important spatiotemporally restricted functions. Autophagy involves the engulfment of cytoplasmic components in a double membrane vesicl...

journal_title：Cell death & disease

authors： Denton D,Xu T,Dayan S,Nicolson S,Kumar S

更新日期：2019-02-08 00:00:00

abstract：:Despite successful antiretroviral drug therapy, a subset of human immunodeficiency virus-1 (HIV)-positive individuals still display synaptodendritic simplifications and functional cognitive impairments referred to as HIV-associated neurocognitive disorders (HANDs). The neurological damage observed in HAND subjects can...

journal_title：Cell death & disease

authors： Wenzel ED,Speidell A,Flowers SA,Wu C,Avdoshina V,Mocchetti I

更新日期：2019-09-12 00:00:00

abstract：:The rapid, typically all-or-none process of mitochondrial outer membrane permeabilization (MOMP) constitutes a primary cell death decision that is controlled by the Bcl-2 family interactome. However, how strict all-or-none MOMP decisions are governed by and emanate from the dynamic interplay of pro- and antiapoptotic ...

journal_title：Cell death & disease

authors： Hantusch A,Das KK,García-Sáez AJ,Brunner T,Rehm M

更新日期：2018-04-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been reported to be involved in a variety of human diseases, including cancers. However, their mechanisms have not yet been fully elucidated. We investigated lncRNA changes that may be associated with pancreatic cancer (PC) by analyzing published microarray data, and identified AGAP2...

journal_title：Cell death & disease

authors： Hui B,Ji H,Xu Y,Wang J,Ma Z,Zhang C,Wang K,Zhou Y

更新日期：2019-02-27 00:00:00

abstract：:The δ opioid receptor (DOR) is involved in the regulation of malignant transformation and tumor progression of hepatocellular carcinoma (HCC). However, regulation of the DOR in HCC remains poorly defined. We found that miR-874 was identified as a negative regulator of the DOR, which is a direct and functional target o...

journal_title：Cell death & disease

authors： Zhang Y,Wei Y,Li X,Liang X,Wang L,Song J,Zhang X,Zhang C,Niu J,Zhang P,Ren Z,Tang B

更新日期：2018-01-26 00:00:00

abstract：:Glioblastoma (GBM) is the most common and aggressive brain tumor and is associated with poor prognosis. GBM cells are frequently resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and finding new combinatorial therapies to sensitize glioma cells to TRAIL remains an important challenge. PIM ki...

journal_title：Cell death & disease

authors： Serrano-Saenz S,Palacios C,Delgado-Bellido D,López-Jiménez L,Garcia-Diaz A,Soto-Serrano Y,Casal JI,Bartolomé RA,Fernández-Luna JL,López-Rivas A,Oliver FJ

更新日期：2019-01-18 00:00:00

abstract：:Osteoclasts are absorptive cells that play a critical role in homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role of epigenetic regulation in osteoclastogenesis. In this study, we investigated the role of DOT1L, which regulates gene expression epigenetically by hi...

journal_title：Cell death & disease

authors： Gao Y,Ge W

更新日期：2018-01-18 00:00:00

abstract：:Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage from reactive oxygen species (ROS). However, its function in trophoblasts at the maternal-fetal interface has not been clarified yet. In th...

journal_title：Cell death & disease

authors： Wu F,Tian F,Zeng W,Liu X,Fan J,Lin Y,Zhang Y

更新日期：2017-06-29 00:00:00

abstract：:The enteric pathogen enterohemorrhagic Escherichia coli (EHEC) is responsible for outbreaks of bloody diarrhea and hemolytic uremic syndrome (HUS) worldwide. Several molecular mechanisms have been described for the pathogenicity of EHEC; however, the role of bacterial metabolism in the virulence of EHEC during infecti...

journal_title：Cell death & disease

authors： Kuo CJ,Wang ST,Lin CM,Chiu HC,Huang CR,Lee DY,Chang GD,Chou TC,Chen JW,Chen CS

更新日期：2018-03-07 00:00:00

abstract：:Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite...

journal_title：Cell death & disease

authors： Li Y,Zhang L,Qu T,Tang X,Li L,Zhang G

更新日期：2017-07-06 00:00:00

abstract：:We explored the activity of SIRT1 activators (SRT501 and SRT2183) alone and in combination with panobinostat in a panel of malignant lymphoid cell lines in terms of biological and gene expression responses. SRT501 and SRT2183 induced growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and r...

journal_title：Cell death & disease

authors： Scuto A,Kirschbaum M,Buettner R,Kujawski M,Cermak JM,Atadja P,Jove R

更新日期：2013-05-16 00:00:00