Tumorigenic potential is restored during differentiation in fusion-reprogrammed cancer cells.

abstract：:The NF-κB family of transcription factors is important for many cellular functions, in particular initiation and propagation of inflammatory and immune responses. However, recent data has suggested that different subunits of the NF-κB family can suppress the inflammatory response. NF-κB1, from the locus nfκb1, can inh...

journal_title：Cell death & disease

authors： Fearn A,Situmorang GR,Fox C,Oakley F,Howarth R,Wilson CL,Kiosia A,Robson MG,Mann DA,Moles A,Sheerin NS

更新日期：2017-06-15 00:00:00

abstract：:Pluripotency makes human pluripotent stem cells (hPSCs) promising for regenerative medicine, but the teratoma formation has been considered to be a major obstacle for their clinical applications. Here, we determined that the downregulation of miR-302 suppresses the teratoma formation, hampers the self-renewal and plur...

journal_title：Cell death & disease

authors： Li HL,Wei JF,Fan LY,Wang SH,Zhu L,Li TP,Lin G,Sun Y,Sun ZJ,Ding J,Liang XL,Li J,Han Q,Zhao RC

更新日期：2016-01-28 00:00:00

abstract：:Cannabinoids exert antiproliferative effects in a wide range of tumoral cells, including hepatocellular carcinoma (HCC) cells. In this study, we examined whether the PPARγ-activated pathway contributed to the antitumor effect of two cannabinoids, Δ9-tetrahydrocannabinol (THC) and JWH-015, against HepG2 and HUH-7 HCC c...

journal_title：Cell death & disease

authors： Vara D,Morell C,Rodríguez-Henche N,Diaz-Laviada I

更新日期：2013-05-02 00:00:00

abstract：:Glucocorticoids (GCs) represent an important component of modern treatment regimens for fludarabine-refractory or TP53-defective chronic lymphocytic leukemia (CLL). However, GC therapy is not effective in all patients. The molecular mechanisms responsible for GC-induced apoptosis and resistance were therefore investig...

journal_title：Cell death & disease

authors： Melarangi T,Zhuang J,Lin K,Rockliffe N,Bosanquet AG,Oates M,Slupsky JR,Pettitt AR

更新日期：2012-08-16 00:00:00

abstract：:We studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-free survival and overall survival. Cell sensitivity to SC66 was inversely correlated with phospho-Akt and COL1...

journal_title：Cell death & disease

authors： Wu YH,Huang YF,Chen CC,Chou CY

更新日期：2019-04-11 00:00:00

abstract：:Glycogen synthase kinase-3β (GSK-3β) has emerged as a critical factor in several pathways involved in hippocampal neuronal maintenance and function. In Huntington's disease (HD), there are early hippocampal deficits both in patients and transgenic mouse models, which prompted us to investigate whether disease-specific...

journal_title：Cell death & disease

authors： L'Episcopo F,Drouin-Ouellet J,Tirolo C,Pulvirenti A,Giugno R,Testa N,Caniglia S,Serapide MF,Cisbani G,Barker RA,Cicchetti F,Marchetti B

更新日期：2016-04-28 00:00:00

abstract：:Epithelial homeostasis plays an essential role in maintaining endometrial function. But the epithelial role in endometrial fibrosis has been less studied. Previously, we showed that ectopic expression of ΔNp63α is associated with fibrosis process and epithelial dysfunction in endometria of patients with intrauterine a...

journal_title：Cell death & disease

authors： Zhao G,Li R,Cao Y,Song M,Jiang P,Wu Q,Zhou Z,Zhu H,Wang H,Dai C,Liu D,Yao S,Lv H,Wang L,Dai J,Zhou Y,Hu Y

更新日期：2020-06-11 00:00:00

abstract：:MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases and cellular process. Decreased expression of miR-181a has been observed in the patients with coronary artery disease, but its function and mechanism in atherogenesis is not clear. This study was...

journal_title：Cell death & disease

authors： Su Y,Yuan J,Zhang F,Lei Q,Zhang T,Li K,Guo J,Hong Y,Bu G,Lv X,Liang S,Ou J,Zhou J,Luo B,Shang J

更新日期：2019-05-07 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating cancer cell proliferation, and invasion, but how the premalignant stromal fibroblasts trigger epithelial changes remain unclear. We demonstrate that atypical ductal hyperplasia-associated fibroblasts (AHFs) are one kind of activated fibroblasts ...

journal_title：Cell death & disease

authors： Sun Y,Yang D,Xi L,Chen Y,Fu L,Sun K,Yin J,Li X,Liu S,Qin Y,Liu M,Hou Y

更新日期：2018-01-26 00:00:00

abstract：:Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, disease treatment, and organ transplantation. As the ethical issue of human ESCs and similarity of pig in human genome and physiological characteristics, the porcine iPSCs (piPSCs) have become an ideal ...

journal_title：Cell death & disease

authors： Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Wang F,Wang Y,Wang X

更新日期：2019-02-20 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi-cycle use of this chemotherapeutic agent. One of the major mechanisms of cancer drug resistance is enhanced activity of a DNA repair enz...

journal_title：Cell death & disease

authors： Fan CH,Liu WL,Cao H,Wen C,Chen L,Jiang G

更新日期：2013-10-24 00:00:00

abstract：:In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamyci...

journal_title：Cell death & disease

authors： Blagosklonny MV

更新日期：2014-12-04 00:00:00

abstract：:Characterized by their slow adhering property, skeletal muscle myogenic progenitor cells (MPCs) have been widely utilized in skeletal muscle tissue engineering for muscle regeneration, but with limited efficacy. Skeletal muscle regeneration is regulated by various cell types, including a large number of rapidly adheri...

journal_title：Cell death & disease

authors： Liu YX,Wu BB,Gong L,An CR,Lin JX,Li QK,Jiang DM,Jin KX,Mechakra A,Bunpetch V,Li Y,Zou YW,Ouyang HW,Zou XH

更新日期：2019-06-03 00:00:00

abstract：:Menin, encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor that leads to multiple endocrine tumors upon loss of its function. Menin functions as a transcriptional activator by tethering MLL complex to mediate histone H3 K4 methylation. It also functions as a repressor. However, the mo...

journal_title：Cell death & disease

authors： Yang YJ,Song TY,Park J,Lee J,Lim J,Jang H,Kim YN,Yang JH,Song Y,Choi A,Lee HY,Jo CH,Han JW,Kim ST,Youn HD,Cho EJ

更新日期：2013-04-11 00:00:00

abstract：:Growing evidence indicates that clear cell renal cell carcinoma (ccRCC) is a metabolism-related disease. Changes in fatty acid (FA) and cholesterol metabolism play important roles in ccRCC development. As a nuclear transcription factor receptor, Liver X receptor (LXR) regulates a variety of key molecules associated wi...

journal_title：Cell death & disease

authors： Wu G,Wang Q,Xu Y,Li J,Zhang H,Qi G,Xia Q

更新日期：2019-05-28 00:00:00

abstract：:Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we conf...

journal_title：Cell death & disease

authors： Xu X,Yin Y,Tang J,Xie Y,Han Z,Zhang X,Liu Q,Qin X,Huang X,Sun B

更新日期：2017-10-12 00:00:00

abstract：:Met, the tyrosine kinase receptor for hepatocyte growth factor (HGF), mainly activates prosurvival pathways, including protection from apoptosis. In this work, we investigated the cardioprotective mechanisms of Met activation by agonist monoclonal antibodies (mAbs). Cobalt chloride (CoCl2), a chemical mimetic of hypox...

journal_title：Cell death & disease

authors： Gallo S,Gatti S,Sala V,Albano R,Costelli P,Casanova E,Comoglio PM,Crepaldi T

更新日期：2014-04-17 00:00:00

abstract：:PTPL1 is a non-receptor protein tyrosine phosphatase involved in apoptosis regulation, although controversial findings have been reported in different cancer types. We report here a proapoptotic role for PTPL1 in PC3 and LNCaP prostate cancer cells, as its absence induces apoptosis resistance upon treatment with diffe...

journal_title：Cell death & disease

authors： Castilla C,Chinchón D,Medina R,Torrubia FJ,Japón MA,Sáez C

更新日期：2013-04-04 00:00:00

abstract：:Cancer-initiating cell (CIC) is critical in cancer development, maintenance and recurrence. The reverse expression pattern of coxsackie and adenovirus receptor (CAR) and αν integrin in bladder cancer decreases the infection efficiency of adenovirus. We constructed Arg-Gly-Asp (RGD)-modified oncolytic adenovirus, carry...

journal_title：Cell death & disease

authors： Yang Y,Xu H,Shen J,Yang Y,Wu S,Xiao J,Xu Y,Liu XY,Chu L

更新日期：2015-05-14 00:00:00

abstract：:Transient receptor potential vanilloid type 4 (TRPV4) is a Ca2+-permeable cation channel that is known to be an osmosensor and thermosensor. Currently, limited evidence shows that TRPV4 plays opposite roles in either promoting or inhibiting cancer development in different cancer types. Furthermore, the precise biologi...

journal_title：Cell death & disease

authors： Liu X,Zhang P,Xie C,Sham KWY,Ng SSM,Chen Y,Cheng CHK

更新日期：2019-06-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Moon H-,Cao Y,Yang J,Lee JH,Choi HS,Jin Y

更新日期：2020-02-12 00:00:00

abstract：:The δ opioid receptor (DOR) is involved in the regulation of malignant transformation and tumor progression of hepatocellular carcinoma (HCC). However, regulation of the DOR in HCC remains poorly defined. We found that miR-874 was identified as a negative regulator of the DOR, which is a direct and functional target o...

journal_title：Cell death & disease

authors： Zhang Y,Wei Y,Li X,Liang X,Wang L,Song J,Zhang X,Zhang C,Niu J,Zhang P,Ren Z,Tang B

更新日期：2018-01-26 00:00:00

abstract：:Japanese encephalitis virus (JEV), which is a causative agent of sporadic encephalitis, harbours itself inside the neural stem/progenitor cells. It is a well-known fact that JEV infects neural stem/progenitor cells and decreases their proliferation capacity. With mass spectrometry-based quantitative proteomic study, i...

journal_title：Cell death & disease

authors： Mukherjee S,Singh N,Sengupta N,Fatima M,Seth P,Mahadevan A,Shankar SK,Bhattacharyya A,Basu A

更新日期：2017-01-19 00:00:00

abstract：:New bone anabolic agents for the effective treatment of bone metabolic diseases like osteoporosis are of high clinical demand. In the present study, we reveal the function of salt-inducible kinase 1 (SIK1) in regulating osteoblast differentiation. Gene knockdown of SIK1 but not of SIK2 or SIK3 expression in primary pr...

journal_title：Cell death & disease

authors： Kim MK,Kwon JO,Song MK,Kim B,Kim H,Lee ZH,Koo SH,Kim HH

更新日期：2019-10-31 00:00:00

abstract：:Urethral hypoplasia, including failure of urethral tube closure, is one of the common phenotypes observed in hereditary human disorders, the mechanism of which remains unclear. The present study was thus designed to study the expression, functions, and related mechanisms of the LIM homeobox transcription factor Isl1 t...

journal_title：Cell death & disease

authors： Su T,Liu H,Zhang D,Xu G,Liu J,Evans SM,Pan J,Cui S

更新日期：2019-09-26 00:00:00

abstract：:Hyperoxia treatment has been known to induce neuronal and glial death in the developing central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in premature infants and a major cause of childhood vision impairment. Studies indicate that, in addition to vascular injury, retinal neurons are als...

journal_title：Cell death & disease

authors： Narayanan SP,Xu Z,Putluri N,Sreekumar A,Lemtalsi T,Caldwell RW,Caldwell RB

更新日期：2014-02-20 00:00:00

abstract：:Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes. However, their functions in cerebral ischemia remain largely unknown. Through an lncRNA array analysis in a rat model of focal cerebral ischemia/reperfusion (I/R), we have identified CAMK2D-associ...

journal_title：Cell death & disease

authors： Xu Q,Deng F,Xing Z,Wu Z,Cen B,Xu S,Zhao Z,Nepomuceno R,Bhuiyan MI,Sun D,Wang QJ,Ji A

更新日期：2016-03-31 00:00:00

abstract：:Global cerebral ischemia/reperfusion (I/R) facilitates the activation of procaspase-3 and promotes apoptosis in hippocampus. But the mechanisms have remained uncharacterized. Protein S-nitrosylation and denitrosylation is an important reversible posttranslational modification, which is a common mechanism in signal tra...

journal_title：Cell death & disease

authors： Sun N,Hao JR,Li XY,Yin XH,Zong YY,Zhang GY,Gao C

更新日期：2013-08-15 00:00:00

abstract：:Treating corneal endothelial diseases tends to be challenging as human corneal endothelial cells (CECs) do not proliferate in vivo. The pathogenesis or mechanisms underlying injured CECs need further studies. The abnormal expression of PAX6, which is an essential transcription factor for corneal homeostasis, exhibits ...

journal_title：Cell death & disease

authors： Yu F,Zhang W,Yan C,Yan D,Zhou M,Chen J,Zhao X,Zhu A,Zhou J,Liu H,Sun H,Fu Y

更新日期：2020-08-12 00:00:00

abstract：:Bu-Shen-Ning-Xin Decoction (BSNXD) administration has alleviated the early pathologic damage of atherosclerosis by inhibiting the adhesion molecule expression and upregulating the estrogen receptor (ER) β expression in endothelial cells, and increasing the serum nitric oxide (NO) level without any effect on serum lipi...

journal_title：Cell death & disease

authors： Wang L,Qiu XM,Hao Q,Li DJ

更新日期：2013-03-21 00:00:00