RGD-modifided oncolytic adenovirus exhibited potent cytotoxic effect on CAR-negative bladder cancer-initiating cells.

abstract：:Cervical cancer is the most common gynecological malignancy in the world; however, the survival rates of advanced-stage and recurrent cervical cancer patients remain poor. The multifaced protein insulin-like growth factor 2 receptor (IGF2R) has various ligands, represented as IGF-2 and mannose-6-phosphate (M6P)-tagged...

journal_title：Cell death & disease

authors： Takeda T,Komatsu M,Chiwaki F,Komatsuzaki R,Nakamura K,Tsuji K,Kobayashi Y,Tominaga E,Ono M,Banno K,Aoki D,Sasaki H

更新日期：2019-11-20 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Moon H-,Cao Y,Yang J,Lee JH,Choi HS,Jin Y

更新日期：2020-02-12 00:00:00

abstract：:Bladder cancer (BCa) is the one of the most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates that DLK1-DIO3 genomic region especially the miRNA cluster in this region is involved in several pathologic processes and various cancers, and miR-323a-3p is a member of ...

journal_title：Cell death & disease

authors： Li J,Xu X,Meng S,Liang Z,Wang X,Xu M,Wang S,Li S,Zhu Y,Xie B,Lin Y,Zheng X,Liu B,Xie L

更新日期：2017-08-24 00:00:00

abstract：:Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...

journal_title：Cell death & disease

authors： Silva-Pavez E,Villar P,Trigo C,Caamaño E,Niechi I,Pérez P,Muñoz JP,Aguayo F,Burzio VA,Varas-Godoy M,Castro AF,Colombo MI,Tapia JC

更新日期：2019-01-25 00:00:00

abstract：:Gallbladder cancer (GBC) is one of the most common malignancy of the biliary tract characterized by its high chemoresistant tendency. Although great progresses have been made in recent decades for treating many cancers with anticancer drugs, effective therapeutics methods for anti-GBC are still lacking. Therefore, inv...

journal_title：Cell death & disease

authors： Wang H,Zhan M,Xu SW,Chen W,Long MM,Shi YH,Liu Q,Mohan M,Wang J

更新日期：2017-05-11 00:00:00

abstract：:Synovial sarcoma is a highly aggressive but rare form of soft tissue malignancy that primarily affects the extremities of the arms or legs, for which current chemotherapeutic agents have not been proven to be very effective. The cyclin-dependent kinase 4/6-retinoblastoma protein (CDK4/6-Rb) pathway of cell cycle contr...

journal_title：Cell death & disease

authors： Li X,Seebacher NA,Garbutt C,Ma H,Gao P,Xiao T,Hornicek FJ,Duan Z

更新日期：2018-05-01 00:00:00

abstract：:We reported previously that adult (HRAS-/-; NRAS-/-) double knockout (DKO) mice showed no obvious external phenotype although lower-than-expected numbers of weaned DKO animals were consistently tallied after crossing NRAS-KO and HRAS-KO mice kept on mixed genetic backgrounds. Using mouse strains kept on pure C57Bl/6 b...

journal_title：Cell death & disease

authors： Fuentes-Mateos R,Jimeno D,Gómez C,Calzada N,Fernández-Medarde A,Santos E

更新日期：2019-11-04 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) has the highest incidence of cancer-related death worldwide and a high medical need for more effective therapies. Small-molecule inhibitors of the bromodomain and extra terminal domain (BET) family such as JQ1, I-BET762 and OTX-015 are active in a wide range of different cancer types...

journal_title：Cell death & disease

authors： Klingbeil O,Lesche R,Gelato KA,Haendler B,Lejeune P

更新日期：2016-09-08 00:00:00

abstract：:The selenoprotein thioredoxin reductase 1 (TrxR1) has several key roles in cellular redox systems and reductive pathways. Here we discovered that an evolutionarily conserved and surface-exposed tryptophan residue of the enzyme (Trp114) is excessively reactive to oxidation and exerts regulatory functions. The results i...

journal_title：Cell death & disease

authors： Xu J,Eriksson SE,Cebula M,Sandalova T,Hedström E,Pader I,Cheng Q,Myers CR,Antholine WE,Nagy P,Hellman U,Selivanova G,Lindqvist Y,Arnér ES

更新日期：2015-01-22 00:00:00

abstract：:Autophagy is an evolutionarily conserved lysosomal degradation pathway that plays important roles in cell maintenance, expansion and differentiation. Removal of genes essential for autophagy from embryonic neural stem and precursor cells reduces the survival and inhibits neuronal differentiation of adult-generated neu...

journal_title：Cell death & disease

authors： Xi Y,Dhaliwal JS,Ceizar M,Vaculik M,Kumar KL,Lagace DC

更新日期：2016-03-03 00:00:00

abstract：:The phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of the catalytic subunit p110 and the regulatory subunit p85. The PI3K/Akt pathway is strongly deregulated in breast cancer (BC) representing one of the mechanisms of resistance to therapies. Therefore, the identification of inhibitors of PI3K componen...

journal_title：Cell death & disease

authors： Folgiero V,Di Carlo SE,Bon G,Spugnini EP,Di Benedetto A,Germoni S,Pia Gentileschi M,Accardo A,Milella M,Morelli G,Bossi G,Mottolese M,Falcioni R

更新日期：2012-12-06 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been reported to be involved in a variety of human diseases, including cancers. However, their mechanisms have not yet been fully elucidated. We investigated lncRNA changes that may be associated with pancreatic cancer (PC) by analyzing published microarray data, and identified AGAP2...

journal_title：Cell death & disease

authors： Hui B,Ji H,Xu Y,Wang J,Ma Z,Zhang C,Wang K,Zhou Y

更新日期：2019-02-27 00:00:00

abstract：:Soluble Axl (sAxl) was recently shown to be strongly released into the blood during liver fibrogenesis and hepatocellular carcinoma suggesting sAxl as a biomarker of liver diseases. In this study we are the first to evaluate sAxl in human serum in comparison to Enhanced Liver Fibrosis (ELF) test and transient elastogr...

journal_title：Cell death & disease

authors： Staufer K,Dengler M,Huber H,Marculescu R,Stauber R,Lackner C,Dienes HP,Kivaranovic D,Schachner C,Zeitlinger M,Wulkersdorfer B,Rauch P,Prager G,Trauner M,Mikulits W

更新日期：2017-10-26 00:00:00

abstract：:Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell deat...

journal_title：Cell death & disease

authors： Kleih M,Böpple K,Dong M,Gaißler A,Heine S,Olayioye MA,Aulitzky WE,Essmann F

更新日期：2019-11-07 00:00:00

abstract：:Dalbergia odorifera has been traditionally used as a medicine to treat many diseases. However, the role of 2,4,5-trimethoxyldalbergiquinol (TMDQ) isolated and extracted from D. odorifera in osteoblast function and the underlying molecular mechanisms remain poorly understood. The aim of this study was to investigate th...

journal_title：Cell death & disease

authors： Yun HM,Park KR,Quang TH,Oh H,Hong JT,Kim YC,Kim EC

更新日期：2015-07-16 00:00:00

abstract：:Our previous studies have shown that microRNA-383 (miR-383) expression is downregulated in the testes of infertile men with maturation arrest (MA). However, the underlying mechanisms of miR-383 involved in the pathogenesis of MA remain unknown. In this study, we showed that downregulation of miR-383 was associated wit...

journal_title：Cell death & disease

authors： Lian J,Tian H,Liu L,Zhang XS,Li WQ,Deng YM,Yao GD,Yin MM,Sun F

更新日期：2010-11-04 00:00:00

abstract：:The WWOX tumor suppressor is a WW domain-containing protein. Its function in the cell has been shown to be mediated, in part, by interacting with its partners through its first WW (WW1) domain. Here, we demonstrated that WWOX via WW1 domain interacts with p53 homolog, ΔNp63α. This protein-protein interaction stabilize...

journal_title：Cell death & disease

authors： Salah Z,Bar-mag T,Kohn Y,Pichiorri F,Palumbo T,Melino G,Aqeilan RI

更新日期：2013-01-31 00:00:00

abstract：:Senescence is a cellular response to damage and stress. The senescence response prevents cancer by suppressing the proliferation of cells with a compromised genome and contributes to optimal wound healing in normal tissues. Persistent senescent cells are also thought to drive aging and age-associated pathologies throu...

journal_title：Cell death & disease

authors： Laberge RM,Adler D,DeMaria M,Mechtouf N,Teachenor R,Cardin GB,Desprez PY,Campisi J,Rodier F

更新日期：2013-07-18 00:00:00

abstract：:MicroRNAs (miRNAs) have been demonstrated to affect the biological processes of cancers and showed great potential for prognostic biomarkers. In this study, we screened differentially expressed miRNAs in ccRCC based on three dimensions of metastasis, prognosis, and differential expression compared to normal tissue usi...

journal_title：Cell death & disease

authors： Li Z,Zhao S,Zhu S,Fan Y

更新日期：2021-01-04 00:00:00

abstract：:Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. Calcineurin has been proven to affect a series of signalling pathways and to exert a proapoptotic effect in cardiomyocytes. However, whether it is able to regulate autophagy remains largely unknown. Here, we report that p...

journal_title：Cell death & disease

authors： He H,Liu X,Lv L,Liang H,Leng B,Zhao D,Zhang Y,Du Z,Chen X,Li S,Lu Y,Shan H

更新日期：2014-01-16 00:00:00

abstract：:Advanced glycation end products (AGEs) can stimulate osteoblast apoptosis and have a critical role in the pathophysiology of diabetic osteoporosis. Mitochondrial abnormalities are closely related to osteoblast dysfunction. However, it remains unclear whether mitochondrial abnormalities are involved in AGE-induced oste...

journal_title：Cell death & disease

authors： Mao YX,Cai WJ,Sun XY,Dai PP,Li XM,Wang Q,Huang XL,He B,Wang PP,Wu G,Ma JF,Huang SB

更新日期：2018-06-04 00:00:00

abstract：:Functional neuronal circuits require a constant remodeling of their network composed of highly interconnected neurons. The plasticity of synapses and the shaping of elaborated dendritic branches are energy demanding and therefore depend on an efficient mitochondrial oxidative phosphorylation (OXPHOS). The spatial and ...

journal_title：Cell death & disease

authors： Gioran A,Nicotera P,Bano D

更新日期：2014-04-10 00:00:00

abstract：:Death-associated protein kinase 1 (DAPK1, DAPk, DAPK) is known for its involvement in apoptosis and autophagy-associated cell death. Here, we identified an unexpected function of DAPK1 in suppressing necroptosis. DAPK1-deficiency renders macrophages and dendritic cells susceptible to necroptotic death. We also observe...

journal_title：Cell death & disease

authors： Wu YH,Chou TF,Young L,Hsieh FY,Pan HY,Mo ST,Brown SB,Chen RH,Kimchi A,Lai MZ

更新日期：2020-05-04 00:00:00

abstract：:Current preclinical models in tumor biology are limited in their ability to recapitulate relevant (patho-) physiological processes, including autophagy. Three-dimensional (3D) growth cultures have frequently been proposed to overcome the lack of correlation between two-dimensional (2D) monolayer cell cultures and huma...

journal_title：Cell death & disease

authors： Bingel C,Koeneke E,Ridinger J,Bittmann A,Sill M,Peterziel H,Wrobel JK,Rettig I,Milde T,Fernekorn U,Weise F,Schober A,Witt O,Oehme I

更新日期：2017-08-24 00:00:00

abstract：:Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuronal loss that initiates in the substantia nigra pars compacta and by the formation of intracellular inclusions mainly constituted by aberrant α-synuclein (α-syn) deposits known as Lewy bodies. Most cases ...

journal_title：Cell death & disease

authors： Vicario M,Cieri D,Vallese F,Catoni C,Barazzuol L,Berto P,Grinzato A,Barbieri L,Brini M,Calì T

更新日期：2019-11-12 00:00:00

abstract：:Accumulating evidence suggested the participation of long noncoding RNAs (lncRNAs) in regulating various biological processes so as to affecting cancer progression. However, the functional role of most lncRNAs in colorectal carcer (CRC) is still largely covered. In the present study, we disclosed SNHG14 as a carcinoge...

journal_title：Cell death & disease

authors： Di W,Weinan X,Xin L,Zhiwei Y,Xinyue G,Jinxue T,Mingqi L

更新日期：2019-07-04 00:00:00

abstract：:Our understanding of the mitochondrial or intrinsic apoptosis pathway and its role in chemotherapy resistance has increased significantly in recent years by a combination of experimental studies and mathematical modelling. This combined approach enhanced the quantitative and kinetic understanding of apoptosis signal t...

journal_title：Cell death & disease

authors： Würstle ML,Zink E,Prehn JH,Rehm M

更新日期：2014-05-29 00:00:00

abstract：:MiR34 involvement in myocardial injury repair and ageing has been well documented in mouse model. Our aim was to establish whether the inhibition of miR34 expression through locked nucleic acid (LNA) could be used as a pharmacological intervention to enhance human heart repair. Cardiac progenitor cells were obtained b...

journal_title：Cell death & disease

authors： Iannolo G,Sciuto MR,Raffa GM,Pilato M,Conaldi PG

更新日期：2018-03-06 00:00:00

abstract：:Treatment options for necrotizing enterocolitis (NEC) remain inadequate. Here we examined if and how prolyl hydroxylase 2 (PHD2) silencing enhances the paracrine effects of bone-marrow-derived mesenchymal stem cells (BM-MSCs) on NEC. In this study, BM-MSCs were transduced with lentiviruses containing GFP (GFP-MSC) or ...

journal_title：Cell death & disease

authors： Chen H,Zhang H,Zheng Y,Min X,Luo Y,Zhou W,Ma F,Li J,Lu Q,Zhang C,Cai H,Sha W

更新日期：2020-03-16 00:00:00

abstract：:Procaspase-3-activating compound 1 (PAC-1) induces procaspase-3 activation via zinc chelation. However, whether PAC-1 employs other mechanisms remains unknown. Here we systematically screened for potent PAC-1 targets using 29 enhanced green fluorescent protein-labeled reporter cell lines and identified hypoxia-inducib...

journal_title：Cell death & disease

authors： Li F,Wei A,Bu L,Long L,Chen W,Wang C,Zhao C,Wang L

更新日期：2018-10-04 00:00:00