ΔNp63α-induced DUSP4/GSK3β/SNAI1 pathway in epithelial cells drives endometrial fibrosis.

abstract：:Serum deprivation or withdrawal induces apoptosis in endothelial cells, resulting in endothelial cell dysfunction that is associated with cardiovascular disease. However, there is still limited information on the role of miRNA in serum deprivation-induced apoptosis. Here we found that serum deprivation increased caspa...

journal_title：Cell death & disease

authors： Kim JH,Lee DK,Kim J,Choi S,Park W,Ha KS,Kim TH,Choe J,Won MH,Kwon YG,Kim YM

更新日期：2017-05-18 00:00:00

abstract：:The high resistance against current therapies found in non-small-cell lung cancer (NSCLC) has been associated to cancer stem-like cells (CSCs), a population for which the identification of targets and biomarkers is still under development. In this study, primary cultures from early-stage NSCLC patients were establishe...

journal_title：Cell death & disease

authors： Herreros-Pomares A,de-Maya-Girones JD,Calabuig-Fariñas S,Lucas R,Martínez A,Pardo-Sánchez JM,Alonso S,Blasco A,Guijarro R,Martorell M,Escorihuela E,Chiara MD,Duréndez E,Gandía C,Forteza J,Sirera R,Jantus-Lewintre E,Farr

更新日期：2019-09-10 00:00:00

abstract：:The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target. However, directly inhibiting this target requires the disruption of high-affinity protein-protei...

journal_title：Cell death & disease

authors： Leverson JD,Zhang H,Chen J,Tahir SK,Phillips DC,Xue J,Nimmer P,Jin S,Smith M,Xiao Y,Kovar P,Tanaka A,Bruncko M,Sheppard GS,Wang L,Gierke S,Kategaya L,Anderson DJ,Wong C,Eastham-Anderson J,Ludlam MJ,Sampath D,F

更新日期：2015-01-15 00:00:00

abstract：:Interleukin-17 receptor B (IL-17RB), a member of the IL-17 receptor family activated by IL-17B/IL-17E, has been shown to be involved in inflammatory diseases. However, the regulation and function of IL-17RB in Helicobacter pylori (H. pylori) infection, especially in the early-phase is still unknown. Here, we found tha...

journal_title：Cell death & disease

authors： Teng YS,Liu YG,Chen XH,Wang TT,Cheng P,Lv YP,Kong H,Mao FY,Hao CJ,Yang SM,Chen W,Zhang JY,Peng LS,Han B,Ma Q,Han J,Zou QM,Zhuang Y

更新日期：2019-01-28 00:00:00

abstract：:Homeostatic chemokines, such as CXCL12, can affect neuronal activity by the regulation of inhibitory and excitatory neurotransmission, but the mechanisms involved are still undefined. Our previous studies have shown that CXCL12 protects cortical neurons from excitotoxicity by promoting the function of the gene-repress...

journal_title：Cell death & disease

authors： Nicolai J,Burbassi S,Rubin J,Meucci O

更新日期：2010-04-01 00:00:00

abstract：:Soluble Axl (sAxl) was recently shown to be strongly released into the blood during liver fibrogenesis and hepatocellular carcinoma suggesting sAxl as a biomarker of liver diseases. In this study we are the first to evaluate sAxl in human serum in comparison to Enhanced Liver Fibrosis (ELF) test and transient elastogr...

journal_title：Cell death & disease

authors： Staufer K,Dengler M,Huber H,Marculescu R,Stauber R,Lackner C,Dienes HP,Kivaranovic D,Schachner C,Zeitlinger M,Wulkersdorfer B,Rauch P,Prager G,Trauner M,Mikulits W

更新日期：2017-10-26 00:00:00

abstract：:The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand bindi...

journal_title：Cell death & disease

authors： Fujita Y,Takashima R,Endo S,Takai T,Yamashita T

更新日期：2011-09-01 00:00:00

abstract：:Many recent studies have uncovered the necessary role for the receptor-interacting protein kinase 1 (RIP1) in regulating apoptosis and necrosis that cells undergo in response to various cellular stresses. However, the functional significance of RIP1 in promoting cancer cells survival remains poorly understood. Here, w...

journal_title：Cell death & disease

authors： Lei FX,Jin L,Liu XY,Lai F,Yan XG,Farrelly M,Guo ST,Zhao XH,Zhang XD

更新日期：2018-06-07 00:00:00

abstract：:In this study, the roles of p53 in impaired spermatogenic male germ cells of p53-deficient medaka were investigated by analyzing histological changes, and gene expressions of 42Sp50, Oct 4 and vitellogenin (VTG2) by RT-PCR or in situ hybridization in the testes. We found that a small number of oocyte-like cells (testi...

journal_title：Cell death & disease

authors： Yasuda T,Oda S,Li Z,Kimori Y,Kamei Y,Ishikawa T,Todo T,Mitani H

更新日期：2012-10-04 00:00:00

abstract：:Uncontrollable inflammatory response acts as a driver of sepsis-associated liver injury (SALI). IL-22 plays an important role in regulating inflammatory responses, but its role in SALI remains unknown. The aim of the study was to assess the association of serum IL-22 with SALI in pediatric patients and to enclose the ...

journal_title：Cell death & disease

authors： Shao L,Xiong X,Zhang Y,Miao H,Ren Y,Tang X,Song J,Wang C

更新日期：2020-11-11 00:00:00

abstract：:Glycogen synthase kinase-3β (GSK-3β) has emerged as a critical factor in several pathways involved in hippocampal neuronal maintenance and function. In Huntington's disease (HD), there are early hippocampal deficits both in patients and transgenic mouse models, which prompted us to investigate whether disease-specific...

journal_title：Cell death & disease

authors： L'Episcopo F,Drouin-Ouellet J,Tirolo C,Pulvirenti A,Giugno R,Testa N,Caniglia S,Serapide MF,Cisbani G,Barker RA,Cicchetti F,Marchetti B

更新日期：2016-04-28 00:00:00

abstract：:Following the publication of this article, the authors realized there was an error in Figure 6H in which two versions of the figure appear.This does not impact the conclusions of the article. ...

journal_title：Cell death & disease

authors： Wei Y,Zhou J,Wu J,Huang J

更新日期：2019-08-23 00:00:00

abstract：:Arachidonic acid (AA) is largely released during injury, but it has not been fully studied yet how AA modulates wound repair with stem cells. Therefore, we investigated skin wound-healing effect of AA-stimulated human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in vivo and its molecular mechanism i...

journal_title：Cell death & disease

authors： Oh SY,Lee SJ,Jung YH,Lee HJ,Han HJ

更新日期：2015-05-07 00:00:00

abstract：:The nuclear localization signal (NLS) in kinesin-14 KIFC1 is associated with nuclear importins and Ran gradient, but detailed mechanism remains unknown. In this study, we found that KIFC1 proteins have specific transport characteristics during cell cycle. In the absence of KIFC1, cell cycle kinetics decrease significa...

journal_title：Cell death & disease

authors： Wei YL,Yang WX

更新日期：2019-05-24 00:00:00

abstract：:Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cancer cells often resist chemotherapy by evading apoptosis. Antagonists of an inhibitor of apoptosis proteins (IAPs) can restore defective a...

journal_title：Cell death & disease

authors： Fichtner M,Bozkurt E,Salvucci M,McCann C,McAllister KA,Halang L,Düssmann H,Kinsella S,Crawford N,Sessler T,Longley DB,Prehn JHM

更新日期：2020-11-30 00:00:00

abstract：:Cell death plays a pivotal role in animal development and tissue homeostasis. Dysregulation of this process is associated with a wide variety of human diseases, including developmental and immunological disorders, neurodegenerative diseases and tumors. While the fundamental role of JNK pathway in cell death has been e...

journal_title：Cell death & disease

authors： Wu C,Li Z,Ding X,Guo X,Sun Y,Wang X,Hu Y,Li T,La X,Li J,Li JA,Li W,Xue L

更新日期：2019-11-26 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the major type of primary liver cancer. Genomic studies have revealed that HCC is a heterogeneous disease with multiple subtypes. BRG1, encoded by the SMARCA4 gene, is a key component of SWI/SNF chromatin-remodeling complexes. Based on TCGA studies, somatic mutations of SMARCA4 occur ...

journal_title：Cell death & disease

authors： Wang P,Song X,Cao D,Cui K,Wang J,Utpatel K,Shang R,Wang H,Che L,Evert M,Zhao K,Calvisi DF,Chen X

更新日期：2020-02-04 00:00:00

abstract：:p63 is a p53 family transcription factor, which besides unique roles in epithelial development, shares tumor suppressive activity with its homolog p53. The p63 gene has different transcriptional start sites, which generate two N-terminal isoforms (transactivation domain (TA)p63 and amino terminal truncated protein(ΔN)...

journal_title：Cell death & disease

authors： Celardo I,Grespi F,Antonov A,Bernassola F,Garabadgiu AV,Melino G,Amelio I

更新日期：2013-05-23 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) has the highest incidence of cancer-related death worldwide and a high medical need for more effective therapies. Small-molecule inhibitors of the bromodomain and extra terminal domain (BET) family such as JQ1, I-BET762 and OTX-015 are active in a wide range of different cancer types...

journal_title：Cell death & disease

authors： Klingbeil O,Lesche R,Gelato KA,Haendler B,Lejeune P

更新日期：2016-09-08 00:00:00

abstract：:Recent cases of successful control of human immunodeficiency virus (HIV) by bone marrow transplant in combination with suppressive antiretroviral therapy (ART) and very early initiation of ART have provided proof of concept that HIV infection might now be cured. Current efforts focusing on gene therapy, boosting HIV-s...

journal_title：Cell death & disease

authors： Badley AD,Sainski A,Wightman F,Lewin SR

更新日期：2013-07-11 00:00:00

abstract：:Synapsin I is a phosphoprotein that coats the cytoplasmic side of synaptic vesicles and regulates their trafficking within nerve terminals. Autoantibodies against Syn I have been described in sera and cerebrospinal fluids of patients with numerous neurological diseases, including limbic encephalitis and clinically iso...

journal_title：Cell death & disease

authors： Rocchi A,Sacchetti S,De Fusco A,Giovedi S,Parisi B,Cesca F,Höltje M,Ruprecht K,Ahnert-Hilger G,Benfenati F

更新日期：2019-11-14 00:00:00

abstract：:Despite successful antiretroviral drug therapy, a subset of human immunodeficiency virus-1 (HIV)-positive individuals still display synaptodendritic simplifications and functional cognitive impairments referred to as HIV-associated neurocognitive disorders (HANDs). The neurological damage observed in HAND subjects can...

journal_title：Cell death & disease

authors： Wenzel ED,Speidell A,Flowers SA,Wu C,Avdoshina V,Mocchetti I

更新日期：2019-09-12 00:00:00

abstract：:N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial-mesenchymal transition. However, the role of NMI in the regulation of cancer stem cells (CSCs) remains poorly understood. In this stud...

journal_title：Cell death & disease

authors： Feng X,Xu X,Xiao X,Zou K,Yu W,Wu J,Tang R,Gao Y,Hao J,Zhao X,Liao Y,Chen Y,Huang W,Guo W,Kang L,Deng W

更新日期：2017-05-11 00:00:00

abstract：:Numerous evidences have shown that circular RNAs (circRNAs) play a key role in regulating the pathogenesis of cancer. However, the mechanism of circRNAs in urothelial carcinoma of bladder (UCB) remains largely unclear. In this study, we found circFAM114A2 was significantly downregulated both in UCB tissue specimens an...

journal_title：Cell death & disease

authors： Liu T,Lu Q,Liu J,Xie S,Feng B,Zhu W,Liu M,Liu Y,Zhou X,Sun W,Zhang Y,Chen X,Fang F,Guo H,Yang R

更新日期：2020-01-22 00:00:00

abstract：:The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target. Although this proposition is supported by the clinical success of proteasome inhibitors in some malignancies, most cancers are resistant to proteasome inhibition. The ...

journal_title：Cell death & disease

authors： Parzych K,Chinn TM,Chen Z,Loaiza S,Porsch F,Valbuena GN,Kleijnen MF,Karadimitris A,Gentleman E,Keun HC,Auner HW

更新日期：2015-12-31 00:00:00

abstract：:The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic transcription factor NF-κB. Recently, missense mutations in CARMA2sh have been shown to cause...

journal_title：Cell death & disease

authors： Scudiero I,Mazzone P,D'Andrea LE,Ferravante A,Zotti T,Telesio G,De Rubis G,Reale C,Pizzulo M,Muralitharan S,Vito P,Stilo R

更新日期：2017-02-23 00:00:00

abstract：:The Pierre Robin Sequence (PRS), consisting of cleft palate, glossoptosis and micrognathia, is a common human birth defect. However, how this abnormality occurs remains largely unknown. Here we report that neural crest cell (NCC)-specific knockout of transferrin receptor (Tfrc), a well known transferrin transporter pr...

journal_title：Cell death & disease

authors： Lei R,Zhang K,Liu K,Shao X,Ding Z,Wang F,Hong Y,Zhu M,Li H,Li H

更新日期：2016-06-30 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Moon H-,Cao Y,Yang J,Lee JH,Choi HS,Jin Y

更新日期：2020-02-12 00:00:00

abstract：:Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer's disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and ...

journal_title：Cell death & disease

authors： Chen X,Jiang XM,Zhao LJ,Sun LL,Yan ML,Tian Y,Zhang S,Duan MJ,Zhao HM,Li WR,Hao YY,Wang LB,Xiong QJ,Ai J

更新日期：2017-06-01 00:00:00

abstract：:Erythropoietin (EPO) has been well known as a hematopoietic cytokine over the past decades. However, recent reports have demonstrated that EPO plays a neuroprotective role in the central nervous system, and EPO has been considered as a therapeutic target in neurodegenerative diseases such as ischemic stroke. Despite t...

journal_title：Cell death & disease

authors： Yoo SJ,Cho B,Lee D,Son G,Lee YB,Soo Han H,Kim E,Moon C,Moon C

更新日期：2017-08-17 00:00:00