Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents.

abstract：:Dia1, which belongs to the diaphanous-related formin family, influences a variety of cellular processes through straight actin elongation activity. Recently, novel DIA1 mutants such as p.R1213X (p.R1204X) and p.A265S, have been reported to cause an autosomal dominant sensorineural hearing loss (DFNA1). Additionally, a...

journal_title：Cell death & disease

authors： Ninoyu Y,Sakaguchi H,Lin C,Suzuki T,Hirano S,Hisa Y,Saito N,Ueyama T

更新日期：2020-07-16 00:00:00

abstract：:Vascular endothelial growth factor receptor (VEGFR) and neuropilins (NRPs), a co-receptor of VEGF, play a key role in the formation and development of blood vessels and in tumour growth and metastasis. However, whether VEGFR1/2 and NRP1 are regulated by the same upstream mechanism is unclear, especially in gastric can...

journal_title：Cell death & disease

authors： Mei B,Chen J,Yang N,Peng Y

更新日期：2020-04-17 00:00:00

abstract：:The acquisition of MDR1-mediated chemoresistance poses a major obstacle to the success of conventional chemotherapeutic agents. HSF1 is also involved in chemoresistance, and several studies have demonstrated the relationship between HSF1 and MDR1 but without any consistent results. Paclitaxel- and doxorubicin-resistan...

journal_title：Cell death & disease

authors： Mun GI,Choi E,Lee Y,Lee YS

更新日期：2020-05-26 00:00:00

abstract：:Primary cells respond to irradiation by activation of the DNA damage response and cell cycle arrest, which eventually leads to senescence or apoptosis. It is not clear in detail which signaling pathways or networks regulate the induction of either apoptosis or senescence. Primary human fibroblasts are able to withstan...

journal_title：Cell death & disease

authors： Bluwstein A,Kumar N,Léger K,Traenkle J,Oostrum Jv,Rehrauer H,Baudis M,Hottiger MO

更新日期：2013-02-14 00:00:00

abstract：:Caveolin-1 (CAV1) is a crucial regulator of lipid accumulation and metabolism. Previous studies have shown that global Cav1 deficiency affects lipid metabolism and hepatic steatosis. We aimed to analyze the consequences of hepatocyte-specific Cav1 knockout under healthy conditions and upon non-alcoholic fatty liver di...

journal_title：Cell death & disease

authors： Han M,Piorońska W,Wang S,Nwosu ZC,Sticht C,Wang S,Gao Y,Ebert MP,Dooley S,Meyer C

更新日期：2020-02-06 00:00:00

abstract：:The Pierre Robin Sequence (PRS), consisting of cleft palate, glossoptosis and micrognathia, is a common human birth defect. However, how this abnormality occurs remains largely unknown. Here we report that neural crest cell (NCC)-specific knockout of transferrin receptor (Tfrc), a well known transferrin transporter pr...

journal_title：Cell death & disease

authors： Lei R,Zhang K,Liu K,Shao X,Ding Z,Wang F,Hong Y,Zhu M,Li H,Li H

更新日期：2016-06-30 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein. Because TP53 inactivating mutations, frequently found in human tumors, could interfere with Granzyme B-mediated cell...

journal_title：Cell death & disease

authors： Chollat-Namy M,Ben Safta-Saadoun T,Haferssas D,Meurice G,Chouaib S,Thiery J

更新日期：2019-09-20 00:00:00

abstract：:Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) poses a serious threat to the world's public health yet without a cure. Certain JEV-infected neural cells express a subset of previously identified intrinsic antiviral interferon stimulated genes (ISGs), indicating brain cells retain autonomous ant...

journal_title：Cell death & disease

authors： Zhang B,He Y,Xu Y,Mo F,Mi T,Shen QS,Li C,Li Y,Liu J,Wu Y,Chen G,Zhu W,Qin C,Hu B,Zhou G

更新日期：2018-06-18 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating cancer cell proliferation, and invasion, but how the premalignant stromal fibroblasts trigger epithelial changes remain unclear. We demonstrate that atypical ductal hyperplasia-associated fibroblasts (AHFs) are one kind of activated fibroblasts ...

journal_title：Cell death & disease

authors： Sun Y,Yang D,Xi L,Chen Y,Fu L,Sun K,Yin J,Li X,Liu S,Qin Y,Liu M,Hou Y

更新日期：2018-01-26 00:00:00

abstract：:Recent studies identified a highly tumorigenic subpopulation of glioma stem cells (GSCs) within malignant gliomas. GSCs are proposed to originate from transformed neural stem cells (NSCs). Several pathways active in NSCs, including the Notch pathway, were shown to promote proliferation and tumorigenesis in GSCs. Notch...

journal_title：Cell death & disease

authors： Tchorz JS,Tome M,Cloëtta D,Sivasankaran B,Grzmil M,Huber RM,Rutz-Schatzmann F,Kirchhoff F,Schaeren-Wiemers N,Gassmann M,Hemmings BA,Merlo A,Bettler B

更新日期：2012-06-21 00:00:00

abstract：:Epidermal keratinocyte differentiation on the body surface is a carefully choreographed process that leads to assembly of a barrier that is essential for life. Perturbation of keratinocyte differentiation leads to disease. Activator protein 1 (AP1) transcription factors are key controllers of this process. We have sho...

journal_title：Cell death & disease

authors： Rorke EA,Adhikary G,Young CA,Rice RH,Elias PM,Crumrine D,Meyer J,Blumenberg M,Eckert RL

更新日期：2015-02-19 00:00:00

abstract：:Given the dense stroma and poor vascularization, access to nutrients is limited in the microenvironment of pancreatic ductal adenocarcinoma (PDA). PDA cells can efficiently recycle various metabolic substrates through the activation of different rescuing pathways, including the autophagy pathway. However, the precise ...

journal_title：Cell death & disease

authors： Meng Q,Xu J,Liang C,Liu J,Hua J,Zhang Y,Ni Q,Shi S,Yu X

更新日期：2018-12-11 00:00:00

abstract：:Autophagy is an evolutionarily conserved lysosomal degradation pathway that plays important roles in cell maintenance, expansion and differentiation. Removal of genes essential for autophagy from embryonic neural stem and precursor cells reduces the survival and inhibits neuronal differentiation of adult-generated neu...

journal_title：Cell death & disease

authors： Xi Y,Dhaliwal JS,Ceizar M,Vaculik M,Kumar KL,Lagace DC

更新日期：2016-03-03 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gastric cancer (GC) patients. Here, we have identified a novel subset of CD45+CD33lowCD11bdim MDSCs in the periphe...

journal_title：Cell death & disease

authors： Mao FY,Zhao YL,Lv YP,Teng YS,Kong H,Liu YG,Wu XL,Hao CJ,Chen W,Duan MB,Han B,Ma Q,Wang TT,Peng LS,Zhang JY,Cheng P,Su CY,Fu XL,Zou QM,Guo G,Guo XL,Zhuang Y

更新日期：2018-07-09 00:00:00

abstract：:Emerging evidence suggests that long noncoding RNA (lncRNA) plays pivotal roles in regulating various biological process in human cancers. Titin-antisense RNA1 (TTN-AS1) has been regarded as a tumor promoting lncRNA in numerous cancers. However, the clinical significance and biological function of TTN-AS1 in lung aden...

journal_title：Cell death & disease

authors： Jia Y,Duan Y,Liu T,Wang X,Lv W,Wang M,Wang J,Liu L

更新日期：2019-07-30 00:00:00

abstract：:Reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress are paradoxically implicated in myocardial ischemia/reperfusion (I/R) injury and cardioprotection. However, the precise interpretation for the dual roles of ROS and its relationship with the ER stress during I/R remain elusive. Here we investigated th...

journal_title：Cell death & disease

authors： Wang ZH,Liu JL,Wu L,Yu Z,Yang HT

更新日期：2014-06-19 00:00:00

abstract：:Unloading-induced bone loss is a threat to human health and can eventually result in osteoporotic fractures. Although the underlying molecular mechanism of unloading-induced bone loss has been broadly elucidated, the pathophysiological role of long noncoding RNAs (lncRNAs) in this process is unknown. Here, we identifi...

journal_title：Cell death & disease

authors： Wang K,Wang Y,Hu Z,Zhang L,Li G,Dang L,Tan Y,Cao X,Shi F,Zhang S,Zhang G

更新日期：2020-05-19 00:00:00

abstract：:As a deubiqutinase Otub1 stabilizes and promotes the oncogenic activity of the transcription factor c-Maf in multiple myeloma (MM), a malignancy of plasma cells. In the screen for bioactive inhibitors of the Otub1/c-Maf axis for MM treatment, nanchangmycin (Nam), a polyketide antibiotic, was identified to suppress c-M...

journal_title：Cell death & disease

authors： Xu Y,Sun T,Zeng K,Xu M,Chen J,Xu X,Zhang Z,Cao B,Tang X,Wu D,Kong Y,Zeng Y,Mao X

更新日期：2020-09-30 00:00:00

abstract：:Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer's disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and ...

journal_title：Cell death & disease

authors： Chen X,Jiang XM,Zhao LJ,Sun LL,Yan ML,Tian Y,Zhang S,Duan MJ,Zhao HM,Li WR,Hao YY,Wang LB,Xiong QJ,Ai J

更新日期：2017-06-01 00:00:00

abstract：:miRNA let-7e is involved in stem cell differentiation, and metalloproteinases are among its potential target genes. We hypothesized that the inhibitory action of let-7e on regulation of MMP9 expression could represent a crucial mechanism during differentiation of adipose-derived stem cells (ASCs). ASCs were differenti...

journal_title：Cell death & disease

authors： Ventayol M,Viñas JL,Sola A,Jung M,Brüne B,Pi F,Mastora C,Hotter G

更新日期：2014-02-06 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most prevalent form of malignant brain tumor. Amlexanox, a novel compound, has been shown to have anti-cancer potential. In this study, the anti-tumoral effects and the underlying mechanisms of amlexanox were investigated. Amlexanox significantly suppressed proliferation and invasi...

journal_title：Cell death & disease

authors： Liu Y,Lu J,Zhang Z,Zhu L,Dong S,Guo G,Li R,Nan Y,Yu K,Zhong Y,Huang Q

更新日期：2017-08-31 00:00:00

abstract：:Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs to the repeats-in-toxin family, is believed to be one of its virulence factors and to have an important role in the bacterium's pathogenic...

journal_title：Cell death & disease

authors： Kelk P,Abd H,Claesson R,Sandström G,Sjöstedt A,Johansson A

更新日期：2011-03-10 00:00:00

abstract：:Diffusely infiltrating gliomas are among the most prognostically discouraging neoplasia in human. Temozolomide (TMZ) in combination with radiotherapy is currently used for the treatment of glioblastoma (GBM) patients, but less than half of the patients respond to therapy and chemoresistance develops rapidly. Epigeneti...

journal_title：Cell death & disease

authors： Haemmig S,Baumgartner U,Glück A,Zbinden S,Tschan MP,Kappeler A,Mariani L,Vajtai I,Vassella E

更新日期：2014-06-05 00:00:00

abstract：:UV irradiation elicits acute inflammation in the skin by increasing proinflammatory cytokine production in keratinocytes. However, the downstream protein target(s) that link UV radiation to the activation of signaling pathways responsible for cytokine expression have not been fully elucidated. In this study, we report...

journal_title：Cell death & disease

authors： Lee SJ,Lee KB,Son YH,Shin J,Lee JH,Kim HJ,Hong AY,Bae HW,Kwon MA,Lee WJ,Kim JH,Lee DH,Jeong EM,Kim IG

更新日期：2017-10-26 00:00:00

abstract：:Interleukin-17 receptor B (IL-17RB), a member of the IL-17 receptor family activated by IL-17B/IL-17E, has been shown to be involved in inflammatory diseases. However, the regulation and function of IL-17RB in Helicobacter pylori (H. pylori) infection, especially in the early-phase is still unknown. Here, we found tha...

journal_title：Cell death & disease

authors： Teng YS,Liu YG,Chen XH,Wang TT,Cheng P,Lv YP,Kong H,Mao FY,Hao CJ,Yang SM,Chen W,Zhang JY,Peng LS,Han B,Ma Q,Han J,Zou QM,Zhuang Y

更新日期：2019-01-28 00:00:00

abstract：:It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the relationship between CS...

journal_title：Cell death & disease

authors： Ffrench B,Gasch C,Hokamp K,Spillane C,Blackshields G,Mahgoub TM,Bates M,Kehoe L,Mooney A,Doyle R,Doyle B,O'Donnell D,Gleeson N,Hennessy BT,Stordal B,O'Riain C,Lambkin H,O'Toole S,O'Leary JJ,Gallagher MF

更新日期：2017-10-19 00:00:00

abstract：:Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K27 hypomethylation accompanied by H3K27 hyperacetylation. Hyperacetylati...

journal_title：Cell death & disease

authors： Wiese M,Hamdan FH,Kubiak K,Diederichs C,Gielen GH,Nussbaumer G,Carcaboso AM,Hulleman E,Johnsen SA,Kramm CM

更新日期：2020-08-21 00:00:00

abstract：:The unfolded protein response (UPR) triggered by endoplasmic reticulum (ER) stress is a feature of many neurodegenerative diseases including Alzheimer's disease, Huntington's disease and Parkinson's disease (PD). Although the vast majority of PD is sporadic, mutations in a number of genes including PARK7 which encodes...

journal_title：Cell death & disease

authors： Yang J,Kim KS,Iyirhiaro GO,Marcogliese PC,Callaghan SM,Qu D,Kim WJ,Slack RS,Park DS

更新日期：2019-02-12 00:00:00

abstract：:An increasing interest in liver cancer stemness arises owing to its aggressive behavior and poor prognosis. CD133, a widely known liver cancer stem cell marker, plays critical roles in the maintenance of liver cancer stemness. Thus, exploring the regulatory mechanism of CD133 expression is significant. In the present ...

journal_title：Cell death & disease

authors： Wang Y,Wu G,Fu X,Xu S,Wang T,Zhang Q,Yang Y

更新日期：2019-06-13 00:00:00

abstract：:Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that specifically recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif. The Pin1-mediated structural transformation posttranslationally regulates the biofunctions of multiple proteins. Pin1 is involved in many cel...

journal_title：Cell death & disease

authors： Chen Y,Wu YR,Yang HY,Li XZ,Jie MM,Hu CJ,Wu YY,Yang SM,Yang YB

更新日期：2018-08-29 00:00:00