Abstract:
:Arachidonic acid (AA) is largely released during injury, but it has not been fully studied yet how AA modulates wound repair with stem cells. Therefore, we investigated skin wound-healing effect of AA-stimulated human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in vivo and its molecular mechanism in vitro. We found that transplantation of hUCB-MSCs pre-treated with AA enhanced wound filling, re-epithelization, and angiogenesis in a mouse skin excisional wound model. AA significantly promoted hUCB-MSCs migration after a 24 h incubation, which was inhibited by the knockdown of G-protein-coupled receptor 40 (GPR40). AA activated mammalian target of rapamycin complex 2 (mTORC2) and Aktser473 through the GPR40/phosphoinositide 3-kinase (PI3K) signaling, which was responsible for the stimulation of an atypical protein kinase C (PKC) isoform, PKCζ. Subsequently, AA stimulated phosphorylation of p38 MAPK and transcription factor Sp1, and induced membrane type 3-matrix metalloproteinase (MT3-MMP)-dependent fibronectin degradation in promoting hUCB-MSCs motility. Finally, the silencing of MT3-MMP in AA-stimulated hUCB-MSCs failed to promote the repair of skin wounds owing to impaired cell motility. In conclusion, AA enhances skin wound healing through induction of hUCB-MSCs motility by MT3-MMP-mediated fibronectin degradation, which relies on GPR40-dependent mTORC2 signaling pathways.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Oh SY,Lee SJ,Jung YH,Lee HJ,Han HJdoi
10.1038/cddis.2015.114subject
Has Abstractpub_date
2015-05-07 00:00:00pages
e1750issn
2041-4889pii
cddis2015114journal_volume
6pub_type
杂志文章abstract::Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-κB signalling has been shown to be critical for this profound cell-autonomous resistance against chemotherapeutic drugs and death receptor-induced apoptosis, bu...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.417
更新日期:2014-10-09 00:00:00
abstract::Functional neuronal circuits require a constant remodeling of their network composed of highly interconnected neurons. The plasticity of synapses and the shaping of elaborated dendritic branches are energy demanding and therefore depend on an efficient mitochondrial oxidative phosphorylation (OXPHOS). The spatial and ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.144
更新日期:2014-04-10 00:00:00
abstract::Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extrac...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.134
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abstract::Normal cells require adhesion to extracellular matrix for survival. Cell detachment causes a drastic increase in reactive oxygen species (ROS) that promotes anoikis. In the present study, we observed that upon detachment from matrix, human mammary epithelial cells strongly upregulate manganese superoxide dismutase (Mn...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.20
更新日期:2013-02-21 00:00:00
abstract::β-Catenin has been widely implicated in the regulation of mammalian development and cellular homeostasis. However, the mechanisms by which Wnt/β-catenin signaling components regulate physiological events during brain development remain undetermined. Inactivation of glycogen synthase kinase (GSK)-3β leads to β-catenin ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.439
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abstract::New bone anabolic agents for the effective treatment of bone metabolic diseases like osteoporosis are of high clinical demand. In the present study, we reveal the function of salt-inducible kinase 1 (SIK1) in regulating osteoblast differentiation. Gene knockdown of SIK1 but not of SIK2 or SIK3 expression in primary pr...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1915-4
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abstract::Diffuse large B cell lymphoma (DLBCL) is a common and fatal hematological malignancy. Long noncoding RNAs (lncRNAs) have emerged as crucial biomarkers and regulators in many cancers. Novel lncRNA biomarker in DLBCL needs to be investigated badly, as well as its function and molecular mechanism. To further explore, mic...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1479-3
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abstract::Intrinsic apoptosis relies on the ability of the BCL-2 family to induce the formation of pores on the outer mitochondrial membrane. Previous studies have shown that both BAX and BAK are essential during murine embryogenesis, and reports in human cancer cell lines identified non-canonical roles for BAX and BAK in mitoc...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03002-x
更新日期:2020-09-25 00:00:00
abstract::Mediators produced by the airway epithelium control the activation, recruitment, and survival of pulmonary dendritic cells (DC) that present antigen to CD4(+) T cells during the genesis and exacerbation of allergic asthma. The epithelial-derived acute phase protein, serum amyloid A (SAA), induces DC maturation and TH1...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.327
更新日期:2013-09-05 00:00:00
abstract::GATA3 has emerged as a prominent transcription factor required for maintaining mammary-gland homeostasis. GATA3 loss is associated with aggressive breast cancer development, but the mechanism by which breast cancer is affected by the loss of GATA3 function remains unclear. Here, we report that GATA3 expression is posi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-2062-7
更新日期:2019-11-04 00:00:00
abstract::Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, their precise mechanism of communication in gastric cancer remains largely unclear. Here, we found that patients with GC showed a significantly higher mast cell infiltration in tumors. Mas...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1100-1
更新日期:2018-10-10 00:00:00
abstract::The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice. However, the relevant mechanisms are unknown. Here, we examined changes in granulocyte/erythroid cell ratios, iron content, and expression of iron-metabolism proteins, inclu...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1951-0
更新日期:2019-09-24 00:00:00
abstract::Calcium ions play a critical role in neuronal cell death. Pigment epithelium-derived factor (PEDF) is a promising neuroprotective protein for photoreceptor cells but the mechanisms mediating its effects against retinal degeneration are still not well characterized. We addressed this question in the rd1 degenerating mo...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0613-y
更新日期:2018-05-01 00:00:00
abstract::Mitochondrial reactive oxygen species (mtROS) homeostasis plays an essential role in preventing oxidative injury in endothelial cells, an initial step in atherogenesis. Resveratrol (RSV) possesses a variety of cardioprotective activities, however, little is known regarding the effects of RSV on mtROS homeostasis in en...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.530
更新日期:2014-12-18 00:00:00
abstract::The mitochondrial permeability transition pore (mPTP) plays a critical role in the pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although the pore structure is still unresolved, the mechanism through which cyclophilin D (CypD) regulates mPTP opening is the subject of intensive studies...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02864-5
更新日期:2020-08-19 00:00:00
abstract::In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing so via means of systemic analysis pivotal to inform pathophysiological...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0578-x
更新日期:2018-06-04 00:00:00
abstract::Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, disease treatment, and organ transplantation. As the ethical issue of human ESCs and similarity of pig in human genome and physiological characteristics, the porcine iPSCs (piPSCs) have become an ideal ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1417-4
更新日期:2019-02-20 00:00:00
abstract::Estrogen-dependent breast cancer is often treated with the aromatase inhibitors or estrogen receptor (ER) antagonists. Tamoxifen as a major ER antagonist is usually used to treat those patients with ERα-positive breast cancer. However, a majority of patients with ERα positive fail to respond to tamoxifen due to the pr...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.361
更新日期:2016-11-03 00:00:00
abstract::Acute lung injury (ALI) is a pulmonary disorder, which can result in fibrosis of the lung tissues. Recently, mesenchymal stem cell (MSC) has become a novel therapeutic method for ALI. However, the potential mechanism by which MSC regulates the progression of ALI remains blurry. The present study focused on investigati...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03034-3
更新日期:2020-10-15 00:00:00
abstract::Polo-like kinase 1 (PLK1) is an important mitotic kinase and its expression is tightly regulated in the cell cycle and in the DNA damage response. PLK1 expression is previously shown to be suppressed by p53 and/or p21. Here, we demonstrate that the CCAAT box in the PLK1 promoter is pivotal for p53/p21-mediated PLK1 re...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.527
更新日期:2014-01-09 00:00:00
abstract::Neuronal apoptosis and survival are tightly controlled processes that regulate cell fate during the development of the central nervous system and its homeostasis throughout adulthood. A new study in primary cultures of cerebellar granule neurons identified common transcriptional cascades during rescue from apoptosis b...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.309
更新日期:2015-11-05 00:00:00
abstract::Long noncoding RNAs (lncRNAs) participate in organ fibrosis and various pulmonary diseases, but its role in idiopathic pulmonary fibrosis (IPF) is not fully understood. In this study, we found lncRNA Hoxaas3 (Hoxaas3) was up-regulated in the mice model of BLM-induced PF and TGF-β1-induced fibrogenesis in lung fibrobla...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02889-w
更新日期:2020-08-26 00:00:00
abstract::Hepatocellular carcinoma is the sixth most common cancer and gives rise to numerous deaths around the world every year. However, the molecular mechanism that controls hepatocarcinogenesis remains largely unknown. Here we found out an uncharacterized long noncoding RNA named lncAKHE. We found that lncAKHE was highly ex...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0554-5
更新日期:2018-05-01 00:00:00
abstract::The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation. In addition, WTAP is also a regulator of the nuclear complex required for ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0843-z
更新日期:2018-07-23 00:00:00
abstract::Circular RNAs (circRNAs) have been shown to play critical roles in cancer biology, but their functions in nonalcoholic steatohepatitis (NASH) remain unexplored. Full length of circRNA_002581 was amplified and sequenced, followed by RNA immunoprecipitation, RNA-Fluorescence in Situ Hybridization and dual luciferase rep...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2293-7
更新日期:2020-02-13 00:00:00
abstract::Back pain is a leading cause of global disability and is strongly associated with intervertebral disc (IVD) degeneration (IDD). Hallmarks of IDD include progressive cell loss and matrix degradation. The Akt signaling pathway regulates cellularity and matrix production in IVDs and its inactivation is known to contribut...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1985-3
更新日期:2019-10-03 00:00:00
abstract::Circular RNAs (circRNAs), non-coding RNAs generated by precursor mRNA back-splicing of exons, have been reported to fulfill multiple roles in cancer. However, the role of quite a lot circRNAs in colorectal cancer (CRC) remains mostly unknown. Herein, we explored the expression profiles of circRNAs in 5 paired samples ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2514-0
更新日期:2020-05-11 00:00:00
abstract::Diffusely infiltrating gliomas are among the most prognostically discouraging neoplasia in human. Temozolomide (TMZ) in combination with radiotherapy is currently used for the treatment of glioblastoma (GBM) patients, but less than half of the patients respond to therapy and chemoresistance develops rapidly. Epigeneti...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.245
更新日期:2014-06-05 00:00:00
abstract::The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as well as solid tumors, but shows dose-dependent potentially life-threatening toxicities and can induce secondary malignancies. Thus, the clinical utility of CTX wo...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.108
更新日期:2017-03-16 00:00:00
abstract::Skeletal muscle atrophy is one of the clinical symptoms of myotonic dystrophy type 1 (DM1). A decline in skeletal muscle regeneration is an important contributor to muscle atrophy. Skeletal muscle satellite cells (SSCs) drive skeletal muscle regeneration. Increased autophagy can reduce the proliferative capacity of SS...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02756-8
更新日期:2020-07-18 00:00:00