Long non-coding RNA C2dat1 regulates CaMKIIδ expression to promote neuronal survival through the NF-κB signaling pathway following cerebral ischemia.

abstract：:Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cance...

journal_title：Cell death & disease

authors： Cheteh EH,Augsten M,Rundqvist H,Bianchi J,Sarne V,Egevad L,Bykov VJ,Östman A,Wiman KG

更新日期：2017-06-01 00:00:00

abstract：:Current practices for the therapy of chondrosarcoma, including wide-margin surgical resection and chemotherapy, are less than satisfactory. Recently, emerging evidence has demonstrated that long non-coding RNAs (lncRNAs) have an essential role in the initiation and progression of tumors. As a typical lncRNA, HOTAIR is...

journal_title：Cell death & disease

authors： Bao X,Ren T,Huang Y,Sun K,Wang S,Liu K,Zheng B,Guo W

更新日期：2017-02-09 00:00:00

abstract：:Adaptive responses of skeletal muscle regulate the nuclear shuttling of the sarcomeric protein Ankrd2 that can transduce different stimuli into specific adaptations by interacting with both structural and regulatory proteins. In a genome-wide expression study on Ankrd2-knockout or -overexpressing primary proliferating...

journal_title：Cell death & disease

authors： Bean C,Verma NK,Yamamoto DL,Chemello F,Cenni V,Filomena MC,Chen J,Bang ML,Lanfranchi G

更新日期：2014-01-16 00:00:00

abstract：:Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor growth, the underlying mechanisms are poorly understood. Here, we demonstrated for the first time that human umbilical cord MSCs (hUCMSCs) dramatically increased the growth of lung adenocarcinoma (LUAD) cancer cells in a xenograft tumor...

journal_title：Cell death & disease

authors： Dong L,Pu Y,Zhang L,Qi Q,Xu L,Li W,Wei C,Wang X,Zhou S,Zhu J,Wang X,Liu F,Chen X,Su C

更新日期：2018-02-13 00:00:00

abstract：:One of the significant challenges for chemotherapy is the appearance of resistance to compounds. Although several signaling pathways have been implicated in the development of Adriamycin (ADM) resistance, mechanisms involved in ADM-resistant osteosarcoma progression remain unknown. The present study attempted to illus...

journal_title：Cell death & disease

authors： Shen P,Cheng Y

更新日期：2020-05-13 00:00:00

abstract：:The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin has been shown to induce apoptosis in different cancer cells and to suppress growth of human cancer xenografts in vivo. However, its direct targets remain unknown. In this...

journal_title：Cell death & disease

authors： Polier G,Ding J,Konkimalla BV,Eick D,Ribeiro N,Köhler R,Giaisi M,Efferth T,Desaubry L,Krammer PH,Li-Weber M

更新日期：2011-07-21 00:00:00

abstract：:Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations. Patients with Costello syndrome present craniofacial abnormalities, cardiac defects, and cancer predisposition, as well as skin abnormalities, including papillomas, keratosis pilaris, and eczematous dermatitis. However, the ...

journal_title：Cell death & disease

authors： Katata Y,Inoue SI,Asao A,Kobayashi S,Terui H,Inoue-Shibui A,Abe T,Niihori T,Aiba S,Ishii N,Kure S,Aoki Y

更新日期：2020-08-13 00:00:00

abstract：:Intrinsic apoptosis relies on the ability of the BCL-2 family to induce the formation of pores on the outer mitochondrial membrane. Previous studies have shown that both BAX and BAK are essential during murine embryogenesis, and reports in human cancer cell lines identified non-canonical roles for BAX and BAK in mitoc...

journal_title：Cell death & disease

authors： Joshi P,Bodnya C,Rasmussen ML,Romero-Morales AI,Bright A,Gama V

更新日期：2020-09-25 00:00:00

abstract：:The phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of the catalytic subunit p110 and the regulatory subunit p85. The PI3K/Akt pathway is strongly deregulated in breast cancer (BC) representing one of the mechanisms of resistance to therapies. Therefore, the identification of inhibitors of PI3K componen...

journal_title：Cell death & disease

authors： Folgiero V,Di Carlo SE,Bon G,Spugnini EP,Di Benedetto A,Germoni S,Pia Gentileschi M,Accardo A,Milella M,Morelli G,Bossi G,Mottolese M,Falcioni R

更新日期：2012-12-06 00:00:00

abstract：:Vascular endothelial growth factor receptor (VEGFR) and neuropilins (NRPs), a co-receptor of VEGF, play a key role in the formation and development of blood vessels and in tumour growth and metastasis. However, whether VEGFR1/2 and NRP1 are regulated by the same upstream mechanism is unclear, especially in gastric can...

journal_title：Cell death & disease

authors： Mei B,Chen J,Yang N,Peng Y

更新日期：2020-04-17 00:00:00

abstract：:Long-term use of glucocorticoids is a widespread clinical problem, which currently has no effective solution other than discontinuing the use. Eicosapentaenoic acid (EPA), an omega-3 long chain polyunsaturated fatty acid (n-3 PUFA), which is largely contained in fish or fish oil, has been reported to promote cell viab...

journal_title：Cell death & disease

authors： Gao B,Han YH,Wang L,Lin YJ,Sun Z,Lu WG,Hu YQ,Li JQ,Lin XS,Liu BH,Jie Q,Yang L,Luo ZJ

更新日期：2016-05-26 00:00:00

abstract：:Mammalian folliculogenesis is a complex process in which primordial follicles develop into pre-ovulatory follicles, followed by ovulation to release mature oocytes. In this study, we explored the role of miR-144 in ovulation. miR-144 was one of the differentially expressed microRNAs, which showed 5.59-fold changes, in...

journal_title：Cell death & disease

authors： Zhou J,Lei B,Li H,Zhu L,Wang L,Tao H,Mei S,Li F

更新日期：2017-02-09 00:00:00

abstract：:Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Although studies have implicated bioactive sphingolipids (SL) in senescence, the specific mechanisms remain unclear. Here, using MCF10A mammary epithelial cells, we demonstr...

journal_title：Cell death & disease

authors： Trayssac M,Clarke CJ,Stith JL,Snider JM,Newen N,Gault CR,Hannun YA,Obeid LM

更新日期：2021-01-04 00:00:00

abstract：:Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells (MSCs) in processes which are tightly controlled by various growth factors, signaling molecules, transcriptional factors and microRNAs. Recently, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) was identified as a ...

journal_title：Cell death & disease

authors： Jeong BC,Kang IH,Hwang YC,Kim SH,Koh JT

更新日期：2014-11-20 00:00:00

abstract：:Cornelia de Lange Syndrome is a severe genetic disorder characterized by malformations affecting multiple systems, with a common feature of severe mental retardation. Genetic variants within four genes (NIPBL (Nipped-B-like), SMC1A, SMC3, and HDAC8) are believed to be responsible for the majority of cases; all these g...

journal_title：Cell death & disease

authors： Pistocchi A,Fazio G,Cereda A,Ferrari L,Bettini LR,Messina G,Cotelli F,Biondi A,Selicorni A,Massa V

更新日期：2013-10-17 00:00:00

abstract：:Aneuploidy including trisomy results in developmental disabilities and is the leading cause of miscarriages in humans. Unlike trisomy 21, pathogenic mechanisms of trisomy 18 remain unclear. Here, we successfully generated induced pluripotent stem cells (iPSCs) from human amniotic fluid cells (AFCs) with trisomy 18 pre...

journal_title：Cell death & disease

authors： Li T,Zhao H,Han X,Yao J,Zhang L,Guo Y,Shao Z,Jin Y,Lai D

更新日期：2017-10-26 00:00:00

abstract：:The adaptation of mitochondrial homeostasis to ischemic injury is not fully understood. Here, we studied the role of dynamin-related protein 1 (Drp1) in this process. We found that mitochondrial morphology was altered in the early stage of ischemic injury while mitochondrial dysfunction occurred in the late stage of i...

journal_title：Cell death & disease

authors： Duan C,Kuang L,Xiang X,Zhang J,Zhu Y,Wu Y,Yan Q,Liu L,Li T

更新日期：2020-04-20 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Sun S,Zhang Y,Zheng J,Duan B,Cui J,Chen Y,Deng W,Ye B,Liu L,Chen Y,Du J,Gu L

更新日期：2019-08-22 00:00:00

abstract：:Detailed understanding of the mechanistic steps underlying tumor initiation and malignant progression is critical for insights of potentially novel therapeutic modalities. Cellular reprogramming is an approach of particular interest because it can provide a means to reset the differentiation state of the cancer cells ...

journal_title：Cell death & disease

authors： Yao J,Zhang L,Hu L,Guo B,Hu X,Borjigin U,Wei Z,Chen Y,Lv M,Lau JT,Wang X,Li G,Hu YP

更新日期：2016-07-28 00:00:00

abstract：:Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...

journal_title：Cell death & disease

authors： Cai S,Chen Y,Shang Y,Cui J,Li Z,Li Y

更新日期：2018-02-15 00:00:00

abstract：:Although many articles have uncovered that Wnt signaling is involved in radioresistance, the mechanism is rarely reported. Here we generated two radioresistant cells rECA109 and rKyse150 from parental esophageal cancer cells ECA109 and Kyse150. We then found that Wnt signaling activity was higher in radioresistant cel...

journal_title：Cell death & disease

authors： Zhao Y,Yi J,Tao L,Huang G,Chu X,Song H,Chen L

更新日期：2018-04-01 00:00:00

abstract：:Members of the transforming growth factor-β (TGF-β) superfamily participate in numerous biological phenomena in multiple tissues, including in cell proliferation, differentiation, and migration. TGF-β superfamily proteins therefore have prominent roles in wound healing, fibrosis, bone formation, and carcinogenesis. Ho...

journal_title：Cell death & disease

authors： Goto K,Tong KI,Ikura J,Okada H

更新日期：2011-12-01 00:00:00

abstract：:Correction to: NPG Asia Materials (2018) https://doi.org/10.1038/s41427-018-0014-9 published online on 16 April 2018. ...

journal_title：Cell death & disease

authors： Press E,Alaga KC,Barr K,Shao Q,Bosen F,Willecke K,Laird DW

更新日期：2018-05-24 00:00:00

abstract：:Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite...

journal_title：Cell death & disease

authors： Li Y,Zhang L,Qu T,Tang X,Li L,Zhang G

更新日期：2017-07-06 00:00:00

abstract：:Increasing studies showed that long-noncoding RNAs (lncRNAs) play important roles in the biological processes, including cancer initiation and progression. However, little is known about the exact role and regulation mechanism of lncRNA UCA1 during the progression of gastric cancer (GC). In this study, we found that U...

journal_title：Cell death & disease

authors： Gong P,Qiao F,Wu H,Cui H,Li Y,Zheng Y,Zhou M,Fan H

更新日期：2018-11-21 00:00:00

abstract：:The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target. Although this proposition is supported by the clinical success of proteasome inhibitors in some malignancies, most cancers are resistant to proteasome inhibition. The ...

journal_title：Cell death & disease

authors： Parzych K,Chinn TM,Chen Z,Loaiza S,Porsch F,Valbuena GN,Kleijnen MF,Karadimitris A,Gentleman E,Keun HC,Auner HW

更新日期：2015-12-31 00:00:00

abstract：:Proteases modulate critical processes in cutaneous tissue repair to orchestrate inflammation, cell proliferation and tissue remodeling. However, the functional consequences and implications in healing impairments of most cleavage events are not understood. Using iTRAQ-based Terminal Amine Isotopic Labeling of Substrat...

journal_title：Cell death & disease

authors： Sabino F,Madzharova E,Auf dem Keller U

更新日期：2020-08-21 00:00:00

abstract：:The pressure towards innovation and creation of new model systems in regenerative medicine and cancer research has fostered the development of novel potential therapeutic applications. Kidney injuries provoke a high request of organ transplants making it the most demanding system in the field of regenerative medicine....

journal_title：Cell death & disease

authors： Grassi L,Alfonsi R,Francescangeli F,Signore M,De Angelis ML,Addario A,Costantini M,Flex E,Ciolfi A,Pizzi S,Bruselles A,Pallocca M,Simone G,Haoui M,Falchi M,Milella M,Sentinelli S,Di Matteo P,Stellacci E,Gallucci M,

更新日期：2019-02-27 00:00:00

abstract：:The FDA-approved anti-androgen Enzalutamide (Enz) has been used successfully as the last line therapy to extend castration-resistant prostate cancer (CRPC) patients' survival by an extra 4.8 months. However, CRPC patients eventually develop Enz-resistance that may involve the induction of the androgen receptor (AR) sp...

journal_title：Cell death & disease

authors： Chou FJ,Lin C,Tian H,Lin W,You B,Lu J,Sahasrabudhe D,Huang CP,Yang V,Yeh S,Niu Y,Chang C

更新日期：2020-11-02 00:00:00

abstract：:Drug resistance is one of the major hurdles for cancer treatment. However, the underlying mechanisms are still largely unknown and therapeutic options remain limited. In this study, we show that microRNA (miR)-587 confers resistance to 5-fluorouracil (5-FU)-induced apoptosis in vitro and reduces the potency of 5-FU in...

journal_title：Cell death & disease

authors： Zhang Y,Talmon G,Wang J

更新日期：2015-08-06 00:00:00