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Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410.

Abstract：

:Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor growth, the underlying mechanisms are poorly understood. Here, we demonstrated for the first time that human umbilical cord MSCs (hUCMSCs) dramatically increased the growth of lung adenocarcinoma (LUAD) cancer cells in a xenograft tumor model. Then, we observed that hUCMSC-derived extracellular vesicles (hUCMSC-EVs) contribute to the hUCMSC-promoted LUAD cell growth through a direct effect on LUAD cells. Furthermore, we showed that hUCMSC-EV-mediated LUAD growth is associated with increased proliferation and decreased apoptosis in LUAD cells, concomitant with reduced PTEN expression mediated by the hUCMSC-EV-transmitted miR-410. Our findings provide novel insights into the intercellular communications between cancer cells and MSCs through MSC-EV-miRNA and suggest that modification of hUCMSC-EVs might be an attractive therapeutic option for the clinical application of hUCMSC-EVs that would reduce unwanted side effects.

journal_name

Cell Death Dis

journal_title

Cell death & disease

authors

Dong L,Pu Y,Zhang L,Qi Q,Xu L,Li W,Wei C,Wang X,Zhou S,Zhu J,Wang X,Liu F,Chen X,Su C

doi

10.1038/s41419-018-0323-5

subject

Has Abstract

pub_date

2018-02-13 00:00:00

pages

218

issue

2

issn

2041-4889

pii

10.1038/s41419-018-0323-5

journal_volume

9

pub_type

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